The effects of burimamide and metiamide on basal gastric function in the cat.

abstract：:1. A series of opioid agonists, antagonists and their (+)-stereoisomers were tested for antiarrhythmic activity in the rat coronary artery occlusion model. 2. Naloxone (0.01-2 mg kg-1) significantly reduced the incidence and severity of cardiac arrhythmias, in accordance with previous published studies. 3. The non-opi...

journal_title：British journal of pharmacology

authors： Sarne Y,Flitstein A,Oppenheimer E

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Adenosine is considered to be an important modulator of intestinal motility. This study was undertaken to investigate the role of adenosine in the modulation of contractility in the mouse duodenum and to characterize the adenosine receptor subtypes involved. EXPERIMENTAL APPROACH:RT-PCR was used...

journal_title：British journal of pharmacology

authors： Zizzo MG,Mastropaolo M,Lentini L,Mulè F,Serio R

更新日期：2011-11-01 00:00:00

abstract：:1. In mouse triangularis sterni nerve-muscle preparations, reduced extracellular Na+ concentrations and low concentrations of the Na+ channel blocking toxins tetrodotoxin (TTX, 18-36 nM) and mu-conotoxin GIIIB (0.4-2.0 microM) selectively decreased the amplitude of the component of perineural waveforms associated with...

journal_title：British journal of pharmacology

authors： Braga MF,Anderson AJ,Harvey AL,Rowan EG

更新日期：1992-05-01 00:00:00

abstract：:1. The effects of the nonpeptide angiotensin II receptor (AT) antagonists losartan and PD 123319 on actions of angiotensin II in the rat caudal artery and rat vas deferens preparations were investigated. 2. Angiotensin II (1.0 microM) increased perfusion pressure in isolated segments of the rat caudal artery. This inc...

journal_title：British journal of pharmacology

authors： Cox SL,Ben A,Story DF,Ziogas J

更新日期：1995-03-01 00:00:00

abstract：:1. The distribution of sympathetic adrenergic nerves on the rat middle cerebral artery and on the arterioles which originated from it was determined by use of gloxylic histochemistry. 2. Whereas the middle cerebral artery and proximal arterioles arising from this artery received a sympathetic innervation, the distal r...

journal_title：British journal of pharmacology

authors： Edwards FR,Hards D,Hirst GD,Silverberg GD

更新日期：1989-04-01 00:00:00

abstract：:1. In circular smooth muscle of the guinea-pig gastric fundus, transmural nerve stimulation evoked a cholinergic excitatory junction potential (e.j.p.), and blockade of the e.j.p. by atropine revealed a non-adrenergic non-cholinergic (NANC) inhibitory junction potential (i.j.p.). 2. The amplitude of the e.j.p. was inc...

journal_title：British journal of pharmacology

authors： Ohno N,Xue L,Yamamoto Y,Suzuki H

更新日期：1996-03-01 00:00:00

abstract：:The influence of endogenous and exogenous acidic amino acids on the binding of [3H]-MK-801, a selective, non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has been investigated in rat cerebral cortex crude synaptic membranes (CSM). Removal of endogenous glutamate and aspartate from CSM by repeated w...

journal_title：British journal of pharmacology

authors： Foster AC,Wong EH

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The homeostatic control of arterial BP is well understood with changes in BP resulting from changes in cardiac output (CO) and/or total peripheral resistance (TPR). A mechanism-based and quantitative analysis of drug effects on this interrelationship could provide a basis for the prediction of dr...

journal_title：British journal of pharmacology

authors： Snelder N,Ploeger BA,Luttringer O,Rigel DF,Webb RL,Feldman D,Fu F,Beil M,Jin L,Stanski DR,Danhof M

更新日期：2013-08-01 00:00:00

abstract：:1. The effects of varying H+ and other cation concentrations on phospholipase activity were investigated on two particulate fractions from human lung, corresponding to the mitochondrial and microsomal fractions. 2. Three 14C-labelled substrates, arachidonyl-phosphatidylcholine (PC), -phosphatidylethanolamine (PE) and ...

journal_title：British journal of pharmacology

authors： Yeats DA,Bakhle YS

更新日期：1990-07-01 00:00:00

abstract：:1. Release-regulating alpha 2-autoreceptors in human brain were characterized pharmacologically in cortical slices from patients undergoing neurosurgery to remove subcortical tumours; the slices were prelabelled with [3H]-noradrenaline ([3H]-NA) and stimulated electrically (3 Hz, 2 ms, 24 mA) under superfusion conditi...

journal_title：British journal of pharmacology

authors： Raiteri M,Bonanno G,Maura G,Pende M,Andrioli GC,Ruelle A

更新日期：1992-12-01 00:00:00

abstract：:The selective monoamine oxidase (MAO) inhibitors clorgyline, selegiline and AGN 1135 did not cause a change in responses of the cat nictitating membrane to preganglionic sympathetic nerve stimulation at 5 Hz. Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response t...

journal_title：British journal of pharmacology

authors： Finberg JP,Youdim MB

更新日期：1985-06-01 00:00:00

abstract：:Rat vas deferens preparations became desensitized to the alpha 1-adrenoceptor antagonist thymoxamine: after 6 h in vitro, the t 1/2 value (time to attain half the occupancy of receptors occupied at equilibrium) of the response to this drug was 1.50 fold greater in control strips (strips exposed to thymoxamine at 6 h) ...

journal_title：British journal of pharmacology

authors： Onnen I

更新日期：1984-09-01 00:00:00

abstract：:Rabbits treated with 2-deoxy-D-glucose (2DG) (300 mg/kg) show an increased intake of food and water. Pretreatment with haloperidol (1 mg/kg) abolishes the increase in water intake but does not prevent the increase in food intake. ...

journal_title：British journal of pharmacology

authors： Anderson J,Sharman DF,Stephens DB

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:High resting heart rate is a predictor for total and cardiovascular mortality independent of other risk factors in patients with coronary artery disease. We tested the hypothesis that a reduction of resting heart rate with the cardiac pacemaker I(f) current inhibitor ivabradine prevents the endot...

journal_title：British journal of pharmacology

authors： Drouin A,Gendron ME,Thorin E,Gillis MA,Mahlberg-Gaudin F,Tardif JC

更新日期：2008-06-01 00:00:00

abstract：:1. The present study was aimed to determine whether propranolol improves contractile function of the ischaemic/reperfused heart through protection of the mitochondrial function during ischaemia. 2. Isolated perfused rat hearts were subjected to 35-min ischaemia followed by 60-min reperfusion. Pre-treatment with propra...

journal_title：British journal of pharmacology

authors： Iwai T,Tanonaka K,Kasahara S,Inoue R,Takeo S

更新日期：2002-06-01 00:00:00

abstract：:1 The effects of indomethacin and eicosa-5,8,11,14-tetraynoic acid (ETYA) on the contractile response of the transmurally stimulated rabbit portal vein were studied in vitro.2 When the veins were stimulated for 240 pulses at 1 and 2 Hz, the responses were potentiated by indomethacin and ETYA. However, responses to 4 a...

journal_title：British journal of pharmacology

authors： Greenberg R

更新日期：1974-09-01 00:00:00

abstract：:1. The effects of low oxygen tension on tone and on the responsiveness to contractile and relaxant agents were examined on circumflex coronary artery rings isolated from sheep. 2. When artery rings (2-2.5 mm o.d.) were set at their optimal resting tension, introduction of hypoxia (0% O2) caused a sustained contraction...

journal_title：British journal of pharmacology

authors： Kwan YW,Wadsworth RM,Kane KA

更新日期：1989-04-01 00:00:00

abstract：:The monamine oxidase (MAO) inhibitors harmaline, tranylcypromine, deprenyl, clorgyline and iproniazid were injected intraperitoneally for five days to rabbits at doses that produced significant MAO inhibition. The first three inhibitors raised the concentrations of pyruvate and lactate in blood, decreased the activity...

journal_title：British journal of pharmacology

authors： Ali BH

更新日期：1985-12-01 00:00:00

abstract：:1. Fluoxetine (Prozac) is widely used as an antidepressant drug and is assumed to be a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor (SSRI). Claims that its beneficial psychotropic effects extend beyond those in treatment of depression have drawn clinical and popular attention to this compound, raising the q...

journal_title：British journal of pharmacology

authors： Tytgat J,Maertens C,Daenens P

更新日期：1997-12-01 00:00:00

abstract：:Drug induced long QT syndrome (LQTS) can lead to cardiac arrhythmias and sudden death, and has emerged as a worldwide problem. Most drugs that cause this are thought to directly block a specific cardiac ion channel (KCNH2 or hERG) that carries the rapidly activating delayed rectifier potassium current, I(Kr). In this ...

journal_title：British journal of pharmacology

authors： Eckhardt LL,Rajamani S,January CT

更新日期：2005-05-01 00:00:00

abstract：:Peroxynitrite, a potent oxidant formed by the reaction of nitric oxide and superoxide causes thymocyte necrosis, in part, via activation of the nuclear enzyme poly(ADP-ribose) synthetase (PARS). The cytotoxic PARS pathway initiated by DNA strand breaks and excessive PARS activation has been shown to deplete cellular e...

journal_title：British journal of pharmacology

authors： Virág L,Szabó C

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Animal models of drug-seeking suggest that exposure to cues associated with self-administered drugs and drug primes might precipitate relapse via activation of central dopaminergic substrates. EXPERIMENTAL APPROACH:The effects of priming injections of dopamine and 5-HT agonists on drug-seeking a...

journal_title：British journal of pharmacology

authors： Schenk S,Gittings D,Colussi-Mas J

更新日期：2011-04-01 00:00:00

abstract：:1 Dose-related increases in airways resistance (Raw) and decreases in dynamic lung compliance (Cdyn) were recorded in guinea-pigs and rats following intravenous injection of propranolol and of the cardioselective beta-adrenoceptor blocking drugs, atenolol and practolol. 2 The bronchoconstriction reached a peak in 2 to...

journal_title：British journal of pharmacology

authors： Maclagan J,Ney UM

更新日期：1979-07-01 00:00:00

abstract：:Current treatments of schizophrenia are compromised by their inability to treat all symptoms of the disease and their side-effects. Whilst existing antipsychotic drugs are effective against positive symptoms, they have negligible efficacy against the prefrontal cortex (PFC)-associated cognitive deficits and negative s...

journal_title：British journal of pharmacology

authors： Pratt JA,Winchester C,Egerton A,Cochran SM,Morris BJ

更新日期：2008-03-01 00:00:00

abstract：:Alcohol-use disorders are chronically relapsing conditions characterized by cycles of use, abstinence and relapse. The ventral pallidum (VP) is a key node in the neural circuits controlling relapse to alcohol seeking and a key target of pharmacotherapies for relapse prevention. There has been a significant increase in...

journal_title：British journal of pharmacology

authors： Prasad AA,McNally GP

更新日期：2020-09-01 00:00:00

abstract：:YM471, (Z)-4'-[4,4-difluoro-5-[2-(4-dimethylaminopiperidino)-2-oxoethylidene]-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl]-2-phenylbenzanilide monohydrochloride, is a newly synthesized potent vasopressin (AVP) receptor antagonist. Its effects on binding to and signal transduction by cloned human AVP receptors (V(1...

journal_title：British journal of pharmacology

authors： Tsukada J,Tahara A,Tomura Y,Wada Ki,Kusayama T,Ishii N,Yatsu T,Uchida W,Taniguchi N,Tanaka A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Montelukast and S-carbocysteine have been used in asthmatic patients as an anti-inflammatory or mucolytic agent respectively. S-carbocysteine also exhibits anti-inflammatory properties. EXPERIMENTAL APPROACH:Ovalbumin (OVA) sensitized BALB/c mice were challenged with OVA for 3 days followed by s...

journal_title：British journal of pharmacology

authors： Takeda K,Shiraishi Y,Matsubara S,Miyahara N,Matsuda H,Okamoto M,Joetham A,Gelfand EW

更新日期：2010-07-01 00:00:00

abstract：:1. The effects of 5-hydroxytryptamine (5-HT) uptake inhibitors, agonists and antagonists have been evaluated on mouse marble-burying behaviour, a putative test for anxiolytic agents. The high levels of locomotor activity occurring on first exposure to a circular runway (runway were used as a separate test of non-speci...

journal_title：British journal of pharmacology

authors： Njung'e K,Handley SL

更新日期：1991-09-01 00:00:00

abstract：:Knock-out (KO) mouse technology has given pharmacologists a powerful tool to study function in the absence of selective antagonists or inhibitors. Such KO technology can confirm predicted function, serendipitously reveal unrecognized function, or help define the mode of action of a drug. In this issue, Liles et al. de...

journal_title：British journal of pharmacology

authors： Docherty JR

更新日期：2007-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common age related neurodegenerative disease. Currently, there are no disease modifying drugs, existing therapies only offer short-term symptomatic relief. Two of the pathognomonic indicators of AD are the presence of extracellular protein aggregates consisting primarily of the Aβ ...

journal_title：British journal of pharmacology

authors： Kenche VB,Barnham KJ

更新日期：2011-05-01 00:00:00