Decreased synthesis of DNA in regenerating rat liver after the administration of reserpine.

abstract：BACKGROUND AND PURPOSE:Our team previously demonstrated that diabetes induces a deterioration in vascular dynamics, in parallel with the enhanced formation of advanced glycation end products. The aim of this study was to determine whether prevention of the arterial stiffening by pyridoxamine in diabetes is associated w...

journal_title：British journal of pharmacology

authors： Chang KC,Liang JT,Tsai PS,Wu MS,Hsu KL

更新日期：2009-08-01 00:00:00

abstract：:1. Inducible NO synthase (iNOS) expression and activity were measured in the mouse macrophage cell line J774 after exposure to bacterial lipopolysaccharide (LPS) with or without interferon-gamma (IFN-gamma). 2. Inhibition of NOS activity by concomitant N(G)-monomethyl-L-arginine (L-NMMA) treatment further increased iN...

journal_title：British journal of pharmacology

authors： Llovera M,Pearson JD,Moreno C,Riveros-Moreno V

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tumour cell migration and adhesion constitute essential features of metastasis. G-protein coupled receptor 55 (GPR55), a lysophospholipid receptor, has been shown to play an important role in carcinogenesis. Here, we investigated the involvement of GPR55 in migration and metastasis of colon cance...

journal_title：British journal of pharmacology

authors： Kargl J,Andersen L,Hasenöhrl C,Feuersinger D,Stančić A,Fauland A,Magnes C,El-Heliebi A,Lax S,Uranitsch S,Haybaeck J,Heinemann A,Schicho R

更新日期：2016-01-01 00:00:00

abstract：:Gut inflammation occurring in patients with inflammatory bowel diseases (IBD) is associated with an excessive immune response that is directed against constituents of the normal bacterial flora and results in the production of large amounts of inflammatory cytokines. Anti-cytokine compounds, such as the neutralizing T...

journal_title：British journal of pharmacology

authors： Caprioli F,Caruso R,Sarra M,Pallone F,Monteleone G

更新日期：2012-02-01 00:00:00

abstract：:1. To investigate the role of long-term stimulation of nicotinic acetylcholine receptors (AChRs) on the regulation of membrane potential, non-contracting C2C12 myotubes were stimulated for 1-4 days with carbachol (10 microM) and membrane potentials were measured by the intracellular microelectrode technique after wash...

journal_title：British journal of pharmacology

authors： Henning RH,Nelemans SA,van den Akker J,den Hertog A

更新日期：1994-02-01 00:00:00

abstract：:1. The signal transduction pathway for vasorelaxation induced by human alpha-calcitonin gene-related peptide (human alpha-CGRP) was studied in rat thoracic aortic rings preconstricted with noradrenaline (10(-7) M). 2. Vasorelaxation by human alpha-CGRP was inhibited by haemoglobin (10(-6) M) and methylene blue (10(-5)...

journal_title：British journal of pharmacology

authors： Gray DW,Marshall I

更新日期：1992-11-01 00:00:00

abstract：:1. The effects of cocaine, 6-hydroxydopamine (6-OHDA), reserpine and 17-beta-oestradiol on the sensitivity of the rat anococcygeus muscle to noradrenaline (NA), acetylcholine (ACh) and KCl were investigated.2. Cocaine (10(-5)M) increased the sensitivity of the anococcygeus to NA (100-fold) but not to ACh or KCl.3. 6-O...

journal_title：British journal of pharmacology

authors： Gibson A,Pollock D

更新日期：1973-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although botulinum toxin type A (BoNT/A) is approved for chronic migraine treatment, its mechanism of action is still unknown. Dural neurogenic inflammation (DNI) commonly used to investigate migraine pathophysiology can be evoked by trigeminal pain. Here, we investigated the reactivity of crania...

journal_title：British journal of pharmacology

authors： Lacković Z,Filipović B,Matak I,Helyes Z

更新日期：2016-01-01 00:00:00

abstract：:1. The effects of melanotrophin release inhibiting factor (MIF) and its cyclic analogue cyclo (Leu-Gly) on tolerance to the analgesic effect of morphine were studied in male Sprague-Dawley rats. 2. Tolerance to morphine was induced by implantation of four morphine pellets (each containing 75 mg of morphine free base) ...

journal_title：British journal of pharmacology

authors： Bhargava HN

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Animal models of drug-seeking suggest that exposure to cues associated with self-administered drugs and drug primes might precipitate relapse via activation of central dopaminergic substrates. EXPERIMENTAL APPROACH:The effects of priming injections of dopamine and 5-HT agonists on drug-seeking a...

journal_title：British journal of pharmacology

authors： Schenk S,Gittings D,Colussi-Mas J

更新日期：2011-04-01 00:00:00

abstract：:1. The effect of intravenous administration of dexamphetamine [+)-Amp) on rat pupil diameter was investigated. In all experiments, the vagosympathetic trunks were sectioned bilaterally at the cervical level. 2. In rats anaesthetized with urethane, (+)-Amp (0.1-0.3 mg kg-1, i.v.) produced a dose-related increase in pup...

journal_title：British journal of pharmacology

authors： Hey JA,Ito T,Koss MC

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N-arachidonoyl 5-HT (NA-5HT) has anti-nociceptive effects reported to be mediated by inhibitory actions at the transient receptor potential vanilloid receptor 1 (TRPV1) and fatty acid amide hydrolase (FAAH). Anandamide and N-arachidonoyl dopamine (NA-DA), endocannabinoids that activate TRPV1 or a...

journal_title：British journal of pharmacology

authors： Gilmore AJ,Heblinski M,Reynolds A,Kassiou M,Connor M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Orally administered withanoside IV (a compound isolated from the roots of Withania somnifera) improved memory deficits in mice with a model of Alzheimer's disease induced by the amyloid peptide Abeta(25-35). Sominone, an aglycone of withanoside IV, was identified as an active metabolite after ora...

journal_title：British journal of pharmacology

authors： Tohda C,Joyashiki E

更新日期：2009-08-01 00:00:00

abstract：:GR231118 (also known as 1229U91 and GW1229), a purported Y(1) antagonist and Y(4) agonist was radiolabelled using the chloramine T method. [(125)I]-GR231118 binding reached equilibrium within 10 min at room temperature and remained stable for at least 4 h. Saturation binding experiments showed that [(125)I]-GR231118 b...

journal_title：British journal of pharmacology

authors： Dumont Y,Quirion R

更新日期：2000-01-01 00:00:00

abstract：:Following the discovery of the first effective antiviral compound (idoxuridine) in 1959, nucleoside analogues, especially acyclovir (ACV) for the treatment of herpesvirus infections, have dominated antiviral therapy for several decades. However, ACV and similar acyclic nucleosides suffer from low aqueous solubility an...

journal_title：British journal of pharmacology

authors： De Clercq E,Field HJ

更新日期：2006-01-01 00:00:00

abstract：:1. Simultaneous computer modelling of control and guanfacine-masked [3H]-MK 912 saturation curves as well as guanfacine competition curves revealed that the drugs bound to two alpha 2-adrenoceptor subtypes in the rat cerebral cortex with very different selectivities. These alpha 2-adrenoceptor subtypes were designated...

journal_title：British journal of pharmacology

authors： Uhlén S,Xia Y,Chhajlani V,Felder CC,Wikberg JE

更新日期：1992-08-01 00:00:00

abstract：:A new arylamino-pyridazine gamma-aminobutyric acid (GABA) derivative, SR 42641, has been tested for its ability to antagonize the actions of GABA on mammalian sensory neurones. SR 42641 and bicuculline reversibly decreased GABAA-induced depolarizations and currents recorded intracellularly from dorsal root ganglion ne...

journal_title：British journal of pharmacology

authors： Desarmenien M,Desaulles E,Feltz P,Hamann M

更新日期：1987-02-01 00:00:00

abstract：:We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by alpha-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages. DFMO potentiated LPS-stimulated nitrite production in both a concentration- and t...

journal_title：British journal of pharmacology

authors： Baydoun AR,Morgan DM

更新日期：1998-12-01 00:00:00

abstract：:1. The effect of several metabotropic ligands and di- or tripeptides were tested on the binding of [3H]-L(+)-2-amino-4-phosphonobutyric acid ([3H]-L-AP4) on rat mGlu4 receptor. For selected compounds, the functional activity was determined on this receptor using the guanosine-5'[gamma-35S]-thiotriphosphate [gamma-35S]...

journal_title：British journal of pharmacology

authors： Monastyrskaia K,Lundstrom K,Plahl D,Acuna G,Schweitzer C,Malherbe P,Mutel V

更新日期：1999-11-01 00:00:00

abstract：:There are proposals for the implementation of beta(2)-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that beta(2)-adrenoceptor agonists cause hypertrophy of skeletal muscle. Their use in clinical practice will also need an underst...

journal_title：British journal of pharmacology

authors： Molenaar P,Chen L,Parsonage WA

更新日期：2006-03-01 00:00:00

abstract：:Conductance increases to gamma-aminobutyric acid (GABA) were recorded in the gm6b and opener muscle of the spiny lobsters, Panulirus interruptus and P. argus. GABA-evoked responses were insensitive to picrotoxin at concentrations as high as 5 X 10(-5) M. Some blockade by picrotoxin was observed at higher concentration...

journal_title：British journal of pharmacology

authors： Albert J,Lingle CJ,Marder E,O'Neil MB

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The locus coeruleus (LC) is a major source of noradrenergic projections to the dorsal spinal cord, and thereby plays an important role in the modulation of nociceptive information. The LC receives inputs from substance P (SP)-containing fibres from other regions, and expresses the NK(1) tachykin...

journal_title：British journal of pharmacology

authors： Muto Y,Sakai A,Sakamoto A,Suzuki H

更新日期：2012-06-01 00:00:00

abstract：:The effects of injection of 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA) and N-ethyl-3,4-methylenedioxyamphetamine (MDEA) (all 20 mg kg(-1)) on blood pressure, heart rate, core body temperature and locomotor activity in conscious rats were investigated using radiotelemetry. MDMA and MD...

journal_title：British journal of pharmacology

authors： Bexis S,Docherty JR

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Voltage-gated sodium channels (VGSCs) are assembled from two classes of subunits, a pore-bearing α-subunit (NaV 1) and one or two accessory β-subunits (NaV βs). Neurons in mammals can express one or more of seven isoforms of NaV 1 and one or more of four isoforms of NaV β. The peptide μ-conotoxin...

journal_title：British journal of pharmacology

authors： Zhang MM,Wilson MJ,Azam L,Gajewiak J,Rivier JE,Bulaj G,Olivera BM,Yoshikami D

更新日期：2013-04-01 00:00:00

abstract：:1. We have characterized the human smooth muscle endothelin converting enzyme (ECE) present in the media of the endothelium-denuded human umbilical vein preparation. 2. Endothelin-1 (ET-1) and ET-2 were potent constrictors of umbilical vein with EC50 values of 9.2 nM and 29.6 nM, respectively. ET-1 was at least 30 tim...

journal_title：British journal of pharmacology

authors： Maguire JJ,Johnson CM,Mockridge JW,Davenport AP

更新日期：1997-12-01 00:00:00

abstract：:1. A quantitative in vitro study has been made of the actions of glyceryl trinitrate and sodium nitrite on vascular smooth muscle (dog femoral artery and saphenous vein; rat portal vein); these have been compared with the actions of papaverine, isoprenaline, salbutamol, pentaerythritol tetranitrate and trimetazidine. ...

journal_title：British journal of pharmacology

authors： Mackenzie JE,Parratt JR

更新日期：1977-05-01 00:00:00

abstract：:1 The spasmogenic and spasmolytic effects of beta-lipotropin (LPH) fragments and one analogue were investigated on different parts of the gastro-intestinal tract of guinea-pig and rat in vitro.2 Changes in muscle tone were observed in colon and rectum and to a lesser extent in jejunum and ileum of both species. Rat co...

journal_title：British journal of pharmacology

authors： Nijkamp FP,Van Ree JM

更新日期：1980-04-01 00:00:00

abstract：:1. Arachidonic acid caused larger contractions to indomethacin-tested guinea-pig trachea than in control tracheae. 2. No change in contractions was obtained in tracheae treated with 5,8, 11, 14, eicosatetraynoic acid (ETYA 10 micro M). 3. ETYA (100 micro M) blocked the effect of indomethacin on arachidonic acid-induce...

journal_title：British journal of pharmacology

authors： Mitchell HW

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In the setting of nitrate tolerance, endothelium-dependent relaxation is reduced in several types of peripheral vessels. However, it is unknown whether chronic in vivo administration of nitroglycerine modulates such relaxation in cerebral arteries. EXPERIMENTAL APPROACH:Isometric force and smoot...

journal_title：British journal of pharmacology

authors： Watanabe Y,Kusama N,Itoh T

更新日期：2008-01-01 00:00:00

abstract：:1. In rat aortic rings contracted by phenylephrine, the relaxation induced by isoprenaline was partly inhibited by iberiotoxin, (ibTX), tetraethylammonium, 4-aminopyridine (4-AP) and 1,9-dideoxyforskolin, but not by glibenclamide. 2. In the presence of 4-AP, 1,9-dideoxyforskolin failed to inhibit further the relaxant ...

journal_title：British journal of pharmacology

authors： Satake N,Shibata M,Shibata S

更新日期：1996-10-01 00:00:00