The effects of drugs on the sensitivity of the rat anococcygeus muscle to agonists.

abstract：:The position of dose-response curves for histamine-induced accumulation of [3H]-inositol 1-phosphate ([3H]-IP1) in lithium-treated slices of guinea-pig brain prelabelled with [3H]-inositol differed significantly between cerebellum (EC50 5.1 +/- 1.0 microM) and cerebral cortex (EC50 16.3 +/- 0.7 microM). The Hill coeff...

journal_title：British journal of pharmacology

authors： Carswell H,Young JM

更新日期：1986-12-01 00:00:00

abstract：:A large range of neuroadaptations develop in response to chronic opioid exposure and these are thought to be more or less critical for expression of the major features of opioid addiction: tolerance, withdrawal and processes that may contribute to compulsive use and relapse. This review considers these adaptations at ...

journal_title：British journal of pharmacology

authors： Christie MJ

更新日期：2008-05-01 00:00:00

abstract：:1. The present study was designed to characterize the nociceptive response induced by protein kinase C (PKC) peripheral activation and to investigate if this biochemical event is important for the nociceptive response induced by formaldehyde, and bradykinin (BK). 2. Intraplantar injection of phorbol-12,13-didecanoate ...

journal_title：British journal of pharmacology

authors： Souza AL,Moreira FA,Almeida KR,Bertollo CM,Costa KA,Coelho MM

更新日期：2002-01-01 00:00:00

abstract：:1. The effect of mastoparan on phosphatidylcholine hydrolysis was examined in 1321N1 human astrocytoma cells. Mastoparan (3-30 microM) caused an accumulation of diacylglycerol (DG) and phosphatidic acd (PA) accompanied by choline release in a concentration- and time-dependent manner. 2. In the presence of 2% n-butanol...

journal_title：British journal of pharmacology

authors： Mizuno K,Nakahata N,Ohizumi Y

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Translation of non-clinical markers of delayed ventricular repolarization to clinical prolongation of the QT interval corrected for heart rate (QTc) (a biomarker for torsades de pointes proarrhythmia) remains an issue in drug discovery and regulatory evaluations. We retrospectively analysed 150 d...

journal_title：British journal of pharmacology

authors： Park E,Gintant GA,Bi D,Kozeli D,Pettit SD,Pierson JB,Skinner M,Willard J,Wisialowski T,Koerner J,Valentin JP

更新日期：2018-02-01 00:00:00

abstract：:1. The vascular effects of endothelin and localization of endothelin-like immunoreactivity were characterized in isolated cerebral arteries of dogs. 2. Endothelin-like immunoreactivity was detected in a few populations of endothelial cells of dog basilar artery. 3. Endothelin-1, endothelin-2 and endothelin-3 contracte...

journal_title：British journal of pharmacology

authors： Saito A,Shiba R,Yanagisawa M,Masaki T,Kimura S,Yamada K,Mima T,Shigeno T,Goto K

更新日期：1991-05-01 00:00:00

abstract：:1. In the zymosan rat air pouch model of inflammation we have assessed the time dependence of phospholipase A2 (PLA2) accumulation in the inflammatory exudates as well as cell migration, myeloperoxidase activity, prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) levels. 2. A significant increase in PLA2 activity was d...

journal_title：British journal of pharmacology

authors： Payá M,Terencio MC,Ferrándiz ML,Alcaraz MJ

更新日期：1996-04-01 00:00:00

abstract：:1. We have investigated the in vitro interaction between chloride ions and endothelium as revealed by alterations in vascular contractility and smooth muscle cell membrane potential in isolated pulmonary arteries from Dahl salt-resistant normotensive and salt-sensitive hypertensive rats. 2. Exposure to nitro-l-arginin...

journal_title：British journal of pharmacology

authors： Bieger D,Duggan JA,Tabrizchi R

更新日期：2004-03-01 00:00:00

abstract：:1. The profiles of cyclo-oxygenase (COX) and nitric oxide synthase (NOS) isoforms were determined in the rat carrageenin-induced pleurisy model of acute inflammation. 2. The enzymes were assessed in peripheral blood leucocyte (PBL) cell pellets taken from untreated animals and at 2, 6 and 24 h after injection of the i...

journal_title：British journal of pharmacology

authors： Tomlinson A,Appleton I,Moore AR,Gilroy DW,Willis D,Mitchell JA,Willoughby DA

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Histamine modulates several behaviours and physiological functions, and its deficiency is associated with neuropsychiatric disorders. Gestational intake of valproic acid (VPA) is linked to autism spectrum disorder (ASD), characterized by impaired sociability and stereotypies. VPA effects on the n...

journal_title：British journal of pharmacology

authors： Baronio D,Puttonen HAJ,Sundvik M,Semenova S,Lehtonen E,Panula P

更新日期：2018-03-01 00:00:00

abstract：:It is well documented that metabolic syndrome (i.e. a group of risk factors, such as abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides and low cholesterol level in high-density lipoprotein), which raises the risk for heart disease and diabetes, is associated with inc...

journal_title：British journal of pharmacology

authors： Pechánová O,Varga ZV,Cebová M,Giricz Z,Pacher P,Ferdinandy P

更新日期：2015-03-01 00:00:00

abstract：:1. Nociceptive thresholds to noxious mechanical (paw pressure) and thermal (tail flick) stimuli were recorded in conscious rats. The effects of three selective kappa-opioid receptor agonists on the responses to these stimuli were determined following intravenous, intracerebroventricular or intrathecal administration. ...

journal_title：British journal of pharmacology

authors： Leighton GE,Rodriguez RE,Hill RG,Hughes J

更新日期：1988-03-01 00:00:00

abstract：:A new C5a receptor antagonist, the cyclic peptide Phe-[Orn-Pro-D-cyclohexylalanine-Trp-Arg], (F-[OPdChaWR]), was tested for its ability to antagonize the neutropenic effects of both C5a and endotoxin in rats. Human recombinant C5a (2 microg kg(-1) i.v.) caused rapid neutropenia, characterized by an 83% decrease in cir...

journal_title：British journal of pharmacology

authors： Short A,Wong AK,Finch AM,Haaima G,Shiels IA,Fairlie DP,Taylor SM

更新日期：1999-02-01 00:00:00

abstract：LINKED ARTICLES:This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc. ...

journal_title：British journal of pharmacology

authors： Summers RJ

更新日期：2017-05-01 00:00:00

abstract：:1. Leptin, a pleiotropic hormone believed to regulate body weight, has recently been associated with inflammatory states and immune activity. Here we have studied the effect of leptin on expression of IFN-gamma-induced nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2), both prominent markers of macrophage act...

journal_title：British journal of pharmacology

authors： Raso GM,Pacilio M,Esposito E,Coppola A,Di Carlo R,Meli R

更新日期：2002-11-01 00:00:00

abstract：:Alcohol-use disorders are chronically relapsing conditions characterized by cycles of use, abstinence and relapse. The ventral pallidum (VP) is a key node in the neural circuits controlling relapse to alcohol seeking and a key target of pharmacotherapies for relapse prevention. There has been a significant increase in...

journal_title：British journal of pharmacology

authors： Prasad AA,McNally GP

更新日期：2020-09-01 00:00:00

abstract：:1. The interaction between endogenous nitric oxide (NO) and factors from the rat submandibular salivary gland such as epidermal growth factor (EGF) on gastric mucosal integrity in the rat has been investigated. 2. Bolus administration of the NO synthase inhibitor, NG nitro-L-arginine methyl ester (L-NAME; 6.25-50 mg k...

journal_title：British journal of pharmacology

authors： Tepperman BL,Soper BD

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:7-Ketocholesterol, an oxysterol present in atherosclerotic lesions, induces smooth muscle cell (SMC) death, thereby destabilizing plaques. Statins protect patients from myocardial infarction, though they induce SMC apoptosis. We investigated whether statins and 7-ketocholesterol exerted additive ...

journal_title：British journal of pharmacology

authors： Martinet W,Schrijvers DM,Timmermans JP,Bult H

更新日期：2008-07-01 00:00:00

abstract：:Irritable bowel syndrome is characterized by visceral hyperalgesia commonly associated with stress and inflammatory processes. We investigated the role of tachykinin NK2 receptors in the ability of trinitrobenzenesulphonic acid (TNBS) and stress to enhance the sensitivity of the rat rectum to distension using a select...

journal_title：British journal of pharmacology

authors： Toulouse M,Coelho AM,Fioramonti J,Lecci A,Maggi C,Buéno L

更新日期：2000-01-01 00:00:00

abstract：:The effect of a substance P antagonist, [D-Pro2, D-Trp7,9]-substance P (SPA), on gastric emptying and gastrointestinal transit in the rat was studied in order to elucidate a possible physiological role of endogenous substance P and other tachykinins in gastrointestinal motility. SPA was given by intraperitoneal inject...

journal_title：British journal of pharmacology

authors： Holzer P,Holzer-Petsche U,Leander S

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:P2X(7), receptors are potently inhibited by extracellular acidification. The underlying molecular basis remains unknown. This study aimed to examine the role of extracellular histidine, lysine, aspartic acid and glutamic acid residues in the functional inhibition of rat P2X(7) receptors by acidic...

journal_title：British journal of pharmacology

authors： Liu X,Ma W,Surprenant A,Jiang LH

更新日期：2009-01-01 00:00:00

abstract：:1. The vascular actions of the proteinase-activated receptor-2-activating peptides (PAR2APs), SLIGRL-NH2 (SL-NH2) and SLIGKV-NH2 (KV-NH2) as well as the reverse-sequence peptide, LSIGRL-NH2 (LS-NH2) and an N-acylated PAR2AP derivative, trans-cinnamoyl-LIGRLO-NH2 (tcLI-NH2), were studied in rat intact and endothelium-d...

journal_title：British journal of pharmacology

authors： Roy SS,Saifeddine M,Loutzenhiser R,Triggle CR,Hollenberg MD

更新日期：1998-04-01 00:00:00

abstract：:1. The aim of this study was to investigate the relationship between airway reactivity, leukocyte influx and nitric oxide (NO), in conscious guinea-pigs after aerosolized lipopolysaccharide (LPS) exposure. 2. Inhaled histamine (1 mM, 20 s), causing no bronchoconstriction before LPS exposure (30 microg ml(-1), 1 h), ca...

journal_title：British journal of pharmacology

authors： Toward TJ,Broadley KJ

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N-type voltage-gated calcium (Cav 2.2) channels are critical determinants of increased neuronal excitability and neurotransmission accompanying persistent neuropathic pain. Although Cav 2.2 channel antagonists are recommended as first-line treatment for neuropathic pain, calcium-current blocking ...

journal_title：British journal of pharmacology

authors： Moutal A,Li W,Wang Y,Ju W,Luo S,Cai S,François-Moutal L,Perez-Miller S,Hu J,Dustrude ET,Vanderah TW,Gokhale V,Khanna M,Khanna R

更新日期：2018-06-01 00:00:00

abstract：:1. We examined the effects of selective and nonselective cyclo-oxygenase (COX) inhibitors on various functional changes in the rat stomach induced by topical application of taurocholate (TC) and investigated the preferential role of COX isozymes in these responses. 2. Rat stomachs mounted in ex vivo chambers were perf...

journal_title：British journal of pharmacology

authors： Hirata T,Ukawa H,Yamakuni H,Kato S,Takeuchi K

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inhibitory junction potentials (IJP) are responsible for smooth muscle relaxation in the gastrointestinal tract. The aim of this study was to pharmacologically characterize the neurotransmitters [nitric oxide (NO) and adenosine triphosphate (ATP)] and receptors involved at the inhibitory neuromus...

journal_title：British journal of pharmacology

authors： Grasa L,Gil V,Gallego D,Martín MT,Jiménez M

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Munich Wistar Frömter (MWF) rat strain represents an experimental model to study cardiovascular alterations under conditions of progressive albuminuria. The aim of this study was to evaluate the association between genetic predisposition to albuminuria and the development of arterial stiffnes...

journal_title：British journal of pharmacology

authors： Gil-Ortega M,García-Prieto CF,Ruiz-Hurtado G,Steireif C,González MC,Schulz A,Kreutz R,Fernández-Alfonso MS,Arribas S,Somoza B

更新日期：2015-09-01 00:00:00

abstract：:1. (+)-Tubocurarine, hexamethonium, atropine, ouabain, and removal of potassium from the bathing medium were examined for their effects on indirectly evoked twitches (IT) of mouse phrenic nerve-diaphragm muscles in the presence or absence of neostigmine. 2. Neostigmine increased the amplitude of IT. The twitch potenti...

journal_title：British journal of pharmacology

authors： Nishimura M,Ohtani H,Yagasaki O

更新日期：1989-01-01 00:00:00

abstract：:1. Des-Arg9 bradykinin (DAB), a classical B1-kinin receptor agonist was without effect when applied to the basolateral surface of rat isolated colon epithelium. Three hours after tissues were isolated DAB caused, after a delay of up to 2 min, a maintained increase of short circuit current (SCC). 2. The SCC increase in...

journal_title：British journal of pharmacology

authors： Teather S,Cuthbert AW

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Voltage-gated sodium channels (VGSCs) are assembled from two classes of subunits, a pore-bearing α-subunit (NaV 1) and one or two accessory β-subunits (NaV βs). Neurons in mammals can express one or more of seven isoforms of NaV 1 and one or more of four isoforms of NaV β. The peptide μ-conotoxin...

journal_title：British journal of pharmacology

authors： Zhang MM,Wilson MJ,Azam L,Gajewiak J,Rivier JE,Bulaj G,Olivera BM,Yoshikami D

更新日期：2013-04-01 00:00:00