Induction of bradykinin B1 receptors in rat colonic epithelium.

abstract：:1. The action of substance P (SP) on the release of gamma-aminobutyric acid (GABA) and acetylcholine (ACh) and on contraction were studied in strips of the guinea-pig urinary bladder. Substance P induced a dose-dependent contraction of strips of guinea-pig urinary bladder (EC50 = 1.2 x 10(-9) M). This contraction was ...

journal_title：British journal of pharmacology

authors： Shirakawa J,Nakanishi T,Taniyama K,Kamidono S,Tanaka C

更新日期：1989-10-01 00:00:00

abstract：:Recent advances have improved our understanding of the renin-angiotensin system (RAS). These have included the recognition that angiotensin (Ang)-(1-7) is a biologically active product of the RAS cascade. The identification of the ACE homologue ACE2, which forms Ang-(1-7) from Ang II, and the GPCR Mas as an Ang-(1-7) ...

journal_title：British journal of pharmacology

authors： Simões e Silva AC,Silveira KD,Ferreira AJ,Teixeira MM

更新日期：2013-06-01 00:00:00

abstract：:1 We have examined the effect of the histone deacetylase inhibitors apicidin, trichostatin A (TSA) and n-butyrate on the histone acetylation and the differentiation of human eosinophilic leukemia HL-60 clone 15 cells into eosinophils. 2 Viability of the cells incubated with apicidin (100 nm), TSA (30 nm) or n-butyrate...

journal_title：British journal of pharmacology

authors： Ishihara K,Hong J,Zee O,Ohuchi K

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Palmitoylethanolamide (PEA) is an endogenous congener of anandamide and potentiates its actions at cannabinoid CB1 and CB2 receptors, and at transient receptor potential vanilloid type-1 (TRPV1) channels. The other endocannabinoid, 2-arachidonoylglycerol (2-AG), was recently suggested to act as a...

journal_title：British journal of pharmacology

authors： Petrosino S,Schiano Moriello A,Cerrato S,Fusco M,Puigdemont A,De Petrocellis L,Di Marzo V

更新日期：2016-04-01 00:00:00

abstract：:1. The central and regional cardiovascular responses to intravenous (0.3, 1.0, 3.0 and 10.0 micrograms kg-1 min-1) and intracoronary (0.3, 0.9, 3.0 and 4.5 micrograms kg-1 min-1) infusions of elgodipine, a phenyldihydropyridine, and its solvent were studied in anaesthetized pigs. 2. Elgodipine (i.v.) caused dose-depen...

journal_title：British journal of pharmacology

authors： Sassen LM,Soei LK,Koning MM,Verdouw PD

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ajmaline is a widely used antiarrhythmic drug. Its action on voltage-gated ion channels in skeletal muscle is not well documented and we have here elucidated its effects on Na(+) and K(+) channels. EXPERIMENTAL APPROACH:Sodium (I(Na)) and potassium (I(K)) currents in amphibian skeletal muscle fi...

journal_title：British journal of pharmacology

authors： Friedrich O,V Wegner F,Wink M,Fink RH

更新日期：2007-05-01 00:00:00

abstract：:Three neurotoxin homologues (CM10 and CM12 from Naja haje annulifera and S5C10 from Dendroaspis jamesoni kaimosae) and two short neurotoxins (CM14 from Naja haje annulifera and erabutoxin b from Laticauda semifasciata) were examined by circular dichroism (c.d.) and tested for neuromuscular activity on chick biventer c...

journal_title：British journal of pharmacology

authors： Harvey AL,Hider RC,Hodges SJ,Joubert FJ

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Microglial phenotype and phagocytic activity are deregulated in Parkinson's disease (PD). PPARγ agonists are neuroprotective in experimental PD, but their role in regulating microglial phenotype and phagocytosis has been poorly investigated. We addressed it by using the PPARγ agonist MDG548. EXP...

journal_title：British journal of pharmacology

authors： Lecca D,Janda E,Mulas G,Diana A,Martino C,Angius F,Spolitu S,Casu MA,Simbula G,Boi L,Batetta B,Spiga S,Carta AR

更新日期：2018-08-01 00:00:00

abstract：:1. The goal of this study was to investigate the effects of the delayed pharmacological preconditioning produced by an adenosine A(1)-receptor agonist (A(1)-DPC) against ventricular arrhythmias induced by ischaemia and reperfusion, compared to those of ischaemia-induced delayed preconditioning (I-DPC). 2. Eighty-nine ...

journal_title：British journal of pharmacology

authors： Tissier R,Souktani R,Parent de Curzon O,Lellouche N,Henry P,Giudicelli JF,Berdeaux A,Ghaleh B

更新日期：2001-12-01 00:00:00

abstract：:Two structurally distinct peptides, angiotensin IV and LVV-haemorphin 7, both competitive high-affinity inhibitors of insulin-regulated aminopeptidase (IRAP), were found to enhance aversion-associated and spatial memory in normal rats and to improve performance in a number of memory tasks in rat deficits models. These...

journal_title：British journal of pharmacology

authors： Albiston AL,Diwakarla S,Fernando RN,Mountford SJ,Yeatman HR,Morgan B,Pham V,Holien JK,Parker MW,Thompson PE,Chai SY

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:An alteration in the communication between the innate and adaptive immune cells is a hallmark of ulcerative colitis (UC). Semaphorin-3E (SEMA3E), a secreted guidance protein, regulates various immune responses. EXPERIMENTAL APPROACH:We investigated the expression of SEMA3E in colonic biopsies of...

journal_title：British journal of pharmacology

authors： Kermarrec L,Eissa N,Wang H,Kapoor K,Diarra A,Gounni AS,Bernstein CN,Ghia JE

更新日期：2019-05-01 00:00:00

abstract：:1. Prolongation of action potentials by cooling or pharmacological treatment can restore conduction in demyelinated axons. We have assessed the ability of pyrethroids (in vitro) to modify action potential kinetics and to reverse conduction block in lesioned peripheral nerve. 2. Fast Na+ currents were isolated in mamma...

journal_title：British journal of pharmacology

authors： Lees G

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Na+/Ca2+ exchanger (NCX) may contribute to triggered activity and transmural dispersion of repolarization, which are substrates of torsades de pointes (TdP) type arrhythmias. This study examined the effects of selective inhibition of the NCX by SEA0400 on the occurrence of dofetilide-induced ...

journal_title：British journal of pharmacology

authors： Farkas AS,Makra P,Csík N,Orosz S,Shattock MJ,Fülöp F,Forster T,Csanády M,Papp JG,Varró A,Farkas A

更新日期：2009-03-01 00:00:00

abstract：:1. The cyclic nucleotide phosphodiesterase (PDE) of guinea-pig eosinophils was partially characterized and the effects of selective inhibitors of PDE isoenzymes upon opsonized zymosan (OZ)-stimulated respiratory burst were studied. 2. PDE activity in eosinophil lysates appeared to be membrane-associated, displayed sub...

journal_title：British journal of pharmacology

authors： Dent G,Giembycz MA,Rabe KF,Barnes PJ

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:11β-hydroxysteroid dehydrogenase type I (11β-HSD1), a target for Type 2 diabetes mellitus, converts inactive glucocorticoids into bioactive forms, increasing tissue concentrations. We have compared the pharmacokinetic-pharmacodynamic (PK/PD) relationship of target inhibition after acute and repea...

journal_title：British journal of pharmacology

authors： Morentin Gutierrez P,Gyte A,deSchoolmeester J,Ceuppens P,Swales J,Stacey C,Eriksson JW,Sjöstrand M,Nilsson C,Leighton B

更新日期：2015-10-01 00:00:00

abstract：:1. The relationship between the capacity of the chick biventer preparation, both intact tissue and homogenate, to inactivate acetylcholine and the ability of eserine to increase the sensitivity of the tissue to acetylcholine have been investigated.2. At concentrations of eserine of 2.69 x 10(-9)M and 2.69 x 10(-8)M th...

journal_title：British journal of pharmacology

authors： Baldwin DW,Lesser E

更新日期：1971-07-01 00:00:00

abstract：:Cyclo-oxygenase (COX) inhibitors potentiate opioid inhibition of GABAergic synaptic transmission in rat periaqueductal grey (PAG) (Vaughan et al., 1997). In the present study, the relative contribution of cyclo-oxygenase-1 (COX-1) and COX-2 inhibition to this phenomenon was examined by use of whole-cell patch clamp re...

journal_title：British journal of pharmacology

authors： Vaughan CW

更新日期：1998-04-01 00:00:00

abstract：:1. The effect of purified crotapotin, a non-toxic non-enzymatic chaperon protein normally complexed to a phospholipase A2 (PLA2) in South America rattlesnake venom, was studied in the acute inflammatory response induced by carrageenin (1 mg/paw), compound 48/80 (3 micrograms/paw) and 5-hydroxytryptamine (5-HT) (3 micr...

journal_title：British journal of pharmacology

authors： Landucci EC,Antunes E,Donato JL,Faro R,Hyslop S,Marangoni S,Oliveira B,Cirino G,de Nucci G

更新日期：1995-02-01 00:00:00

abstract：:1 Amodiaquine was found to be a potent inhibitor in vitro of gastric histamine methyltransferase from human and canine corpus and from pig antrum. The ID50 for the enzyme, purified from pig antrum mucosa by ultracentrifugation and chromatography on DEAE-cellulose, was 2.5 muM. 2 In six dogs with Heidenhanin pouches th...

journal_title：British journal of pharmacology

authors： Barth H,Lorenz W,Troidl H

更新日期：1975-11-01 00:00:00

abstract：:1. Murine left atrium lacks inotropic beta(2)-adrenoceptor function. We investigated whether beta(2)-adrenoceptors are involved in the cardiostimulant effects of (-)-adrenaline on spontaneously beating right atria and paced right ventricular myocardium of C57BL6 mice. We also studied a negative inotropic effect of (-)...

journal_title：British journal of pharmacology

authors： Heubach JF,Rau T,Eschenhagen T,Ravens U,Kaumann AJ

更新日期：2002-05-01 00:00:00

abstract：:1. The measurement of changes in spike generation and membrane resistance in the guinea-pig taenia coli, using the sucrose gap extracellular recording method, has been shown to be a useful way to demonstrate the intrinsic sympathomimetic activity of the beta adrenoceptor blocking agents.2. Pronethalol, INPEA, MJ 1999,...

journal_title：British journal of pharmacology

authors： Davis WG

更新日期：1970-01-01 00:00:00

abstract：:1. In guinea-pigs previously sensitized with ovalbumin, the intra-plantar administration of the antigen induced dose-dependent and sustained oedema. An intense infiltrate of neutrophils and eosinophils was observed at the peak of the oedema (4 h). 2. Oedema induced by ovalbumin at the doses of 50 or 200 micrograms/paw...

journal_title：British journal of pharmacology

authors： da Motta JI,Cunha FQ,Vargaftig BB,Ferreira SH

更新日期：1994-05-01 00:00:00

abstract：:1. The effects of dimethothiazine have been studied on the response of afferent fibres from primary and secondary endings of muscle spindles in the soleus muscle of the decerebrate cat during stretching of the muscle under controlled conditions.2. Dimethothiazine in doses of 1 to 4 mg/kg intravenously reduced the disc...

journal_title：British journal of pharmacology

authors： Maxwell DR,Rhodes KF

更新日期：1970-07-01 00:00:00

abstract：:1. Gastric acid secretory responses to pentagastrin were characterized in the rat isolated gastric mucosa. In particular, the mechanisms underlying fade, declining response upon continued stimulation, and tachyphylaxis, progressively reduced responses upon repeated stimulation, were investigated. 2. Pentagastrin, 10(-...

journal_title：British journal of pharmacology

authors： Hirst BH,Holland J,Parsons ME,Price CA

更新日期：1988-12-01 00:00:00

abstract：:1. Losigamone is a novel anticonvulsant the mechanism of action of which is not known. This study investigated the effect of losigamone on spontaneous, NMDA- and AMPA-induced depolarizations in the cortical wedge preparation of the DBA/2 mouse (which are susceptible to sound-induced seizures) and on endogenous amino a...

journal_title：British journal of pharmacology

authors： Srinivasan J,Richens A,Davies JA

更新日期：1997-12-01 00:00:00

abstract：:Measurements of affinity and efficacy are fundamental for work on agonists both in drug discovery and in basic studies on receptors. In this review I wish to consider methods for measuring affinity and efficacy at G protein coupled receptors (GPCRs). Agonist affinity may be estimated in terms of the dissociation const...

journal_title：British journal of pharmacology

authors： Strange PG

更新日期：2008-04-01 00:00:00

abstract：:1. We investigated the potent 5-hydroxytryptamine (5-HT)-mediated vasorelaxation of the sheep pulmonary vein. Here we present evidence that this response is due to activation of 5-HT4 receptors. 2. 5-HT (1-1000 nM) caused concentration-dependent, maintained relaxations (pEC50 = 8.4 +/- 0.1) of isolated rings of sheep ...

journal_title：British journal of pharmacology

authors： Cocks TM,Arnold PJ

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study investigated whether the pathophysiological changes induced by burn and smoke inhalation are modulated by parenteral administration of Na(2)S, a H(2)S donor. EXPERIMENTAL APPROACH:The study used a total of 16 chronically instrumented, adult female sheep. Na(2)S was administered...

journal_title：British journal of pharmacology

authors： Esechie A,Enkhbaatar P,Traber DL,Jonkam C,Lange M,Hamahata A,Djukom C,Whorton EB,Hawkins HK,Traber LD,Szabo C

更新日期：2009-11-01 00:00:00

abstract：:1. Rat spinal cord neurones grown in tissue culture were used to examine the electrophysiological effects of the neurokin in (NK)-selective agonists (pGlu6, Pro9) substance P(6-11) (septide; NK1, 10(-6)M) and (pGlu5, MePhe8, MeGly9)SP(1-7) (DiMe-C7; NK3, 10(-6)M). In addition, the effect of the neurokinin antagonist (...

journal_title：British journal of pharmacology

authors： Wienrich M,Reuss K,Harting J

更新日期：1989-11-01 00:00:00

abstract：:We examined whether a specific aminopeptidase P (APP) inhibitor, apstatin, increases vasodepressor responses to bradykinin in anaesthetized rats, and whether it would augment blood pressure responses further after treatment with the angiotensin-converting enzyme inhibitor (ACEi), lisinopril. Apstatin doubled the maxim...

journal_title：British journal of pharmacology

authors： Kitamura S,Carbini LA,Carretero OA,Simmons WH,Scicli AG

更新日期：1995-01-01 00:00:00