Abstract:
:1. The effects of dimethothiazine have been studied on the response of afferent fibres from primary and secondary endings of muscle spindles in the soleus muscle of the decerebrate cat during stretching of the muscle under controlled conditions.2. Dimethothiazine in doses of 1 to 4 mg/kg intravenously reduced the discharge frequency of primary and secondary endings. Higher doses of dimethothiazine had little further significant effect on the discharge frequency.3. The discharge frequency recorded from de-efferented muscle spindles in soleus of the decerebrate cat were similar to the discharge frequencies obtained in preparations with intact ventral roots which had received a high dose of dimethothiazine.4. Dimethothiazine had little significant effect on the discharge frequency of afferent fibres from muscle spindles in the soleus muscle of decerebrate preparations where the ventral roots were cut.5. These effects of dimethothiazine on muscle spindle activity were not related to any changes in blood pressure of the decerebrate cat.6. Dimethothiazine appears to reduce the effects of both the dynamic and static fusimotor fibres on the spindle.7. The doses of dimethothiazine which effect spindle discharge frequency are similar to those required to reduce decerebrate rigidity.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Maxwell DR,Rhodes KFdoi
10.1111/j.1476-5381.1970.tb10360.xsubject
Has Abstractpub_date
1970-07-01 00:00:00pages
520-32issue
3eissn
0007-1188issn
1476-5381journal_volume
39pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:The human, rat, and mouse P2X(7) receptors have been previously characterized, and in this study we report the cloning and pharmacological properties of the guinea pig orthologue. EXPERIMENTAL APPROACH:A cDNA encoding for the guinea pig P2X(7) receptor was isolated from a guinea pig brain librar...
journal_title:British journal of pharmacology
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doi:10.1038/sj.bjp.0707596
更新日期:2008-02-01 00:00:00
abstract::Ischaemia is amongst the leading causes of death. Despite this importance, there are only a few therapeutic approaches to protect from ischaemia-reperfusion injury (IRI). In experimental studies, the amino acid glycine effectively protected from IRI. In the prevention of IRI by glycine in cells and isolated perfused o...
journal_title:British journal of pharmacology
pub_type: 杂志文章,评审
doi:10.1111/j.1476-5381.2011.01711.x
更新日期:2012-04-01 00:00:00
abstract:UNLABELLED:Sensory neurons play important roles in many disorders, including inflammatory diseases, such as sepsis. Sepsis is a potentially lethal systemic inflammatory reaction to a local bacterial infection, affecting thousands of patients annually. Although associated with a high mortality rate, sepsis outcome depen...
journal_title:British journal of pharmacology
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更新日期:2013-12-01 00:00:00
abstract::Osteoarthritis (OA) is the most common disease of joints, which are complex organs where cartilage, bone and synovium cooperate to allow a range of movements. During progression of the disease, the function of all three main components is jeopardized. Nevertheless, the involvement of each tissue in OA development is s...
journal_title:British journal of pharmacology
pub_type: 杂志文章,评审
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更新日期:2019-05-01 00:00:00
abstract::1. Treatment of rat mesangial cells with interleukin 1 beta (IL-1 beta) or tumour necrosis factor alpha (TNF alpha) has been shown to induce a macrophage-type of nitric oxide (NO) synthase. Here we report that adenosine 3':5'-cyclic monophosphate (cyclic AMP) is another mediator that triggers induction of NO synthase ...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1994.tb13019.x
更新日期:1994-05-01 00:00:00
abstract::1. The actions of bretylium tosylate on neuromuscular transmission in the rat phrenic nerve diaphragm preparation have been investigated by electro-2. On the guinea-pig ileum, threshold doses elicit repeated maximal spike contractions which are blocked by atropine. In the presence of atropine, higher concentrations of...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1971.tb07070.x
更新日期:1971-04-01 00:00:00
abstract::1. Contractile responses to short trains of nerve stimulation have been characterized in small, medium and large arteries from the rat mesenteric circulation (5th - 6th, 2nd - 3rd and 1st order, respectively). In addition, sources of calcium for smooth muscle contraction have been investigated. 2. Nerve stimulation (1...
journal_title:British journal of pharmacology
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doi:10.1038/sj.bjp.0703925
更新日期:2001-03-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1038/sj.bjp.0703905
更新日期:2001-03-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1985.tb12939.x
更新日期:1985-02-01 00:00:00
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更新日期:2006-10-01 00:00:00
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更新日期:2001-03-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:
更新日期:1971-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1476-5381.1984.tb10814.x
更新日期:1984-07-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1982.tb09177.x
更新日期:1982-04-01 00:00:00
abstract::1. It has recently been shown that both alpha(1)- and alpha(2)-adrenoceptors mediate vasoconstriction in the canine external carotid circulation. The present study set out to identify the specific subtypes (alpha(1A), alpha(1B) and alpha(1D) as well as alpha(2A), alpha(2B) and alpha(2C)) mediating the above response. ...
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更新日期:2001-03-01 00:00:00
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更新日期:2000-08-01 00:00:00
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更新日期:2009-10-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:1992-05-01 00:00:00
abstract::Adenosine alone at 0.1 and 1.0 mg per tracheal segment stimulated mucus secretion by 52% and 88%, respectively, compared to baseline (P less than 0.0001). The site of the potent secretagogue effect of adenosine in canine trachea was consistent with A2 activation. A2 site activation and enhanced secretion were also ind...
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更新日期:1985-09-01 00:00:00
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更新日期:1992-03-01 00:00:00
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更新日期:1993-05-01 00:00:00
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更新日期:1986-07-01 00:00:00
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更新日期:2014-02-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:1995-05-01 00:00:00
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更新日期:1996-06-01 00:00:00
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更新日期:2017-02-01 00:00:00