Effects of ranatensin, a polypeptide from frog skin, on isolated smooth muscle.

abstract：:1. The ability of the neuroprotective agent, lifarizine (RS-87476), to mitigate veratridine-, cyanide- and glutamate-induced toxicity in rat embryonic cerebrocortical neurones in primary culture has been compared with that of tetrodotoxin (TTX), nitrendipine, (+)-MK-801 and (-)-MK-801. Lactate dehydrogenase (LDH) rele...

journal_title：British journal of pharmacology

authors： May GR,Rowand WS,McCormack JG,Sheridan RD

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fibroblast-to-myofibroblast differentiation is associated with scarring, an important issue in corneal surgery. Moxifloxacin (MOX), commonly applied to prevent post-operative infection, would benefit more if it modifies fibroblast-to-myofibroblast differentiation other than antimicrobial activity...

journal_title：British journal of pharmacology

authors： Chen TC,Chang SW,Wang TY

更新日期：2013-03-01 00:00:00

abstract：:1. Intracellular recordings were made from neurones in vitro in the rat substantia nigra zona compacta and ventral tegmental area; the neurones had the characteristic properties of dopamine-containing cells, and fired action potentials spontaneously. 2. Cocaine (1-10 microM) inhibited spontaneous firing, hyperpolarize...

journal_title：British journal of pharmacology

authors： Lacey MG,Mercuri NB,North RA

更新日期：1990-04-01 00:00:00

abstract：:1. We examined the effects of selective and nonselective cyclo-oxygenase (COX) inhibitors on various functional changes in the rat stomach induced by topical application of taurocholate (TC) and investigated the preferential role of COX isozymes in these responses. 2. Rat stomachs mounted in ex vivo chambers were perf...

journal_title：British journal of pharmacology

authors： Hirata T,Ukawa H,Yamakuni H,Kato S,Takeuchi K

更新日期：1997-10-01 00:00:00

abstract：:1. The concentration-response curves for rate of mucus output, labelled-glycoprotein output and smooth muscle contraction in response to methacholine, phenylephrine and salbutamol were determined in the ferret trachea in vitro. 2. The potencies of methacholine and phenylephrine are both in order: smooth muscle contrac...

journal_title：British journal of pharmacology

authors： Kyle H,Widdicombe JG,Wilffert B

更新日期：1988-06-01 00:00:00

abstract：:1. Cumulative concentration-response curves (CRC) to prostaglandin E1 (PGE1), PGE2, PGD2 and PGF2alpha (0.01-30 microM) and to the thromboxane A2 (TXA2) receptor agonist U-46619 (0.01-30 microM) were constructed in human isolated detrusor muscle strips both in basal conditions and during electrical field stimulation. ...

journal_title：British journal of pharmacology

authors： Palea S,Toson G,Pietra C,Trist DG,Artibani W,Romano O,Corsi M

更新日期：1998-07-01 00:00:00

abstract：:1 We investigated the peripheral haemodynamic effects of human alpha-calcitonin gene-related peptide (CGRP) following administration of endothelin-1 or NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide production, in conscious, chronically-instrumented, Long Evans rats. 2 Infusion of endothelin-1...

journal_title：British journal of pharmacology

authors： Gardiner SM,Compton AM,Kemp PA,Bennett T,Foulkes R,Hughes B

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Proteinase activated receptor 2 (PAR2) is a GPCR associated with inflammation, metabolism and disease. Clues to understanding how to block PAR2 signalling associated with disease without inhibiting PAR2 activation in normal physiology could be provided by studies of biased signalling. EXPERIMENT...

journal_title：British journal of pharmacology

authors： Suen JY,Cotterell A,Lohman RJ,Lim J,Han A,Yau MK,Liu L,Cooper MA,Vesey DA,Fairlie DP

更新日期：2014-09-01 00:00:00

abstract：:1. Hypercholesterolaemia often occurs in patients with type 2 diabetes, who therefore encounter administration of HMG-CoA reductase inhibitors. Alteration of pancreatic beta-cell function leading to an impaired insulin secretory response to glucose plays a crucial role in the pathogenesis of type 2 diabetes. Therefore...

journal_title：British journal of pharmacology

authors： Yada T,Nakata M,Shiraishi T,Kakei M

更新日期：1999-03-01 00:00:00

abstract：:1 We have investigated the effects of loperamide on intracellular Ca(2+) stores and membrane K(+) channels in insulin-secreting hamster insulinoma (HIT-T15) cells. 2 In cell-attached patch-clamp mode, loperamide (3-250 micro M) activated large single-channel currents. The loperamide-activated currents were tentatively...

journal_title：British journal of pharmacology

authors： He LP,Mears D,Atwater I,Rojas E,Cleemann L

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although there are many new specific phosphodiesterase inhibitors with anti-inflammatory activity, none have yet reached the market because of their low therapeutic efficacy. Our study was aimed to evaluate the anti-inflammatory and anti-arthritic effect of an established phosphodiesterase inhibi...

journal_title：British journal of pharmacology

authors： Gomaa A,Elshenawy M,Afifi N,Mohammed E,Thabit R

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Bleomycin (BLM), one of the most common sclerosants, is often used to treat venous malformations (VMs). The present study was designed to investigate whether endothelial mesenchymal transition (EndoMT) contributes to the therapeutic effects of BLM. EXPERIMENTAL APPROACH:Endothelial and mesenchym...

journal_title：British journal of pharmacology

authors： Zhang W,Chen G,Ren JG,Zhao YF

更新日期：2013-11-01 00:00:00

abstract：:1. Acute moderate hypoxia modifies the catalytic activity and expression of certain isoenzymes of hepatic cytochrome P450 (P450). The aim of this study was to document whether hypoxia affects hepatic P450 directly or through the release of serum mediators. 2. Rabbits were subjected to a FiO(2) of 8% for 48 h, sacrific...

journal_title：British journal of pharmacology

authors： Fradette C,Bleau AM,Pichette V,Chauret N,Du Souich P

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Intrathecal (i.t.) injection of orexin A (OX-A) increases blood pressure and heart rate (HR), but the effects of OX-A on sympathetic and phrenic, nerve activity, and the baroreflex(es), somato-sympathetic and hypoxic chemoreflex(es) are unknown. EXPERIMENTAL APPROACH:Urethane-anaesthetized, vagotomized and ...

journal_title：British journal of pharmacology

authors： Shahid IZ,Rahman AA,Pilowsky PM

更新日期：2011-02-01 00:00:00

abstract：:1. We have investigated pre- and post-junctional responsiveness in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice. The response to a single stimulus was not significantly different between wild-type and knock-out mice. The isometric contraction to 10 Hz stimulation for 4 s was significantly lar...

journal_title：British journal of pharmacology

authors： Cleary L,Vandeputte C,Docherty JR

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Disruptions of executive function, including attentional deficits, are a hallmark of a number of diseases. ACh in the prefrontal cortex regulates attentive behaviour; however, the role of α7 nicotinic ACh receptor (α7nAChR) in attention is contentious. EXPERIMENTAL APPROACH:In order to probe att...

journal_title：British journal of pharmacology

authors： Kolisnyk B,Al-Onaizi MA,Prado VF,Prado MA

更新日期：2015-10-01 00:00:00

abstract：:1. The action of adrenaline on the K(+) balance of the isolated heart was found to depend on the ionic composition and the temperature of the perfusion fluids used.2. When the perfusion fluid contained 145 mM Na(+), 1.7 mM Ca(++) and 3-9 mM K(+), adrenaline caused the hearts to gain K(+); when the K(+) concentration w...

journal_title：British journal of pharmacology

authors： Stafford A

更新日期：1969-07-01 00:00:00

abstract：:Myeloperoxidase (MPO), a member of the haem peroxidase-cyclooxygenase superfamily, is abundantly expressed in neutrophils and to a lesser extent in monocytes and certain type of macrophages. MPO participates in innate immune defence mechanism through formation of microbicidal reactive oxidants and diffusible radical s...

journal_title：British journal of pharmacology

authors： Malle E,Furtmüller PG,Sattler W,Obinger C

更新日期：2007-11-01 00:00:00

abstract：:1. Reserpine given to rats before the enhanced synthesis of DNA begins 14h after partial hepatectomy markedly depresses thymidine uptake into DNA at 24 hours.2. At this time decreased activity of liver thymidine kinase but unchanged thymidine 5'-nucleotidase were observed.3. Reserpine has no effect on DNA synthesis wh...

journal_title：British journal of pharmacology

authors： Cihák A,Vaptzarova K

更新日期：1973-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Endothelial cell proliferation, migration and adhesion are necessary for the formation of new blood vessels. We reported previously that baicalein strongly inhibited proliferation of rat heart endothelial cells and here we assess effects on migration and adhesion of these cells. EXPERIMENTAL APP...

journal_title：British journal of pharmacology

authors： Hsieh YC,Hsieh SJ,Chang YS,Hsueh CM,Hsu SL

更新日期：2007-08-01 00:00:00

abstract：:1. The effects of fenoverine, an antispasmodic drug, have been studied on the Ca2+ channel currents of isolated cells from rat portal vein and pregnant myometrium by the patch-clamp technique (whole-cell configuration). 2. Fenoverine inhibited both fast and slow Ca2+ channel currents in a concentration-dependent manne...

journal_title：British journal of pharmacology

authors： Mironneau J,Arnaudeau S,Mironneau C

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Evidence suggests that phosphorylation of TRPV1 is an important component underlying its aberrant activation in pathological pain states. To date, the detailed pharmacology of diverse TRPV1 receptor agonists and antagonists has yet to be reported for native TRPV1 under phosphorylating conditions....

journal_title：British journal of pharmacology

authors： Mogg AJ,Mill CE,Folly EA,Beattie RE,Blanco MJ,Beck JP,Broad LM

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recent findings suggest that the noxious gas H(2)S is produced endogenously, and that physiological concentrations of H(2)S are able to modulate pain and inflammation in rodents. This study was undertaken to evaluate the ability of endogenous and exogenous H(2)S to modulate carrageenan-induced sy...

journal_title：British journal of pharmacology

authors： Ekundi-Valentim E,Santos KT,Camargo EA,Denadai-Souza A,Teixeira SA,Zanoni CI,Grant AD,Wallace J,Muscará MN,Costa SK

更新日期：2010-04-01 00:00:00

abstract：:1. The interactive effects of different metabotropic glutamate (mGlu) receptor subtypes to regulate phosphoinositide turnover have been studied in neonatal rat cerebral cortex and hippocampus by use of agonists and antagonists selective between group I and II mGlu receptors. 2, The group II-selective agonist 2R,4R-4-a...

journal_title：British journal of pharmacology

authors： Mistry R,Golding N,Challiss RA

更新日期：1998-02-01 00:00:00

abstract：:1. Pharmacological inhibitors of protein kinase A (PKA) and protein phosphatases 1/2A were used to determine whether basal L-type Ca(2+) current (I(Ca)) observed in the absence of exogenous beta-adrenergic receptor stimulation is sustained by PKA-mediated phosphorylation. Amphotericin B was used to record whole-cell I...

journal_title：British journal of pharmacology

authors： Bracken N,Elkadri M,Hart G,Hussain M

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Diabetes mellitus is associated with a specific cardiomyopathy. We compared the cardioprotective effects of an endothelin-A receptor blocker (ET(A)-RB) with those of an angiotensin-converting enzyme inhibitor (ACE-I) in rats with streptozotocin (STZ)-induced diabetes. EXPERIMENTAL APPROACH:Diabe...

journal_title：British journal of pharmacology

authors： Wölkart G,Pang X,Stessel H,Kirchengast M,Brunner F

更新日期：2007-08-01 00:00:00

abstract：:Preclinical and clinical data suggest that a modification in GABA(B) receptor expression and function may contribute to the symptoms of major depression and the response to antidepressants. This includes laboratory animal experiments demonstrating that antidepressants modify brain GABA(B) receptor expression and funct...

journal_title：British journal of pharmacology

authors： Ghose S,Winter MK,McCarson KE,Tamminga CA,Enna SJ

更新日期：2011-01-01 00:00:00

abstract：:There are proposals for the implementation of beta(2)-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that beta(2)-adrenoceptor agonists cause hypertrophy of skeletal muscle. Their use in clinical practice will also need an underst...

journal_title：British journal of pharmacology

authors： Molenaar P,Chen L,Parsonage WA

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The renal sodium-glucose cotransporter 2 (SGLT2) plays an important role in the reuptake of filtered glucose in the proximal tubule and therefore may be an attractive target for the treatment of diabetes mellitus. This study characterizes the pharmacological profile of TS-071 ((1S)-1,5-anhydro-1-...

journal_title：British journal of pharmacology

authors： Yamamoto K,Uchida S,Kitano K,Fukuhara N,Okumura-Kitajima L,Gunji E,Kozakai A,Tomoike H,Kojima N,Asami J,Toyoda H,Arai M,Takahashi T,Takahashi K

更新日期：2011-09-01 00:00:00

abstract：:1. The present study was designed to investigate tolerance to several pharmacological effects of apomorphine. 2. Changes in blood pressure, heart rate, plasma noradrenaline levels, rectal temperature, respiratory rate and retching plus vomiting were compared after administration of apomorphine (200 micrograms kg-1, i....

journal_title：British journal of pharmacology

authors： Montastruc JL,Llau ME,Senard JM,Tran MA,Rascol O,Montastruc P

更新日期：1996-03-01 00:00:00