Comparison of mucus flow rate, radiolabelled glycoprotein output and smooth muscle contraction in the ferret trachea in vitro.

abstract：BACKGROUND AND PURPOSE:Sulphatides are sulphated glycosphingolipids expressed on the surface of many cell types, particularly neurones. Changes in sulphatide species or content have been associated with epilepsy and Alzheimer's disease. As the large conductance, calcium sensitive K(+) channel (BK(Ca)) are modulated by ...

journal_title：British journal of pharmacology

authors： Chi S,Qi Z

更新日期：2006-12-01 00:00:00

abstract：:1. Intrathecal (i.t.) injection of nociceptin at small doses (fmol order) elicited a behavioural response consisting of scratching, biting and licking in conscious mice. Here we have examined the involvement of substance P-containing neurons by using i.t. injection of tachykinin neurokinin (NK)1 receptor antagonists a...

journal_title：British journal of pharmacology

authors： Sakurada T,Katsuyama S,Sakurada S,Inoue M,Tan-No K,Kisara K,Sakurada C,Ueda H,Sasaki J

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The human prostacyclin receptor (hIP), a G-protein coupled receptor (GPCR) expressed mainly on platelets and vascular smooth muscle cells, plays important protective roles in the cardiovascular system. We hypothesized that significant insights could be gained into the structure and function of th...

journal_title：British journal of pharmacology

authors： Stitham J,Arehart E,Gleim SR,Li N,Douville K,Hwa J

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Agmatine, a putative neurotransmitter, plays a vital role in learning and memory. Although it is considered an endogenous ligand of imidazoline receptors, agmatine exhibits high affinity for α-adrenoceptors, NOS and NMDA receptors. These substrates within the locus coeruleus (LC) are critically i...

journal_title：British journal of pharmacology

authors： Shelkar GP,Gakare SG,Chakraborty S,Dravid SM,Ugale RR

更新日期：2016-09-01 00:00:00

abstract：:The vasorelaxant activity of eicosapentaenoic acid (EPA, 20:5n-3), the omega-3 polyunsaturated fatty acid, was investigated in isolated Wistar Kyoto (WKY) rat aortae by measuring isometric tension. Eicosapentaenoic acid (1 - 100 microM) relaxed rat aortae contracted with high K(+) (80 mM) or noradrenaline (NA, 1 micro...

journal_title：British journal of pharmacology

authors： Engler MB,Engler MM,Browne A,Sun YP,Sievers R

更新日期：2000-12-01 00:00:00

abstract：:1. The ability of the putative, selective post-junctional alpha 2-adrenoceptor antagonist, SK&F 104078 to antagonize the effects of structurally-diverse agonists at pre-junctional alpha 2-adrenoceptors in the guinea-pig ileum and rat vas deferens in vitro and in the rat heart in vivo, and at post-junctional alpha 2-ad...

journal_title：British journal of pharmacology

authors： Akers I,Coates J,Drew GM,Sullivan AT

更新日期：1991-04-01 00:00:00

abstract：:1 Effects of dopamine and noradrenaline were compared in helically-cut strips of canine cerebral arteries. 2 Dopamine caused a greater maximal contraction than noradrenaline, although the ED50 for noradrenaline was appreciably less. The contraction induced by these amines was reversed to a relaxation by treatment with...

journal_title：British journal of pharmacology

authors： Toda N

更新日期：1976-09-01 00:00:00

abstract：:1. We investigated the potent 5-hydroxytryptamine (5-HT)-mediated vasorelaxation of the sheep pulmonary vein. Here we present evidence that this response is due to activation of 5-HT4 receptors. 2. 5-HT (1-1000 nM) caused concentration-dependent, maintained relaxations (pEC50 = 8.4 +/- 0.1) of isolated rings of sheep ...

journal_title：British journal of pharmacology

authors： Cocks TM,Arnold PJ

更新日期：1992-10-01 00:00:00

abstract：:1 Sera of rabbits immunized against a nocotinic receptor-rich fraction, obtained from the electric organ of Torpedo marmorata, were tested for their pharmacological activity on different in vitro preparations. 2 Sera containing antibodies against the nicotinic receptor blocked neuromuscular transmission in the phrenic...

journal_title：British journal of pharmacology

authors： Berti F,Clementi F,Conti-Tronconi B,Folco GC

更新日期：1976-05-01 00:00:00

abstract：:We have studied the recovery of receptor binding and of isoprenaline-stimulated cyclic AMP responses after chronic (2-5 days) exposure of tissue-cultured living rat heart cells to several beta-adrenoceptor antagonists. Most experiments were performed with [3H]- (+/-)-carazolol and [3H]-(+/-)-CGP 12177, as prototypes o...

journal_title：British journal of pharmacology

authors： Becker C,Porzig H

更新日期：1984-07-01 00:00:00

abstract：:1. The bovine pulmonary vein contracts in response to acetylcholine, histamine, 5-hydroxytryptamine and bradykinin. The tissue is particularly sensitive to 5-hydroxytryptamine (>0.1 ng/ml). Specific Schultz-Dale reactions were elicited in the pulmonary vein in response to horse plasma.2. The Schultz-Dale reaction is i...

journal_title：British journal of pharmacology

authors： Eyre P

更新日期：1971-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:K(v)11.1 channels are involved in regulating cellular excitability in various tissues including brain, heart and smooth muscle. In these tissues, at least two isoforms, K(v)11.1a and K(v)11.1b, with different kinetics, are expressed. K(v)11.1 activators are potential therapeutic agents, but their...

journal_title：British journal of pharmacology

authors： Larsen AP,Bentzen BH,Grunnet M

更新日期：2010-10-01 00:00:00

abstract：:Antidromic stimulation of sensory peripheral branches of the trigeminal system (mental nerve) leads to cutaneous vasodilatation and increases vascular permeability in the rat. Antidromic vasodilatation is observed only at high intensity stimulation (10 V, 15 Hz, 0.2 or 5 ms) supporting the participation of afferent C-...

journal_title：British journal of pharmacology

authors： Couture R,Cuello AC,Henry JL

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Partial agonists selective for α4β2 nicotinic ACh receptors have been developed for smoking cessation as they induce weak activation of native α4β2* receptors and inhibit effect of nicotine. However, it is unclear whether at brain functions there is an existence of receptor reserve that allows we...

journal_title：British journal of pharmacology

authors： Chen Y,Broad LM,Phillips KG,Zwart R

更新日期：2012-02-01 00:00:00

abstract：:1. Previous work from our laboratory has shown that cannabis induces aggressive behaviour in rats that have been deprived of rapid eye movement (REM) sleep. It was suggested that this effect was related to brain catecholamines, with dopamine playing an agonist role and noradrenaline an inhibitory one. The present pape...

journal_title：British journal of pharmacology

authors： Carlini EA,Lindsey CJ,Tufik S

更新日期：1977-11-01 00:00:00

abstract：:1. The ratio of the content of vasopressin to that of oxytocin (V/O ratio) was estimated in the supraoptic nucleus (SON), paraventricular nucleus (PVN) and posterior pituitary gland (PIT) of guinea-pigs.2. Extracts were assayed for antidiuretic activity to estimate vasopressin and for milk-ejecting activity to estimat...

journal_title：British journal of pharmacology

authors： Bisset GW,Errington ML,Richards CD

更新日期：1973-06-01 00:00:00

abstract：:1 The role of histamine H1- and H2-receptors in mediating the cutaneous inflammatory response produced by exogenous histamine and the release of endogenous histamine from mast cells has been investigated by a method which permits simultaneous, quantitative measurement of vasodilatation, vascular permeability and oedem...

journal_title：British journal of pharmacology

authors： Owen DA,Poy E,Woodward DF,Daniel D

更新日期：1980-08-01 00:00:00

abstract：:1. The effects of 2-amino-5-phosphonovalerate and kynurenate, either alone or in combination, were tested on responses evoked by the excitatory amino acid agonists quinolinate, ibotenate, N-methyl-D-aspartate and N-methyl-DL-aspartate by use of an in vitro preparation of mouse neocortex and artificial cerebrospinal fl...

journal_title：British journal of pharmacology

authors： Burton NR,Smith DA,Stone TW

更新日期：1988-03-01 00:00:00

abstract：:1 The effects of raising or lowering [Ca(2+)](o) or [Mg(2+)](o) on potential changes evoked by 5-hydroxytryptamine (5-HT) and by the nicotinic agonist, 1,1-dimethyl-4-phenyl piperazinium (DMPP) have been investigated.2 Changes in membrane potential were measured at the ganglion or in postganglionic axons by the sucros...

journal_title：British journal of pharmacology

authors： Nash HL,Wallis DI

更新日期：1981-07-01 00:00:00

abstract：:Ever increasing use of engineered carbon nanoparticles in nanopharmacology for selective imaging, sensor or drug delivery systems has increased the potential for blood platelet-nanoparticle interactions. We studied the effects of engineered and combustion-derived carbon nanoparticles on human platelet aggregation in v...

journal_title：British journal of pharmacology

authors： Radomski A,Jurasz P,Alonso-Escolano D,Drews M,Morandi M,Malinski T,Radomski MW

更新日期：2005-11-01 00:00:00

abstract：:1. The functional role of the nitric oxide (NO)/guanosine 3':5'-cyclic monophosphate (cyclic GMP) pathway in experimental myocardial ischaemia and reperfusion was studied in rat isolated hearts. 2. Rat isolated hearts were perfused at constant pressure with Krebs-Henseleit buffer for 25 min (baseline), then made ischa...

journal_title：British journal of pharmacology

authors： du Toit EF,McCarthy J,Miyashiro J,Opie LH,Brunner F

更新日期：1998-03-01 00:00:00

abstract：:1. Antilaminin IgG decreased the dF/dt of mouse isolated atria and inhibited the mechanical effect of acetylcholine in a non-competitive fashion. 2. Inhibitors of nicotinic and muscarinic cholinoceptors impaired the negative inotropic action of antilaminin IgG in mouse isolated atria. Hemicholinium and tetrodotoxin al...

journal_title：British journal of pharmacology

authors： Bacman S,Borda E,Denduchis B,Lustig L,Sterin-Borda L

更新日期：1989-06-01 00:00:00

abstract：:1. The possible roles of endothelial and smooth muscle cell hyperpolarization and nitric oxide (NO) in endothelium-dependent relaxation were examined in isolated rings of pig right coronary artery. 2. The effects of hyperpolarization were prevented with high K+ (30-125 mM), isotonic Krebs solutions. Functional antagon...

journal_title：British journal of pharmacology

authors： Kilpatrick EV,Cocks TM

更新日期：1994-06-01 00:00:00

abstract：:Biological nitrogen oxide signalling and stress is an area of extreme clinical, pharmacological, toxicological, biochemical and chemical research interest. The utility of nitric oxide and derived species as signalling agents is due to their novel and vast chemical interactions with a variety of biological targets. Her...

journal_title：British journal of pharmacology

authors： Heinrich TA,da Silva RS,Miranda KM,Switzer CH,Wink DA,Fukuto JM

更新日期：2013-08-01 00:00:00

abstract：:The modulatory effects of protein kinase C (PKC) on the activation of cytosolic phospholipase A2 (cPLA2) and adenylyl cyclase (AC) have recently been described. Since the signalling cascades associated with these events play critical roles in various functions of macrophages, we set out to investigate the crosstalk be...

journal_title：British journal of pharmacology

authors： Lin WW,Chen BC

更新日期：1998-12-01 00:00:00

abstract：:1 The mechanism underlying the enhancement by superoxide dismutase (SOD) of endothelium-dependent relaxation was investigated in rabbit mesenteric resistance arteries. 2 SOD (200 U ml(-1)) increased the production of H(2)O(2) in smooth muscle cells (as indicated by the use of an H(2)O(2)-sensitive fluorescent dye). 3 ...

journal_title：British journal of pharmacology

authors： Itoh T,Kajikuri J,Hattori T,Kusama N,Yamamoto T

更新日期：2003-05-01 00:00:00

abstract：:1. Dose-dependent vasodilator responses to dopamine, isoprenaline, noradrenaline, 3-isobutyl-1-methylxanthine (IBMX) and sodium nitroprusside were obtained in isolated perfused mesentery preparations, taken from reserpine-treated rats of different ages. The preparations were pretreated with phenoxybenzamine (1 microM)...

journal_title：British journal of pharmacology

authors： Wanstall JC,O'Donnell SR

更新日期：1989-09-01 00:00:00

abstract：:1. Membranes from rat cerebral cortex, myocardium and extraorbital lacrimal gland were used as sources of M1, M2 and M3 muscarinic acetylcholine receptors respectively and the affinities of seven antagonists for the three subtypes were examined under different experimental conditions. 2. The affinities for the membran...

journal_title：British journal of pharmacology

authors： Pedder EK,Eveleigh P,Poyner D,Hulme EC,Birdsall NJ

更新日期：1991-06-01 00:00:00

abstract：:1. The effects of dopamine on the L-type Ca2+ current (ICa,L) of both atrial and ventricular single myocytes and on the force of contraction of atrial trabeculae in rat heart were investigated. 2. Dopamine increased atrial ICa,L at concentrations higher than 1 microM, but had little or no effect on ICa,L at lower conc...

journal_title：British journal of pharmacology

authors： Zhao H,Matsuoka S,Fujioka Y,Noma A

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuropeptides are involved in the regulation of food intake in the central nervous system, but they might also act on peripheral fat tissue via neuropeptide receptors. EXPERIMENTAL APPROACH:We investigated the receptor expression and activity of pituitary adenylate cyclase-activating polypeptide...

journal_title：British journal of pharmacology

authors： Gericke MT,Kosacka J,Koch D,Nowicki M,Schröder T,Ricken AM,Nieber K,Spanel-Borowski K

更新日期：2009-06-01 00:00:00