A cholinoceptor antiserum: its pharmacological properties.

abstract：:1. We have shown earlier that pilocarpine strongly inhibits mouse and human liver coumarin 7-hydroxylase activity of CYP 2A and pentoxyresorufin O-deethylase activity of CYP 2B in vitro. Since pilocarpine, like coumarin, contains a lactone structure we have studied in more detail its inhibitory potency on mouse and hu...

journal_title：British journal of pharmacology

authors： Kinonen T,Pasanen M,Gynther J,Poso A,Järvinen T,Alhava E,Juvonen RO

更新日期：1995-11-01 00:00:00

abstract：:1. Pre-eclampsia is a serious pregnancy disorder associated with widespread activation of the maternal vascular endothelium. Recent evidence implicates a role for oxidative stress in the aetiology of this condition. 2. Reactive oxygen species, particularly superoxide anions, invokes endothelial cell activation through...

journal_title：British journal of pharmacology

authors： Crocker IP,Kenny LC,Thornton WA,Szabo C,Baker PN

更新日期：2005-03-01 00:00:00

abstract：UNLABELLED:During life, new neurons are continually added to hippocampal circuitry, with evidence suggesting that these adult-born neurons are functionally linked to cognition and emotion. The mammalian brain contains actively dividing neural stem cells in discrete regions, including the subventricular zone of the late...

journal_title：British journal of pharmacology

authors： Downer EJ

更新日期：2014-03-01 00:00:00

abstract：:1 Cellulose sulphate, like heparin, prolonged the clotting time in partial thromboplastin time (PTT) assays, inhibited the amidolytic activity of thrombin, was without effect on amidolysis catalysed by activated coagulation factor X(Xa), and potentiated the inhibition of both thrombin and Xa by antithrombin III (AT). ...

journal_title：British journal of pharmacology

authors： Kindness G,Long WF,Williamson FB

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Rho kinase (ROCK) activation is involved in neuroinflammatory processes leading to progression of neurodegenerative diseases such as Parkinson's disease. Furthermore, ROCK plays a major role in angiogenesis. Neuroinflammation and angiogenesis are mechanisms involved in developing l-DOPA-induced d...

journal_title：British journal of pharmacology

authors： Lopez-Lopez A,Labandeira CM,Labandeira-Garcia JL,Muñoz A

更新日期：2020-12-01 00:00:00

abstract：:The role of nitric oxide (NO) in striatal dopamine release has been controversial. Most NO synthase inhibitors affect more than one isoform of the enzyme and exert vasoconstrictor effects which may also affect striatal dopamine function. We now report on the effect of a soluble monosodium salt of the selective brain N...

journal_title：British journal of pharmacology

authors： Silva MT,Rose S,Hindmarsh JG,Aislaitner G,Gorrod JW,Moore PK,Jenner P,Marsden CD

更新日期：1995-01-01 00:00:00

abstract：:1. PD 81,723 has been shown to enhance binding of adenosine to A1 receptors by stabilizing G protein-receptor coupling ('allosteric enhancement'). Evidence has been provided that in the perfused hearts and isolated atria PD 81,723 causes a sensitization to adenosine via this mechanism. 2. We have studied the effect of...

journal_title：British journal of pharmacology

authors： Brandts B,Bünemann M,Hluchy J,Sabin GV,Pott L

更新日期：1997-07-01 00:00:00

abstract：:1. The effects of the nitrosothiol, S-nitroso N-acetylpenicillamine (SNAP) which liberates nitric oxide (NO), on ethanol-mediated gastric damage, blood flow and cyclic GMP levels in siaoloadenectomized (SALX) rats have been investigated. 2. Intraluminal instillation of ethanol (5-50% w/v) dose-dependently induced haem...

journal_title：British journal of pharmacology

authors： Tripp MA,Tepperman BL

更新日期：1995-05-01 00:00:00

abstract：:1. In the present paper, we describe the in vitro pharmacological properties of LF 16.0335 (1-[[3-[(2,4-dimethylquinolin-8-yl)oxymethyl]-2,4-dichloro-p henyl]sulphonyl] -2(S) - [[4 -[4-(aminoiminomethyl)phenylcarbonyl]piperazin-1-yl]ca rbonyl]pyrrolidine), a novel and potent nonpeptide antagonist of the human bradykin...

journal_title：British journal of pharmacology

authors： Pruneau D,Luccarini JM,Fouchet C,Defrêne E,Franck RM,Loillier B,Duclos H,Robert C,Cremers B,Bélichard P,Paquet JL

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tetracyclines were recently found to induce tumour cell death, but the early processes involved in this cytotoxic effect remain unclear. EXPERIMENTAL APPROACH:Viability of human and mouse melanoma cells was determined by MTT assay and flow cytometry. Kinase/protein/caspase activation was measure...

journal_title：British journal of pharmacology

authors： Shieh JM,Huang TF,Hung CF,Chou KH,Tsai YJ,Wu WB

更新日期：2010-07-01 00:00:00

abstract：:The interaction of a new nonribose ligand (LUF5831) with the human adenosine A1 receptor was investigated in the present study. Radioligand binding experiments were performed in the absence and presence of diverse allosteric modulators on both wild-type (wt) and mutant (T277A) adenosine A1 receptors. Thermodynamic dat...

journal_title：British journal of pharmacology

authors： Heitman LH,Mulder-Krieger T,Spanjersberg RF,von Frijtag Drabbe Künzel JK,Dalpiaz A,IJzerman AP

更新日期：2006-03-01 00:00:00

abstract：:The molecular mechanisms involved in veratridine-induced chromaffin cell death have been explored. We have found that exposure to veratridine (30 microM, 1 h) produces a delayed cellular death that reaches 55% of the cells 24 h after veratridine exposure. This death has the features of apoptosis as DNA fragmentation c...

journal_title：British journal of pharmacology

authors： Jordán J,Galindo MF,Calvo S,González-García C,Ceña V

更新日期：2000-08-01 00:00:00

abstract：:1. Guinea-pig tracheal smooth muscle cells were isolated and maintained in culture for 14-21 days prior to the study of the effect of a selective bradykinin B1 agonist and B2 antagonists upon bradykinin-stimulated phospholipase C and D activities. 2. Bradykinin-stimulated phospholipase C activity was determined by mas...

journal_title：British journal of pharmacology

authors： Pyne S,Pyne NJ

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pulmonary vascular dysfunction is a key event in acute lung injury. We recently demonstrated that PGE2 , via activation of E-prostanoid (EP)4 receptors, strongly enhances microvascular barrier function in vitro. The aim of this study was to investigate the beneficial effects of concomitant EP4 re...

journal_title：British journal of pharmacology

authors： Konya V,Maric J,Jandl K,Luschnig P,Aringer I,Lanz I,Platzer W,Theiler A,Bärnthaler T,Frei R,Marsche G,Marsh LM,Olschewski A,Lippe IT,Heinemann A,Schuligoi R

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Tobacco smoke represents a relevant risk factor for coronary heart disease (CHD). Although peroxisome proliferator-activated receptor (PPAR)gamma activation reduces inflammation and atherosclerosis, expression of PPARgamma in cells and its modulation by smoking are poorly investigated. We previou...

journal_title：British journal of pharmacology

authors： Amoruso A,Gunella G,Rondano E,Bardelli C,Fresu LG,Ferrero V,Ribichini F,Vassanelli C,Brunelleschi S

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:β-Adrenoceptor stimulation induces glucose uptake in several insulin-sensitive tissues by poorly understood mechanisms. EXPERIMENTAL APPROACH:We used a model system in CHO-K1 cells expressing the human β(2)-adrenoceptor and glucose transporter 4 (GLUT4) to investigate the signalling mechanisms i...

journal_title：British journal of pharmacology

authors： Dehvari N,Hutchinson DS,Nevzorova J,Dallner OS,Sato M,Kocan M,Merlin J,Evans BA,Summers RJ,Bengtsson T

更新日期：2012-03-01 00:00:00

abstract：:Oxidized low density lipoproteins (oxLDL) are thought to play a major role in atherosclerosis. OxLDL act in part through alteration of intracellular signalling pathways in cells of the vascular wall. We recently reported that the EGF receptor (EGFR) signalling pathway is activated by lipid peroxidation products (among...

journal_title：British journal of pharmacology

authors： Vacaresse N,Vieira O,Robbesyn F,Jürgens G,Salvayre R,Negre-Salvayre A

更新日期：2001-04-01 00:00:00

abstract：:1. The nature and cellular mechanisms that are responsible for endothelium-dependent relaxations resistant to indomethacin and NG-nitro-L-arginine methyl ester (L-NAME) were investigated in phenylephrine (PE) precontracted isolated carotid arteries from the rabbit. 2. In the presence of the cyclo-oxygenase inhibitor, ...

journal_title：British journal of pharmacology

authors： Dong H,Waldron GJ,Galipeau D,Cole WC,Triggle CR

更新日期：1997-02-01 00:00:00

abstract：:1. The effects of dopamine on vasoconstrictor responses to field stimulation of sympathetic nerves and to exogenous noradrenaline were studied in the isolated ear artery of the rabbit. Responses to noradrenaline were unchanged at the start of the dopamine infusions but were enhanced as the infusions continued and also...

journal_title：British journal of pharmacology

authors： Hope W,McCulloch MW,Rand MJ,Story DF

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:MLN4924 prevents the formation of active cullin-RING ubiquitin ligase complexes and thus inhibits NF-κB signalling. Here, we evaluated the effects of this compound on monocytes and dendritic cells (DCs). EXPERIMENTAL APPROACH:Monocytes and DCs were challenged with TNF or LPS in the presence and ...

journal_title：British journal of pharmacology

authors： El-Mesery M,Seher A,Stühmer T,Siegmund D,Wajant H

更新日期：2015-03-01 00:00:00

abstract：:1. The inhibitory effects of sodium nitroprusside (SNP), a nitric oxide (NO) donor, on mean arterial pressure (MAP) responses to NG-nitro-L-arginine (L-NNA) (NO synthase inhibitor), angiotensin II (AII) and noradrenaline (NA) were compared with those of pinacidil (KATP channel opener) and nifedipine (L-type calcium an...

journal_title：British journal of pharmacology

authors： Wang YX,Zhou T,Pang CC

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hypoxia in tumours is known to cause resistance to conventional chemotherapeutic drugs. In contrast, little is known about the effects of hypoxia on targeted anti-cancer drugs. This study evaluated the effect of hypoxia on a series of clinically approved tyrosine kinase inhibitors (TKIs). EXPERI...

journal_title：British journal of pharmacology

authors： Ahmadi M,Ahmadihosseini Z,Allison SJ,Begum S,Rockley K,Sadiq M,Chintamaneni S,Lokwani R,Hughes N,Phillips RM

更新日期：2014-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult onset disorder characterized by progressive neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to atrophy and paralysis of voluntary muscles responsible for motion and breathing. Except for a minority of patients harbouring genetic mutatio...

journal_title：British journal of pharmacology

authors： Manzano R,Toivonen JM,Moreno-Martínez L,de la Torre M,Moreno-García L,López-Royo T,Molina N,Zaragoza P,Calvo AC,Osta R

更新日期：2020-09-28 00:00:00

abstract：:1. Inhibition of nitric oxide generation with Nw-nitro-L-arginine (nitroarginine) reduced vasodilator responses to bradykinin and acetylcholine and enhanced those to nitroprusside in the rat isolated perfused kidney, preconstricted with phenylephrine. 2. Inhibition of cyclo-oxygenase with indomethacin, decreased the v...

journal_title：British journal of pharmacology

authors： Fulton D,McGiff JC,Quilley J

更新日期：1992-11-01 00:00:00

abstract：:1. The effects of the spasmogenic agents, carbachol (CCh), histamine, 5-hydroxytryptamine (5-HT) and 9,11-epithio-11,12-methano-thromboxane A2 (STA2) were investigated on smooth muscle tissues of the dog trachea. 2. CCh (10 microM) produced a larger contraction than high K (128 mM), 10 microM histamine, 5-HT or STA2. ...

journal_title：British journal of pharmacology

authors： Katsuyama H,Suzuki S,Nishiye E

更新日期：1990-05-01 00:00:00

abstract：:1. A grease-gap technique has been used to measure d.c. potentials, in response to the application of excitatory amino acids and electrical stimulation of the Schaffer collateral-commissural pathway, in the CA1 region of rat hippocampal slices. The actions of L-glutamate (L-Glu) have been quantified and compared to th...

journal_title：British journal of pharmacology

authors： Frenguelli BG,Blake JF,Brown MW,Collingridge GL

更新日期：1991-02-01 00:00:00

abstract：:1. Despite the observation of pharmacological responses to neuropeptide Y (NPY) in mammalian kidneys, there are species differences in the ease with which specific NPY binding sites can be demonstrated; we have investigated whether this can be explained by differential metabolism of NPY by a membrane-bound peptidase. ...

journal_title：British journal of pharmacology

authors： Price JS,Kenny AJ,Huskisson NS,Brown MJ

更新日期：1991-10-01 00:00:00

abstract：:1. The receptor for glucagon-like peptide-1 (GLP-1) can be activated by both its physiological hormone and a peptide discovered in the venom of the Gila Monster, exendin-4, which shows promise as an antidiabetic agent. 2. Exendin-4 displays receptor-binding properties not observed for GLP-1. Firstly, exendin-4 can be ...

journal_title：British journal of pharmacology

authors： Al-Sabah S,Donnelly D

更新日期：2003-09-01 00:00:00

abstract：:We investigated the ability of N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide (AC-5216), a novel mitochondrial benzodiazepine receptor (MBR) ligand, to produce anti-anxiety and antidepressant-like effects in various animal models. AC-5216 showed high affinity for MBRs prepared from rat...

journal_title：British journal of pharmacology

authors： Kita A,Kohayakawa H,Kinoshita T,Ochi Y,Nakamichi K,Kurumiya S,Furukawa K,Oka M

更新日期：2004-08-01 00:00:00

abstract：:In moderate-to-severe asthma, adding an inhaled long-acting β2 -adenoceptor agonist (LABA) to an inhaled corticosteroid (ICS) provides better disease control than simply increasing the dose of ICS. Acting on the glucocorticoid receptor (GR, gene NR3C1), ICSs promote anti-inflammatory/anti-asthma gene expression. In vi...

journal_title：British journal of pharmacology

authors： Newton R,Giembycz MA

更新日期：2016-12-01 00:00:00