Abstract:
:1 The role of histamine H1- and H2-receptors in mediating the cutaneous inflammatory response produced by exogenous histamine and the release of endogenous histamine from mast cells has been investigated by a method which permits simultaneous, quantitative measurement of vasodilatation, vascular permeability and oedema formation. 2 Histamine and the selective H1-receptor agonist, 2-(2-aminoethyl) pyridine, both produced vasodilatation, increased vascular permeability and oedema formation whereas the selective H2-receptor agonist, dimaprit, produced only vasodilatation. 3 Mepyramine and cimetidine both reduced the vasodilatation response to histamine, the combination of antagonists being superior to either antagonist alone. Mepyramine (but not cimetidine) virtually abolished extravascular albumin accumulation and oedema formation. 4 Mepyramine and cimetidine both reduced the vasodilatation response produced by active cutaneous anaphylaxis and compound 48/80. However, mepyramine was less effective in reducing the vascular permeability response to mast cell degranulation than to histamine. 5 In conclusion, the vasodilator response to histamine is mediated by both H1- and H2-receptors; the permeability response to histamine is mediated solely by H1-receptors. A combination of H1- and H2-receptor antagonists appears to be more effective than either antagonist alone in reducing cutaneous inflammatory reactions involving histamine.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Owen DA,Poy E,Woodward DF,Daniel Ddoi
10.1111/j.1476-5381.1980.tb07912.xsubject
Has Abstractpub_date
1980-08-01 00:00:00pages
615-23issue
4eissn
0007-1188issn
1476-5381journal_volume
69pub_type
杂志文章abstract::Effects of hypoxia on atrioventricular conduction were investigated in the Langendorff-perfused isolated heart of the rabbit with various extracellular calcium concentrations ([Ca2+]) as well as in the presence of verapamil, nifedipine, N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7) and chlorpromazine. The ...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1986.tb09496.x
更新日期:1986-05-01 00:00:00
abstract::1 The effects of microiontophoretically applied morphine and its interactions with the effects of microiontophoretic applications of either acetylcholine, (-)-noradrenaline or 5-hydroxytryptamine have been studied on single neurones in the brain stem of rats anaesthetized with urethane.2 Morphine excited or inhibited ...
journal_title:British journal of pharmacology
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doi:10.1111/j.1476-5381.1974.tb09591.x
更新日期:1974-01-01 00:00:00
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更新日期:1969-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although there are many new specific phosphodiesterase inhibitors with anti-inflammatory activity, none have yet reached the market because of their low therapeutic efficacy. Our study was aimed to evaluate the anti-inflammatory and anti-arthritic effect of an established phosphodiesterase inhibi...
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更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dilatation of cerebral and dural arteries causes a throbbing, migraine-like pain, indicating that these structures are involved in migraine. Clinical trials suggest that adenosine 5'-triphosphate-sensitive K(+) (K(ATP)) channel opening may cause migraine by dilatating intracranial arteries, inclu...
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1038/sj.bjp.0701726
更新日期:1998-04-01 00:00:00
abstract::1. The interactions between N-methyl-D-aspartate (NMDA) and metabotropic glutamate receptors (mGluRs) were investigated in striatal slices, by utilizing intracellular recordings, both in current- and voltage-clamp mode. 2. Bath-application (50 microM) or focal application of NMDA induced a transient membrane depolariz...
journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1997-03-01 00:00:00
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更新日期:2008-07-01 00:00:00
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更新日期:2011-09-01 00:00:00
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doi:10.1111/j.1476-5381.1993.tb12796.x
更新日期:1993-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-11-01 00:00:00
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更新日期:1998-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1476-5381.1988.tb11611.x
更新日期:1988-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjp.0705929
更新日期:2004-11-01 00:00:00
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doi:10.1038/sj.bjp.0705682
更新日期:2004-03-01 00:00:00
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更新日期:1970-07-01 00:00:00
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更新日期:1991-06-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1972-07-01 00:00:00
abstract::In this issue MacMillan and McCarron in 2010 demonstrated that the phospholipase C (PLC) inhibitor U-73122 can potently inhibit Ca(2+) release from isolated smooth muscle cells independent of its effect on PLC. Their data suggest that the PLC inhibitor can block the sarcoplasmic/endoplasmic reticulum calcium ATPase pu...
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pub_type: 评论,杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1977-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1972-11-01 00:00:00
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更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1974-07-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1995-04-01 00:00:00
abstract::1 The N6-2-O-dibutyryl derivative of adenosine 3',5'-monophosphate (db cyclic AMP) has been micro-injected into the third cerebral ventricle of the unanaesthetized, restrained mouse and the effects on body temperature and thermoregulatory activities observed. 2 Db cyclic AMP (4, 16 and 32 micrograms) injected intracer...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1980.tb08723.x
更新日期:1980-11-01 00:00:00