Pharmacological actions of a new -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats.

abstract：BACKGROUND AND PURPOSE:Protease-activated receptor 1 (PAR1) has been demonstrated to be involved in the pathogenesis of viral diseases. However, its role remains controversial. The goal of our study was to investigate the contribution of PAR1 to respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) infecti...

journal_title：British journal of pharmacology

authors： Lê VB,Riteau B,Alessi MC,Couture C,Jandrot-Perrus M,Rhéaume C,Hamelin MÈ,Boivin G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It has been extensively reported that the leading anti-diabetic drug, metformin, exerts significant anticancer effects. This hydrophilic, cationic drug requires cation transporters for cellular entry where it activates its intracellular target, the AMPK signalling pathway. However, clinical resul...

journal_title：British journal of pharmacology

authors： Cai H,Everett RS,Thakker DR

更新日期：2019-08-01 00:00:00

abstract：:1. Plasma exudation and blood flow changes induced by intradermal injection of prostaglandins E2 (PGE2), I2 (PG12), D2 (PGD2) and F2 alpha (PGF2 alpha) were measured in rabbit dorsal skin by the use of [131I]-albumin and 133Xe. 2. Little plasma exudation was produced by any of the prostaglandins when injected alone. 3...

journal_title：British journal of pharmacology

authors： Williams TJ

更新日期：1979-03-01 00:00:00

abstract：:1. The potential influences of nitric oxide (NO) and prostaglandins on the renal effects of angiotensin II (Ang II) have been investigated in the captopril-treated anaesthetized rat by examining the effect of indomethacin or the NO synthase inhibitor, N(omega)-nitro-L-arginine methyl ester (L-NAME), on the renal respo...

journal_title：British journal of pharmacology

authors： Clayton JS,Clark KL,Johns EJ,Drew GM

更新日期：1998-08-01 00:00:00

abstract：:Mast cells participate in allergies, and also in immunity and inflammation by secreting proinflammatory cytokines. Flavonoids are naturally occurring polyphenolic plant compounds, one group of which -- the flavonols, inhibits histamine and some cytokine release from rodent basophils and mast cells. However, the effect...

journal_title：British journal of pharmacology

authors： Kempuraj D,Madhappan B,Christodoulou S,Boucher W,Cao J,Papadopoulou N,Cetrulo CL,Theoharides TC

更新日期：2005-08-01 00:00:00

abstract：:1. The accumulation of (3)H-gamma-aminobutyric acid (GABA) by the isolated rat retina has been measured.2. When retinae were incubated at 37 degrees C in a medium containing (3)H-GABA, tissue:medium ratios of about 25:1 were attained after a 30 min incubation.3. After incubations of 40 min at 37 degrees C, almost all ...

journal_title：British journal of pharmacology

authors： Goodchild M,Neal MJ

更新日期：1973-03-01 00:00:00

abstract：:1. Effects of oestradiol on the electrical and mechanical properties of the rabbit basilar artery were investigated by use of microelectrode, patch-clamp and isometric tension recording methods. 2. Oestradiol (10 nM-100 microM) relaxed arterial tissue pre-contracted by excess [K]o solution (30 mM) in a concentration-d...

journal_title：British journal of pharmacology

authors： Ogata R,Inoue Y,Nakano H,Ito Y,Kitamura K

更新日期：1996-01-01 00:00:00

abstract：:1. The effects of forskolin, a direct activator of adenylate cyclase and sodium nitroprusside, a direct activator of guanylate cyclase, were studied on rabbit isolated ear arteries preconstricted with 80 mM potassium. 2. Bolus injection of these two compounds resulted in vasodilatation. They had similar potencies in t...

journal_title：British journal of pharmacology

authors： Wood LM,Owen DA

更新日期：1989-03-01 00:00:00

abstract：:1. We examined the effects of eprosartan, an AT(1) receptor antagonist, on the progression of left ventricular (LV) dysfunction and remodelling in dogs with heart failure (HF) produced by intracoronary microembolizations (LV ejection fraction, EF 30 to 40%). 2. Dogs were randomized to 3 months of oral therapy with low...

journal_title：British journal of pharmacology

authors： Suzuki G,Mishima T,Tanhehco EJ,Sharov VG,Todor A,Rostogi S,Gupta RC,Chaudhry PA,Anagnostopoulos PV,Nass O,Goldstein S,Sabbah HN

更新日期：2003-01-01 00:00:00

abstract：:1. We studied the effects of various K+ channel blockers on the vasodilator responses of guinea-pig isolated basilar arteries to nitrergic nerve stimulation, the nitric oxide (NO) donor sodium nitroprusside (SNP), and the membrane permeable guanosine-3',5'-cyclic monophosphate (cyclic GMP) analogue 8-bromo-cyclic GMP ...

journal_title：British journal of pharmacology

authors： Jiang F,Li CG,Rand MJ

更新日期：1998-01-01 00:00:00

abstract：:1 Human luteal tissue slices from days 18, 21 and 25 of the menstrual cycle were superfused in vitro with Medium 199 alone or containing cloprostenol (1 microgram/ml). Concentrations of progesterone, oestradiol-17beta and prostaglandins F2alpha and E2 were determined in the superfusate samples. 2 Secretion of steroids...

journal_title：British journal of pharmacology

authors： McDougall AN,Walker FM,Watson J

更新日期：1977-07-01 00:00:00

abstract：:1. Intracellular recordings were made from neurones in vitro in the rat substantia nigra zona compacta and ventral tegmental area; the neurones had the characteristic properties of dopamine-containing cells, and fired action potentials spontaneously. 2. Cocaine (1-10 microM) inhibited spontaneous firing, hyperpolarize...

journal_title：British journal of pharmacology

authors： Lacey MG,Mercuri NB,North RA

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iridoid glycosides containing the double bond scaffold of cyclopentapyran are reversible and orthosteric agonists of glucagon-like peptide-1 (GLP-1) receptors and exert anti-nociceptive and neuroprotective actions. Morroniside, derived from the medicinal herb Cornus officinalis, is an atypical se...

journal_title：British journal of pharmacology

authors： Xu M,Wu HY,Liu H,Gong N,Wang YR,Wang YX

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Insulin stimulates the transport of glucose in target tissues by triggering the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Resistance to insulin, the major abnormality in type 2 diabetes, results in a decreased GLUT4 translocation efficiency. Thus, special attention is...

journal_title：British journal of pharmacology

authors： Lanzerstorfer P,Stadlbauer V,Chtcheglova LA,Haselgrübler R,Borgmann D,Wruss J,Hinterdorfer P,Schröder K,Winkler SM,Höglinger O,Weghuber J

更新日期：2014-12-01 00:00:00

abstract：:1 A simple double-isotope assay for phospholipase A2 activity of perfused organs is described; Guinea-pig lungs perfused through the pulmonary circulation exhibit a low background enzyme activity. This activity is blocked by dexamethasone, betamethasone and hydrocortisone, mepacrine, procaine or chlorpromazine. Aspiri...

journal_title：British journal of pharmacology

authors： Blackwell GJ,Flower RJ,Nijkamp FP,Vane JR

更新日期：1978-01-01 00:00:00

abstract：:1. Adenosine has been shown to be responsible for the hyperaemic response of the hepatic artery to portal vein occlusion (the hepatic arterial 'buffer response'). 2. The effect of adenosine receptor blockade and of adenosine uptake inhibition on the hepatic arterial response to portal vein occlusion was investigated i...

journal_title：British journal of pharmacology

authors： Mathie RT,Alexander B

更新日期：1990-07-01 00:00:00

abstract：:1 The D3 dopamine receptor presumably activates Gi/Go subtypes of G-proteins, like the structurally analogous D2 receptor, but its signalling targets have not been clearly established due to weak functional signals from cloned receptors as heterologously expressed in mostly non-neuronal cell lines. 2 In this study, re...

journal_title：British journal of pharmacology

authors： Zaworski PG,Alberts GL,Pregenzer JF,Im WB,Slightom JL,Gill GS

更新日期：1999-11-01 00:00:00

abstract：:1. This study describes the effects of hypoxia on relaxing responses and cAMP production induced by the known vasodilator peptides: alphaCGRP, amylin (AMY) and adrenomedullin (AM) on isolated pig coronary arteries in vitro. 2. Hypoxic incubation increased the vasorelaxant effect of alphaCGRP (four-fold; P<0.05), AMY (...

journal_title：British journal of pharmacology

authors： Hasbak P,Eskesen K,Schifter S,Edvinsson L

更新日期：2005-07-01 00:00:00

abstract：:1. Two-electrode voltage clamp was used to study the effects of adenosine 3':5'-cyclic monophosphate (cyclic AMP) and guanosine 3':5'-cyclic monophosphate (cyclic GMP) on voltage-dependent ion channels in salivary gland cells of the leech, Haementeria ghilianii. 2. Intracellular cyclic AMP specifically blocked delayed...

journal_title：British journal of pharmacology

authors： Everill B,Berry MS

更新日期：1995-09-01 00:00:00

abstract：:A large range of neuroadaptations develop in response to chronic opioid exposure and these are thought to be more or less critical for expression of the major features of opioid addiction: tolerance, withdrawal and processes that may contribute to compulsive use and relapse. This review considers these adaptations at ...

journal_title：British journal of pharmacology

authors： Christie MJ

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Some neurosteroids, notably 3alpha-hydroxysteroids, positively modulate GABA(A) receptors, but sulphated steroids negatively modulate these receptors. Recently, other lipophilic amphiphiles have been suggested to positively modulate GABA receptors. We examined whether there was similarity among t...

journal_title：British journal of pharmacology

authors： Chisari M,Shu HJ,Taylor A,Steinbach JH,Zorumski CF,Mennerick S

更新日期：2010-05-01 00:00:00

abstract：:1 The reversible fatty acid amide hydrolase (FAAH) inhibitor OL135 reverses mechanical allodynia in the spinal nerve ligation (SNL) and mild thermal injury (MTI) models in the rat. The purpose of this study was to investigate the role of the cannabinoid and opioid systems in mediating this analgesic effect. 2 Elevated...

journal_title：British journal of pharmacology

authors： Chang L,Luo L,Palmer JA,Sutton S,Wilson SJ,Barbier AJ,Breitenbucher JG,Chaplan SR,Webb M

更新日期：2006-05-01 00:00:00

abstract：:The oestrogenic and antioestrogenic activities of a series of substituted derivatives of 1,1,2 triphenylbut-1-ene have been determined using primary cultures of rat pituitary gland cells to monitor prolactin synthesis in vitro. The relative binding affinity of the agonists for the oestrogen receptor was consistent wit...

journal_title：British journal of pharmacology

authors： Jordan VC,Koch R,Mittal S,Schneider MR

更新日期：1986-01-01 00:00:00

abstract：:1. The agonist action of the opioid peptide dynorphin A(1-8) on the myenteric plexus-longitudinal muscle of the guinea-pig ileum has been characterized. 2. The endogenous opioid peptide dynorphin A(1-8) was rapidly degraded by slices of myenteric plexus-longitudinal muscle of the guinea-pig ileum. 3. A product of the ...

journal_title：British journal of pharmacology

authors： Dixon DM,Traynor JR

更新日期：1990-11-01 00:00:00

abstract：:1. The role of both exogenously administered and endogenously generated bradykinin (BK) on LPS-induced eosinophil accumulation in the mice pleural cavity was investigated by means of treatment with BK selective receptor agonists/antagonists and captopril. 2. Intrathoracic (i.t.) injection of LPS (250 ng cavity(-1)) in...

journal_title：British journal of pharmacology

authors： Silva AR,Larangeira AP,Pacheco P,Calixto JB,Henriques MG,Bozza PT,Castro-Faria-Neto HC

更新日期：1999-05-01 00:00:00

abstract：:1 Non-adrenergic non-cholinergic (NANC) vasodilator nerves regulate tone in certain vascular beds. We have investigated the mechanisms of the NANC dilator response in the isolated small mesenteric artery of the rabbit by use of the tension myograph. 2 Small second or third order (150-300 microm in diameter) arteries o...

journal_title：British journal of pharmacology

authors： Kakuyama M,Vallance P,Ahluwalia A

更新日期：1998-01-01 00:00:00

abstract：:1. To elucidate whether K+ channels play a role in the action of epithelium-dependent bronchodilatation, we studied responses in human bronchial strips in the presence of indomethacin and NG-nitro-L-arginine methylester under isometric conditions, in vitro. 2. Mechanical removal of the epithelium increased the contrac...

journal_title：British journal of pharmacology

authors： Tamaoki J,Tagaya E,Isono K,Kondo M,Konno K

更新日期：1997-06-01 00:00:00

abstract：:1. First developed as an antiallergic drug, tranilast inhibits chemical mediator release from mast cells. In the present study, we examine the effects of tranilast on angiogenesis in vitro and in vivo and discuss the application of tranilast for angiogenic diseases. 2. Tranilast inhibited significantly the proliferati...

journal_title：British journal of pharmacology

authors： Isaji M,Miyata H,Ajisawa Y,Takehana Y,Yoshimura N

更新日期：1997-11-01 00:00:00

abstract：:1 The effects of the putative 5-hydroxytryptamine (5-HT) receptor antagonists, methysergide, mianserin and methergoline, the dopamine receptor antagonists, haloperidol, thioridazine and clozapine, and the noradrenaline (NA) receptor antagonists, phentolamine, phenoxybenzamine and propranolol on the behavioural respons...

journal_title：British journal of pharmacology

authors： Dourish CT

更新日期：1982-09-01 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors have been demonstrated to be a pivotal target for ethanol action. The present study examined the actions of acute ethanol exposure on NMDA-induced responses and the acute tolerance to ethanol actions in rat sympathetic preganglionic neurons (SPNs) in vitro and in vivo. NMDA (50 mi...

journal_title：British journal of pharmacology

authors： Lin HH,Hsieh WK,Shiu JY,Chiu TH,Lai CC

更新日期：2003-11-01 00:00:00