Actions of cocaine on rat dopaminergic neurones in vitro.

abstract：:Levetiracetam, the alpha-ethyl analogue of the nootropic piracetam, is a widely used antiepileptic drug (AED) that provides protection against partial seizures and is also effective in the treatment of primary generalized seizure syndromes including juvenile myoclonic epilepsy. Levetiracetam was discovered in 1992 thr...

journal_title：British journal of pharmacology

authors： Rogawski MA

更新日期：2008-08-01 00:00:00

abstract：:The properties of the ATPase released during electrical field stimulation (EFS) (8 Hz, 25 s) of the sympathetic nerves of the superfused rabbit isolated vas deferens were investigated. Superfusate collected during EFS rapidly metabolised exogenous ATP (100 microM) and 50% was broken down in 5.67+/-0.65 min. The main m...

journal_title：British journal of pharmacology

authors： Westfall TD,Menzies JR,Liberman R,Waterston S,Ramphir N,Westfall DP,Sneddon P,Kennedy C

更新日期：2000-11-01 00:00:00

abstract：:1. Series of analogues of acetylcholine have been prepared in which the acetyl group was replaced by phenylacetyl, cyclohexylacetyl, diphenylacetyl, dicyclohexylacetyl, (+/-)-phenylcyclohexylacetyl, benziloyl and (+/-)-phenylcyclohexylhydroxyacetyl groups and the trimethylammonium group was replaced by Me(2)EtN(+), Me...

journal_title：British journal of pharmacology

authors： Abramson FB,Barlow RB,Mustafa MG,Stephenson RP

更新日期：1969-09-01 00:00:00

abstract：:1 Effects of dopamine and noradrenaline were compared in helically-cut strips of canine cerebral arteries. 2 Dopamine caused a greater maximal contraction than noradrenaline, although the ED50 for noradrenaline was appreciably less. The contraction induced by these amines was reversed to a relaxation by treatment with...

journal_title：British journal of pharmacology

authors： Toda N

更新日期：1976-09-01 00:00:00

abstract：:1. The pharmacology of the slow afterhyperpolarization (sAHP) was studied in cultured rat hippocampal pyramidal neurones. 2. Clotrimazole, its in vivo metabolite, 2-chlorophenyl-bisphenyl-methanol (CBM) and the novel analogues, UCL 1880 and UCL 2027, inhibited the sI(AHP) with similar IC50s (1-2 microM). 3. Clotrimazo...

journal_title：British journal of pharmacology

authors： Shah MM,Miscony Z,Javadzadeh-Tabatabaie M,Ganellin CR,Haylett DG

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Azithromycin has been reported to modify activation of macrophages towards the M2 phenotype. Here, we have sought to identify the mechanisms underlying this modulatory effect of azithromycin on human monocytes, classically activated in vitro. EXPERIMENTAL APPROACH:Human blood monocytes were prim...

journal_title：British journal of pharmacology

authors： Vrančić M,Banjanac M,Nujić K,Bosnar M,Murati T,Munić V,Stupin Polančec D,Belamarić D,Parnham MJ,Eraković Haber V

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of the present study was to assess the interaction of nitrergic neurotransmission within the bed nucleus of the stria terminalis (BNST) with local glutamatergic and noradrenergic neurotransmission in the control of cardiovascular responses to acute restraint stress in rats. EXPERIMENTAL ...

journal_title：British journal of pharmacology

authors： Barretto-de-Souza L,Adami MB,Benini R,Crestani CC

更新日期：2018-10-01 00:00:00

abstract：:Constitutively active mu-opioid receptors (mu* receptors) are reported to be formed following prolonged agonist treatment of cells or whole animals. mu* receptors signal in the absence of activating ligand and a blockade of mu* activation of G-proteins by naloxone and naltrexone has been suggested to underlie the prof...

journal_title：British journal of pharmacology

authors： Connor M

更新日期：2009-04-01 00:00:00

abstract：:1. Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. 2. Heptaminol had no action on the sodium, potassium and calcium voltage-dependent ionic conductances. 3. The hypothesis of an action via an internal alkalinization wa...

journal_title：British journal of pharmacology

authors： Allard B,Jacquemond V,Lemtiri-Chlieh F,Pourrias B,Rougier O

更新日期：1991-11-01 00:00:00

abstract：:The inhibitory effects of three prostanoid analogues, EP 045, EP 092 and pinane thromboxane A2 (PTA2), on the aggregation of human platelets in vitro have been investigated. In diluted platelet-rich plasma (PRP), EP 045 (20 microM) and EP 092 (1 microM) completely inhibited irreversible aggregation responses to thromb...

journal_title：British journal of pharmacology

authors： Armstrong RA,Jones RL,Peesapati V,Will SG,Wilson NH

更新日期：1985-03-01 00:00:00

abstract：:1 Nateglinide, a novel oral hypoglycemic agent, rapidly reaches the maximum serum concentration after oral administration, suggesting that it is rapidly absorbed in the gastrointestinal tract. The aim of this work is to clarify the intestinal absorption mechanism of nateglinide by means of in vitro studies. 2 We exami...

journal_title：British journal of pharmacology

authors： Okamura A,Emoto A,Koyabu N,Ohtani H,Sawada Y

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:5alpha,8alpha-Epidioxy-22E-ergosta-6, 22-dien-3beta-ol (ergosterol peroxide) is a major antitumour sterol produced by edible or medicinal mushrooms. However, its molecular mechanism of action has yet to be determined. Here, we examine the anticancer and anti-inflammatory effects of ergosterol per...

journal_title：British journal of pharmacology

authors： Kobori M,Yoshida M,Ohnishi-Kameyama M,Shinmoto H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pyrazole derivatives have recently been suggested as selective blockers of transient receptor potential cation (TRPC) channels but their ability to distinguish between the TRPC and Orai pore complexes is ill-defined. This study was designed to characterize a series of pyrazole derivatives in term...

journal_title：British journal of pharmacology

authors： Schleifer H,Doleschal B,Lichtenegger M,Oppenrieder R,Derler I,Frischauf I,Glasnov TN,Kappe CO,Romanin C,Groschner K

更新日期：2012-12-01 00:00:00

abstract：:The effect of the imidazolidine Sgd 101/75 (2-[2-methylindazol-4-imino]-imidazolidine HCl) on blood pressure, as well as its alpha-adrenoceptor agonist activity and affinity for these receptors, were examined in various animal preparations. After both intravenous administration to conscious spontaneously hypertensive ...

journal_title：British journal of pharmacology

authors： Mathy MJ,Thoolen MJ,Timmermans PB,van Zwieten PA

更新日期：1984-02-01 00:00:00

abstract：:Dopamine, noradrenaline (NA) and adrenaline (Ad) depletion by 6-hydroxydopamine (6-OHDA) and pargyline plus 6-OHDA was investigated in the cat left ventricle, mesenteric and renal arteries, renal cortex, renal medulla and adrenal medulla. Catecholamine concentrations in plasma were also analyzed in these two experimen...

journal_title：British journal of pharmacology

authors： Caramona MM,Soares-da-Silva P

更新日期：1985-10-01 00:00:00

abstract：:1. Neurogenic responses to transmural electrical stimulation were examined in endothelium-denuded extrameningeal (vertebral and carotid) and intrameningeal (spinal, basilar and middle cerebral) arteries isolated from dogs. 2. In the extrameningeal arteries, transmural electrical stimulation produced a phasic contracti...

journal_title：British journal of pharmacology

authors： Kohno Y,Saito T,Saito H,Aoyama H,Nojyo Y,Kigoshi S,Muramatsu I

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The bladder urothelium is now known to have active properties. Our aim was to investigate the contractile properties of the urinary mucosa in response to the tachykinin neurokinin A (NKA) and carbachol. EXPERIMENTAL APPROACH:Discrete concentration-response curves for carbachol and NKA were obtai...

journal_title：British journal of pharmacology

authors： Sadananda P,Chess-Williams R,Burcher E

更新日期：2008-04-01 00:00:00

abstract：:Initiation of 60 min ischaemia to rat isolated hearts produced a depression in developed tension and heart rate. Subsequent reperfusion caused a greatly exacerbated creatine phosphokinase (CPK) efflux and limited functional recovery. Sulphinpyrazone (100 ng ml-1 and 1 microgram ml-1) significantly reduced CPK release,...

journal_title：British journal of pharmacology

authors： Karmazyn M

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N-arachidonoyl 5-HT (NA-5HT) has anti-nociceptive effects reported to be mediated by inhibitory actions at the transient receptor potential vanilloid receptor 1 (TRPV1) and fatty acid amide hydrolase (FAAH). Anandamide and N-arachidonoyl dopamine (NA-DA), endocannabinoids that activate TRPV1 or a...

journal_title：British journal of pharmacology

authors： Gilmore AJ,Heblinski M,Reynolds A,Kassiou M,Connor M

更新日期：2012-11-01 00:00:00

abstract：:Zanapezil (TAK-147 (3-[1benzylpiperdin-4-yl]-1-(2,3,4,5-tetrahydro-1 H-1-benzazepin-8-yl) propan-1-one fumarate)) is a selective acetylcholine (ACh) esterase inhibitor under investigation as a drug for Alzheimer's disease (AD) treatment. In this study, the effects of TAK-147 at 2 mg kg(-1) p.o. for 21 days, compared t...

journal_title：British journal of pharmacology

authors： Hatip-Al-Khatib I,Iwasaki K,Yoshimitsu Y,Arai T,Egashira N,Mishima K,Ikeda T,Fujiwara M

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:While remifentanil can be used either during labour or fetal surgery, more should be known about the transplacental transfer of this opioid. The aim of this study was to investigate the placental transfer and haemodynamic effects of remifentanil after i.v. administration to pregnant ewes. EXPERI...

journal_title：British journal of pharmacology

authors： Coonen JB,Marcus MA,Joosten EA,van Kleef M,Neef C,van Aken H,Gogarten W

更新日期：2010-12-01 00:00:00

abstract：:1. Ezetimibe potently inhibits the transport of cholesterol across the intestinal wall, thereby reducing plasma cholesterol in preclinical animal models of hypercholesterolemia. The effect of ezetimibe on known absorptive processes was determined in the present studies. 2. Experiments were conducted in the hamster and...

journal_title：British journal of pharmacology

authors： van Heek M,Farley C,Compton DS,Hoos L,Davis HR

更新日期：2001-09-01 00:00:00

abstract：:Rodent models of chronic pain may elucidate pathophysiological mechanisms and identify potential drug targets, but whether they predict clinical efficacy of novel compounds is controversial. Several potential analgesics have failed in clinical trials, in spite of strong animal modelling support for efficacy, but there...

journal_title：British journal of pharmacology

authors： Berge OG

更新日期：2011-10-01 00:00:00

abstract：:Despite the importance of members of the GPCR superfamily as targets of a broad range of effective medicines many GPCRs remain poorly characterised. GPR84 is an example. Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings and clinical trials to treat idiopathic pulmonar...

journal_title：British journal of pharmacology

authors： Marsango S,Barki N,Jenkins L,Tobin AB,Milligan G

更新日期：2020-09-01 00:00:00

abstract：:Gut inflammation occurring in patients with inflammatory bowel diseases (IBD) is associated with an excessive immune response that is directed against constituents of the normal bacterial flora and results in the production of large amounts of inflammatory cytokines. Anti-cytokine compounds, such as the neutralizing T...

journal_title：British journal of pharmacology

authors： Caprioli F,Caruso R,Sarra M,Pallone F,Monteleone G

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Many dementia patients exhibit behavioural and psychological symptoms (BPSD) that include psychosis, aggressivity, depression and anxiety. Antipsychotic drugs are frequently prescribed but fail to significantly attenuate mood deficits, may interfere with cognitive function and are associated with...

journal_title：British journal of pharmacology

authors： Kołaczkowski M,Mierzejewski P,Bieńkowski P,Wesołowska A,Newman-Tancredi A

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N-docosahexaenoylethanolamine (DHEA) is the ethanolamine conjugate of the long-chain polyunsaturated n-3 fatty acid docosahexaenoic (DHA; 22: 6n-3). Its concentration in animal tissues and human plasma increases when diets rich in fish or krill oil are consumed. DHEA displays anti-inflammatory pr...

journal_title：British journal of pharmacology

authors： Meijerink J,Poland M,Balvers MG,Plastina P,Lute C,Dwarkasing J,van Norren K,Witkamp RF

更新日期：2015-01-01 00:00:00

abstract：:1. We compared the ability of rat amylin, rat calcitonin gene-related peptide (CGRP) and rat and salmon calcitonins to elevate cyclic AMP levels and to inhibit [U-14C]-glucose incorporation into glycogen in insulin-stimulated intact rat soleus muscle and in two cell lines derived from rodent skeletal muscle, L6 and C2...

journal_title：British journal of pharmacology

authors： Pittner RA,Wolfe-Lopez D,Young AA,Beaumont K

更新日期：1996-03-01 00:00:00

abstract：:1. Protection against 1-methyl-4-phenylpyridinium ion (MPP+) neurotoxicity by two nitric oxide-related compounds, N omega-nitro-L-arginine (L-NOARG) and L-arginine, was studied in the corpus striatum by means of two MPP+ perfusions separated by 24 h. Dopamine extracellular output after the second MPP+ (1, 5 and 10 mM)...

journal_title：British journal of pharmacology

authors： Santiago M,Machado A,Cano J

更新日期：1994-03-01 00:00:00

abstract：:1. The effect of frusemide, ethacrynic acid and indanyloxyacetic acid was investigated on spontaneous calcium-activated chloride (ICl(Ca)) and potassium currents (IK(Ca)) in rabbit portal vein cells with the perforated patch technique. 2. Frusemide (0.3-1.0 x 10(-3) M) reduced the amplitude of spontaneous transient in...

journal_title：British journal of pharmacology

authors： Greenwood IA,Hogg RC,Large WA

更新日期：1995-07-01 00:00:00