Abstract:
:1. Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. 2. Heptaminol had no action on the sodium, potassium and calcium voltage-dependent ionic conductances. 3. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. 4. The action of heptaminol was suppressed in sodium-free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. 5. These results could be explained by a stimulation of the Na/H antiport by heptaminol.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Allard B,Jacquemond V,Lemtiri-Chlieh F,Pourrias B,Rougier Odoi
10.1111/j.1476-5381.1991.tb12493.xsubject
Has Abstractpub_date
1991-11-01 00:00:00pages
714-8issue
3eissn
0007-1188issn
1476-5381journal_volume
104pub_type
杂志文章abstract::1 The activity pattern of analogues of the enkephalins was determined in four parallel assays, the inhibition of the electrically evoked contraction of the guinea-pig ileum and mouse vas deferens at 36 degrees C and the inhibition of [(3)H]-naltrexone and [(3)H]-leucine-enkephalin binding at 0 to 4 degrees C in homoge...
journal_title:British journal of pharmacology
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doi:10.1111/j.1476-5381.1980.tb10422.x
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abstract:BACKGROUND AND PURPOSE:Pituitary adenylate cyclase-activating polypeptide (PACAP) is an excitatory neuropeptide with central and peripheral cardiovascular actions. Intrathecal PACAP increases splanchnic sympathetic nerve activity and heart rate, but not mean arterial pressure (MAP). We hypothesize that the three PACAP ...
journal_title:British journal of pharmacology
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journal_title:British journal of pharmacology
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abstract:BACKGROUND AND PURPOSE:Strontium ranelate, a drug approved and until recently used for the treatment of osteoporosis, mediates its effects on bone at least in part via the calcium-sensing (CaS) receptor. However, it is not known whether bone-targeted CaS receptor positive allosteric modulators (PAMs; calcimimetics) rep...
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pub_type: 杂志文章
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abstract::1. The effects of capsaicin on voltage-gated Ca2+ currents (ICa), and intracellular Ca2+ concentrations [( Ca2+]i) in cultured dorsal root ganglion (DRG) neurones of the rat were examined in vitro by use of combined patch clamp-microfluorometric recordings. 2. Under voltage-clamp conditions, capsaicin (0.1-10 microM) ...
journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1990-10-01 00:00:00
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更新日期:2009-11-01 00:00:00
abstract::1. The modulation by alpha 2-adrenoceptors of the jaw-opening reflex (digastric electromyographic responses) elicited by orofacial electrical stimulation (OF-JOR) in pentobarbitone anaesthetized rats was investigated. 2. Increasing doses of clonidine (0.1-1000 micrograms kg-1, i.v.) reduced, in a dose-dependent manner...
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更新日期:1994-04-01 00:00:00
abstract::1. The functional role of the nitric oxide (NO)/guanosine 3':5'-cyclic monophosphate (cyclic GMP) pathway in experimental myocardial ischaemia and reperfusion was studied in rat isolated hearts. 2. Rat isolated hearts were perfused at constant pressure with Krebs-Henseleit buffer for 25 min (baseline), then made ischa...
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更新日期:1998-03-01 00:00:00
abstract::The Mediterranean diet (MedDiet) is one of the most widely described and evaluated dietary patterns in scientific literature. It is characterized by high intakes of vegetables, legumes, fruits, nuts, grains, fish, seafood, extra virgin olive oil, and a moderate intake of red wine. A large body of observational and exp...
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pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1994.tb13019.x
更新日期:1994-05-01 00:00:00
abstract::1. The effects of four specific inhibitors of 5-hydroxytryptamine (K-HT) uptake on morphine-, methadone- or pethidine-induced antinociception was studied in rats. Antinociception was assessed by means of hot plate (55 degrees C) reaction times. The effect of the compounds on the uptake of [3H]-5-HT into rat whole brai...
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更新日期:2000-11-01 00:00:00
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pub_type: 评论,杂志文章
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更新日期:2012-07-01 00:00:00
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更新日期:1969-03-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:2016-04-01 00:00:00
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更新日期:1988-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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更新日期:2002-07-01 00:00:00
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更新日期:2010-06-01 00:00:00
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更新日期:2011-05-01 00:00:00