On the role of 5-hydroxytryptamine in drug-induced antinociception.

abstract：:The effects of histamine and of H1- and H2-receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea-pigs. Histamine and H2-receptor agonists (dimaprit, impromidine) dose-dependently decrease the positive chronotropic and inotropic effects, and the seve...

journal_title：British journal of pharmacology

authors： Blandina P,Brunelleschi S,Fantozzi R,Giannella E,Mannaioni PF,Masini E

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor agonists display a promising analgesic profile in preclinical studies. However, supraspinal N/OFQ produced hyperalgesia in rodents and such effects have not been addressed in primates. Thus, the aim of this study was to investigate the effects...

journal_title：British journal of pharmacology

authors： Ding H,Hayashida K,Suto T,Sukhtankar DD,Kimura M,Mendenhall V,Ko MC

更新日期：2015-07-01 00:00:00

abstract：:The opioid receptors are key targets in the treatment of acute and chronic pain, and the development of novel analgesics with reduced side effects is crucial in the search for more effective medications. The crystal structures of opioid receptors have provided a wealth of knowledge on many aspects of opioid receptor p...

journal_title：British journal of pharmacology

authors： Marino KA,Shang Y,Filizola M

更新日期：2018-07-01 00:00:00

abstract：:1. The in vitro hemisected spinal cord from young rat was used to investigate the mechanism of serotoninergic modulation of primary afferent-mediated synaptic transmission in the dorsal horn through activation of the 5-HT3 receptor. 2. Dorsal root-evoked excitatory post-synaptic potentials (DR-EPSPs) were recorded int...

journal_title：British journal of pharmacology

authors： Khasabov SG,Lopez-Garcia JA,Asghar AU,King AE

更新日期：1999-06-01 00:00:00

abstract：:Nociceptive tail flick latencies (TFL) were recorded in response to noxious thermal stimuli applied to lightly anaesthetized rats. The effects of intrathecally administered dopamine receptor agonists alone and combined with dopamine receptor antagonists were examined upon the TFL. Experiments were repeated on animals ...

journal_title：British journal of pharmacology

authors： Barasi S,Ben-Sreti MM,Clatworthy AL,Duggal KN,Gonzalez JP,Robertson J,Rooney KF,Sewell RD

更新日期：1987-01-01 00:00:00

abstract：:Noradrenaline (NA) and adrenaline (Ad) are modulators of cytokine production. Here we investigated the role of these neurotransmitters in the regulation of macrophage inflammatory protein (MIP)-1alpha expression. Pretreatment of RAW 264.7 macrophages with NA or Ad decreased, in a concentration-dependent manner (1 nM-1...

journal_title：British journal of pharmacology

authors： Haskó G,Shanley TP,Egnaczyk G,Németh ZH,Salzman AL,Vizi ES,Szabó C

更新日期：1998-11-01 00:00:00

abstract：:1. The effects of the glycine/NMDA receptor antagonist, (+)-HA-966 on the neurochemical and behavioural responses to amphetamine have been determined in the mouse and rat. 2. In vehicle-treated control mice, (+)-HA-966 (30-100 mg kg-1) did not affect dopamine synthesis in either the nucleus accumbens or striatum and w...

journal_title：British journal of pharmacology

authors： Hutson PH,Bristow LJ,Thorn L,Tricklebank MD

更新日期：1991-08-01 00:00:00

abstract：:1 Citrated platelet-rich plasma was prepared from New Zealand white rabbits before, during and after administration of chlorpromazine (2 mg/kg) intramuscularly once daily for 3 to 4 weeks. 2 In these plasmas, the velocity of platelet aggregation by 5-hydroxytryptamine (5-HT) added at 1, 3 and 10 microM increased great...

journal_title：British journal of pharmacology

authors： Baldacci M,Baldacci M,Bergel TD,Born GV,Hickman M

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dilatation of cerebral and dural arteries causes a throbbing, migraine-like pain, indicating that these structures are involved in migraine. Clinical trials suggest that adenosine 5'-triphosphate-sensitive K(+) (K(ATP)) channel opening may cause migraine by dilatating intracranial arteries, inclu...

journal_title：British journal of pharmacology

authors： Ploug KB,Boni LJ,Baun M,Hay-Schmidt A,Olesen J,Jansen-Olesen I

更新日期：2008-05-01 00:00:00

abstract：:We compared the modulation of synaptic transmission by adenosine A(1) receptors in the hippocampus of aged (24 months) and young adult rats (6 weeks). The adenosine A(1) receptor agonist, N(6)-cyclopentyladenosine, was less potent (P:<0.05) to inhibit synaptic transmission in aged (EC(50)=53 nM) than young adult (EC(5...

journal_title：British journal of pharmacology

authors： Sebastião AM,Cunha RA,de Mendonça A,Ribeiro JA

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Pancreatic cancer is a solid tumour that is often fatal. Hence, there is an urgent need to identify new drug targets for this disease. Highly proliferating cancer cells have an increased demand for nutrients and, therefore, need to up-regulate selective amino acid transporters. Here, we investiga...

journal_title：British journal of pharmacology

authors： Coothankandaswamy V,Cao S,Xu Y,Prasad PD,Singh PK,Reynolds CP,Yang S,Ogura J,Ganapathy V,Bhutia YD

更新日期：2016-12-01 00:00:00

abstract：:Photorelaxation of vascular smooth muscle (VSM) is caused by the release of nitric oxide (NO) from a finite molecular store that can be depleted by irradiating pre-contracted arteries with visible light. The ability of an 'exhausted' vessel to respond to a further period of illumination is lost temporarily but then re...

journal_title：British journal of pharmacology

authors： Megson IL,Holmes SA,Magid KS,Pritchard RJ,Flitney FW

更新日期：2000-08-01 00:00:00

abstract：:The tachykinin, neurokinin A (NKA), contracts guinea-pig airways both in vitro and in vivo, preferentially activating smooth muscle NK(2) receptors, although smooth muscle NK(1) receptors may also contribute. In vitro evidence suggests that NKA activates epithelial NK(1) receptors, inducing the release of nitric oxide...

journal_title：British journal of pharmacology

authors： Ricciardolo FL,Trevisani M,Geppetti P,Nadel JA,Amadesi S,Bertrand C

更新日期：2000-03-01 00:00:00

abstract：:1. We studied the effects of various K+ channel blockers on the vasodilator responses of guinea-pig isolated basilar arteries to nitrergic nerve stimulation, the nitric oxide (NO) donor sodium nitroprusside (SNP), and the membrane permeable guanosine-3',5'-cyclic monophosphate (cyclic GMP) analogue 8-bromo-cyclic GMP ...

journal_title：British journal of pharmacology

authors： Jiang F,Li CG,Rand MJ

更新日期：1998-01-01 00:00:00

abstract：:1. In circular smooth muscle of the guinea-pig gastric fundus, transmural nerve stimulation evoked a cholinergic excitatory junction potential (e.j.p.), and blockade of the e.j.p. by atropine revealed a non-adrenergic non-cholinergic (NANC) inhibitory junction potential (i.j.p.). 2. The amplitude of the e.j.p. was inc...

journal_title：British journal of pharmacology

authors： Ohno N,Xue L,Yamamoto Y,Suzuki H

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Saponins isolated from Panax notoginseng (Burk.) F.H. Chen have been shown to relieve thrombogenesis and facilitate haemostasis. However, it is not known which saponin accounts for this haemostatic effect. Hence, in the present study we aimed to identify which saponins contribute to its haemostat...

journal_title：British journal of pharmacology

authors： Gao B,Huang L,Liu H,Wu H,Zhang E,Yang L,Wu X,Wang Z

更新日期：2014-01-01 00:00:00

abstract：:1. Endothelial cell damage in glomeruli and kidney arterioles appears to play a pivotal role in glomerular inflammatory diseases. Glomerular endothelial cells, a specialized microvascular cell type involved in the regulation of glomerular ultrafiltration, die by apoptosis in response to tumour necrosis factor-alpha (T...

journal_title：British journal of pharmacology

authors： Messmer UK,Winkel G,Briner VA,Pfeilschifter J

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Down's syndrome is a common genetic cause of intellectual disability, for which there are no drug therapies. Mechanistic studies in a model of Down's syndrome [Ts65Dn (TS) mice] demonstrated that impaired cognitive function was due to excessive neuronal inhibitory tone. These deficits were normal...

journal_title：British journal of pharmacology

authors： Colas D,Chuluun B,Warrier D,Blank M,Wetmore DZ,Buckmaster P,Garner CC,Heller HC

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The beneficial effect of 5-HT6 receptor antagonism in cognition remains controversial. This study has been undertaken to reassess the cognition enhancing properties of acute vs subchronic treatment with the selective 5-HT6 receptor antagonist SB-271046 in unimpaired rats, as well as against scopo...

journal_title：British journal of pharmacology

authors： Marcos B,Chuang TT,Gil-Bea FJ,Ramirez MJ

更新日期：2008-10-01 00:00:00

abstract：:1. Use of the antihyperglycaemic agent, metformin, is often associated with a small rise in circulating lactate. This study investigates the source of the lactate and examines the effect of metformin on glucose metabolism by the intestine and liver of rats. 2. Changes in plasma glucose and lactate were measured in the...

journal_title：British journal of pharmacology

authors： Bailey CJ,Wilcock C,Day C

更新日期：1992-04-01 00:00:00

abstract：:1. The aim of this study was to determine the conditions under which the alpha2-adrenoceptor agonist UK14304 produces vasoconstriction in the porcine isolated ear artery. 2. UK14304 (0.3 microM) produced a small contraction of porcine isolated ear arteries which was 7.8+/-3.3% of the response to 60 mM KCl. Similar siz...

journal_title：British journal of pharmacology

authors： Roberts RE,Tomlinson AE,Kendall DA,Wilson VG

更新日期：1998-07-01 00:00:00

abstract：:Ligands targeting GPCRs can be categorized according to their intrinsic efficacy to trigger a specific, receptor-mediated response. A ligand endowed with the same level of efficacy as the endogenous agonist can be classified as a full agonist, whereas a compound that displays greater efficacy, that is, higher receptor...

journal_title：British journal of pharmacology

authors： Schrage R,De Min A,Hochheiser K,Kostenis E,Mohr K

更新日期：2016-10-01 00:00:00

abstract：:The aim of this study was to investigate the structure-activity relationship of S-alkyl-L-isothiocitrulline-containing dipeptides towards three partially purified recombinant human nitric oxide synthase (NOS) isozymes, as well as the effects of these compounds on cytokine-induced NO production by human DLD-1 cells. In...

journal_title：British journal of pharmacology

authors： Park JM,Higuchi T,Kikuchi K,Urano Y,Hori H,Nishino T,Aoki J,Inoue K,Nagano T

更新日期：2001-04-01 00:00:00

abstract：:1 Noradrenaline and clonidine were applied by microiontophoresis to single neurones in the cerebral cortex and medullary reticular formation of anaesthetized rats.2 Of a total of 247 neurones studied, 79% of medullary units and 60% of cortical units responded in the same manner to both noradrenaline and clonidine. The...

journal_title：British journal of pharmacology

authors： Anderson C,Stone TW

更新日期：1974-07-01 00:00:00

abstract：:1. Murine left atrium lacks inotropic beta(2)-adrenoceptor function. We investigated whether beta(2)-adrenoceptors are involved in the cardiostimulant effects of (-)-adrenaline on spontaneously beating right atria and paced right ventricular myocardium of C57BL6 mice. We also studied a negative inotropic effect of (-)...

journal_title：British journal of pharmacology

authors： Heubach JF,Rau T,Eschenhagen T,Ravens U,Kaumann AJ

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A non-psychoactive phytocannabinoid, cannabidiol (CBD), shows promising results as an effective potential antiepileptic drug in some forms of refractory epilepsy. To elucidate the mechanisms by which CBD exerts its anti-seizure effects, we investigated its effects at synaptic connections and on t...

journal_title：British journal of pharmacology

authors： Khan AA,Shekh-Ahmad T,Khalil A,Walker MC,Ali AB

更新日期：2018-06-01 00:00:00

abstract：:Midbrain dopaminergic (DA) neurones sustain important physiological functions such as control of motricity, signalling of the error in prediction of rewards and modulation of emotions and cognition. Moreover, their degeneration leads to Parkinson's disease and they may be dysfunctional in other pathological states, su...

journal_title：British journal of pharmacology

authors： Seutin V

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Non-alcoholic fatty liver disease (NAFLD) is considered to be one of the most common chronic liver diseases across worldwide. Astaxanthin (Ax) is a carotenoid, and beneficial effects of astaxanthin, including anti-oxidative, anti-inflammatory, and anti-tumour activity, have been identified. The p...

journal_title：British journal of pharmacology

authors： Wu L,Mo W,Feng J,Li J,Yu Q,Li S,Zhang J,Chen K,Ji J,Dai W,Wu J,Xu X,Mao Y,Guo C

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Intrathecal (i.t.) injection of orexin A (OX-A) increases blood pressure and heart rate (HR), but the effects of OX-A on sympathetic and phrenic, nerve activity, and the baroreflex(es), somato-sympathetic and hypoxic chemoreflex(es) are unknown. EXPERIMENTAL APPROACH:Urethane-anaesthetized, vagotomized and ...

journal_title：British journal of pharmacology

authors： Shahid IZ,Rahman AA,Pilowsky PM

更新日期：2011-02-01 00:00:00

abstract：:We studied the effects of the novel Na(+)/Ca(2+) exchange inhibitor KB-R7943, 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulphonate, on the native nicotinic receptors present at the bovine adrenal chromaffin cells, as well as on rat brain alpha(3)beta(4) and alpha(7) nicotinic acetylcholine receptors (A...

journal_title：British journal of pharmacology

authors： Pintado AJ,Herrero CJ,García AG,Montiel C

更新日期：2000-08-01 00:00:00