5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro.

abstract：:1. NaF (10 mM) produced a 2-3 fold increase in adenylate cyclase activity in homogenates of NG108-15 cells incubated in the presence of 1 microM GTP. Higher concentrations of NaF suppressed adenylate cyclase activity. 2. In the presence of the adenosine receptor agonist 5'-(N-ethyl)-carboxamidoadenosine (NECA; 100 mic...

journal_title：British journal of pharmacology

authors： Kelly E,Keen M,Nobbs P,MacDermot J

更新日期：1990-06-01 00:00:00

abstract：:1. The subtypes of endothelin receptors that mediate the effects of endothelin-1 (ET-1) on mean arterial pressure (MAP), heart rate (HR), mean circulatory filling pressure (MCFP), arterial resistance (RA), cardiac output (CO) and venous resistance (RV) were characterized in 9 groups of pentobarbitone-anaesthetized rat...

journal_title：British journal of pharmacology

authors： Palacios B,Lim SL,Pang CC

更新日期：1997-11-01 00:00:00

abstract：:Burimamide, an H(2)-receptor blocking agent, has been shown capable of blocking the uptake and metabolism of [(14)C]-histamine, both in the guinea-pig isolated atrium and in murine neoplastic mast cells. This occurs even at concentrations far below the dose range capable of blocking the positive chronotropic effect of...

journal_title：British journal of pharmacology

authors： Fantozzi R,Mannaioni PF,Moroni F

更新日期：1973-10-01 00:00:00

abstract：:1. The aim of the present study was to test the effects of DAU 6215 (endo-N-(8-methyl-8-azabicyclo-[3.2.1]-octo-3-yl)-2,3-dihydro-2-ox o-1H- benzimidazole-1-carboxamide carboxamide hydrochloride), a newly synthesized, selective 5-hydroxytryptamine3 (5-HT3) antagonist, on the cell membrane properties and on characteriz...

journal_title：British journal of pharmacology

authors： Passani MB,Pugliese AM,Azzurrini M,Corradetti R

更新日期：1994-06-01 00:00:00

abstract：:1 The influence of dopamine receptor agonists on gastric acid secretion stimulated by thyrotropin-releasing hormone (TRH) was studied in the perfused stomach of anaesthetized rats. 2 Intraventricular TRH produced a dose-dependent stimulation of basal gastric acid secretion. 3 Pretreatment with apomorphine, bromocripti...

journal_title：British journal of pharmacology

authors： Maeda-Hagiwara M,Watanabe K

更新日期：1983-05-01 00:00:00

abstract：:The effect of leukaemia inhibitory factor (LIF) in modulating cholinergic and sensory nerve function was examined using guinea-pig tracheal explants. Specific LIF receptors (LIFR) were immunolocalized to both cholinergic and sensory nerves. Release of SP in culture was not influenced by LIF. Similarly, maximum contrac...

journal_title：British journal of pharmacology

authors： Knight DA,D'Aprile AC,Spalding LJ,Goldie RG,Thompson PJ

更新日期：2000-07-01 00:00:00

abstract：:Adrenergic transmission was investigated in the dog mesenteric vein by recording electrical responses of single smooth muscle cells to perivascular nerve stimulation. Perivascular nerve stimulation generated an excitatory junction potential (e.j.p.) and a slow depolarization of the membrane. The amplitude of the e.j.p...

journal_title：British journal of pharmacology

authors： Suzuki H

更新日期：1984-03-01 00:00:00

abstract：:1. Measurements were made of the uptake, metabolism and release of [(3)H]-adrenaline by human platelets in citrated plasma or in an artificial medium.2. Radioactive adrenaline was not taken up at 0-2 degrees C. At 37 degrees C there was a slow uptake which continued for at least 5 hours.3. About half of the radioactiv...

journal_title：British journal of pharmacology

authors： Born GV,Smith JB

更新日期：1970-08-01 00:00:00

abstract：:1. A study has been made of serum, mixed and parotid salivary levels attained in normal volunteers following oral dosage of 500 mg phenoxymethylpenicillin tablets, 500 mg crushed phenoxymethylpenicillin tablets in capsules, 500 mg ampicillin, 500 mg cloxacillin and 500 mg cephalexin.2. High mixed saliva levels were ob...

journal_title：British journal of pharmacology

authors： Speirs CF,Stenhouse D,Stephen KW,Wallace ET

更新日期：1971-09-01 00:00:00

abstract：:1. Short-circuit current (SCC) technique was used to study the adrenoceptors involved in the electrogenic chloride secretion by cultured cauda epididymal epithelium of rats. Stimulation of the epithelium with noradrenaline (primarily beta 1-adrenoceptor selective agonist), salbutamol (beta 2-adrenoceptor selective ago...

journal_title：British journal of pharmacology

authors： Leung AY,Yip WK,Wong PY

更新日期：1992-09-01 00:00:00

abstract：:Inhibition of myocardial Ca2+ channels was investigated for three dihydropyridines with different structural features: Ro 18-3981, darodipine (PY 108-068) and nifedipine. Ro 18-3981 contains a sulphamoyl acetyl side-chain. In voltage-clamps experiments with isolated cardiac myocytes of guinea-pig, Ro 18-3981 caused a ...

journal_title：British journal of pharmacology

authors： Holck M,Osterrieder W

更新日期：1987-05-01 00:00:00

abstract：:1. Functional GABA-gated chloride channels are formed when cRNA encoding the Drosophila melanogaster GABA receptor subunit RDL is injected into the cytoplasm of Xenopus oocytes. Two-electrode voltage-clamp was used to investigate allosteric modulation of GABA-induced currents recorded from the expressed, bicuculline-i...

journal_title：British journal of pharmacology

authors： Hosie AM,Sattelle DB

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recent studies suggest that the effects of cyclooxygenase-2 (COX-2) inhibition are mediated by cannabinoid receptor activation. However, some non-steroidal anti-inflammatory drugs inhibit the enzyme fatty acid amide hydrolase, which regulates levels of some endocannabinoids. Whether COX-2 directl...

journal_title：British journal of pharmacology

authors： Staniaszek LE,Norris LM,Kendall DA,Barrett DA,Chapman V

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N-arachidonoyl-serotonin (AA-5-HT) is an inhibitor of fatty acid amide hydrolase (FAAH)-catalysed hydrolysis of the endocannabinoid/ endovanilloid compound, anandamide (AEA). We investigated if AA-5-HT antagonizes the transient receptor potential vanilloid-1 (TRPV1) channel and, as FAAH and TRPV1...

journal_title：British journal of pharmacology

authors： Maione S,De Petrocellis L,de Novellis V,Moriello AS,Petrosino S,Palazzo E,Rossi FS,Woodward DF,Di Marzo V

更新日期：2007-03-01 00:00:00

abstract：:1. The intravenous, subcutaneous and oral toxicity of ambenoxan in mice is reported.2. Ambenoxan is a centrally acting skeletal muscle relaxant shown to be effective in mice, rats, rabbits, dogs and monkeys without loss of the righting reflex.3. It had no peripheral neuromuscular blocking properties.4. Decerebrate rig...

journal_title：British journal of pharmacology

authors： Shapero M,Southgate PJ

更新日期：1970-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is increasing evidence that not only the monoaminergic but also the glutamatergic system is involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). Hyperactivity of glutamate metabolism might be causally related to a hypoactive state in the dopaminergic system. A...

journal_title：British journal of pharmacology

authors： Ludolph AG,Udvardi PT,Schaz U,Henes C,Adolph O,Weigt HU,Fegert JM,Boeckers TM,Föhr KJ

更新日期：2010-05-01 00:00:00

abstract：:1. This study examined the impact of allopurinol on the renal functional responses to a 30 min period of ischaemia in anaesthetized rats. 2. Immediately on reperfusion, blood pressure rose transiently, while renal blood flow remained stable throughout at control values. Glomerular filtration rate was decreased by some...

journal_title：British journal of pharmacology

authors： Hestin D,Johns EJ

更新日期：1999-09-01 00:00:00

abstract：:1. The involvement of nitric oxide (NO) in the regulation of angiogenesis was examined in the in vivo system of the chorioallantoic membrane (CAM) of the chick embryo and in the matrigel tube formation assay. 2. Sodium nitroprusside (SNP) (0.37-28 nmol/disc), which releases NO spontaneously, caused a dose-dependent in...

journal_title：British journal of pharmacology

authors： Pipili-Synetos E,Sakkoula E,Haralabopoulos G,Andriopoulou P,Peristeris P,Maragoudakis ME

更新日期：1994-03-01 00:00:00

abstract：:1. The role of alpha- and beta-adrenoceptor subtypes in the regulation of plasma glucose and immunoreactive insulin (IRI) levels has been investigated in normal conscious fasted rats by employing selective agonists and antagonists. 2. Adrenaline (0.2 mg kg-1)-induced hyperglycaemia was abolished by the selective alpha...

journal_title：British journal of pharmacology

authors： John GW,Doxey JC,Walter DS,Reid JL

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Up-regulation of thioredoxin interacting protein (TXNIP), an endogenous inhibitor of thioredoxin (Trx), compromises cellular antioxidant and anti-apoptotic defences and stimulates pro-inflammatory cytokines expression, implying a role for TXNIP in apoptosis. Here we have examined the causal role ...

journal_title：British journal of pharmacology

authors： Al-Gayyar MM,Abdelsaid MA,Matragoon S,Pillai BA,El-Remessy AB

更新日期：2011-09-01 00:00:00

abstract：:1 A procedure involving two guinea-pig isolated hearts perfused in series is described for detecting in the recipient heart the release of a possible coronary vasodilator metabolite from the donor heart. 2 Adrenaline and isoprenaline stimulated the rate and force of contraction and produced a multiphasic coronary vasc...

journal_title：British journal of pharmacology

authors： Broadley KJ

更新日期：1976-09-01 00:00:00

abstract：:1. The effects of seven agonist and three antagonist adenosine receptor ligands were compared on the guinea-pig sinoatrial (SA) node (isolated right atrium) and atrioventricular (AV) node (perfused whole heart). Single agonist concentration-effect curves were obtained to 5'-N-ethylcarboxamidoadenosine (NECA), R(-)-N6-...

journal_title：British journal of pharmacology

authors： Meester BJ,Shankley NP,Welsh NJ,Wood J,Meijler FL,Black JW

更新日期：1998-06-01 00:00:00

abstract：:1. TRPM8 (CMR1) is a Ca(2+)-permeable channel, which can be activated by low temperatures, menthol, eucalyptol and icilin. It belongs to the transient receptor potential (TRP) family, and therefore is related to vanilloid receptor type-1 (VR1, TRPV1). We tested whether substances which are structurally related to ment...

journal_title：British journal of pharmacology

authors： Behrendt HJ,Germann T,Gillen C,Hatt H,Jostock R

更新日期：2004-02-01 00:00:00

abstract：:1 Physiologically, perisinusoidal hepatic stellate cells (HSC) are quiescent and store retinoids. During liver injury and in cell culture, HSC transform into proliferating myofibroblast-like cells that express alpha-smooth muscle actin (alpha-sma) and produce excessive amounts of extracellular matrix. During transform...

journal_title：British journal of pharmacology

authors： Chi X,Anselmi K,Watkins S,Gandhi CR

更新日期：2003-06-01 00:00:00

abstract：:The effects of a new selective beta1-adrenoceptor agonist, (--)-1-(4-hydroxyphenoxy)-3-isopropyl-amino-propanol-2-hydrochloride (H 133/22), on amylase secretion from the rat parotid gland were investigated in an in vitro system. The results were compared to the secretory responses obtained with noradrenaline, adrenali...

journal_title：British journal of pharmacology

authors： Carlsöö B,Danielsson A,Henriksson R

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ajmaline is a widely used antiarrhythmic drug. Its action on voltage-gated ion channels in skeletal muscle is not well documented and we have here elucidated its effects on Na(+) and K(+) channels. EXPERIMENTAL APPROACH:Sodium (I(Na)) and potassium (I(K)) currents in amphibian skeletal muscle fi...

journal_title：British journal of pharmacology

authors： Friedrich O,V Wegner F,Wink M,Fink RH

更新日期：2007-05-01 00:00:00

abstract：:1. In order to determine whether the renin-angiotensin system is involved in myocardial ischaemia-reperfusion injury, we investigated and compared the effects on infarct size of two different drugs which interfere with this system, i.e., an angiotensin II (AT1) antagonist, EXP3174, and an angiotensin I-converting enzy...

journal_title：British journal of pharmacology

authors： Richard V,Ghaleh B,Berdeaux A,Giudicelli JF

更新日期：1993-11-01 00:00:00

abstract：:The properties of the ATPase released during electrical field stimulation (EFS) (8 Hz, 25 s) of the sympathetic nerves of the superfused rabbit isolated vas deferens were investigated. Superfusate collected during EFS rapidly metabolised exogenous ATP (100 microM) and 50% was broken down in 5.67+/-0.65 min. The main m...

journal_title：British journal of pharmacology

authors： Westfall TD,Menzies JR,Liberman R,Waterston S,Ramphir N,Westfall DP,Sneddon P,Kennedy C

更新日期：2000-11-01 00:00:00

abstract：:1. The drug HA-966 (1-hydroxy-3-amino-pyrrolidone-2), which chemically resembles the cyclic form of GABA, has been studied for neuro-pharmacological properties and for effects on the catecholamine content of the corpus striatum.2. The acute effects on spontaneous behaviour of rodents included flaccid catalepsy and rev...

journal_title：British journal of pharmacology

authors： Bonta IL,De Vos CJ,Grijsen H,Hillen FC,Noach EL,Sim AW

更新日期：1971-11-01 00:00:00

abstract：:I.c.v. self-administration of MDMA (0.01-2 micro g per infusion), alone and in combination with CP 55,940 (0.4 micro g infusion(-1)), was studied on an operant responding procedure. On the basis of individual preference for one of two levers, developed during training, rats were allowed to self-administer vehicle from...

journal_title：British journal of pharmacology

authors： Braida D,Sala M

更新日期：2002-08-01 00:00:00