Efficacy of preoperative versus postoperative ketorolac tromethamine 0.5% in reducing inflammation after cataract surgery.

Abstract:

PURPOSE:To compare the efficacy of 30 minute preoperative versus 1 day postoperative administration of ketorolac tromethamine 0.5% ophthalmic solution (Acular) in reducing anterior chamber inflammation after cataract surgery. SETTING:The Hermann Eye Center, The University of Texas Health Science Center-Houston, Texas, USA. METHODS:Fifty eyes of 48 consecutive patients scheduled for phacoemulsification with intraocular lens implantation were included. Before surgery, patients were randomly assigned to start the study drug 30 minutes preoperatively or 1 day postoperatively. No other antiinflammatory agents were used intraoperatively or postoperatively. Main outcome measures were flare and cell counts. RESULTS:Preoperative and postoperative flare and cell counts did not differ significantly between the 2 treatment groups at any time. Both groups showed significant increases in flare (P =.0001) and cells (P =.0001) 1 day postoperatively. Flare and cells returned to baseline levels by day 28 in both groups. There was no significant difference at any time between the 2 groups in the change from the preoperative level of inflammation. CONCLUSIONS:There was no difference between administering ketorolac 30 minutes preoperatively versus 1 day postoperatively in reducing inflammation.

authors

El-Harazi SM,Ruiz RS,Feldman RM,Villanueva G,Chuang AZ

doi

10.1016/s0886-3350(00)00519-8

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

1626-30

issue

11

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(00)00519-8

journal_volume

26

pub_type

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