Abstract：
:Cell adhesion provides not only physical linkage but also communication between the cell and its environment. As such, it is important to many cellular functions. Recently, the probability distribution of forming a low number of specific adhesive bonds in a short-duration contact has been described (Chesla et al., Biophys. J. , 1998, 75:1553-1572). This model assumes that binding occurs between a single receptor species and a single ligand species. However, cell adhesion molecules rarely work alone in physiological settings. To account for these in vivo situations, we extended the previous model to include concurrent interactions of multiple receptor-ligand species, introducing the concept of independent binding. Closed-form solutions have been obtained for cases where competition is absent or can be neglected. In two companion papers (Williams et al., Biophys. J., 2000, 79:1858-1866; 2000, 79:1867-1875), the model developed herein has been applied to analyze two sets of experiments designed such that the validity of the theory was also tested.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Zhu C,Williams TEdoi
10.1016/S0006-3495(00)76434-4subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1850-7issue
4eissn
0006-3495issn
1542-0086pii
S0006-3495(00)76434-4journal_volume
79pub_type
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