Androgen-regulated expression of a novel member of the aldo-keto reductase superfamily in regrowing rat prostate.

abstract：:The first mutation in a gene associated with a neuronal migration disorder was identified in patients with Kallmann Syndrome, characterized by hypogonadotropic hypogonadism and anosmia. This pathophysiological association results from a defect in the development of the GnRH and the olfactory system. A recent genetic s...

journal_title：Endocrinology

authors： Hutchins BI,Kotan LD,Taylor-Burds C,Ozkan Y,Cheng PJ,Gurbuz F,Tiong JD,Mengen E,Yuksel B,Topaloglu AK,Wray S

更新日期：2016-05-01 00:00:00

abstract：:Age-associated changes in the reproductive hormones-the gonadal steroid hormones and the gonadotropins-have been identified as potential risk factors for Alzheimer's disease (AD). However, levels of gonadotropins and estrogens are closely linked in vivo, and it has proven difficult to separate the effects of gonadotro...

journal_title：Endocrinology

authors： Barron AM,Verdile G,Taddei K,Bates KA,Martins RN

更新日期：2010-11-01 00:00:00

abstract：:NADPH-cytochrome P-450 reductase (EC 1.6.2.4), the enzyme involved in progesterone 17-hydroxylation, was purified to apparent homogeneity by detergent solubilization of the microsomal fractions of liver and testis from untreated rats. The enzymes from these two tissues were then compared with regard to several paramet...

journal_title：Endocrinology

authors： Hales DB,Betz G

更新日期：1986-08-01 00:00:00

abstract：:Dopaminergic inhibition of PRL release stimulated by agents that affect cytosolic Ca2+ concentrations, C-kinase activity, and cAMP levels was studied in perifused rat anterior pituitary cells cultured on cytodex beads. We used A23187 (20 microM) to increase intracellular Ca2+, the phorbol ester 12-O-tetradecanoyl-phor...

journal_title：Endocrinology

authors： Delbeke D,Dannies PS

更新日期：1985-08-01 00:00:00

abstract：:Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin driving GnRH release and neurokinin B (NKB) and dynorphin acting as start and stop signals, respectively. In this study, we tested this hypothesis...

journal_title：Endocrinology

authors： Goodman RL,Hileman SM,Nestor CC,Porter KL,Connors JM,Hardy SL,Millar RP,Cernea M,Coolen LM,Lehman MN

更新日期：2013-11-01 00:00:00

abstract：:Although tamoxifen (TAM), a selective estrogen receptor modulator, has been widely used in the treatment of hormone-responsive breast cancer, its estrogen-like effect increases the risk of endometrial cancer. However, the molecular mechanisms of TAM-induced endometrial carcinoma still remain unclear. In this report, w...

journal_title：Endocrinology

authors： Bai JX,Yan B,Zhao ZN,Xiao X,Qin WW,Zhang R,Jia LT,Meng YL,Jin BQ,Fan DM,Wang T,Yang AG

更新日期：2013-02-01 00:00:00

abstract：:In bone, early events in inflammation involve the production and release of primary proinflammatory cytokines, such as interleukin-1 beta. By activation of target cells, these cytokines are thought to induce a second wave of cytokines, including monocyte chemoattractant protein-1 (MCP-1). MCP-1 is a cytokine that stim...

journal_title：Endocrinology

authors： Rahimi P,Wang CY,Stashenko P,Lee SK,Lorenzo JA,Graves DT

更新日期：1995-06-01 00:00:00

abstract：:The pharmacokinetics of TRH and its metabolite deamido-TRH (TRH-OH) were evaluated and compared. After a 60- to 90-min infusion of the appropriate peptide into rats, the MCR, half-life of disappearance (t 1/2), and volume of distribution were calculated. The MCR of TRH averaged 4 ml/min, whereas that of TRH-OH was 6.5...

journal_title：Endocrinology

authors： Safran M,Wu CF,Matys R,Alex S,Emerson CH

更新日期：1984-09-01 00:00:00

abstract：:The effect of naloxone (N-allylnoroxymorphone), a narcotic antagonist, on the morphine blockade of ovulation was studied. Female rats were treated with morphine (50 mg/kg) at the critical period, resulting in ovulatory blockade. The administration of naloxone (0.5 mg/kg) effectively reversed the anti-ovulatory effect ...

journal_title：Endocrinology

authors： Packman PM,Rothchild JA

更新日期：1976-07-01 00:00:00

abstract：:We recently described a preclinical model of Graves' orbitopathy (GO), induced by genetic immunization of eukaryotic expression plasmid encoding human TSH receptor (TSHR) A-subunit by muscle electroporation in female BALB/c mice. The onset of orbital pathology is characterized by muscle inflammation, adipogenesis, and...

journal_title：Endocrinology

authors： Berchner-Pfannschmidt U,Moshkelgosha S,Diaz-Cano S,Edelmann B,Görtz GE,Horstmann M,Noble A,Hansen W,Eckstein A,Banga JP

更新日期：2016-04-01 00:00:00

abstract：:A protein [steroidogenesis-inducing protein (SIP)] has been isolated from human ovarian follicular fluid and shown previously to stimulate steroidogenesis in Leydig cells, adrenal cells, and early luteal cells. Since proteins and peptides known to regulate steroidogenesis, such as gonadotropins and growth factors, als...

journal_title：Endocrinology

authors： Khan SA,Teerds K,Dorrington J

更新日期：1992-02-01 00:00:00

abstract：:The SMA1-mouse is a novel ethyl-nitroso-urea (ENU)-induced mouse mutant that carries an a-->g missense mutation in exon 5 of the GH gene, which translates to a D167G amino acid exchange in the mature protein. Mice carrying the mutation are characterized by dwarfism, predominantly due to the reduction (sma1/+) or absen...

journal_title：Endocrinology

authors： Meyer CW,Korthaus D,Jagla W,Cornali E,Grosse J,Fuchs H,Klingenspor M,Roemheld S,Tschöp M,Heldmaier G,De Angelis MH,Nehls M

更新日期：2004-05-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) is a pleiotropic cytokine known to control the proliferation and survival of stem cells including primordial germ cells and gonocytes. This led us to study the origin and regulation of testicular LIF. The LIF transcript was detected in the rat testis by RT-PCR from 13.5 days postcoitum...

journal_title：Endocrinology

authors： Piquet-Pellorce C,Dorval-Coiffec I,Pham MD,Jégou B

更新日期：2000-03-01 00:00:00

abstract：:Thyroid hormone and retinoic acid (RA) are essential for normal neural development in vivo, yet all in vitro differentiation strategies of embryonic stem (ES) cells use only RA. We developed a novel differentiation strategy of mouse ES cells using T(3). A dominant-negative knock-in point mutation (P398H) was introduce...

journal_title：Endocrinology

authors： Liu YY,Tachiki KH,Brent GA

更新日期：2002-07-01 00:00:00

abstract：:Although the main role of prolactin (PRL) in pregnant rodents is to sustain progesterone production by the corpus luteum, progesterone treatment of PRL or PRL receptor (PRL-R) null mice is unable to prevent fetal loss. We have previously shown that the rat decidua is a site of PRL production and action. In this report...

journal_title：Endocrinology

authors： Bao L,Tessier C,Prigent-Tessier A,Li F,Buzzio OL,Callegari EA,Horseman ND,Gibori G

更新日期：2007-05-01 00:00:00

abstract：:PTH-related protein (PTHrP) has been shown to be a major factor responsible for hypercalcemia of malignancy. PTHrP acts via the PTH/PTHrP receptor, and therefore, PTH antagonists might be expected to reverse the hypercalcemia in malignancy. In the present studies, the PTH antagonists [Tyr34]bovine (b) PTH-(7-34)NH2, [...

journal_title：Endocrinology

authors： Kukreja SC,D'Anza JJ,Wimbiscus SA,Fisher JE,McKee RL,Caulfield MP,Rosenblatt M

更新日期：1994-05-01 00:00:00

abstract：:Insulin is a potent regulator of Sp1 transcription factor. To examine if glucagon, which usually antagonizes insulin, regulates Sp1, we assessed the levels of Sp1 by Western blotting from H-411E cells exposed to glucagon with or without insulin. Glucagon alone (1.5 x 10(-9) to 1.5 x 10(-5) M) stimulated Sp1 accumulati...

journal_title：Endocrinology

authors： Keembiyehetty CN,Candelaria RP,Majumdar G,Raghow R,Martinez-Hernandez A,Solomon SS

更新日期：2002-04-01 00:00:00

abstract：:The effect of collagenase dissociation of virgin mouse mammary glands on the level of mammary epithelial cytosolic estrogen receptors (ER) and progesterone receptors (PR) was assessed. After cell dissociation, ER was present in mammary epithelial cells at concentrations similar to those found in the whole gland. Howev...

journal_title：Endocrinology

authors： Edery M,Imagawa W,Larson L,Nandi S

更新日期：1985-01-01 00:00:00

abstract：:To assess the consequences of prolonged exposure to elevated levels of LH/human chorionic gonadotropin (hCG) in the female, we developed a transgenic (TG) mouse model (hCGbeta+) that overexpresses the hCGbeta-subunit cDNA. Because of the promoter used, ubiquitin C, the transgene is expressed in multiple tissues, inclu...

journal_title：Endocrinology

authors： Rulli SB,Kuorelahti A,Karaer O,Pelliniemi LJ,Poutanen M,Huhtaniemi I

更新日期：2002-10-01 00:00:00

abstract：:The disappearance of 125-I-ACTH from the circulation of 4 pregnant and fetal sheep has been followed after a single injection to the ewe or fetus. The mean metabolic clearance rate for the fetus and the ewe was 55 and 34 ml/min/kg respectively, giving a half-life in each case of about 1 min. The higher fetal than mate...

journal_title：Endocrinology

authors： Jones CT,Luther E,Ritchie JW,Worthington D

更新日期：1975-01-01 00:00:00

abstract：:Immunoreactive beta-endorphin (ir-beta EP) and immunoreactive N-acetyl-endorphin (ir-NacEP) have been demonstrated in the rat thyroid by specific RIA and characterized by reverse phase HPLC. In addition, pituitary and thyroid ir-beta EP and ir-NacEP levels have been determined after manipulation of the pituitary-thyro...

journal_title：Endocrinology

authors： Cheng MC,Smith AI,Funder JW

更新日期：1986-08-01 00:00:00

abstract：:Targeted disruption [knockout (KO)] of the mouse prolactin (PRL) gene created an animal model of primary isolated PRL deficiency in which there is no detectable PRL bioactivity. Pituitary glands of young adult female PRLKO mice were hyperplastic, and many cells had expanded cytoplasms with granular accumulations of an...

journal_title：Endocrinology

authors： Cruz-Soto ME,Scheiber MD,Gregerson KA,Boivin GP,Horseman ND

更新日期：2002-11-01 00:00:00

abstract：:Both fructose consumption and increased intracellular glucocorticoid activation have been implicated in the pathogenesis of the metabolic syndrome. Glucocorticoid activation by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) depends on hexose-6-phosphate dehydrogenase (H6PD), which physically interacts with 11β-HSD...

journal_title：Endocrinology

authors： Senesi S,Legeza B,Balázs Z,Csala M,Marcolongo P,Kereszturi E,Szelényi P,Egger C,Fulceri R,Mandl J,Giunti R,Odermatt A,Bánhegyi G,Benedetti A

更新日期：2010-10-01 00:00:00

abstract：:GnRH regulates the secretion of LH and FSH, which stimulate the secretion of testicular hormones. Acting in a reciprocal fashion, these hormones, including testosterone and inhibin, exert a negative feedback effect on GnRH and gonadotropin secretion. Endogenous opioid peptides (EOPs) have been implicated to play a rol...

journal_title：Endocrinology

authors： Chowen-Breed J,Fraser HM,Vician L,Damassa DA,Clifton DK,Steiner RA

更新日期：1989-04-01 00:00:00

abstract：:Activators of protein kinase C, such as phorbol myristate acetate (PMA) and the synthetic diacylglycerol dioctanoylglycerol (diC8), either stimulate or inhibit PTH release depending on the extracellular Ca2+ concentration. By increasing PTH release at high extracellular Ca2+, these agents, in effect, block high Ca2(+)...

journal_title：Endocrinology

authors： Shoback DM,Chen TH

更新日期：1990-07-01 00:00:00

abstract：:The effect of 3 alpha-hydroxy-4-pregnen-20-one (3HP), a Sertoli cell steroid, on the secretion of gonadotropins from rat anterior pituitary cells in culture was examined and subsequently compared with the action of other gonadal steroids and steroids structurally related to 3HP. Pituitary cells from randomly cycling, ...

journal_title：Endocrinology

authors： Wood PH,Wiebe JP

更新日期：1989-07-01 00:00:00

abstract：:Although it is well known that chronic treatment with glucocorticoids inhibits somatic growth, the mechanism of action of this inhibitory effect is not completely understood. It is likely that glucocorticoids act at various levels, including pituitary, hypothalamus, and peripheral organs modulating GH synthesis, secre...

journal_title：Endocrinology

authors： Señarís RM,Lago F,Coya R,Pineda J,Diéguez C

更新日期：1996-12-01 00:00:00

abstract：:The effect of methysergide (MES, 2.5 mg/100 g body wt), a serotonin antagonist, on prolactin release has been studied in lactating and ovariectomized rats. MES caused significant increases in prolactin release in both animals. Studies in ovariectomized, hypophysectomized rats indicate that this effect is not due to a ...

journal_title：Endocrinology

authors： Gallo RV,Rabii J,Moberg GP

更新日期：1975-11-01 00:00:00

abstract：:We tested the hypothesis that depressed duodenal calcium absorption in the streptozotocin diabetic rat is the consequence of diabetes rather than nephrotoxicity of the diabetogenic agent causing abnormal renal vitamin D metabolism. We treated streptozotocin diabetic rats with insulin and compared their duodenal calciu...

journal_title：Endocrinology

authors： Schneider LE,Nowosielski LM,Schedl HP

更新日期：1977-01-01 00:00:00

abstract：:In the ewe, photoperiod modulates LH and PRL secretion as well as median eminence (ME) dopaminergic activity. The studies reported here were designed to characterize the functional significance of this photoperiodic modulation of ME dopaminergic neuron activity in relation to the regulation of LH and PRL secretion. Th...

journal_title：Endocrinology

authors： Viguié C,Thibault J,Thiéry JC,Tillet Y,Malpaux B

更新日期：1997-01-01 00:00:00