Abstract:
:We report a case of de novo acute myelomonocytic leukaemia with the t(2;11)(q31;p15) translocation in a Japanese female infant. The NUP98-HOXD13 fusion transcript generated by the translocation was detected in the patient's bone marrow cells by reverse transcription-polymerase chain reaction (RT-PCR). Additionally, ectopic expression of the normal allele of the HOXD13 gene was observed in this patient, suggesting that it might be associated with leukaemogenic development. This case is the third report of t(2;11) leukaemia with NUP98-HOXD13 and the first report showing that NUP98 rearrangements are associated with infant leukaemia, as well as therapy-related acute myelogenous leukaemia or myelodysplastic syndrome.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Shimada H,Arai Y,Sekiguchi S,Ishii T,Tanitsu S,Sasaki Mdoi
10.1046/j.1365-2141.2000.02172.xsubject
Has Abstractpub_date
2000-07-01 00:00:00pages
210-3issue
1eissn
0007-1048issn
1365-2141pii
bjh2172journal_volume
110pub_type
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