Why Does the Gastric Bypass Control Type 2 Diabetes Mellitus?

Abstract:

:The remarkable control of diabetes by the gastric bypass remains to be explained. Although it may be totally due to the weight loss Induced by the operation, it is likely that the detour of the hormonally active foregut plays a role as well. This keynote address explores the pathophysiology of non-insulin-dependent diabetes mellitus and reviews the data which support the thesis that the gastric antrum, duodenum, and proximal jejunum modulate glucose metabolism and insulin action.

journal_name

Obes Surg

journal_title

Obesity surgery

authors

Pories WJ

doi

10.1381/096089292765559891

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

303-313

issue

4

eissn

0960-8923

issn

1708-0428

journal_volume

2

pub_type

杂志文章
  • Pre- and post-prandial plasma ghrelin levels do not correlate with satiety or failure to achieve a successful outcome after Roux-en-Y gastric bypass.

    abstract:BACKGROUND:We tested the hypothesis that the amount of weight lost after Roux-en-Y gastric bypass (RYGBP) correlates with plasma ghrelin levels. METHODS:36 morbidly obese patients were studied 3 years after RYGBP (6 men, 30 women) with mean initial BMI 51 kg/m2 and 8 healthy controls (2 men, 6 women) with mean BMI 25 ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/0960892054621071

    authors: Christou NV,Look D,McLean AP

    更新日期:2005-08-01 00:00:00

  • Concomitant Hiatal Hernia Repair Is more Common in Laparoscopic Sleeve Gastrectomy than During Laparoscopic Roux-en-Y Gastric Bypass: an Analysis of 130,772 Cases.

    abstract::Obesity is associated with the development of gastroesophageal reflux disease (GERD) and hiatal hernia (HH). This study aimed to assess practice patterns regarding concomitant HH repair (HHR) during laparoscopic sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). The incidence of concomitant HHR with LSG or L...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-018-3594-0

    authors: Docimo S Jr,Rahmana U,Bates A,Talamini M,Pryor A,Spaniolas K

    更新日期:2019-02-01 00:00:00

  • Endoscopic dilation with Savary-Gilliard bougies of stomal strictures after laparosocopic gastric bypass in morbidly obese patients.

    abstract:BACKGROUND:Anastomotic strictures after bariatric surgery are a frequent complication that requires endoscopic management, but the optimal technique for dilation remains to be determined. The aim of this study was to evaluate the safety and efficacy of dilation with Savary-Gilliard bougies (SGB) in morbidly obese patie...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-007-9372-z

    authors: Fernández-Esparrach G,Bordas JM,Llach J,Lacy A,Delgado S,Vidal J,Cárdenas A,Pellisé M,Ginès A,Sendino O,Zabalza M,Castells A

    更新日期:2008-02-01 00:00:00

  • Gastric bypass increases ethanol and water consumption in diet-induced obese rats.

    abstract:BACKGROUND:Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment for morbid obesity. Increased alcohol abuse after RYGB resulted in recommendations to exclude patients with alcohol abuse histories from RYGB. The purpose of our study was to examine the effects of a RYGB on ethanol intake in diet-induced obes...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-012-0749-2

    authors: Thanos PK,Subrize M,Delis F,Cooney RN,Culnan D,Sun M,Wang GJ,Volkow ND,Hajnal A

    更新日期:2012-12-01 00:00:00

  • Multicenter, Phase 1, Open Prospective Trial of Gastric Electrical Stimulation for the Treatment of Obesity: First-in-Human Results with a Novel Implantable System.

    abstract:BACKGROUND AND AIMS:To assess safety of the Exilis™ gastric electrical stimulation (GES) system and to investigate whether the settings can be adjusted for comfortable chronic use in subjects with morbid obesity. Gastric emptying and motility and meal intake were evaluated. METHOD:In a multicenter, phase 1, open prosp...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-020-04422-6

    authors: Paulus GF,van Avesaat M,van Rijn S,Alleleyn AME,Swain JM,Abell TL,Williams DB,Bouvy ND,Masclee AAM

    更新日期:2020-05-01 00:00:00

  • Aspiration Therapy As a Tool to Treat Obesity: 1- to 4-Year Results in a 201-Patient Multi-Center Post-Market European Registry Study.

    abstract:PURPOSE:The objective of this post-market study was to evaluate long-term safety and efficacy of aspiration therapy (AT) in a clinical setting in five European clinics. MATERIALS AND METHODS:The AspireAssist® System (Aspire Bariatrics, Inc. King of Prussia, PA) is an endoscopic weight loss therapy utilizing a customiz...

    journal_title:Obesity surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11695-017-3096-5

    authors: Nyström M,Machytka E,Norén E,Testoni PA,Janssen I,Turró Homedes J,Espinos Perez JC,Turro Arau R

    更新日期:2018-07-01 00:00:00

  • Conversion from sleeve gastrectomy to Roux-en-Y gastric bypass--indications and outcome.

    abstract:BACKGROUND:Due to excellent weight loss success in the short-time follow-up, sleeve gastrectomy (SG) has gained popularity as sole and definitive bariatric procedure. In the long-term follow-up, weight loss failure and intractable severe reflux can necessitate further surgical intervention. METHODS:A retrospective ana...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-010-0125-z

    authors: Langer FB,Bohdjalian A,Shakeri-Leidenmühler S,Schoppmann SF,Zacherl J,Prager G

    更新日期:2010-07-01 00:00:00

  • Is laparoscopic duodenojejunal bypass with sleeve an effective alternative to Roux en Y gastric bypass in morbidly obese patients: preliminary results of a randomized trial.

    abstract:BACKGROUND:The incidence of obesity and related metabolic disorders in India and that of stomach carcinoma is one of the highest in the world. Hence, one requires a procedure that allows postoperative surveillance of the stomach with the best outcomes in terms of weight control and resolution of co-morbidities. Here, w...

    journal_title:Obesity surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11695-011-0507-x

    authors: Praveen Raj P,Kumaravel R,Chandramaliteeswaran C,Rajpandian S,Palanivelu C

    更新日期:2012-03-01 00:00:00

  • "Black Esophagus" and Gastric Volvulus Following Slipped Laparoscopic Adjustable Gastric Band.

    abstract::To review the entity "black esophagus" and sequela of a slipped laparoscopic adjustable band. The patient's history, physical examination, imaging, and endoscopic findings were reviewed. Detailed review of pathophysiology, presentation, diagnosis, management, and natural history was conducted. "Black esophagus," also ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-018-3354-1

    authors: Moore C,Matthews LR,Danner O,Taha A,Bashan-Gilzenrat A,Nguyen J,Childs E,Udobi K

    更新日期:2018-09-01 00:00:00

  • Vertical Banded Gastroplasty in the Severely Obese under Age Twenty-One.

    abstract::BACKGROUND: The severely obese under 21 years of age are at high risk of missing normal development during a crucial period of life and should be considered for surgical treatment. Vertical banded gastroplasty allows patients to be treated effectively while continuing to have normal digestion and absorption without th...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089295765558114

    authors: Mason EE,Scott DH,Doherty C,Cullen JJ,Rodriguez EM,Maher JW,Soper RT

    更新日期:1995-02-01 00:00:00

  • Surgical Management of a Chronic Sleeve Gastrocolic Fistula with Near Total Gastrectomy and Roux-en-Y Reconstruction.

    abstract:BACKGROUND:Management of the leak is determined by the duration of the leak from the initial surgery. Acute leaks occurring less than 72 hours after surgery are best managed with reoperation and primary repair. Intermediate leaks, greater than 72 hours but less than 12 weeks, can be managed with non-operative managemen...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-020-04689-9

    authors: Dugan N,Nimeri A

    更新日期:2020-09-01 00:00:00

  • Effect of vertical banded gastroplasty on hypertension, diabetes and dyslipidemia.

    abstract:BACKGROUND:Operations for morbid obesity that are effective in inducing weight loss improve blood pressure, glycemic control and dyslipidemia. Our purpose was to study the effectiveness of VBG in improving hypertension, diabetes and dyslipidemias in morbidly obese patients. METHODS:Retrospective analysis of a cohort o...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089202321088075

    authors: Arribas del Amo D,Elía Guedea M,Aguilella Diago V,Martínez Díez M

    更新日期:2002-06-01 00:00:00

  • Conversion to modified duodenal switch for relieving intractable dumping syndrome and constipation after laparoscopic Roux-en-Y gastric bypass.

    abstract:BACKGROUND:Dumping syndrome is not infrequent after laparoscopic Roux-en-Y gastric bypass and could result in dreaded complications, such as hypoglycemia or syncope. Those patients who failed medical therapy and diet modification, regarded as intractable dumping syndrome, may be considered as candidates for revisional ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-015-1607-9

    authors: Huang CK,Wang MY,Hsin MC,Chang PC

    更新日期:2015-05-01 00:00:00

  • Resolution of Erosive Esophagitis After Conversion from Vertical Sleeve Gastrectomy to Roux-en-Y Gastric Bypass.

    abstract:BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) has become the preferred bariatric procedure in many countries. However, there is one shortcoming of LSG in the long-term follow-up, and this is the onset of gastro-esophageal reflux disease (GERD) and erosive esophagitis (EE). Conversion to Roux-en-Y gastric bypass (RYG...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-020-04913-6

    authors: Lim CH,Lee PC,Lim E,Eng A,Chan WH,Tan HC,Ho E,Kovalik JP,Ganguly S,Tan J

    更新日期:2020-12-01 00:00:00

  • Bariatric and associated operations in private and academic practices.

    abstract:BACKGROUND:The types of bariatric and the associated operations performed by academic and private surgeons were surveyed. METHODS:A survey containing 8 questions regarding type of practice, type of surgery, associated procedures during bariatric surgery, years in practice and bariatric training was e-mailed to all mem...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/0960892042584058

    authors: Frezza EE,Robinson M

    更新日期:2004-11-01 00:00:00

  • Subcutaneous placement of lap band port without fascial fixation provides safe and durable access.

    abstract:BACKGROUND:Laparoscopic adjustable gastric band access port has been routinely sutured to the anterior fascia of the abdominal wall using nonabsorbable sutures. We present our technique demonstrating that nonfascial fixation with using a mesh allows for a safe and durable placement of the port in the superficial subcut...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-014-1286-y

    authors: Akkary E,Olgers F

    更新日期:2014-11-01 00:00:00

  • Clinical Characteristics and Outcome of Morbidly Obese Bariatric Patients with Concurrent Hepatitis C Viral Infection.

    abstract:BACKGROUND:Hepatitis C virus (HCV) is an important cause of liver cirrhosis and its complications. The safety and efficacy of bariatric surgery in patients with HCV infection is not clear. METHODS:Charts were reviewed to identify patients with HCV infection before bariatric surgery. Bariatric surgical patients with no...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-018-3615-z

    authors: Han ML,Lee WJ,Chen JC,Ser KH,Chen SC,Lee YC

    更新日期:2019-03-01 00:00:00

  • C-peptide predicts the remission of type 2 diabetes after bariatric surgery.

    abstract:BACKGROUND:C-peptide is a surrogate of the pancreatic beta cell mass. However, the clinical significance of C-peptide in a diabetic patient after bariatric surgery has not been studied clearly. METHODS:From February 2005 to January 2009, a total of 205 (124 females and 81 males) consecutive morbidly obese patients wit...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-011-0565-0

    authors: Lee WJ,Chong K,Ser KH,Chen JC,Lee YC,Chen SC,Su YH,Tsai MH

    更新日期:2012-02-01 00:00:00

  • Outcomes, satiety, and adverse upper gastrointestinal symptoms following laparoscopic adjustable gastric banding.

    abstract:BACKGROUND:Follow-up is critical to the success of laparoscopic adjustable gastric banding (LAGB). Few data guide this and expected norms of satiety, adverse symptoms, and outcomes have not been defined. METHODS:Consecutive patients, who underwent LAGB, were evaluated using a newly developed instrument that assessed s...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-010-0073-7

    authors: Burton PR,Brown W,Laurie C,Lee M,Korin A,Anderson M,Hebbard G,O'Brien PE

    更新日期:2011-05-01 00:00:00

  • Evaluation of the radiological gastric capacity and evolution of the BMI 2-3 years after sleeve gastrectomy.

    abstract:BACKGROUND:Sleeve gastrectomy is a restrictive procedure for treatment of obese patients with different body mass index (BMI) and presents good results in terms of a reduction of percentage of excess weight loss and BMI. There is no consensus which is the optimal technique regarding to the diameter of the gastric tube,...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-009-9874-y

    authors: Braghetto I,Cortes C,Herquiñigo D,Csendes P,Rojas A,Mushle M,Korn O,Valladares H,Csendes A,Maria Burgos A,Papapietro K

    更新日期:2009-09-01 00:00:00

  • Effect of Resection Distance from Pylorus on Weight Loss Outcomes in Laparoscopic Sleeve Gastrectomy.

    abstract:BACKGROUND:Despite the established efficacy and safety of laparoscopic sleeve gastrectomy (LSG), controversy still exists on optimal operative technique, the resection distance from pylorus (DP) being among the most controversial issues. This study aimed to examine the effect of resection distance from pylorus on % exc...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-019-03923-3

    authors: Avlanmis O,Isil RG,Burcu B

    更新日期:2019-09-01 00:00:00

  • Does the Size of the Upper Pouch Affect Weight Loss after Vertical Banded Gastroplasty.

    abstract::BACKGROUND: The importance of creating a small 10-20 ml upper pouch when performing a vertical banded gastroplasty (VBG) is often stated in the literature. In order to test the hypothesis that weight loss is superior in patients with a small upper pouch, we examined the weight loss curves for three different pouch siz...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089295765557430

    authors: Näslund E,Backman L,Granström L,Stockeld D

    更新日期:1995-11-01 00:00:00

  • Effect of a high fat diet on quantitative features of adipocytes in the omentum: an experimental, stereological and ultrastructural study.

    abstract:BACKGROUND:Omental adipose tissue specimens of female rats that were fed a high fat (HF) diet were evaluated stereologically and histopathologically. To our knowledge, there is no stereological study on numerical density, nuclear height and volume of adipocytes in omental adipose tissue in the female rat fed a HF diet ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089206778869942

    authors: Aslan H,Altunkaynak BZ,Altunkaynak ME,Vuraler O,Kaplan S,Unal B

    更新日期:2006-11-01 00:00:00

  • Age, Obesity Surgery, and Weight Loss.

    abstract::Some centers consider an age over 50 to be a contraindication for obesity surgery. This study was conducted to examine the relationship between age and one-year postoperative weight of patients receiving gastric restrictive surgery (n = 616) for morbid obesity. Patients were divided into four age groups (18-29, 30-39,...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089291765561457

    authors: Rand CS,Macgregor AM

    更新日期:1991-03-01 00:00:00

  • Management of Type 2 Late Sleeve Leak by Laparoscopic Suturing and Conversion to Roux-en-Y Gastric Bypass: Video Report.

    abstract:BACKGROUND:Laparoscopic sleeve forming gastrectomy (SFG) is a commonly performed bariatric procedure for the surgical management of morbid obesity. Staple line gastric leaks occur infrequently but are the most feared complication causing prolonged morbidity (Burgos et al., Obes Surg 19(12):1672-7, 2009; Márquez et al.,...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-015-1813-5

    authors: Praveenraj P,Gomes RM,Kumar S,Senthilnathan P,Parthasarathi R,Rajapandian S,Palanivelu C

    更新日期:2015-10-01 00:00:00

  • Conversional surgery: single-step conversion of laparoscopic adjustable gastric band to laparoscopic sleeve gastrectomy.

    abstract:BACKGROUND:Although some patients attain good outcomes after adjustable gastric band (LAGB), a certain quantity have experienced complications and insufficient weight loss. The objective of this study is to assess the safety and outcome of laparoscopic sleeve gastrectomy (LSG) as a conversion surgery after a failed LAG...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-014-1358-z

    authors: Al Sharqawi N,Al Sabah S,Al Mulla A,Al Anezi K,Jumaa T

    更新日期:2014-10-01 00:00:00

  • Serum vaspin concentrations in relation to insulin sensitivity following RYGB-induced weight loss.

    abstract:BACKGROUND:Recently, vaspin was identified as a novel adipokine with insulin-sensitizing effects that might be implicated in endogenous glucose regulation. Our objective was to evaluate the impact of acute weight loss and metabolic changes on serum vaspin concentrations in morbidly obese subjects following laparoscopic...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-009-9882-y

    authors: Handisurya A,Riedl M,Vila G,Maier C,Clodi M,Prikoszovich T,Ludvik B,Prager G,Luger A,Kautzky-Willer A

    更新日期:2010-02-01 00:00:00

  • Gastric cancer after Roux-en-Y gastric bypass.

    abstract::Roux-en-Y gastric bypass (RYGBP) is one of the most commonly performed surgical procedures for morbid obesity. Several complications that may develop in the short- and long-term have been reported. We present a patient who presented with cancer in the bypassed stomach 8 years after RYGBP. Although the development of t...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/0960892053576668

    authors: Escalona A,Guzmán S,Ibáñez L,Meneses L,Huete A,Solar A

    更新日期:2005-03-01 00:00:00

  • Laparoscopic Adjustable Gastric Banding Revisions in Singapore: a 10-Year Experience.

    abstract:BACKGROUND:Bariatric surgery is increasingly being carried out and revisional procedures have also risen in concert. A review of the complications and revisions might elucidate technical and patient factors that influence the outcomes of bariatric surgeries in Asian patients. The objective of this study is to review th...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-015-1852-y

    authors: Ngiam KY,Khoo VY,Kong L,Cheng AK

    更新日期:2016-05-01 00:00:00

  • Histological findings in the liver before and after gastric bypass.

    abstract:BACKGROUND:Bariatric surgery results in massive loss of excess weight, changes in co-morbidities and improvement in quality of life. In these patients, liver histology taken before or during surgery reveals several histological abnormalities. In a prospective study of patients previously submitted to gastric bypass, we...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089206776944904

    authors: Csendes A,Smok G,Burgos AM

    更新日期:2006-05-01 00:00:00