Abstract：
BACKGROUND:C-peptide is a surrogate of the pancreatic beta cell mass. However, the clinical significance of C-peptide in a diabetic patient after bariatric surgery has not been studied clearly. METHODS:From February 2005 to January 2009, a total of 205 (124 females and 81 males) consecutive morbidly obese patients with type 2 diabetes mellitus (T2DM) enrolled in a surgically supervised weight loss program with at least 1 year follow-up were examined. Among them, 147 patients (71.7%) received gastric bypass procedures, while the other 58 patients (28.3%) received restrictive-type procedures. RESULTS:The mean C-peptide before the surgery was 5.3 ± 3.5 ng/ml. One hundred nineteen patients (58.0%) had an elevated C-peptide (>4 ng/ml), while 2 patients (1.0%) had a low C-peptide (<1.0 ng/ml). Multivariate analysis confirmed that waist circumference, triglycerides, and HbA1c were the independent predictors for the elevation of C-peptide. It was observed that the mean C-peptide levels decreased to 1.7 ± 0.9 ng/ml 1 year after bariatric surgery with a mean reduction of 64.1%. One year after surgery, 160 patients (78.0%) out of a total of 205 patients had a remission of their T2DM. Patients in the bypass group had a higher diabetes remission rate (91.2%; 134 out of 147) in comparison to patients in the restrictive group (44.8%; 26 out of 58, p < 0.001). The diabetes remission rates for those with preoperative C-peptide <3, 3-6, and > 6 ng/ml were 26 out of 47 (55.3%), 87 out of 108 (82.0%), and 47 out of 52 (90.3%), p < 0.001, respectively. CONCLUSIONS:Baseline C-peptide is commonly elevated in morbidly obese patients with T2DM. There was a marked reduction in C-peptide after a significant weight reduction 1 year after surgery with a T2DM remission rate of 78.0%. Thus, bariatric surgery is recommended for obesity-related T2DM patients with elevated C-peptide.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Lee WJ,Chong K,Ser KH,Chen JC,Lee YC,Chen SC,Su YH,Tsai MHdoi
10.1007/s11695-011-0565-0subject
Has Abstractpub_date
2012-02-01 00:00:00pages
293-8issue
2eissn
0960-8923issn
1708-0428journal_volume
22pub_type
杂志文章相关文献
OBESITY SURGERY文献大全abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGBP) is presently one of the most popular surgical procedures for obesity. One of the possible long-term problems is weight regain, usually after a period of successful weight loss. Weight regain after RYGBP can be due to new eating habits, like sweet-eating or grazing, or volume ...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-009-9807-9
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND AND AIMS:Since redo surgery is associated with a high risk of morbidity and mortality after bariatric surgery in case of leakage, we sought to evaluate whether endoscopic drainage and debridement of collections following bariatric surgery is an efficient step-up approach to the management of these complicati...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-015-1854-9
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Obesity has become a global epidemic. Surgical treatment of obesity and metabolic disorders in China is increasing rapidly, but it is still a new discipline even to health professionals. As an important member of the multidisciplinary team, the knowledge and attitudes of nurses provide crucial health care to...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-019-04173-z
更新日期：2020-02-01 00:00:00
abstract：:The ability to obtain accurate histories for a comparative study of compulsive overeating and alcoholism was severely compromised by the high degree of denial, shame and self-blame present in these two overlapping disease entities. Areas of overlap included similar progression of the disease, familial tendencies, and ...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/096089293765559827
更新日期：1993-02-01 00:00:00
abstract：:Obesity and metabolic surgery (OMS) leads to several metabolic improvements, which often occur prior to substantial weight loss. Therefore, other factors in addition to weight loss contribute to the metabolic benefits. This literature review offers an overview of studies investigating bile acids (BAs) and their metabo...
journal_title：Obesity surgery
pub_type： 杂志文章,评审
doi：10.1007/s11695-016-2272-3
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Obesity is a major risk factor for nonalcoholic fatty liver disease (NAFLD), affecting 25% of the worldwide population. Weight loss through bariatric surgery can improve much of the liver steatosis, inflammation, and fibrosis. However, it is not known whether there is reversal of the elastic fiber deposition pr...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-020-04722-x
更新日期：2020-10-01 00:00:00
abstract：:Obesity is an enduring chronic disease, with multifactorial etiology. Many procedures and solutions have been proposed in the last 25 years. If patients do not meet the criteria for bariatric surgery, intragastric balloons may be used to achieve weight reduction. Contraindications to balloon therapy are a large hiatal...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/096089206776944887
更新日期：2006-05-01 00:00:00
abstract：INTRODUCTION:Surgical training today is all about minimally invasive surgery. With little or no experience and/or confidence in rapid, emergent conversion to an open procedure, how does the surgeon expeditiously do so? OBJECTIVES:The intent of this paper is to help those inexperienced in "open" techniques to quickly r...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-016-2095-2
更新日期：2016-04-01 00:00:00
abstract：INTRODUCTION/PURPOSE:The assessment of the patients' motivation as a predictor of behavioral change via five stages (pre-contemplation, contemplation, preparation, action, and maintenance) and four processes (emotional re-evaluation, weight management actions, environmental restructuring, and weight consequences evalua...
journal_title：Obesity surgery
pub_type： 杂志文章,多中心研究
doi：10.1007/s11695-019-04001-4
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Gastroesophageal reflux disease (GERD) is probably the main drawback of laparoscopic sleeve gastrectomy (LSG). Herein, we critically discuss the issue and report the results of the first international consensus conference held in Montpellier, France, during June 2019. METHODS:Fifty international bariatric e...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-020-04749-0
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the effect of chest physiotherapy (CP) applied to patients undergoing bariatric surgery on pulmonary functions, dyspnea levels, functional capacity, and quality of life. METHODS:The patients were randomized and divided into two groups each comprising 74 patients. CP and...
journal_title：Obesity surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11695-019-04165-z
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) restricts gastric volume to achieve weight loss. We aimed to compare the efficacy of LSG with and without antrectomy for achieving weight loss. METHODS:The prospective randomized study comprised 127 obese patients that underwent either LSG with antrectomy (2 cm to pylor...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-019-04177-9
更新日期：2020-02-01 00:00:00
abstract：:On August 9-10, 2017, the American College of Surgeons hosted a symposium on metabolic surgery, with 12 follow-on papers published serially in the Bulletin of the College. The current synopsis outlines the varied contents of these papers, often in the original words of their authors, who are cited within their topic s...
journal_title：Obesity surgery
pub_type： 杂志文章,评审
doi：10.1007/s11695-020-04451-1
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:This study aimed to compare the safety and effectiveness of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in patients aged 60 years old or older. METHODS:The available literature was searched for eligible studies up to November 2019. The meta-analysis was performed by the RevMan 5.3 software. RE...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-020-04577-2
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Although prejudice may not be verbal in nature, the lack of response from professional and non-professional medical personnel regarding the obese patients' needs (medical equipment, comfortable surroundings, properly fitting attire, etc.), leads one to assume that obese patients continue to be a target of un...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/096089202321144513
更新日期：2002-02-01 00:00:00
abstract：INTRODUCTION:This technique aims to evaluate fixation of the sleeved distal part of the stomach to the root of the transverse mesocolon and greater omentum after its shortening in a T-shaped design. METHODS:Sleeve gastrectomy is done in a standard five-port technique. Then, we fix the distal end of the staple line usi...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-019-04382-6
更新日期：2020-03-01 00:00:00
abstract：INTRODUCTION:Marginal ulcer is one of the most common complications after Roux-en-Y gastric bypass and is defined as an ulceration of any depth at or near the gastrojejunal anastomosis. Different risk factors have been advocated to be the causative agent. MATERIALS AND METHODS:The weighted discharges from the Nationwi...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-020-04960-z
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Gastro-esophageal reflux disease (GERD) post-sleeve gastrectomy (SG) is a controversial issue and diagnostic dilemma. Strong heterogeneity exists in the assessment of reflux post-SG, and better diagnostic tools are needed to characterize symptomatic reflux. We aimed to determine the discriminant factors of s...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-020-05152-5
更新日期：2021-01-25 00:00:00
abstract：OBJECTIVES:Bariatric surgery is emerging as the most effective treatment option for patients with obesity. Hypothalamic arcuate nucleus plays an important role in metabolic homeostasis. However, the influence of mutations related to the feeding center on weight loss after bariatric surgery is still unclear. We aimed to...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-018-03623-4
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Laparoscopic adjustable gastric banding (LAGB) is a proven method for weight reduction. Less is known about pregnancies in patients after LAGB. METHODS:Information was gathered, through database and survey, on women who underwent LAGB at NYU Medical Center between 2001 and 2008 then became pregnant. RESULT...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-010-0265-1
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) is an effective treatment for morbidly obese patients to improve type 2 diabetes mellitus (T2DM). Recently, T2DM patients with a lower body mass index (BMI) have been receiving more attention, and these patients could benefit from RYGB. METHODS:Fifty-two patients with T2DM un...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-020-04534-z
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Operations for morbid obesity that are effective in inducing weight loss improve blood pressure, glycemic control and dyslipidemia. Our purpose was to study the effectiveness of VBG in improving hypertension, diabetes and dyslipidemias in morbidly obese patients. METHODS:Retrospective analysis of a cohort o...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/096089202321088075
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:Enhanced recovery after surgery has led to early recovery and shorter hospital stay after laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG). This study aims to assess feasibility and outcomes of postoperative day (POD) 1 discharge after LRYGB and LSG from the Metabolic a...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-018-3489-0
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Obesity is a worldwide epidemic associated to comorbidities and increased mortality. Because it is chronic and recurrent and has little response to clinical measures, surgical treatment (bariatric surgery) is a therapeutic option frequently used. Different surgical complications have been associated with thi...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-008-9780-8
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Comprehensive preparative patient education is a key element in bariatric patient success. The primary objective of this study was to compare attrition rates, demographics, and surgery outcomes between patients who participated in the online vs in-house preparative seminars. METHODS:A retrospective chart re...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-018-3590-4
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Vitamin and mineral deficiencies are common after a sleeve gastrectomy (SG). The aim of this study is to examine the effectiveness of a specialized bariatric multivitamin (WLS Optimum) for SG patients on deficiencies compared with a regular multivitamin (MVS) for up to 5 years. METHODS:Data of all patients ...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-019-04191-x
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to estimate the cumulative radiation dose from computed tomography (CT) scans and upper gastrointestinal fluoroscopic exams in the post-bariatric-surgery population and correlate these values with current concepts of potential radiation-induced cancer risk. METHODS:A retrospect...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-009-9966-8
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:The degree to which U.S. bariatric surgeons use multidisciplinary methods to evaluate patients is unknown. METHODS:We conducted a national survey of practising bariatric surgeons, mailed in 3 waves from September-December 2004, to describe and determine predictors of surgeons' approach to the multidisciplin...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/096089206775222096
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:The motility of the upper gut after Roux-en-Y gastric bypass (RYGBP) is underexplored. We aimed to investigate the oesophago-gastro-Roux limb motor activity during fasting and after food intake. METHODS:Eighteen morbidly obese patients were examined at least 2 years after RYGBP. A high-resolution manometry ...
journal_title：Obesity surgery
pub_type： 临床试验,杂志文章
doi：10.1007/s11695-015-1639-1
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Sleeve gastrectomy (SG) is a safe and efficient procedure with comparable results between conventional and single-incision approach in selected patients. However, the critical point in both approaches is the retraction of the hypertrophic and fatty left lobe of the liver which increases technical difficultie...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-015-2035-6
更新日期：2016-03-01 00:00:00
