Abstract:
:Obesity and metabolic surgery (OMS) leads to several metabolic improvements, which often occur prior to substantial weight loss. Therefore, other factors in addition to weight loss contribute to the metabolic benefits. This literature review offers an overview of studies investigating bile acids (BAs) and their metabolic effects after OMS. Rearrangement of enterohepatic circulation, changes in BA synthesis, BA conjugation, intestinal reabsorption, and alterations in the gut microbiota are potential mechanisms for altered BA profiles after surgery. Increased BA levels are associated with improved glucose homeostasis and lipid profiles, which are mediated by two major receptors: the Transmembrane G-protein Coupled Receptor and the Farnesoid X Receptor. Therefore, pharmacological manipulation of BAs and their receptors may be viable targets for less invasive obesity treatment.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Fouladi F,Mitchell JE,Wonderlich JA,Steffen KJdoi
10.1007/s11695-016-2272-3subject
Has Abstractpub_date
2016-10-01 00:00:00pages
2492-502issue
10eissn
0960-8923issn
1708-0428pii
10.1007/s11695-016-2272-3journal_volume
26pub_type
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