The Contributing Role of Bile Acids to Metabolic Improvements After Obesity and Metabolic Surgery.

Abstract:

:Obesity and metabolic surgery (OMS) leads to several metabolic improvements, which often occur prior to substantial weight loss. Therefore, other factors in addition to weight loss contribute to the metabolic benefits. This literature review offers an overview of studies investigating bile acids (BAs) and their metabolic effects after OMS. Rearrangement of enterohepatic circulation, changes in BA synthesis, BA conjugation, intestinal reabsorption, and alterations in the gut microbiota are potential mechanisms for altered BA profiles after surgery. Increased BA levels are associated with improved glucose homeostasis and lipid profiles, which are mediated by two major receptors: the Transmembrane G-protein Coupled Receptor and the Farnesoid X Receptor. Therefore, pharmacological manipulation of BAs and their receptors may be viable targets for less invasive obesity treatment.

journal_name

Obes Surg

journal_title

Obesity surgery

authors

Fouladi F,Mitchell JE,Wonderlich JA,Steffen KJ

doi

10.1007/s11695-016-2272-3

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

2492-502

issue

10

eissn

0960-8923

issn

1708-0428

pii

10.1007/s11695-016-2272-3

journal_volume

26

pub_type

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