Abstract：
OBJECTIVES:Bariatric surgery is emerging as the most effective treatment option for patients with obesity. Hypothalamic arcuate nucleus plays an important role in metabolic homeostasis. However, the influence of mutations related to the feeding center on weight loss after bariatric surgery is still unclear. We aimed to diagnose monogenic obesity by whole exome sequencing (WES) and explore whether monogenic mutations influence the effectiveness of bariatric surgery. METHODS:We collected obese patients aged 15 to 55 with a BMI > 28 kg/m2 and who underwent laparoscopic sleeve gastrectomy from March 2011 to June 2017 in Shanghai. Data related to weight loss and metabolic characteristics preoperatively and postoperatively were collected, including fasting blood glucose (FBG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides. WES was performed in obese patients using genomic DNA from whole blood samples. RESULTS:We investigated the proportion of 131 obese adults with one mutation as high as to 8.4% and then evaluated the association between these mutations and weight loss. Mutation carriers had less weight loss over both short-term and long-term periods. Survival analyses indicated it was harder to attain the goal of 20% weight loss for mutation carriers (Plog-rank = 0.001; Pbreslow < 0.001), and the difference remained significant with a Cox regression model. Improvement in FBG, HDL cholesterol, and triglyceride levels postoperatively was observed in both groups, while there were significant differences between the two groups. CONCLUSIONS:Our data indicated that 8.4% of obesity cases were caused by change in genetics, and mutations had negative effects on the efficacy of bariatric surgery.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Li Y,Zhang H,Tu Y,Wang C,Di J,Yu H,Zhang P,Bao Y,Jia W,Yang J,Hu Cdoi
10.1007/s11695-018-03623-4subject
Has Abstractpub_date
2019-04-01 00:00:00pages
1169-1173issue
4eissn
0960-8923issn
1708-0428pii
10.1007/s11695-018-03623-4journal_volume
29pub_type
杂志文章相关文献
OBESITY SURGERY文献大全abstract：BACKGROUND:The incidence of obesity and related metabolic disorders in India and that of stomach carcinoma is one of the highest in the world. Hence, one requires a procedure that allows postoperative surveillance of the stomach with the best outcomes in terms of weight control and resolution of co-morbidities. Here, w...
journal_title：Obesity surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11695-011-0507-x
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Obesity is an independent risk factor for cardiovascular disease, especially in its morbid form. Bariatric surgery is an effective therapeutic option for sustained weight loss. However, there is no consensus in these cases regarding the performance of functional tests for preoperative evaluations. The aim of...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-008-9692-7
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:The HospitAl stay, Readmission, and Mortality rates (HARM) score is a quality indicator that is easily determined from routine administrative data. However, the HARM score has not yet been applied to patients undergoing bariatric surgery. OBJECTIVE:The aims of the present study were to adjust the HARM score...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-018-3253-5
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Sleeve gastrectomy (SG) is the most common bariatric procedure performed worldwide. However, without a standardised surgical technique, heterogeneous outcomes and complications such as gastro-oesophageal reflux disease (GERD) have been reported. The aim of this study was to identify reproducible anatomical c...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-020-05156-1
更新日期：2021-01-26 00:00:00
abstract：BACKGROUND:Vagal nerve stimulation (VNS) has recently been indicated as a novel method for treating obesity. However, the optimal stimulation parameters were unknown and mechanisms were poorly understood. The aim of this study was to investigate the effects of VNS on food intake and body weight in diet-induced obesity ...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-019-04365-7
更新日期：2020-03-01 00:00:00
abstract：:Over the last four decades, as the rates of obesity have increased, so have the challenges associated with its anesthetic management. In the present review, we discuss perioperative anesthesia management issues that are modifiable by the early involvement of the surgical team. We sum up available evidence or expert op...
journal_title：Obesity surgery
pub_type： 杂志文章,评审
doi：10.1007/s11695-015-1635-5
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Biliopancreatic diversion (BPD) has been shown to be one of the most effective techniques for losing weight, although the relationship between body composition and diet after the procedure is not well known. Our aim was to assess dietary changes and their effects on body composition. METHODOLOGY:This longit...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-015-1658-y
更新日期：2015-11-01 00:00:00
abstract：:An older female underwent bariatric surgery which was followed by a significant weight loss and diarrhea, from which C. difficile was isolated just before her hospitalization. Less than 48 hours after admission, she became febrile, developed deep venous thrombosis of the leg and a pulmonary embolus. Blood cultures gre...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/096089204323093507
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:The components of esophageal function important to success with laparoscopic adjustable gastric banding (LAGB) are not well understood. A pattern of delayed, however, successful bolus transit across the LAGB is observed. METHODS:Successful LAGB patients underwent a high-resolution video manometry study in w...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-009-0063-9
更新日期：2010-09-01 00:00:00
abstract：:In France, 1,000 obese persons per month undergo a bariatric operation. Obesity surgery requires coordination and monitoring of aftercare. The French public health-care insurer asked the medical associations involved in obesity management to provide guidelines for obesity surgery. The recommendations were developed by...
journal_title：Obesity surgery
pub_type： 杂志文章,评审
doi：10.1381/096089205774859236
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:The revisional surgery for patients with inadequate weight loss after biliopancreatic diversion with duodenal switch (BPD/DS) is controversial. It has not yet been determined whether a common channel should be shortened or gastric pouch volume reduced. Since the revision of the distal anastomosis remains tec...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/096089203322190907
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:Obesity has proven to be associated with respiratory symptoms and impaired pulmonary function, which could increase the incidence of postoperative complications after bariatric surgery. However, the component of obesity that has the most influence on pulmonary function has not been identified, especially in ...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-009-9961-0
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Recent studies have reported trocar site hernia (TSH) rates after bariatric surgery ranging from 0 to 45.2% based on imaging assessment. The objective of this study was to evaluate the TSH rate after sleeve gastrectomy (SG) comprising routine 12 mm epigastric trocar site closure (TSC). MATERIAL:Prospective ...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-019-03971-9
更新日期：2019-11-01 00:00:00
abstract：INTRODUCTION:Laparoscopic single anastomosis gastric bypass (SAGB) is increasingly performed for morbidly obese patients. AIM OF WORK:This pilot study aims primarily at evaluating the incidence of bile gastritis after SAGB. The occurrence of reflux oesophagitis and reflux symptoms were also assessed. PATIENTS AND MET...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-017-2885-1
更新日期：2018-02-01 00:00:00
abstract：INTRODUCTION:Laparoscopic sleeve gastrectomy (LSG) has rapidly become popular with excellent results. However, LSG may exacerbate or increase the risk of "de novo" gastroesophageal reflux disease (GERD). Adding a fundoplication has been proposed to increase the lower esophageal sphincter competency. The aim of this stu...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-020-05189-6
更新日期：2021-01-03 00:00:00
abstract：BACKGROUND:The purpose of the present study is to evaluate the impact of a health psychology-led bariatric rehabilitation service (BRS) on patient weight loss following bariatric surgery at 1 year. METHODS:A single-site open-randomised parallel group control trial based at St. Richard's Hospital in Chichester in the U...
journal_title：Obesity surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11695-014-1428-2
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The volume of the gastric reservoir appears crucial to explain the success of laparoscopic sleeve gastrectomy (LSG) in the treatment of morbid obesity. The aims of this study were to describe a new, easy model to estimate gastric reservoir volume after LSG; to evaluate the volumetric changes 1 year after sur...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-013-1113-x
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Operations for morbid obesity that are effective in inducing weight loss improve blood pressure, glycemic control and dyslipidemia. Our purpose was to study the effectiveness of VBG in improving hypertension, diabetes and dyslipidemias in morbidly obese patients. METHODS:Retrospective analysis of a cohort o...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/096089202321088075
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:Bariatric surgery is increasingly being carried out and revisional procedures have also risen in concert. A review of the complications and revisions might elucidate technical and patient factors that influence the outcomes of bariatric surgeries in Asian patients. The objective of this study is to review th...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-015-1852-y
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:The rise of bariatric surgery has lead to an increasing number of reoperations for failed bariatric procedures. The reasons and types of these operations are varied in nature and remain to be defined. METHODS:A retrospective review of a prospectively collected database was conducted to identify patients who...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-010-0234-8
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:Laparoscopic gastric bypass (LRYGB) is considered as the gold standard procedure for morbid obesity because of sustainable weight loss and coexisting conditions improvements (Sjostrom L et al. The New England journal of medicine 351(26):2683-93, 2004 [1]; Thereaux J et al. Surg Obesity Related Dis: Off J Am Soc...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-015-1616-8
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Obesity is an independent risk factor for hypertension and chronic kidney disease. During the first months after bariatric surgery, an improvement of sodium excretion has been described. The aim of this work was to study the influence of bariatric surgery on sodium excretion at more than a year after the int...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-012-0764-3
更新日期：2013-03-01 00:00:00
abstract：:A 42-year-old patient with a sixth bariatric-related surgical procedure is presented. The steps taken for the management of her intractable nausea, vomiting, abdominal pain, unacceptable weight loss and diarrhea are described, together with the rationale therefor. Bariatric reoperative surgical procedure and outcome a...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/096089295765558006
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:No conclusive data exists supporting the use of any prokinetic agent in the postoperative setting. The study was designed to examine the effect of erythromycin on small bowel motility in a placebo-controlled trial of post gastric bypass patients utilizing a standardized nuclear medicine test. METHODS:A cons...
journal_title：Obesity surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1381/096089202320995538
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:A technique for standard laparoscopic BPD was developed. METHODS:Standard laparoscopic BPD was performed in 26 morbidly obese patients with mean BMI 43. Details of the technique, using 6 trocars, and instrumentation are described. Intestinal limb lengths were measured fully stretched, and the gastric remnan...
journal_title：Obesity surgery
pub_type： 杂志文章,评审
doi：10.1381/096089202762552692
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVE:Evaluate 5-year outcomes of banded gastric bypass (BRYGB) as a primary and conversion bariatric procedure. METHODS:Retrospective review of BRYGB between January 2011and March 2013. Outcomes included percentage of total weight loss (%TWL), weight loss maintenance, and band-related complications. RESULTS:One ...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-019-04229-0
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) has been identified as an innovative surgical approach for the treatment of obesity and is increasingly applied worldwide. However, data on outcome of LSG regarding nutrient deficiencies, protein status, and body composition are scarce. METHODS:Obese subjects (54; f:m =...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-012-0609-0
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:The laparoscopic gastric plication (LGP) is a relative new bariatric procedure that has gained popularity over the last few years, but no real consensus exists and the evidence is unclear, especially in its real efficacy, safety, and durability. METHODS:Retrospective study analyzing the records patients sub...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1007/s11695-016-2242-9
更新日期：2017-01-01 00:00:00
abstract：:End-stage renal failure is most commonly caused by the obesity-related diseases, diabetes mellitus and essential hypertension, and is best treated with renal transplantation. Obesity may contribute to poor patient and graft survival, and is an exclusion criterion in some renal transplant programs. Diet and exercise pr...
journal_title：Obesity surgery
pub_type： 杂志文章
doi：10.1381/0960892053723349
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Sleeve gastrectomy involves the creation of small gastric reservoir based on lesser curvature of the stomach, which is fashioned by a longitudinal gastrectomy that preserves the antrum and pylorus together with its vagal innervation. The main complications in the early postoperative course are bleeding and g...
journal_title：Obesity surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11695-011-0421-2
更新日期：2012-01-01 00:00:00
