Abstract：
BACKGROUND:Bariatric surgery results in massive loss of excess weight, changes in co-morbidities and improvement in quality of life. In these patients, liver histology taken before or during surgery reveals several histological abnormalities. In a prospective study of patients previously submitted to gastric bypass, we determined the changes in liver histology late after the surgery. METHODS:In 16 out of a total of 557 patients who were submitted to open gastric bypass, a second liver biopsy was taken during the repair of an incisional hernia, performed at a mean of 17 months after the gastric bypass. RESULTS:All patients had lost weight, now having a mean BMI of 28.6 kg/m(2) (which had been 44.3 kg/m(2) before gastric bypass). One patient with normal pre-operative liver histology remained normal at the second study. 11 out of 15 who had had liver abnormalities returned to a normal condition or had only minimal change (73.3%). 2 patients (13.3%) showed improvement, while 1 patient presented a slight worsening of liver condition. One patient who had had liver cirrhosis showed no change. CONCLUSION:Gastric bypass for morbid obesity is followed by a dramatic improvement or normalization of liver histological abnormalities in the great majority of the patients. Liver cirrhosis in the one patient remained unchanged.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Csendes A,Smok G,Burgos AMdoi
10.1381/096089206776944904subject
Has Abstractpub_date
2006-05-01 00:00:00pages
607-11issue
5eissn
0960-8923issn
1708-0428journal_volume
16pub_type
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