Gastric bypass increases ethanol and water consumption in diet-induced obese rats.

Abstract:

BACKGROUND:Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment for morbid obesity. Increased alcohol abuse after RYGB resulted in recommendations to exclude patients with alcohol abuse histories from RYGB. The purpose of our study was to examine the effects of a RYGB on ethanol intake in diet-induced obese rats (high-fat diet). METHODS:The animals underwent RYGB and were habituated along with their sham-operated obese controls and with lean rats to increasing concentrations of ethanol in a two-bottle choice paradigm. RESULTS:RYGB rats' daily consumption of ethanol averaged 2 g/kg at 2% habituation and 3.8 g/kg at 4% habituation, twice as much as sham-operated obese controls and 50% more than normal-diet lean controls. Obese controls drank on average 1 g/kg of ethanol (2 and 4%), significantly less (50%) than lean controls did. RYGB rats when given higher ethanol concentrations (6 and 8%) or no ethanol drank significantly more water than lean and obese controls did (66 and 100%, respectively), and their enhanced total fluid intake was associated with increased food intake, which was significantly higher than in lean (66% more calories; food + alcohol) and obese controls (44% more calories). The lower alcohol intake in the obese controls than in the lean rats suggests that obesity may interfere with alcohol's rewarding effects and RYGB may remove this protective effect. CONCLUSIONS:The overall enhancement of consummatory behaviors (both ethanol and water) suggests that RYGB may facilitate alcohol consumption, which in vulnerable individuals could lead to abuse and addiction.

journal_name

Obes Surg

journal_title

Obesity surgery

authors

Thanos PK,Subrize M,Delis F,Cooney RN,Culnan D,Sun M,Wang GJ,Volkow ND,Hajnal A

doi

10.1007/s11695-012-0749-2

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1884-92

issue

12

eissn

0960-8923

issn

1708-0428

journal_volume

22

pub_type

杂志文章
  • Comparison of SAGB QC "classic" titanium port and Velocity port: pilot phase prospective randomized study on perioperative and short-term postoperative implantation outcomes.

    abstract:BACKGROUND:Port implantation in adjustable gastric banding (AGB) is usually considered as the least compelling, however, it is one of the very important parts of the operation. Port placement can take up to 10% of the overall AGB operating time, and inadequate technique can result in complications in the short- and lon...

    journal_title:Obesity surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1381/096089206777346709

    authors: Fried M,Kormanova K,Kasalicky M

    更新日期:2006-06-01 00:00:00

  • Why Does the Gastric Bypass Control Type 2 Diabetes Mellitus?

    abstract::The remarkable control of diabetes by the gastric bypass remains to be explained. Although it may be totally due to the weight loss Induced by the operation, it is likely that the detour of the hormonally active foregut plays a role as well. This keynote address explores the pathophysiology of non-insulin-dependent di...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089292765559891

    authors: Pories WJ

    更新日期:1992-11-01 00:00:00

  • Trocar Injuries in 17,446 Laparoscopic Gastric Bypass-a Nationwide Survey from the Scandinavian Obesity Surgery Registry.

    abstract:BACKGROUND:Although, the vast majority of bariatric procedures worldwide are performed laparoscopically, there is no consensus on the best technique to enter the first trocar, a potentially dangerous maneuver. Three principally different techniques exist: initial pneumoperitoneum by Verres needle, open Hasson technique...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-016-2080-9

    authors: Sundbom M,Ottosson J

    更新日期:2016-09-01 00:00:00

  • The Impact of Pregnancy on Outcomes After Bariatric Surgery.

    abstract:BACKGROUND:Bariatric surgery is performed mostly on obese women of reproductive age. Many studies have analyzed pregnancy outcomes after bariatric surgery, but only a small number have studied the impact of pregnancy on the postoperative outcomes. PURPOSE:To study the effect of pregnancy on outcomes after bariatric su...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-020-04643-9

    authors: Brönnimann A,Jung MK,Niclauss N,Hagen ME,Toso C,Buchs NC

    更新日期:2020-08-01 00:00:00

  • Preoperative Interventions for Patients Being Considered for Bariatric Surgery: Separating the Fact from Fiction.

    abstract::Preoperative interventions aimed at patients referred for bariatric surgery continue to divide funders, commissioners, and practitioners alike. A number of preoperative interventions and variables have been used to influence patient selection. Many of these are believed to lead to better postoperative outcomes by help...

    journal_title:Obesity surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s11695-015-1738-z

    authors: Mahawar KK,Parmar C,Carr WR,Jennings N,Schroeder N,Balupuri S,Small PK

    更新日期:2015-08-01 00:00:00

  • EUS-Guided Intragastric Injection of Botulinum Toxin A in the Preoperative Treatment of Super-Obese Patients: a Randomized Clinical Trial.

    abstract:BACKGROUND:Obesity is a disease that is highly prevalent in Brazil, and the associated comorbidities represent a major global public health challenge. Botulinum toxin type A (BTX-A) is a potent neurotoxin and inhibitor of gastric smooth muscle activity. In theory, BTX-A administration should promote early satiety and w...

    journal_title:Obesity surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11695-018-3470-y

    authors: de Moura EGH,Ribeiro IB,Frazão MSV,Mestieri LHM,de Moura DTH,Dal Bó CMR,Brunaldi VO,de Moura ETH,Nunes GC,Bustamante FAC,Dos Passos Galvão Neto M,Matuguma SE,Bernardo WM,Santo MA

    更新日期:2019-01-01 00:00:00

  • Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy.

    abstract:BACKGROUND:The treatment of pain in obese patients is always a challenge. These patients have low pain thresholds, and the use of opioids can be especially harmful. Intraoperative nervous fiber section and the high temperatures of electrical scalpels probably contribute to the generation of postoperative neuropathic pa...

    journal_title:Obesity surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11695-009-9944-1

    authors: Cabrera Schulmeyer MC,de la Maza J,Ovalle C,Farias C,Vives I

    更新日期:2010-12-01 00:00:00

  • Which Factors Correlate with Marginal Ulcer After Surgery for Obesity?

    abstract:INTRODUCTION:Marginal ulcer is one of the most common complications after Roux-en-Y gastric bypass and is defined as an ulceration of any depth at or near the gastrojejunal anastomosis. Different risk factors have been advocated to be the causative agent. MATERIALS AND METHODS:The weighted discharges from the Nationwi...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-020-04960-z

    authors: Rodrigo DC,Jill S,Daniel M,Kimberly C,Maher EC

    更新日期:2020-12-01 00:00:00

  • Routine abdominal drains after laparoscopic sleeve gastrectomy: a retrospective review of 353 patients.

    abstract::Complications after laparoscopic sleeve gastrectomy (LSG) are usually silent and difficult to interpret. Our purpose was to evaluate the utility of routine placement of intraperitoneal drains at the end of LSG in detection and management of postoperative complications. This is a retrospective study of all patients tha...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-010-0343-4

    authors: Albanopoulos K,Alevizos L,Linardoutsos D,Menenakos E,Stamou K,Vlachos K,Zografos G,Leandros E

    更新日期:2011-06-01 00:00:00

  • Revisional Surgery for Insufficient Loss or Regain of Weight After Roux-en-Y Gastric Bypass: Biliopancreatic Limb Length Matters.

    abstract:INTRODUCTION:Weight regain after laparoscopic Roux-en-Y gastric bypass (RYGB) occurs in up to 35% of patients. Revisional surgery may be applied. Conversion from RYGB to a long biliopancreatic limb (BPL) RYGB is a potential option for revisional surgery and short-term results are promising. METHODS:All patients who un...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-019-04348-8

    authors: Kraljević M,Köstler T,Süsstrunk J,Lazaridis II,Taheri A,Zingg U,Delko T

    更新日期:2020-03-01 00:00:00

  • BioEnterics intragastric balloon: clinical outcomes of the first 100 patients--a Turkish experience.

    abstract:BACKGROUND:The BioEnterics Intragrastric Balloon (BIB) together with restricted diet has been used for the treatment of obesity and morbid obesity. METHODS:A prospective study was conducted on 100 patients who had undergone the BIB procedure between February 2005 and February 2007. RESULTS:Mean age, mean weight, and ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-008-9565-0

    authors: Coskun H,Bostanci O,Dilege E,Bozbora A

    更新日期:2008-09-01 00:00:00

  • Relationship between obstructive sleep apnea and liver abnormalities in morbidly obese patients: a prospective study.

    abstract:BACKGROUND:Morbid obesity is a risk factor of nonalcoholic steatohepatitis (NASH). Obstructive sleep apnea (OSA) could also be an independent risk factor for elevated liver enzymes and NASH. The relationships between liver injuries and OSA in morbidly obese patients requiring bariatric surgery were studied prospectivel...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-007-9085-3

    authors: Jouët P,Sabaté JM,Maillard D,Msika S,Mechler C,Ledoux S,Harnois F,Coffin B

    更新日期:2007-04-01 00:00:00

  • The role of cognitive function in postoperative weight loss outcomes: 36-month follow-up.

    abstract:BACKGROUND:Cognitive dysfunction is associated with reduced postoperative weight loss up to 2 years following surgery, though the role of cognition at more extended follow-up is not yet understood. Thirty-six months following bariatric surgery, we retrospectively compared obese and non-obese patients on 12-week postope...

    journal_title:Obesity surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11695-014-1205-2

    authors: Spitznagel MB,Alosco M,Galioto R,Strain G,Devlin M,Sysko R,Crosby RD,Mitchell JE,Gunstad J

    更新日期:2014-07-01 00:00:00

  • Helicobacter pylori-induced Diarrhea Ileogastrostomy.

    abstract::A retrospective study of all ileogastrostomy procedures (n = 26) performed in 1993 by one surgeon (IGMC) was carried out to investigate the hypothesis that Helicobacter pylori may be implicated in certain severe cases of postoperation nausea and diarrhea. Ten of 26 persons (38.5%) displayed nausea and notable diarrhea...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089294765558548

    authors: Cleator IG,Rae AJ,Birmingham CL

    更新日期:1994-08-01 00:00:00

  • Esophageal Squamous Cell Carcinoma After Adjustable Gastric Banding.

    abstract::The prevalence of morbid obesity has been increasing worldwide. Therefore, multiple laparoscopic adjustable gastric bandings (LAGBs) have been placed in Belgium in the nineties. The procedure was considered as minimal invasive with low morbidity rates. However, some publication cases suggest a possible association bet...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-019-03708-8

    authors: Janse P,Nafteux P,Lannoo M,Steger PH,Sirbu F

    更新日期:2019-03-01 00:00:00

  • γ-Glutamyltransferase Fractions in Obese Subjects with Type 2 Diabetes: Relation to Insulin Sensitivity and Effects of Bariatric Surgery.

    abstract:BACKGROUND/OBJECTIVES:Gamma-glutamyltranspeptidase (GGT) levels are an independent risk marker for the development of type 2 diabetes (T2DM). We investigated the relationship between the newly identified serum GGT fractions and glucose metabolism in obese subjects before and after bariatric surgery. SUBJECTS/METHODS:T...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-017-3017-7

    authors: Franzini M,Musetti V,Guarino D,Caponi L,Paolicchi A,Emdin M,Ferrannini E,Nannipieri M

    更新日期:2018-05-01 00:00:00

  • A Pilot Study: The Effect of Roux-en-Y Gastric Bypass on the Serum MicroRNAs of the Type 2 Diabetes Patient.

    abstract:PURPOSE:The purpose of this study was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on the serum microRNA of the type 2 diabetes (T2D) patient with different body mass indexes (BMI) or blood insulin and C-peptides. MATERIALS AND METHODS:Fifteen patients with T2D who elected to undergo gastric bypass sur...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-015-1711-x

    authors: Lirun K,Sewe M,Yong W

    更新日期:2015-12-01 00:00:00

  • Fluid-Filled Versus Gas-Filled Intragastric Balloons as Obesity Interventions: a Network Meta-analysis of Randomized Trials.

    abstract:BACKGROUND:Four commercially available intragastric balloons have been used for the management of obesity and underwent randomized controlled trials (RCTs), and we aimed to compare them using a network meta-analysis approach. METHODS:Several databases were queried from inception to May 26, 2017, and we included RCTs e...

    journal_title:Obesity surgery

    pub_type: 杂志文章,meta分析

    doi:10.1007/s11695-018-3227-7

    authors: Bazerbachi F,Haffar S,Sawas T,Vargas EJ,Kaur RJ,Wang Z,Prokop LJ,Murad MH,Abu Dayyeh BK

    更新日期:2018-09-01 00:00:00

  • Gastric cancer after Roux-en-Y gastric bypass.

    abstract::Roux-en-Y gastric bypass (RYGBP) is one of the most commonly performed surgical procedures for morbid obesity. Several complications that may develop in the short- and long-term have been reported. We present a patient who presented with cancer in the bypassed stomach 8 years after RYGBP. Although the development of t...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/0960892053576668

    authors: Escalona A,Guzmán S,Ibáñez L,Meneses L,Huete A,Solar A

    更新日期:2005-03-01 00:00:00

  • Conversion from sleeve gastrectomy to Roux-en-Y gastric bypass--indications and outcome.

    abstract:BACKGROUND:Due to excellent weight loss success in the short-time follow-up, sleeve gastrectomy (SG) has gained popularity as sole and definitive bariatric procedure. In the long-term follow-up, weight loss failure and intractable severe reflux can necessitate further surgical intervention. METHODS:A retrospective ana...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-010-0125-z

    authors: Langer FB,Bohdjalian A,Shakeri-Leidenmühler S,Schoppmann SF,Zacherl J,Prager G

    更新日期:2010-07-01 00:00:00

  • Hepatic expression of adiponectin receptors increases with non-alcoholic fatty liver disease progression in morbid obesity in correlation with glutathione peroxidase 1.

    abstract:BACKGROUND:The prevalence of non-alcoholic fatty liver disease (NAFLD) in obesity is very high. The role of adiponectin receptors in NAFLD progression remains still unclear. We speculate that changes in the hepatic expression levels of the two adiponectin receptors may be associated with the expression of oxidative str...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-010-0353-2

    authors: Carazo A,León J,Casado J,Gila A,Delgado S,Martín A,Sanjuan L,Caballero T,Muñoz JA,Quiles R,Ruiz-Extremera A,Alcázar LM,Salmerón J

    更新日期:2011-04-01 00:00:00

  • Acarbose improves hypoglycaemia following gastric bypass surgery without increasing glucagon-like peptide 1 levels.

    abstract:BACKGROUND:Postprandial hypoglycaemia is a severe complication of Roux-en-Y gastric bypass (RYGBP). Acarbose, an α-glucosidase inhibitor (AGI), is employed in its treatment. Several studies have shown that AGIs increase the postprandial levels of glucagon-like peptide 1 (GLP-1). However, an excessive level of GLP-1 is ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-011-0581-0

    authors: Valderas JP,Ahuad J,Rubio L,Escalona M,Pollak F,Maiz A

    更新日期:2012-04-01 00:00:00

  • Purpura fulminans due to Streptococcus pneumoniae sepsis following gastric bypass.

    abstract::An older female underwent bariatric surgery which was followed by a significant weight loss and diarrhea, from which C. difficile was isolated just before her hospitalization. Less than 48 hours after admission, she became febrile, developed deep venous thrombosis of the leg and a pulmonary embolus. Blood cultures gre...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089204323093507

    authors: Cone LA,B Waterbor R,Sofonio MV

    更新日期:2004-05-01 00:00:00

  • Oral Health Implications of Bariatric Surgery in Morbidly Obese Patients: An Integrative Review.

    abstract:BACKGROUND:To identify the implications of bariatric surgery on the oral health of patients with morbid obesity. METHODS:Two reviewers independently performed a search of the electronic databases: MedLine, PubMed, SciELO, LILACS, and Scopus, for clinical trials in humans and cohort studies. The search strategy used wa...

    journal_title:Obesity surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s11695-019-04334-0

    authors: da Silva Azevedo ML,Silva NR,da Costa Cunha Mafra CA,Lins RDAU,Dantas EM,de Vasconcelos Gurgel BC,de Aquino Martins ARL

    更新日期:2020-04-01 00:00:00

  • Reporting results after bariatric surgery: reproducibility of predicted body mass index.

    abstract:BACKGROUND:There is a controversy about the best way to report results after bariatric surgery. Several indices have been proposed over the years such as percentage of total weight loss (%TWL), percentage of excess weight loss (%EWL), and percentage of excess body mass index loss (%EBMIL). More recently, it has been su...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-011-0480-4

    authors: Júnior WS,Campos CS,Nonino CB

    更新日期:2012-04-01 00:00:00

  • Why the Operation We Prefer is the Roux-Y Gastric Bypass.

    abstract::Roux-Y gastric bypass with transection in an anterio-posterior oblique fashion and an 11-12 mm internal diameter gastrojejunostomy supported by an external strip of linea alba fascia is safe and effective as a primary or revision procedure, with a very low failure and revision rate. ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/096089291765561051

    authors: Linner JH,Drew RL

    更新日期:1991-09-01 00:00:00

  • Short- and Long-Term Effects of Abdominal Lipectomy on Weight and Fat Mass in Females: a Systematic Review.

    abstract::Adipose tissue is considered as an endocrine organ, which is developed in specific depots, distinguished either as subcutaneous or visceral. Lipectomy, by means of liposuction or abdominoplasty, is a common plastic surgery procedure, which can remove substantial amounts of subcutaneous fat. This systematic review aims...

    journal_title:Obesity surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s11695-015-1797-1

    authors: Seretis K,Goulis DG,Koliakos G,Demiri E

    更新日期:2015-10-01 00:00:00

  • The Positive Effects of the Human Amniotic Membrane on the Healing of Staple Line After Sleeve Gastrectomy Applied Long-Evans Rat Model.

    abstract:BACKGROUND:The staple line leakage is a dangerous complication of sleeve gastrectomy. Various strategies have been tried to reduce the leakage risk. The amniotic membrane (AmM) is the inner layer of the placental membranes and has anti-inflammatory, anti-fibrosis, and anti-scarring effects, and it also has lower immune...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-019-04027-8

    authors: Ferhatoglu MF,Kıvılcım T,Senol K,Vural G,Kartal A,İncir S,Filiz Aİ,Kebudi A

    更新日期:2019-11-01 00:00:00

  • Biliopancreatic diversion with transitory gastric restriction and duodenal bulb preservation: 88 patients since 1992.

    abstract:BACKGROUND:Over 10 years, 88 patients underwent biliopancreatic diversion with transitory gastric restriction (BPD-TGR) as a first choice operation or after gastric restrictive procedures. METHODS:From 1992 to 1999, BPD-TGR was performed on 71 patients as a first choice operation (Group 1 - BMI 41.9 +/- 6.5). The TGR ...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1381/0960892041590836

    authors: Vassallo C,Negri L,Rovati P,Della Valle A,Tata S,Berbiglia G,Pessina A,Ramaioli F,Dono C,Fariseo M

    更新日期:2004-06-01 00:00:00

  • Bariatric Surgery in Prior Solid Organ Transplantation Patients: Is Race a Predictor of Adverse Outcomes?

    abstract:PURPOSE:Metabolic and bariatric surgery (MBS) is increasingly performed in patients with previous solid organ transplantation (PSOT). In addition, controversy remains about whether racial disparity in outcomes following MBS exists. Therefore, the aim of this analysis was to determine if race independently predicts outc...

    journal_title:Obesity surgery

    pub_type: 杂志文章

    doi:10.1007/s11695-020-04813-9

    authors: Edwards MA,Fagenson AM,Mazzei M,Zhao H

    更新日期:2020-11-01 00:00:00