Abstract:
:There is an increasing evidence that CD3+ cells, bearing gammadelta T cell receptors representing a minor subpopulation of T cells in the peripheral blood of humans are involved in the development of autoimmunity. The aim of the present study was determination of the gammadelta T cell subpopulation levels in the peripheral blood of subjects with Graves' disease and newly diagnosed type 1 diabetes in comparison to age-matched healthy controls. The percentages of CD3+, CD8+, gammadelta TCR+CD8+, gammadelta TCR+CD8- lymphocyte subsets were measured by flow cytometry. In the peripheral blood of newly diagnosed Graves' disease patients we showed a significant decrease of gammadelta TCR+ cells and gammadelta TCR+CD8- subset content in comparison to the percentages observed in subjects after methimazole treatment and in healthy controls. We also found a significant increase of gammadelta TCR+CD8+ cells in the peripheral blood of subjects with insulin-dependent diabetes, treated with insulin for 3-6 months. The present findings confirm our previous hypothesis that gammadelta TCR+CD8+ lymphocyte subset could play a role in the pathogenesis of diabetes type 1, probably as regulatory T cells and could be induced by delivery of exogenous insulin. Our results suggest that gammadelta T cells (gammadelta TCR+CD8- subset) could also play an important role in the development of Graves' disease and that their levels are modulated by thyreostatic treatment.
journal_name
Arch Immunol Ther Exp (Warsz)journal_title
Archivum immunologiae et therapiae experimentalisauthors
Kretowski A,Myśliwiec J,Kinalska Isubject
Has Abstractpub_date
2000-01-01 00:00:00pages
39-42issue
1eissn
0004-069Xissn
1661-4917journal_volume
48pub_type
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journal_title:Archivum immunologiae et therapiae experimentalis
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journal_title:Archivum immunologiae et therapiae experimentalis
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
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更新日期:1976-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
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更新日期:1977-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
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更新日期:1978-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
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更新日期:1978-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:10.1007/s00005-015-0357-7
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
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journal_title:Archivum immunologiae et therapiae experimentalis
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journal_title:Archivum immunologiae et therapiae experimentalis
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doi:
更新日期:2004-07-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
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journal_title:Archivum immunologiae et therapiae experimentalis
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doi:
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00