Influence of WA-335, a factor which blocks serotonin receptors, on neuroleptic-induced catalepsy.

Abstract:

:In a previous study, anticataleptic action of cyproheptadine was reported. The present investigation deals with the influence of WA-335 (9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol), another antagonist of serotonin, on catalepsy induced in rats with spiroperidol, pimozide, fluphenazine and reserpine. WA-335 antagonized catalepsy induced by these neuroleptics (the effect on reserpine-induced catalepsy was weakest). Joint administration of WA-335 and L-DOPA with an inhibitor of peripheral decarboxylase, or WA-335 and amantadine produced a stronger antagonistic effect (spiroperidol catalepsy) than either of these substances separately. WA-335 did not prevent catalepsy induced with physostigmine.

authors

Maj J,Sowińska H,Baran L

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

197-203

issue

2

eissn

0004-069X

issn

1661-4917

journal_volume

24

pub_type

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