Asthma and Cushing's syndrome.

Abstract:

:A female patient was treated with high-dose inhaled fluticasone propionate for her asthma. Over 2 years, she developed features of Cushing's syndrome with proximal myopathy, osteopenia, hypertension, depressive psychosis, and cushingoid appearance. She had biochemical evidence of marked adrenal suppression with a 9:00 AM serum cortisol of 20 nmol/L that returned to normal (315 mol/L) after her therapy was changed to budenoside, 0.8 mg/d. Her appearance, mental state, and myopathy also improved with no loss of asthma control. This case illustrates the potential for developing clinically relevant adverse effects of inhaled corticosteroids when given at licensed doses.

journal_name

Chest

journal_title

Chest

authors

Wilson AM,Blumsohn A,Jung RT,Lipworth BJ

doi

10.1378/chest.117.2.593

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

593-4

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)48657-X

journal_volume

117

pub_type

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