Abstract:
:A female patient was treated with high-dose inhaled fluticasone propionate for her asthma. Over 2 years, she developed features of Cushing's syndrome with proximal myopathy, osteopenia, hypertension, depressive psychosis, and cushingoid appearance. She had biochemical evidence of marked adrenal suppression with a 9:00 AM serum cortisol of 20 nmol/L that returned to normal (315 mol/L) after her therapy was changed to budenoside, 0.8 mg/d. Her appearance, mental state, and myopathy also improved with no loss of asthma control. This case illustrates the potential for developing clinically relevant adverse effects of inhaled corticosteroids when given at licensed doses.
journal_name
Chestjournal_title
Chestauthors
Wilson AM,Blumsohn A,Jung RT,Lipworth BJdoi
10.1378/chest.117.2.593subject
Has Abstractpub_date
2000-02-01 00:00:00pages
593-4issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)48657-Xjournal_volume
117pub_type
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