Abstract:
:The objective of this paper was to determine the time course and extent of platinum uptake into human malignant glioma tissue. An intraoperative, intravenous infusion of carboplatin was given to nine patients (seven glioblastoma and two anaplastic glioma) undergoing tumour excision. Carboplatin dosage was calculated individually to achieve a target systemic free carboplatin exposure. Tumour and peritumoural tissue was harvested at timed intervals following carboplatin administration. Plasma and tumour platinum concentrations were measured by graphite furnace flameless atomic absorption spectrophotometry. Histological examination was also performed on a piece of each tissue sample. The mean carboplatin dose administered was 783, SEM 56 mg (range 485-903). Plasma pharmacokinetics showed a typical elimination curve. The mean peak plasma platinum concentration was 44, SEM 5 micrograms/ml (range 27-74). The mean total elemental plasma platinum area under the curve (AUC) was 9.0, SEM 1.4 mg/ml/min. Platinum was detected in 61 tumour samples, the mean peak concentration being 13 SEM 2 micrograms/g (range 5-21). Platinum was also detected in peritumoural brain and necrotic tumour. No correlation was apparent between the degree of necrosis in each tumour specimen and tumour platinum concentration. Platinum concentrations achieved in tumour were similar to levels that would be cytotoxic for glioma cells in vitro. The results of this study have implications for future studies using capillary permeability modifying agents as adjuncts to brain tumour chemotherapy.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Whittle IR,Malcolm G,Jodrell DI,Reid Mdoi
10.1080/02688699943871subject
Has Abstractpub_date
1999-04-01 00:00:00pages
132-7issue
2eissn
0268-8697issn
1360-046Xjournal_volume
13pub_type
杂志文章abstract:INTRODUCTION:Intraspinal tumours are rare and principally managed surgically. Laminectomy, employed for access to the spinal canal, destroys the posterior tension band leading to a risk of kyphosis. Hemilaminectomy as an alternative may be less destructive, potentially reducing the risk of deformity and causing less po...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2014.1003026
更新日期:2015-06-01 00:00:00
abstract::Since 1976, 133 patients treated by posterior fossa microvascular decompression (MVD) for trigeminal neuralgia (TN) have been followed-up prospectively to determine the incidence of recurrent TN. The follow-up period was between 6 months and 15 years, with 60 patients having been follow-up for more than 5 years. Of th...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:Evidence suggests that reduction of nitric oxide (NO) bioavailability due to oxidative stress plays a central role in the pathophysiology of cerebral vasospasm after subarachnoid haemorrhage (SAH). To prevent SAH-induced cerebral vasospasm, therefore we used nebivolol hydrochloride as a NO-mediated vasodilato...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2017.1297367
更新日期:2017-08-01 00:00:00
abstract::Neuroendoscopy is increasingly used in the management of brain tumours and tumour related hydrocephalus and this study reviews the efficacy of neuroendoscopic interventions in this unit in patients with brain tumours. A series of 87 neuroendoscopic operations carried out in 77 patients with brain tumours over a 6-year...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/0268869021000030276
更新日期:2002-10-01 00:00:00
abstract::Huge calcified chronic subdural hematoma is quite rare. We reported a such case in a old man. The intraoperative photographs of the case fully demonstrated the morphology of the calcified chronic subdural hematoma. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2010.520763
更新日期:2010-12-01 00:00:00
abstract::Ultrasonic aspirators are commonly used to resect brain tumours because they allow safe, rapid and accurate removal of diseased tissue. Since ultrasonic aspirators generate a spray of aerosolized irrigating fluid around the instrument tip, we questioned whether this spray might contain viable tumours cells that could ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::We report three patients who deteriorated after lumbar puncture (LP). Two patients were later found to have type іі (a + b) dural arteriovenous fistulas (DAVF) with high flow retrograde venous drainage on cerebral angiography. The third had a type II (a) DAVF. All patients recovered at least partially after DAVF treat...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1639619
更新日期:2019-07-09 00:00:00
abstract::Until recently, warfarin, clopidogrel and aspirin have provided the mainstay for prevention of thrombotic disease in cardiac patients. However, new classes of drugs have recently emerged that promise better clinical outcomes and lower risks. Use of such agents has increased, but increased risk and severity of intra-cr...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2015.1029433
更新日期:2015-01-01 00:00:00
abstract:OBJECT:Animal models provide a basis for clarifying the complex pathogenesis of delayed cerebral vasospasm (DCVS) and for screening of potential therapeutic approaches. Arbitrary use of experimental parameters in current models can lead to results of uncertain relevance. The aim of this work was to identify and analyze...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688691003746274
更新日期:2010-08-01 00:00:00
abstract::Sixteen patients with surgical infection of the posterior fossa are presented. There were 14 patients with cerebellar abscess, one patient with a solitary posterior fossa subdural empyema, and another with a combined cerebellar abscess and subdural empyema. Two of the cerebellar abscess patients also had supratentoria...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699408995113
更新日期:1994-01-01 00:00:00
abstract::Cavernous angiomas affecting the optic pathway are rare. This report describes the case of a 12-year-old girl who presented with a 10-month history of right-sided blurred vision caused by a cavernous angioma affecting the right side of the optic chiasm. The computed tomography (CT) scan demonstrated a hyperdense image...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2012.685820
更新日期:2012-12-01 00:00:00
abstract::We report a series of 14 patients who underwent partial or complete trigeminal nerve root section for chronic unremitting migrainous neuralgia. They had all suffered attacks with severe pain for over 18 months without remission (mean duration 5.5 years). Symptoms were refractory to extended medical intervention and ha...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699308995070
更新日期:1993-01-01 00:00:00
abstract::A case of spinal extradural cavernous angioma is described. The symptomatology and prognosis of such lesions is discussed and the relevant literature reviewed. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688699308995060
更新日期:1993-01-01 00:00:00
abstract::Spinal cord stimulation (SCS) is an established treatment modality for chronic pain, angina pectoris, and peripheral vascular disease. This study evaluates experience with SCS over a 13-year period with emphasis on surgical complications, revisions and pain relief. It took the form of a retrospective study of medical/...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690120072496
更新日期:2001-08-01 00:00:00
abstract::We present a case of spontaneous 79% regression in the size of a vestibular schwannoma (VS). A 41-year-old lady with a large (36 mm) vestibular schwannoma underwent serial follow-up MRI scans which demonstrated the shrinkage over 9 years; the highest relative spontaneous regression recorded in the literature for vesti...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1582749
更新日期:2019-03-04 00:00:00
abstract:BACKGROUND:Wide-necked and non-saccular aneurysms are difficult to treat with coil embolization. The use of stents has expanded the role of endovascular treatment. METHODS:A retrospective study of 43 patients with wide-necked, fusiform or blister aneurysms treated with stent-assisted coiling or stent alone. The review...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.757292
更新日期:2013-10-01 00:00:00
abstract::Some degree of hydrocephalus is present in almost all cases of medium to large posterior fossa tumours. The initial symptoms in such cases are usually due to the hydrocephalus and the consequent increased supratentorial pressure, and more often precede the symptoms primarily due to the local invasion and compression o...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699309103494
更新日期:1993-01-01 00:00:00
abstract::Utilization of operating theatre time is an important issue in neurosurgery, in a National Health Service Hospital. NHS Trusts are under ever increasing pressure to meet specified 'targets' in relation to admissions and operations. We performed a retrospective audit on the utilization of neurosurgical operating theatr...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690400004852
更新日期:2004-08-01 00:00:00
abstract::This report details an additional case of the very rare instance of a respiratory epithelium-lined intracerebral cyst without communication with the ventricular system. Immunohistologic analysis supports an epithelial rather than neuroectodermal origin. Management using endoneurosurgical techniques is described. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698909002838
更新日期:1989-01-01 00:00:00
abstract::Rhinosporidiosis is a chronic fungal inflammatory disease prevalent in India and Sri Lanka. Its manifestations are mostly nasal and extranasal lesions are relatively rare. Occasional atypical presentations of this disease lead to diagnostic dilemma. Herein we report on a case of nasopharyngeal rhinosporidiosis having ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2018.1472215
更新日期:2018-05-10 00:00:00
abstract::We report three patients treated for cervical radiculopathy by anterior cervical discectomy and BOP grafting. Because of recurrent symptoms re-exploration was carried out 30 months later in the first case, 10 months in second and 8 months in the third case. At reoperation the grafts were disrupted into easily separabl...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699746717
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Traumatic brain injuries result in significant morbidity and mortality. Accurate prediction of prognosis is desirable to inform treatment decisions and counsel family members. Objective To review the currently available prognostic tools for use in traumatic brain injury (TBI), to analyse their value in indiv...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2016.1139048
更新日期:2016-01-01 00:00:00
abstract::The objective of this study was to investigate if there are possible gender differences in relation to outcome following closed severe traumatic brain injury (TBI) in a predominantly Asian population. A study was conducted using our prospectively maintained TBI database of 672 patients with severe TBI admitted into ou...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690600682259
更新日期:2006-04-01 00:00:00
abstract::We report a 10-year-old boy who presented with a subarachnoid haemorrhage from a ruptured hypoglossal artery aneurysm. The aneurysm was clipped via a transcondylar approach. The embryology, occurrence and the surgical approach to aneurysms at this site are discussed. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699646952
更新日期:1996-12-01 00:00:00
abstract::In this study occipital lobectomies were carried out on 12 foetal lambs on about the 100th day of gestation. Three lambs were born alive and had computed tomographic (CT) scans performed on the 13th or 18th day of life. One lamb was found to have hydrocephalus due to ventriculitis. All three lambs had low attenuation ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698709023777
更新日期:1987-01-01 00:00:00
abstract::Purpose: The 2016 WHO tumour classification highlights the role of IDH1/2 gene mutation and 1p/19q co-deletion in classifying grade II/III gliomas. A recent cIMPACT-NOW update proposes the use of the term 'Not Elsewhere Classified' (NEC) for IDH-mutant, non co-deleted tumours. Here we show how the incorporation of ATR...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1600657
更新日期:2019-10-01 00:00:00
abstract::Purpose: The purpose of this study was to validate the cauda scale (TCS) in an external population. TCS was proposed as a tool to be used to predict the likelihood of cauda equina compression.Methods: We analysed the presenting condition of consecutive patients attending the emergency department undergoing a magnetic ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1754337
更新日期:2020-08-01 00:00:00
abstract::We report a 14-year-old boy with cavernous malformation of the optic chiasm. He had a 2-year history of gradually worsening visual disturbance. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a suprasellar mass, findings compatible with craniopharyngioma. The mass was biopsied and histological e...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690601000238
更新日期:2006-10-01 00:00:00
abstract::Background: When treating intracranial aneurysms with open microsurgery, rare cases arise in which an ipsilateral approach leads to poor visualization, lack of proximal control, or potential damage to nearby vital structures due to the anatomy of the aneurysm. Case Description: We describe a patient with a small, unru...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1648754
更新日期:2019-07-31 00:00:00
abstract::To achieve endoscopic procedures more safely and less invasively, an operative strategy with ultrasound-assisted neuroendoscopic surgery is described. The improvement in the endoscope unit is that endoscopic viewing can be stopped on the display, anytime we choose and simultaneously visualize the ongoing view on the s...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690050175283
更新日期:2000-10-01 00:00:00