Abstract:
:Purpose: The 2016 WHO tumour classification highlights the role of IDH1/2 gene mutation and 1p/19q co-deletion in classifying grade II/III gliomas. A recent cIMPACT-NOW update proposes the use of the term 'Not Elsewhere Classified' (NEC) for IDH-mutant, non co-deleted tumours. Here we show how the incorporation of ATRX immunohistochemistry can be used to better delineate the NEC group. Methods: Clinical data was collected for 112 patients (59% male) treated at our unit. Mutations in IDH1/2 genes were detected by pyrosequencing or immunohistochemistry, 1p/19q co-deletion was assessed with fluorescence in situ hybridisation and ATRX status was determined using immunohistochemical techniques. Tumours were grouped on the basis of molecular markers and outcomes compared. Results: The mean age of diagnosis was 42.6 years (20-73 years). There were 88 oligodendrogliomas (II = 47, III = 41), 18 diffuse astrocytomas (II = 9, III = 9) and 6 oligoastrocytomas (II = 4, III = 2). The majority of gliomas (87.5%) had mutations in IDH1/2. 1p/19q co-deletion was significantly associated with oligodendroglial morphology (p = < 0.001) and was mutually exclusive with ATRX mutation. Classification on the basis of molecular information showed a significant different in survival between the groups. Conclusions: ATRX immunohistochemisty is a useful adjunct which can be used with IDH mutation status, 1p/19q co-deletion and histological findings to further define tumour groups. More work is needed to understand the molecular profiles and prognostic implications for non co-deletion, ATRX preserved cases.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Burford C,Laxton R,Sidhu Z,Aizpurua M,King A,Bodi I,Ashkan K,Al-Sarraj Sdoi
10.1080/02688697.2019.1600657subject
Has Abstractpub_date
2019-10-01 00:00:00pages
536-540issue
5eissn
0268-8697issn
1360-046Xjournal_volume
33pub_type
杂志文章abstract::The purpose of this article is to review the contribution of DSA to neurosurgical practice and to outline its advantages and limitations compared to conventional film-screen angiography. DSA is a technique whereby electronic subtraction allows the near instantaneous demonstration of vascular anatomy essentially free o...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698709023774
更新日期:1987-01-01 00:00:00
abstract::Chiari malformations are a pathological continuum of hindbrain maldevelopment and Chiari I malformation (CMI) represents caudal decent of cerebellar tonsils. The surgery aims to relieve tonsillar compression with restoration of the normal cerebrospinal (CSF) flow dynamics. We report the salient features of our surgica...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690801894638
更新日期:2008-06-01 00:00:00
abstract::Attempts at radical excision of craniopharyngioma have been made increasingly possible by progress in neuroradiological imaging and the use of microscopic technique. Between 1977 and 1990, 50 patients of The National Hospital for Neurology and Neurosurgery, London, have undergone radical surgical excision of craniopha...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699109002877
更新日期:1991-01-01 00:00:00
abstract::Symptomatic, paradoxical intracranial tuberculomas is a rare occurrence. A case of tubercular meningitis, developing paradoxical tuberculomas alongside non-functional ventricular catheter is presented. Catheter removal facilitated removal of these paradoxical lesions, with the patient recovering to near-normal state a...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.690915
更新日期:2012-12-01 00:00:00
abstract::We report the case of a metastatic lung carcinoma that had metastasized to the thoracic extradural space and penetrated the dura, resulting in a combined extra and intradural spinal tumour. To our knowledge this is the first such report of a metastatic lung adenocarcinoma demonstrating direct dural invasion. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2017.1324110
更新日期:2019-04-01 00:00:00
abstract::Objective: Meta-analysis to evaluate complications in the use of autogenous bone and bone substitutes and to compare bone substitutes, specifically HA, polyetheretherketone (PEEK) and titanium materials.Methods: Search of PubMed, Cochrane, Embase and Google scholar to identify all citations from 2010 to 2019 reporting...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,meta分析
doi:10.1080/02688697.2020.1742291
更新日期:2020-08-01 00:00:00
abstract::The authors report the rare and first documented case of concomitant microvascular decompression of trigeminal, facial and glossopharyngeal nerves for the management of intractable to medical therapy acute onset of trigeminal neuralgia, facial paresis and dysphagia after mild head injury. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.815327
更新日期:2014-01-01 00:00:00
abstract::A case is presented of a 35-year-old man, who suffered intermittent hydrocephalic attacks due to a large subependymoma arising within the left lateral ventricle. The sparse literature on this rare tumour is reviewed. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688699409002398
更新日期:1994-01-01 00:00:00
abstract::Up to a fifth of Accident and Emergency admissions are head-injury related. Alcohol is involved in a large proportion of adult head injuries and although the incidence of death due to head injury (HI) is relatively low, long-term sequelae including cognitive disturbance are frequent. Contrecoup contusions (CCs) have b...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2010.548879
更新日期:2011-06-01 00:00:00
abstract::Nosocomial infections, pneumonia in particular, are well-known complications of traumatic brain injury (TBI), which are associated with a worse neurological outcome. This review aims to explore the role of vagus nerve activity in immunomodulation as a causative factor. A MEDLINE search revealed numerous reports publis...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2013.835373
更新日期:2014-04-01 00:00:00
abstract::Herpes virus reactivation is a well-known phenomenon rarely described in neurosurgery. We report a case of type 2 herpes simplex virus reactivation following neurosurgery of the posterior fossa. Cerebrospinal fluid analysis revealed a lymphocytic pleocytosis of over 200 x 10(6)/l. Viral reactivation should be consider...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690802425671
更新日期:2009-06-01 00:00:00
abstract::Several studies have demonstrated an association between arterial hypertension (AH) and an increased morbidity and mortality from both cardiovascular diseases and stroke (including subarachnoid haemorrhage, SAH). Among the functional disturbances implicated in hypertension much interest has been focused on the calcium...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699108998477
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:There is an abundance of articles published on low-grade glioma. The aim of this study was to identify and review the 50 most-cited articles on low-grade glioma, and to perform a bibliometric analysis. METHODS:In June 2017, we performed a basic search of the Web of Science database using "low-grade glioma mana...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2018.1549314
更新日期:2019-04-01 00:00:00
abstract::The cerebellar cognitive affective syndrome (CCAS) was first described by Schmahmann and Sherman as a constellation of symptoms including dysexecutive syndrome, spatial cognitive deficit, linguistic deficits and behavioural abnormalities in patients with a lesion in the cerebellum with otherwise normal brain. Neurosur...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2014.920487
更新日期:2014-12-01 00:00:00
abstract::Low-grade (WHO level I) meningiomas are slow-growing, benign tumours typically presenting with unspecific symptoms (e.g. headache), seizures, cranial nerve compression and neuropsychological symptoms determined by location and size of the lesion. Haemorrhagic onset and sequelae are rare, and have been described infreq...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690500208734
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Nowadays the endoscopic endonasal approach is increasingly being used to remove craniopharyngiomas, tuberculum sellae meningiomas and other presellar and parasellar lesions and its value in anterior skull base surgery is undisputed. Herein, we assess the relative advantages, disadvantages and feasibility of ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2018.1480748
更新日期:2018-10-01 00:00:00
abstract::Despite advances in understanding, monitoring, and treatment, the outcome of patients with refractory brain oedema (RBE) remains poor. The concept of wide bone removal for treatment of RBE has been recognized since the nineteenth century. Bifrontal decompressive craniectomy (BDC) is performed as last resort treatment ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690802571094
更新日期:2009-02-01 00:00:00
abstract::The purpose of this study was to assess the accuracy of high field (3 Tesla) MR in target localization for stem cell transplantation. Three patients with Huntington's disease were imaged with a stereotactic frame in place for both MRI and CT. Quality assurance procedures and manual shimming were performed before each ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690310001613844
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:Patients with moyamoya disease (MMD) very rarely develop both cerebral ischaemia and haemorrhage. The aim of this study was to clarify the clinical and radiographic features of MMD in patients who presented with both ischaemia and haemorrhage, compared with MMD patients who presented with one or the other. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.717983
更新日期:2013-04-01 00:00:00
abstract::Two case reports illustrate a long vascular pedicle cranial bone flap. A split or full thickness skull bone flap is based on the pericranium layer. The temporalis muscle with its overlying fascial layers and vascular pedicles form the base of this flap and assure its adequate vascularization. The technique and its use...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::A case is described of oculomotor nerve sheath tumour presenting with signs and symptoms of a posterior fossa space occupying lesion with minimal involvement of the IIIrd nerve. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688699009000685
更新日期:1990-01-01 00:00:00
abstract::Side-effects of iohexol myelography were compared after pre-treatment with oral dexamethasone (n = 42) or placebo (n = 44) in a prospective, randomized, double blind, controlled clinical trial. Although myelogram side-effects were commoner in the placebo group, the differences generally did not reach statistical signi...
journal_title:British journal of neurosurgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/02688699650040151
更新日期:1996-06-01 00:00:00
abstract::Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) has recently been shown to effectively ameliorate medically intractable axial symptoms of Parkinson's disease (PD). The effects of DBS are not limited to the targeted structure, but will affect the distributed anatomical networks to which the target st...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690802448251
更新日期:2008-01-01 00:00:00
abstract::The objective of this study was to assess the technical feasibility, and the clinical and radiological results of interbody fusion with a carbon fibre cage following anterior cervical discectomy. Nineteen consecutive patients, eight male and 11 female, with an age range from 28 to 75 years (mean 45) underwent anterior...
journal_title:British journal of neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1080/02688699746285
更新日期:1997-06-01 00:00:00
abstract::The incidence of haemorrhagic complications of intracranial pressure monitoring (ICPM) has previously been reported. However, in these studies, the techniques employed to access the inside of the cranium varied. While 3-mm essentially blind 'twistdrill' craniostomies have been used, their role has been limited for fea...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690220148897
更新日期:2002-06-01 00:00:00
abstract::A case is described where a reconstruction of a complex defect in the floor of anterior cranial fossa was successfully carried out using multiple layers of vascularised pedicle flaps. The 42-year-old male patient had previously undergone multiple surgical procedures for persistent cerebrospinal fluid (CSF) rhinorrhoea...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699845096
更新日期:1998-06-01 00:00:00
abstract::Aim: Measuring the intracranial pressure (ICP) of the infra-tentorial, posterior fossa compartment has long been avoided due to a lack of precedent and interpretability, as well as concern of damage to the underlying vital structures. In cases of posterior fossa insults however, the supra-tentorial compartment ICPs ca...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1765974
更新日期:2020-05-15 00:00:00
abstract::Background: Vertebral body compression fractures are one of the most common causes of disability and morbidity, especially among the elderly population. The present study was performed in order to evaluate the effect of percutaneous balloon kyphoplasty (BKP) on patients' pain and quality of life (QOL) in Iran.Methods:...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1777254
更新日期:2020-06-09 00:00:00
abstract::Spontaneous intracranial hypotension (SIH) is an uncommon clinical entity that is often diagnosed after a delay, or it is misdiagnosed due to the variety of clinical presentations and the associated radiological findings. We present here a case of SIH associated with chronic subdural haematoma (SDH) and subarachnoid h...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690701790597
更新日期:2008-04-01 00:00:00
abstract::CNS lymphoma involving the trigeminal nerve is a rare condition which presents as a cavernous sinus lesion. It may mimic the radiological appearance of other lesions, and biopsy is essential before considering empirical radiotherapy for lesions in this region. We report the radiological, histopathological and operativ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.835374
更新日期:2014-04-01 00:00:00