Abstract:
:Nosocomial infections, pneumonia in particular, are well-known complications of traumatic brain injury (TBI), which are associated with a worse neurological outcome. This review aims to explore the role of vagus nerve activity in immunomodulation as a causative factor. A MEDLINE search revealed numerous reports published over the last decade describing the "cholinergic anti-inflammatory pathway" between the vagus nucleus and leukocyte activity. Using a combination of lipopolysaccharide stimulation and vagotomy, it has been shown that the parasympathetic fibres terminating in the spleen reduce tumour necrosis factor production. Further pharmacological and receptor knockout studies have identified the α7 subtype of nicotinic receptors as the likely target for this. Vagal activity also induces changes in neutrophil chemotaxis through altered expression of the CD11b integrin which is abolished by splenectomy. By extrapolating this evidence we suggest a possible mechanism for immunosuppression following TBI which also has the potential to be targeted to reduce the incidence of pneumonia. Whilst there is strong supporting evidence for the role of vagal nerve overactivity in post-TBI pneumonia, there have yet to be any clinical investigations and further study is required.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Hall S,Kumaria A,Belli Adoi
10.3109/02688697.2013.835373subject
Has Abstractpub_date
2014-04-01 00:00:00pages
181-6issue
2eissn
0268-8697issn
1360-046Xjournal_volume
28pub_type
杂志文章,评审abstract::The results from the Danish model of acoustic neuroma surgery are presented. In the period from 1976 to 1985, 300 patients with acoustic neuromas were operated upon using the translabyrinthine procedure. Only one small intrameatal tumour was encountered; 96 tumours were medium sized and 203 were larger than 25 mm. Of ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698909002815
更新日期:1989-01-01 00:00:00
abstract::The objective of this paper was to determine the time course and extent of platinum uptake into human malignant glioma tissue. An intraoperative, intravenous infusion of carboplatin was given to nine patients (seven glioblastoma and two anaplastic glioma) undergoing tumour excision. Carboplatin dosage was calculated i...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699943871
更新日期:1999-04-01 00:00:00
abstract::Oxygen extraction fraction images were superimposed on cerebral blood flow images of positron emission tomography (PET) to depict the so-called misery perfusion area in two patients with moyamoya disease. The superimposed image following extra-intracranial bypass surgery was obtained in one case, which convincingly di...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699844880
更新日期:1998-08-01 00:00:00
abstract::We discuss a spontaneous subdural haematoma (SDH) arising from an arachnoid cyst in a healthy adult male, presenting with headache and vomiting. Imaging revealed a large SDH communicating with an arachnoid cyst and intracystic haemorrhage. The patient fully recovered with surgical evacuation. We also discuss the cause...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2016.1187255
更新日期:2017-10-01 00:00:00
abstract::We report a previously undescribed complication of long-term epidural catheter placement for the administration of analgesia in terminal malignancy. Spinal cord compression resulted from a drug-related precipitate forming around the epidural catheter tip, which was successfully treated by surgical decompression. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699844673
更新日期:1998-10-01 00:00:00
abstract::Oesophagus perforation is a possible complication of anterior cervical spine surgery, which generally occurs during the first postoperative days. Delayed perforation is very rare and its management remains controversial. We report the successful management of a delayed oesophagus perforation associated with an osteomy...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2011.609604
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Extra-ventricular neurocytoma (EVN) is rare, mainly described within the cerebral hemispheres or spinal cord. We report a case of sellar neurocytoma presenting with chiasmal compression. CLINICAL PRESENTATION:A 50-year-old woman presented with decreasing vision and a bitemporal field deficit. CT and MRI demo...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2011.633635
更新日期:2012-06-01 00:00:00
abstract:INTRODUCTION:The placement of external ventricular drain (EVD) is a common neurosurgical procedure to drain cerebrospinal fluid (CSF) in many acute neurosurgical conditions that disrupt the normal CSF absorption pathway. Infection is the primary complication with infection rates ranging between 0% and 45%, and this is ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2011.578770
更新日期:2011-10-01 00:00:00
abstract::We report four cases of the use of peroperative cortical mapping during craniotomy under local anaesthesia to define the relationship between the glioma and speech and somatosensory cortex. This enabled a radical subtotal (two cases) or an apparent total (two cases) excision of the tumour close to the somatosensory an...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699209002913
更新日期:1992-01-01 00:00:00
abstract::Objective: Contralateral C7 nerve root transfer surgery has been successfully applied to rescue motor function of a hemiplegic upper extremity in patients with central neurological injury. This surgical technique is challenging, and limited anatomical space makes it difficult to manipulate tissues and may lead to high...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2018.1552754
更新日期:2019-08-01 00:00:00
abstract::Low-grade (WHO level I) meningiomas are slow-growing, benign tumours typically presenting with unspecific symptoms (e.g. headache), seizures, cranial nerve compression and neuropsychological symptoms determined by location and size of the lesion. Haemorrhagic onset and sequelae are rare, and have been described infreq...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690500208734
更新日期:2005-06-01 00:00:00
abstract::In this study occipital lobectomies were carried out on 12 foetal lambs on about the 100th day of gestation. Three lambs were born alive and had computed tomographic (CT) scans performed on the 13th or 18th day of life. One lamb was found to have hydrocephalus due to ventriculitis. All three lambs had low attenuation ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698709023777
更新日期:1987-01-01 00:00:00
abstract::Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) has recently been shown to effectively ameliorate medically intractable axial symptoms of Parkinson's disease (PD). The effects of DBS are not limited to the targeted structure, but will affect the distributed anatomical networks to which the target st...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690802448251
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:There is an abundance of articles published on low-grade glioma. The aim of this study was to identify and review the 50 most-cited articles on low-grade glioma, and to perform a bibliometric analysis. METHODS:In June 2017, we performed a basic search of the Web of Science database using "low-grade glioma mana...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2018.1549314
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:High-grade spondylolysthesis and spondyloptosis management have various options. There were no large series reported to support any particular treatment modality. The aim of surgery is to get solid bony fusion to get relief of instability and its symptoms as well as relief of neurological symptoms. There are ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.743970
更新日期:2013-08-01 00:00:00
abstract::In a two-centre study, intrasellar pituitary tissue pressure was measured at transsphenoidal surgery in 107 patients with pituitary adenomas or intrasellar cysts. 'Normal' ISP in patients under anaesthesia with small microadenomas (< 5 mm diameter) or a partial empty sella was 12 +/- 3 mmHg. Raised ISP (> 15 mmHg) was...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699409029619
更新日期:1994-01-01 00:00:00
abstract::A 39-year-old lady presented with low back pain and neurogenic claudication. Magnetic resonance imagining revealed an intradural neoplasm in the cauda equina region. The patient underwent lumbar laminectomy and total excision of the neoplasm. Biopsy showed it to be a ganglioneuroblastoma, which is rare in the spinal c...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/026886900408513
更新日期:2000-06-01 00:00:00
abstract::Intracerebral metastasis in osteosarcoma is extremely rare. A 14-year-old girl who had previously been operated upon for osteosarcoma of the femur presented with seizures and left hemiparesis. A right parietal lesion with calcification and brain oedema was found. After resection of the mass, pathology revealed an oste...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2011.581771
更新日期:2012-02-01 00:00:00
abstract::The purpose of this study was to assess the accuracy of high field (3 Tesla) MR in target localization for stem cell transplantation. Three patients with Huntington's disease were imaged with a stereotactic frame in place for both MRI and CT. Quality assurance procedures and manual shimming were performed before each ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690310001613844
更新日期:2003-10-01 00:00:00
abstract::A case of cerebellopontine angle epithelial cyst is described. Lesions in this region usually present with hearing loss, tinnitus, dysequilibrium, headaches, facial numbness and occasionally trigeminal neuralgia. Our patient presented with the unusual phenomenon of episodic facial palsy. The literature reporting this ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.1080/026886902317384526
更新日期:2002-04-01 00:00:00
abstract::Purpose: The 2016 WHO tumour classification highlights the role of IDH1/2 gene mutation and 1p/19q co-deletion in classifying grade II/III gliomas. A recent cIMPACT-NOW update proposes the use of the term 'Not Elsewhere Classified' (NEC) for IDH-mutant, non co-deleted tumours. Here we show how the incorporation of ATR...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1600657
更新日期:2019-10-01 00:00:00
abstract::Chordomas constitute <5% of vertebral column tumours and a third of these arise in the upper cervical spine and tend to be clival - usually midline, with occasional eccentric extension. We report a case of cervical chordoma presenting as a lateral neck mass and discuss its origin, diagnosis and management. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2010.508959
更新日期:2011-08-01 00:00:00
abstract::The authors report their experience in the treatment of childhood hydrocephalus by endoscopic choroid plexus coagulation and post-operative ventricular perfusion with artificial CSF. The procedure was carried out on 23 children without mortality. In 12 cases (52%) the procedure was successful in controlling the hydroc...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699008992706
更新日期:1990-01-01 00:00:00
abstract::Choroid plexus xanthogranulomas are uncommon lesions that occur almost exclusively in adults; most of them constitute incidental autopsy findings. A case of symptomatic bilateral xanthogranulomas of choroid plexus in a 6 year-old girl with progressive visual loss is reported. Theories on the pathogenesis of this entit...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690042960
更新日期:2000-02-01 00:00:00
abstract::Simultaneous cerebral blood flow (CBF) and glucose metabolism (CMRglu) studies with a double isotope autoradiographic technique were applied to squirrel monkeys submitted to a unilateral pre- or postganglionic trigeminal lesion. The CBF values were not affected following a pre- or postganglionic lesion per se. In cont...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699209002929
更新日期:1992-01-01 00:00:00
abstract::Chiari malformations are a pathological continuum of hindbrain maldevelopment and Chiari I malformation (CMI) represents caudal decent of cerebellar tonsils. The surgery aims to relieve tonsillar compression with restoration of the normal cerebrospinal (CSF) flow dynamics. We report the salient features of our surgica...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690801894638
更新日期:2008-06-01 00:00:00
abstract::CNS lymphoma involving the trigeminal nerve is a rare condition which presents as a cavernous sinus lesion. It may mimic the radiological appearance of other lesions, and biopsy is essential before considering empirical radiotherapy for lesions in this region. We report the radiological, histopathological and operativ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.835374
更新日期:2014-04-01 00:00:00
abstract::Utilization of operating theatre time is an important issue in neurosurgery, in a National Health Service Hospital. NHS Trusts are under ever increasing pressure to meet specified 'targets' in relation to admissions and operations. We performed a retrospective audit on the utilization of neurosurgical operating theatr...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690400004852
更新日期:2004-08-01 00:00:00
abstract::Subependymomas are rare benign tumours arising from subependymal glial precursors that usually remain asymptomatic or may present due to obstruction of cerebrospinal fluid pathways. We describe the first report of intraventricular haemorrhage from subependymoma and cavernous-like malformation collision tumour in a 74-...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2017.1390063
更新日期:2019-10-01 00:00:00
abstract::Huge calcified chronic subdural hematoma is quite rare. We reported a such case in a old man. The intraoperative photographs of the case fully demonstrated the morphology of the calcified chronic subdural hematoma. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2010.520763
更新日期:2010-12-01 00:00:00