Abstract:
OBJECT:Animal models provide a basis for clarifying the complex pathogenesis of delayed cerebral vasospasm (DCVS) and for screening of potential therapeutic approaches. Arbitrary use of experimental parameters in current models can lead to results of uncertain relevance. The aim of this work was to identify and analyze the most consistent and feasible models and their parameters for each animal. METHODS:An online search of the MEDLINE PubMed and EMBASE medical databases (1969 to week 21 of 2007) was performed using the key words "canine", "mice", "rabbit", "pig", "rat", "cat", and "primate" in combination with "subarachnoid hemorrhage", "model", and "vasospasm". Cross references of each model were checked. Analysis of identified publications was considered in accordance with predetermined eligibility criteria. RESULTS:1254 abstracts were reviewed and 516 studies were included in the analysis. Then, 66 models in 7 animals were identified. Most often used blood amounts (ml) lead to degree (% vessel narrowing) and peak onset (day) of DCVS within animal models as follows: mice endovascular puncture (various, day 3, 20-62%); rat single injection (0.3 ml, day 2, 19-29%); rat double injection (2 x 0.3 ml, day 7, 28-47%); rabbit single injection (3 ml, day 3, 19-55%); rabbit double injection (not established, day 5, not established); dog double injection (2 x 4-5 ml, day 7, 45-66%); primate clot placement (5 ml, day 7, 32-52%). CONCLUSIONS:Among the great number of experimental SAH methods and associated parameters only a fistful reliable and consistent models can be identified and recommended. Implementation of more standardized experimental techniques could increase the relevance of future experimental studies.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Marbacher S,Fandino J,Kitchen NDdoi
10.3109/02688691003746274subject
Has Abstractpub_date
2010-08-01 00:00:00pages
415-34issue
4eissn
0268-8697issn
1360-046Xjournal_volume
24pub_type
杂志文章,评审abstract::Intracerebral haemorrhage is a devastating condition lacking effective therapies, with an uncertain role for surgery in many. Early research described an ischaemic penumbra around the haematoma, representing an area of potential therapeutic intervention. This article discusses the evidence for and against the existenc...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2011.578773
更新日期:2011-08-01 00:00:00
abstract::We report the case of a 32-year-old woman with a left frontal ganglioglioma (WHO grade I). Quantitative analysis based on three dimensional magnetic resonance images revealed a threefold increase of growth rate during pregnancy as compared to pre-pregnancy, causing neurological deterioration and leading to prompt surg...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.703356
更新日期:2013-02-01 00:00:00
abstract::Tumor-to-tumor metastasis with schwannoma as a recipient tumor is very rare. There have been no reports on tumor to spinal schwannoma metastasis. We report a case of a 57-year-old woman who presented with neck pain and who turned out to have cervical spinal nerve schwannoma with breast carcinoma metastasis. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2014.997666
更新日期:2015-06-01 00:00:00
abstract::A system of stereotactic radiosurgery using a linear accelerator is described and the experience with a variety of neurosurgical lesions including gliomas, acoustic neurinomas and arteriovenous malformations is recorded. The system is simple, inexpensive and effective and can be used with any CT scanner and linear acc...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698909002808
更新日期:1989-01-01 00:00:00
abstract::A woman with hypertension and hyperglycemia was diagnosed a metastatic brain carotid body paraganglioma. Her blood pressure, glucose, and norepinephrine were normal after craniotomy. Although most carotid body tumors are benign, a few show distant metastasis. This is the first reported case of intracerebral metastases...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2017.1328042
更新日期:2019-06-01 00:00:00
abstract::We present a case of extradural hematoma resulting from a relatively minor closed injury over the vertex where a plasma cell tumour had invaded the superior sagittal sinus. The patient underwent an emergency craniotomy and evacuation of the hematoma. Hemostasis and prevention of recollection of the hematoma were hampe...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1849552
更新日期:2020-11-26 00:00:00
abstract::We report four patients having an extremely rare and hitherto unreported clinical condition of spondyloptosis of the atlas over axis. Between the year 1999 and 2004, four patients with spondyloptosis were retrospectively analysed. The age of the patients ranged from 12 to 31 years. In three patients, the aetiology of ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690600852274
更新日期:2006-08-01 00:00:00
abstract::Vertebro-PICA aneurysms represent a particular technical challenge because of the extremely narrow operative field and the presence of numerous vital neural and vascular structures. The lack of exposure still remains the limiting factor in most cases. During the 9-year period from January 1980 to October 1989, 8 verte...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699008992709
更新日期:1990-01-01 00:00:00
abstract:OBJECT:To summarize our experience in treating veins during microvascular decompression (MVD) procedures for idiopathic trigeminal neuralgia (TN). METHODS:A total of 210 patients who underwent single MVD for idiopathic TN were retrospectively studied. The offending vessels were summarized. The treatment choices for ve...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2018.1476674
更新日期:2018-10-01 00:00:00
abstract::Coexistence of cerebral aneurysm and untreated craniopharyngioma is extremely rare. We present an extremely rare case of anterior cerebral artery dissecting aneurysm associated with untreated craniopharyngioma, and discuss the relationship between these two lesions. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.701677
更新日期:2013-02-01 00:00:00
abstract::Abstract Cerebral developmental venous anomalies (DVAs) very rarely cause massive haematoma, but should be included in the differential diagnosis of atypical massive intracerebral haematoma (ICH). We describe a case of massive ICH caused only by a DVA and successfully treated by haematoma evacuation with surgical rese...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.815318
更新日期:2014-01-01 00:00:00
abstract::We report a 14-year-old boy with cavernous malformation of the optic chiasm. He had a 2-year history of gradually worsening visual disturbance. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a suprasellar mass, findings compatible with craniopharyngioma. The mass was biopsied and histological e...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690601000238
更新日期:2006-10-01 00:00:00
abstract::We present a series of eight patients undergoing circumferential neural decompression and stabilization of the thoracolumbar spine via a single midline posterior approach, with complete vertebrectomy for a variety of indications. Four had primary tumours, two secondary tumours, one patient had tuberculosis and one had...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690701837273
更新日期:2008-04-01 00:00:00
abstract::We report a case of acute massive cerebellar infarction associated with craniocervical junction (CVJ) complex malformation in a 21-year-old male. Timely surgical intervention prevented the deterioration of his neurological status. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2016.1267329
更新日期:2018-10-01 00:00:00
abstract::Oxygen extraction fraction images were superimposed on cerebral blood flow images of positron emission tomography (PET) to depict the so-called misery perfusion area in two patients with moyamoya disease. The superimposed image following extra-intracranial bypass surgery was obtained in one case, which convincingly di...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699844880
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND CONTEXT:Transforaminal epidural steroid injection (TFESI) is recognised as a treatment for symptomatic lumbar disc herniation, whilst surgical decompression is generally thought to be the most effective treatment option for lumbar spinal stenosis. There is little available literature examining the effect of ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2016.1206188
更新日期:2017-04-01 00:00:00
abstract::Objective: Meta-analysis to evaluate complications in the use of autogenous bone and bone substitutes and to compare bone substitutes, specifically HA, polyetheretherketone (PEEK) and titanium materials.Methods: Search of PubMed, Cochrane, Embase and Google scholar to identify all citations from 2010 to 2019 reporting...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,meta分析
doi:10.1080/02688697.2020.1742291
更新日期:2020-08-01 00:00:00
abstract::Thirteen cases of idiopathic common peroneal nerve palsy were reviewed and the clinical presentation and course evaluated. Incomplete nerve palsy of unknown aetiology has a good prognosis and all the patients in this group made a full recovery without surgical intervention. Those presenting with a clinically and elect...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699108998440
更新日期:1991-01-01 00:00:00
abstract::A simple and inexpensive device is described for measurement of intracranial pressure over prolonged periods. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698808992680
更新日期:1988-01-01 00:00:00
abstract::We report a series of 14 patients who underwent partial or complete trigeminal nerve root section for chronic unremitting migrainous neuralgia. They had all suffered attacks with severe pain for over 18 months without remission (mean duration 5.5 years). Symptoms were refractory to extended medical intervention and ha...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699308995070
更新日期:1993-01-01 00:00:00
abstract::A series of 510 patients with proven aneurysmal subarachnoid haemorrhage (SAH) is reported. The incidence of recurrent haemorrhage during the period awaiting surgery was 13.7%. There was no significant difference in incidence between good and poor grade patients. Following rebleeding there was an immediate mortality o...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698808999657
更新日期:1988-01-01 00:00:00
abstract::OBJECTIVE. To effectively combine functional MRI (fMRI), diffusion tensor tractography (both guided by neuronavigation) along with cortical stimulation (CS) for surgery of eloquent cortex (EC) lesions. MATERIALS AND METHOds. Fifteen patients with lesions adjacent to the eloquent motor and sensory cortex were included....
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.835370
更新日期:2014-04-01 00:00:00
abstract::We report a 10-year-old boy who presented with a subarachnoid haemorrhage from a ruptured hypoglossal artery aneurysm. The aneurysm was clipped via a transcondylar approach. The embryology, occurrence and the surgical approach to aneurysms at this site are discussed. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699646952
更新日期:1996-12-01 00:00:00
abstract::Neuroendoscopy is increasingly used in the management of brain tumours and tumour related hydrocephalus and this study reviews the efficacy of neuroendoscopic interventions in this unit in patients with brain tumours. A series of 87 neuroendoscopic operations carried out in 77 patients with brain tumours over a 6-year...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/0268869021000030276
更新日期:2002-10-01 00:00:00
abstract::Up to a fifth of Accident and Emergency admissions are head-injury related. Alcohol is involved in a large proportion of adult head injuries and although the incidence of death due to head injury (HI) is relatively low, long-term sequelae including cognitive disturbance are frequent. Contrecoup contusions (CCs) have b...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2010.548879
更新日期:2011-06-01 00:00:00
abstract::The azygous anterior cerebral artery (AACA) is a rare anatomical variant, which is frequently associated with saccular aneurysms. These aneurysms are often located in the distal segment of the AACA. Proximal AACA aneurysms are rare and pose considerable challenges, both in radiological characterization and in manageme...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2015.1071333
更新日期:2016-01-01 00:00:00
abstract::Background: Few data are available on the risk factors involved in nosocomial meningitis from multi-drug-resistant Gram-negative bacteria (MDR-GNB). Our aim was to identify the risk factors of prognosis for MDR-GNB nosocomial meningitis.Methods: Retrospective study of patients undergoing neurosurgery and with positive...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1710819
更新日期:2020-06-01 00:00:00
abstract::Subarachnoid hemorrhage with ruptured cerebral artery dissection caused by varicella zoster (VZ) vasculopathy is rare. We report a rare case of vertebral artery (VA) dissection induced by VZ virus, successfully treated with stent-assisted coil embolization and systemic anti viral medication, on six month follow-up cer...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2016.1187256
更新日期:2016-12-01 00:00:00
abstract::Infantile myofibromatosis (IM) is a rare pathological entity characterized by solitary or multiple nodular skin, soft tissues or bony lesions. Craniovertebral (CV) junction lesions are rare. We report the successful management of a solitary IM involving the posterior elements of the CV junction in a 6-month-old child....
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690701882022
更新日期:2008-08-01 00:00:00
abstract::Intraosseous schwannomas (IOS) of non-sacral vertebra are extremely rare; only 14 cases were reported previously. We described a case of IOS involving a cervical vertebral body, successfully treated by surgical resection, with a review of the literature and discussion of this extremely rare tumour. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2010.495168
更新日期:2010-10-01 00:00:00