Abstract:
OBJECTIVE:Evidence suggests that reduction of nitric oxide (NO) bioavailability due to oxidative stress plays a central role in the pathophysiology of cerebral vasospasm after subarachnoid haemorrhage (SAH). To prevent SAH-induced cerebral vasospasm, therefore we used nebivolol hydrochloride as a NO-mediated vasodilator and an antioxidant drug in an experimental rat model of SAH. MATERIALS AND METHODS:Forty female Wistar rats were divided into control, SAH, SAH plus placebo, and SAH plus nebivolol groups. Starting six hours after inducing SAH, 5 mg/kg of nebivolol hydrochloride and of pharmaceutical excipients of nebivolol was given orally once daily for five days to SAH plus nebivolol and SAH plus placebo groups, respectively. The lumen diameter and vessel wall thickness of the basilar artery were measured in brain sections. The serum and brain supernatant levels of nitric oxide (NO) were analysed. The brain supernatant levels of intrinsic antioxidants superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured as markers of the antioxidant status. RESULTS:Nebivolol administration attenuated cerebral vasospasm both by increasing NO levels and by decreasing oxidative stress. Our study also demonstrated that nebivolol administration reverses SAH created imbalance between SOD and GSH-Px by increasing GSH-Px activity relative to SOD. CONCLUSIONS:Nebivolol attenuates the cerebral vasospasm after SAH both increasing NO levels and decreasing oxidative stress. Therefore, it may promise to prevent SAH-induced cerebral vasospasm as an anti-spasmodic and anti-oxidant agent.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Aladag MA,Turkoz Y,Parlakpinar H,Gul Mdoi
10.1080/02688697.2017.1297367subject
Has Abstractpub_date
2017-08-01 00:00:00pages
439-445issue
4eissn
0268-8697issn
1360-046Xjournal_volume
31pub_type
杂志文章abstract::OBJECTIVE. To effectively combine functional MRI (fMRI), diffusion tensor tractography (both guided by neuronavigation) along with cortical stimulation (CS) for surgery of eloquent cortex (EC) lesions. MATERIALS AND METHOds. Fifteen patients with lesions adjacent to the eloquent motor and sensory cortex were included....
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.835370
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abstract::A patient with von Recklinghausen's disease presented with a right sixth nerve palsy. Investigations demonstrated unilateral dolichoectasia of the intracranial carotid artery and sphenoid wing dysplasia. This case demonstrates an association not previously documented, that of unilateral fusiform dilatation of the caro...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699409027975
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abstract::Despite advances in understanding, monitoring, and treatment, the outcome of patients with refractory brain oedema (RBE) remains poor. The concept of wide bone removal for treatment of RBE has been recognized since the nineteenth century. Bifrontal decompressive craniectomy (BDC) is performed as last resort treatment ...
journal_title:British journal of neurosurgery
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doi:10.1080/02688690802571094
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abstract::Sixteen patients with surgical infection of the posterior fossa are presented. There were 14 patients with cerebellar abscess, one patient with a solitary posterior fossa subdural empyema, and another with a combined cerebellar abscess and subdural empyema. Two of the cerebellar abscess patients also had supratentoria...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699408995113
更新日期:1994-01-01 00:00:00
abstract::Traumatic brain injury (TBI) and acute ischaemic stroke are major causes of mortality and morbidity and there is an urgent demand for new neuroprotective strategies following the translational failure of neuroprotective drug trials. Oxygen therapy--especially normobaric, may offer a simple and effective therapeutic st...
journal_title:British journal of neurosurgery
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abstract::Twelve patients with facial nerve neurinoma have been treated at The National Hospital, Queen Square, London, during the last 20 years. Nine tumours lay in the middle fossa arising from the area of the geniculate ganglion, two lay in the posterior fossa arising from the segment of the facial nerve in the internal audi...
journal_title:British journal of neurosurgery
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abstract::Utilization of operating theatre time is an important issue in neurosurgery, in a National Health Service Hospital. NHS Trusts are under ever increasing pressure to meet specified 'targets' in relation to admissions and operations. We performed a retrospective audit on the utilization of neurosurgical operating theatr...
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abstract::Knowledge of post-traumatic cerebral haemodynamic disturbances might be beneficial for predicting the management outcome when measuring the basal cerebral arteries blood flow velocity by ultrasonic transcranial Doppler device immediately after severe head injury. Thirty patients who sustained severe brain injury under...
journal_title:British journal of neurosurgery
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abstract::Giant anterior circulation aneurysms and some basilar aneurysms can cause problems due to their size, the presence of clot in the aneurysm and the difficulty of applying a clip without kinking the perforating vessels. By utilising cardiopulmonary bypass via the femoro-femoral perforating vessels. By utilising cardiopu...
journal_title:British journal of neurosurgery
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journal_title:British journal of neurosurgery
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abstract::Spinal cord stimulation (SCS) is an established treatment modality for chronic pain, angina pectoris, and peripheral vascular disease. This study evaluates experience with SCS over a 13-year period with emphasis on surgical complications, revisions and pain relief. It took the form of a retrospective study of medical/...
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abstract::Shunt migration into the cranial ventricle is a rare complication of shunt surgery. We encountered this complication in an infant within three weeks of insertion. The shunt tube was removed and replaced by another tube with a reservoir, following which the child did well. ...
journal_title:British journal of neurosurgery
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doi:10.1080/02688699944230
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abstract::Herpes virus reactivation is a well-known phenomenon rarely described in neurosurgery. We report a case of type 2 herpes simplex virus reactivation following neurosurgery of the posterior fossa. Cerebrospinal fluid analysis revealed a lymphocytic pleocytosis of over 200 x 10(6)/l. Viral reactivation should be consider...
journal_title:British journal of neurosurgery
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abstract::Sixty patients with borderline or frank insufficiency of their cerebrovascular reserve undergoing carotid endarterectomy were given enough short acting barbiturates, during cross clamping of the internal carotid artery, to cause EEG burst suppression. Arterial and venous concentrations of lactate were measured in bloo...
journal_title:British journal of neurosurgery
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doi:10.3109/02688698909002828
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abstract::Racial differences in the incidence and rate of rupture of intracranial aneurysms are well recognized. A retrospective study of racial differences between Maori and European New Zealanders presenting to the Auckland Regional Neurosurgical Unit between 1985 and 1990 was conducted. It was found that the incidence per 10...
journal_title:British journal of neurosurgery
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doi:10.3109/02688699309103475
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journal_title:British journal of neurosurgery
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journal_title:British journal of neurosurgery
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journal_title:British journal of neurosurgery
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更新日期:2019-01-17 00:00:00
abstract::Modern cancer therapy has improved the prognosis for several tumour types. This, however, does not apply to the largest group of brain tumours, the malignant astrocytomas grades III-IV. Hence, there is need for new ideas to improve treatment. Ca2+ and the Ca(2+)-binding protein calmodulin have been shown to be involve...
journal_title:British journal of neurosurgery
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journal_title:British journal of neurosurgery
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journal_title:British journal of neurosurgery
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