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Visual acuity impairment in patients with retinitis pigmentosa at age 45 years or older.

Abstract：

OBJECTIVE:To determine the severity of visual acuity impairment in patients, age 45 years or older, with either isolated or identifiable genetic subtypes of retinitis pigmentosa (RP) and Usher syndrome. DESIGN:Multicenter, retrospective, cross-sectional analysis. PARTICIPANTS:Visual acuity data were obtained on 999 patients with different genetic subtypes of RP and Usher syndrome, age 45 years or older, from 4 major eye care centers in the United States. INTERVENTION:The best-corrected visual acuity obtained on these patients from the eye with better vision on their most recent visit was used for the analysis. MAIN OUTCOME MEASURE:Best-corrected visual acuity was the main parameter analyzed for the study, and it was obtained with Snellen or Feinbloom low vision charts or with a B-VAT II monitor (Mentor). RESULTS:The final analyses were done on 982 patients (17 patients with a sector form of RP were analyzed separately). Of the 982 patients, 506 (52%) had a visual acuity of 20/40 or better, and 678 (69%) had a visual acuity of 20/70 or better in at least one eye. There were 243 (25%) patients who had a visual acuity of 20/200 or worse in both eyes. Five (0.5%) patients had no light perception in both eyes. The odds ratio for any patient having a visual acuity of 20/200 or worse in this population was 1.4 for each difference of 10 years of age. Similarly, the odds ratio of a patient having a visual acuity of 20/40 or better in at least one eye was 0.95 for a 10-year age difference. CONCLUSIONS:In this large population of patients with RP and Usher syndrome from four centers, it was rare for such patients to lose all vision in both eyes. One fourth of the patients had a visual acuity of 20/200 or worse in both eyes, and more than half of the population had a visual acuity of 20/40 or better in at least one eye. These data can be used to counsel such patients on the extent of potential visual acuity impairment from their disease.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Grover S,Fishman GA,Anderson RJ,Tozatti MS,Heckenlively JR,Weleber RG,Edwards AO,Brown J Jr

doi

10.1016/S0161-6420(99)90342-1

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

1780-5

issue

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(99)90342-1

journal_volume

106

pub_type

杂志文章,多中心研究

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Visual acuity impairment in patients with retinitis pigmentosa at age 45 years or older.