Abstract:
:The thyroid hormone analogue DITPA is a promising potential new treatment for heart failure. Although the mechanism of action is incompletely determined, it is clear that DITPA improves systolic as well as diastolic function. It is also clear that the effects of DITPA are intrinsic to the muscle and not the result of changes in the structure or geometry of the left ventricle. On the basis of these experimental studies, we applied to the USA Food and Drug Administration for an Investigational New Drug application to study the use of DITPA in patients. These studies are currently in progress. While we await the outcome of these clinical trials, it is important to emphasize that even if the end-point is not a new drug to treat heart failure, our investigations are based on a systematic evaluation integrating biochemistry and physiology. We believe that this is the way to approach the problem of developmental pharmacology.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Spooner PH,Morkin E,Goldman Sdoi
10.1097/00019501-199909000-00008subject
Has Abstractpub_date
1999-09-01 00:00:00pages
395-9issue
6eissn
0954-6928issn
1473-5830journal_volume
10pub_type
杂志文章,评审abstract:BACKGROUND:We and others have demonstrated that administration of thrombolytic agents causes the generation of thrombosis-promoting agents. At present, we have studied whether formation in vivo of excessive amounts of plasmin is responsible for the activation of coagulation in patients treated with recombinant tissue-t...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199304000-00009
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:The degree of coronary collateral development is not same in every patient with similar degree of coronary stenosis. In animal studies monocyte chemoattractant protein-1 (MCP-1) has been found to be related to collateral vessel development. In this study we investigated whether a higher serum MCP-1 level is ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32833fd29b
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:Early evaluation of patients with chest pain is important not only for the detection of acute myocardial infarction (AMI) but also for identification of patients at high risk for future cardiac events. A multimarker strategy applying results of early measurements of different biochemical markers of cardiac ne...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200508000-00009
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Low-molecular-weight heparins may have a higher benefit to risk ratio than unfractionated heparin in preventing perioperative thrombosis. The antithrombotic effects of low-molecular-weight heparins, given as adjunctive therapy to alteplase and aspirin, have not previously been compared with those of unfracti...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:To determine whether a quantitative measurement of peak systolic velocity (PSV) during dobutamine stress echocardiography (DSE) detects severe coronary artery disease (CAD) and predicts mortality in patients with end-stage renal disease. METHODS:One hundred and forty renal transplant candidates had DSE and c...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32832ac5eb
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:To maintain the integrity of tissues, endothelial cells play critical roles. Fas ligand (FasL) is well known to deliver a death signal through its receptor, Fas. The Fas/FasL system may concomitantly induce expressions of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) besides triggering ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200302000-00010
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Coronary artery ectasia has been defined as localized or diffuse nonobstructive lesions of the epicardial coronary arteries with a luminal dilation exceeding the 1.5-fold of normal adjacent segment or vessel diameter. Although coronary artery disease is supposed to be responsible for more than 50% of coronar...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200606000-00007
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:The plasma level of homocysteine is an independent risk factor for atherosclerotic vascular disease. The relationship between plasma homocysteine level and the onset of coronary artery disease (CAD) has not been established. OBJECTIVE:To investigate the relationship between plasma homocysteine level and the...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199910000-00002
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:The effects of initial tests on long-term events have been unknown. PATIENTS AND METHODS:In this observational retrospective study, we analyzed the effects of initial noninvasive tests by myocardial perfusion imaging (MPI) and computed tomography angiography (CTA) on long-term major adverse cardiac events (...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000645
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Ga-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, Ga-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. MATERIALS AND METHODS:Ga-NOTA-RGD PET was perform...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283608c32
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Fetuin-A is a circulating glycoprotein that is involved in various stages of atherosclerosis. Despite the fact that emerging evidence suggests fetuin-A acts as a calcification inhibitor that protects against advanced calcified atherosclerosis in dialyzed patients, the role of fetuin-A in cardiovascular diseas...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32832fe5d5
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Cardiac hypertrophy is associated with numerous alterations in the coronary circulation. OBJECTIVE:To test the hypothesis that, during angioplasty, the coronary collateral blood flow during repetitive coronary occlusions increases more in hypertensives than it does in normotensives. METHODS:We studied 34 p...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199705000-00004
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to clarify clinical and angiographical characteristics of acetylcholine (ACh)-induced spasm in the right and left coronary artery. METHODS AND RESULTS:We performed 557 consecutive procedures of spasm provocation tests of ACh from January 1991 to December 2000 in patients withou...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200206000-00005
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Diabetes is a strong predictor of a poor outcome after coronary artery bypass grafting (CABG). The prevalence of prediabetes and its impact on the prognosis after CABG is not well described. In this study, we evaluated the prevalence and prognostic impact of the different states of abnormal glucose regulatio...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283645c94
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Different cardiovascular risk calculators and risk-based thresholds for initiating statin therapy are currently in use. Using coronary computed tomography angiography, we sought to compare the Pooled-Cohort Equation [atherosclerotic cardiovascular disease (ASCVD) score] with the Systematic COronary Risk Eval...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000398
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Although atherosclerosis is supposed to be responsible for more than 50% of coronary artery ectasia, the precise pathology of coronary artery ectasia is not clearly understood. A histopathological examination of ectatic segments has revealed mainly destruction of the media layer of the artery. In the present...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200512000-00007
更新日期:2005-12-01 00:00:00
abstract:AIM:The purpose of this study was a head-to-head comparison of tomographic imaging (SPECT) with technetium-99m (Tc-99m)-sestamibi and thallium-201 (Tl-201) using dipyridamole-low-level bicycle exercise stress for the assessment of coronary artery disease. METHODS:We studied 38 consecutive patients referred for the eva...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Congenital coronary artery fistula (CAF) is a very rare cardiovascular anomaly and only 400 cases have been reported. The purpose of this study was to analyse the experience of surgical treatments in CAF and evaluate the surgical indications, techniques and long-term results. METHODS:A retrospective study r...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199412000-00006
更新日期:1994-12-01 00:00:00
abstract::The coronary microvasculature plays a key role in determining and modulating coronary blood flow across the spectrum of myocardial demand. Our understanding of this complex system has been limited partly due to our inability to visualize the anatomy of an extensive microvascular bed and its complicated functional path...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/MCA.0000000000000119
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:The role of thrombolytic therapy (TT) and percutaneous coronary interventions (PCIs) in subgroups of patients with right ventricular infarction (RVI) has not been evaluated. METHODS AND RESULTS:We risk-stratified 302 patients with RVI into three subsets upon admission. Class A (n=197) comprised patients wit...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200202000-00008
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the outcome for men and women with chest pain or other symptoms suggestive of acute myocardial infarction (AMI) and a normal ECG on admission. METHODS:All patients who presented to our emergency room over a 21-month period with chest pain or other symptoms suggestive of ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the safety and efficacy of the novel NovaCross microcatheter system in patients with ischemic heart disease due to coronary chronic total occlusions (CTO). METHODS:A total of 191 subjects between the ages of 25-80 years were recruited in 10 investigational sites. Each s...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000947
更新日期:2020-11-01 00:00:00
abstract:AIM:The aim of this study was to assess the effect on adherence to statin therapy and assess the effect of beneficial changes in behavior that resulted in weight loss in patients who underwent coronary artery calcium (CAC) scoring with cardiac computed tomography. BACKGROUND:Despite convincing data demonstrating the b...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000207
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:This study was designed to evaluate whether differences between sexes exist in serum-lipoprotein (a) [Lp(a)] and arterial-wall-apolipoprotein (a) [Apo(a)] levels in patients with advanced coronary artery disease. METHODS:The concentrations of Lp(a) in serum and Apo(a) in aortic biopsies were studied in 76 m...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199504000-00013
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:The N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a sensitive indicator of hemodynamic stress and its increased level is associated with higher mortality in acute coronary syndrome (ACS) patients. Virtual histology-intravascular ultrasound (VH-IVUS) can provide quantitative information on plaque ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32832a196e
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Circulating leukocytes are recruited at atherosclerotic sites through a family of adhesion molecules. Circulating forms of adhesion molecules in peripheral blood can be quantified now. OBJECTIVE:To evaluate the relationship between circulating adhesion molecules and severity of coronary atherosclerosis. ME...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200002000-00013
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the association of plasma osmolality with all-cause mortality in ST-segment elevation myocardial infarction (STEMI) patients treated with a primary percutaneous coronary intervention. METHODS:This study included 3748 patients (mean age 58.3±11.8 years, men 81%) with ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000426
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:This cross-sectional study aimed to investigate the long-term quality of life (QOL) influencing of patients following a percutaneous coronary intervention (PCI) as well as its influencing factors. PATIENTS AND METHODS:From June 2013 to April 2014, 428 PCI patients were enrolled in this questionnaire survey....
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000712
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to explore the individual effects of the CYP2C19 G681A polymorphism and omeprazole use and their interaction on clopidogrel responsiveness in acute coronary syndrome (ACS). The CYP2C19 G681A polymorphism and omeprazole use were both known for retarding the effects of clopidogrel unde...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000808
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The Cardiac Health Profile (CHP) is a new questionnaire for assessing health-related quality of life of patients with cardiovascular diseases. It consists of three parts assessed as follows: the degree of angina pectoris (the CCS scale), the quality of life and subjective scoring of psychosocial 'cost-benefi...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00