Thyroid hormone and thyroid hormone analogues in the treatment of heart failure.

Abstract:

:The thyroid hormone analogue DITPA is a promising potential new treatment for heart failure. Although the mechanism of action is incompletely determined, it is clear that DITPA improves systolic as well as diastolic function. It is also clear that the effects of DITPA are intrinsic to the muscle and not the result of changes in the structure or geometry of the left ventricle. On the basis of these experimental studies, we applied to the USA Food and Drug Administration for an Investigational New Drug application to study the use of DITPA in patients. These studies are currently in progress. While we await the outcome of these clinical trials, it is important to emphasize that even if the end-point is not a new drug to treat heart failure, our investigations are based on a systematic evaluation integrating biochemistry and physiology. We believe that this is the way to approach the problem of developmental pharmacology.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Spooner PH,Morkin E,Goldman S

doi

10.1097/00019501-199909000-00008

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

395-9

issue

6

eissn

0954-6928

issn

1473-5830

journal_volume

10

pub_type

杂志文章,评审
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    authors: Gram J,Munkvad S,Leebeek FW,Kluft C,Jespersen J

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    authors: Sahinarslan A,Kocaman SA,Topal S,Ercin U,Bukan N,Yalcin R,Timurkaynak T

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    authors: Eggers KM,Oldgren J,Nordenskjöld A,Lindahl B

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    doi:

    authors: Jun L,Arnout J,Vanhove P,Dol F,Lormeau JC,Herbert JM,Collen D,Van de Werf F

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  • The diagnostic and prognostic value of tissue Doppler imaging during dobutamine stress echocardiography in end-stage renal disease.

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    authors: Sharma R,Mehta RL,Brecker SJ,Gaze DC,Gregson H,Streather CP,Collinson PO,Pellerin D

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  • Dual response to Fas ligation in human endothelial cells: apoptosis and induction of chemokines, interleukin-8 and monocyte chemoattractant protein-1.

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    pub_type: 杂志文章

    doi:10.1097/00019501-200302000-00010

    authors: Yamaoka-Tojo M,Yamaguchi S,Nitobe J,Abe S,Inoue S,Nozaki N,Okuyama M,Sata M,Kubota I,Nakamura H,Tomoike H

    更新日期:2003-02-01 00:00:00

  • Decreased nitrate-mediated dilatation in patients with coronary artery ectasia: an ultrasonographic evaluation of brachial artery.

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200606000-00007

    authors: Aksoy Y,Acikgoz N,Sivri N,Bariskaner E,Akturk E,Turhan H,Yetkin E

    更新日期:2006-05-01 00:00:00

  • Plasma homocysteine level and development of coronary artery disease.

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199910000-00002

    authors: Kawashiri M,Kajinami K,Nohara A,Yagi K,Inazu A,Koizumi J,Haraki T,Takegoshi T,Mabuchi H

    更新日期:1999-10-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    authors: Naya M,Uemura Y,Matsumoto N,Momose M,Kato T,Hida S,Yamauchi T,Nakajima T,Suzuki E,Tamaki N,J-COMPASS Extended Follow-Up Study Group.

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    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3283608c32

    authors: Eo JS,Paeng JC,Lee S,Lee YS,Jeong JM,Kang KW,Chung JK,Lee DS

    更新日期:2013-06-01 00:00:00

  • Fetuin-A is associated with calcified coronary artery disease.

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e32832fe5d5

    authors: Mori K,Ikari Y,Jono S,Emoto M,Shioi A,Koyama H,Shoji T,Ishimura E,Inaba M,Hara K,Nishizawa Y

    更新日期:2010-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00019501-199705000-00004

    authors: Kyriakides ZS,Sbarouni E,Paraskevaidis IA,Giakoumakis T,Tsiapras D,Kremastinos DT

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

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    authors: Sueda S,Kohno H,Fukuda H,Inoue K,Suzuki J,Watanabe K,Ochi T,Uraoka T

    更新日期:2002-06-01 00:00:00

  • Prevalence and severity of abnormal glucose regulation and its relation to long-term prognosis after coronary artery bypass grafting.

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3283645c94

    authors: Petursson P,Herlitz J,Lindqvist J,Sjöland H,Gudbjörnsdottir S

    更新日期:2013-11-01 00:00:00

  • Accuracy of Pooled-Cohort Equation and SCORE cardiovascular risk calculators to identify individuals with high coronary atherosclerotic burden - implications for statin treatment.

    abstract:BACKGROUND:Different cardiovascular risk calculators and risk-based thresholds for initiating statin therapy are currently in use. Using coronary computed tomography angiography, we sought to compare the Pooled-Cohort Equation [atherosclerotic cardiovascular disease (ASCVD) score] with the Systematic COronary Risk Eval...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000398

    authors: Tralhão A,Ferreira AM,Gonçalves Pde A,Rodrigues R,Costa C,Guerreiro S,Cardim N,Marques H

    更新日期:2016-11-01 00:00:00

  • Decreased carotid intima-media thickness in patients with coronary artery ectasia compared with patients with coronary artery disease.

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200512000-00007

    authors: Yetkin E,Acikgoz N,Aksoy Y,Bariskaner E,Sivri N,Akturk E,Turhan H,Kosar F,Cehreli S

    更新日期:2005-12-01 00:00:00

  • Head-to-head comparison between technetium-99m-sestamibi and thallium-201 tomographic imaging for the detection of coronary artery disease using combined dipyridamole-exercise stress.

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    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Cramer MJ,Verzijlbergen JF,Van der Wall EE,Niemeyer MG,Zwinderman AH,Ascoop CA,Pauwels EJ

    更新日期:1994-09-01 00:00:00

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199412000-00006

    authors: Chen Y,Belboul A,Roberts D

    更新日期:1994-12-01 00:00:00

  • New insights into the pathophysiology, classification, and diagnosis of coronary microvascular dysfunction.

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    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/MCA.0000000000000119

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    更新日期:2014-08-01 00:00:00

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

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    更新日期:2002-02-01 00:00:00

  • Hospitalisations, infarct development, and mortality in patients with chest pain and a normal admission electrocardiogram in relation to gender.

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Karlson BW,Herlitz J

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    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000947

    authors: Walsh SJ,Dudek D,Bryniarski L,Nicholson W,Karmpaliotis D,Uretsky B,McEntegart M,Assali A,Knaapen P,Kornowski R,Spratt JC,Goodwin M,Hanratty CG

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  • Motivational effects of coronary artery calcium scores on statin adherence and weight loss.

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000207

    authors: Kalia NK,Cespedes L,Youssef G,Li D,Budoff MJ

    更新日期:2015-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00019501-199504000-00013

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    pub_type: 杂志文章

    doi:10.1097/00019501-200002000-00013

    authors: Oishi Y,Wakatsuki T,Nishikado A,Oki T,Ito S

    更新日期:2000-02-01 00:00:00

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000426

    authors: Tatlisu MA,Kaya A,Keskin M,Uzman O,Borklu EB,Cinier G,Hayiroglu MI,Tatlisu K,Eren M

    更新日期:2017-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000712

    authors: Li L,Wang H,Wang Y,Gao X,Liu G,Zhao Z,Lin P

    更新日期:2019-08-01 00:00:00

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    pub_type: 杂志文章

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    authors: Jirungda S,Pussadhamma B,Komanasin N,Senthong V,Leuangwatthananon W

    更新日期:2020-05-01 00:00:00

  • The cardiac health profile: content, reliability and validity of a new disease-specific quality of life questionnaire.

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    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Währborg P,Emanuelsson H

    更新日期:1996-11-01 00:00:00