Abstract:
BACKGROUND:The presence of aerobic Gram-negative bacilli (AGNB) in the oropharynx can be either temporary or persistent. Prolonged colonization (ie, carriage) is distinguished from transient presence (ie, acquisition), which often occurs in healthy individuals but less frequently in those with underlying disease. Prevalence rates of up to 61.1% quoted previously for healthy individuals were obtained by using single sample surveys, which fail to differentiate acquisition from carriage. STUDY OBJECTIVES:To illustrate the need to distinguish carriage from acquisition in a healthy population at risk of acquisition of AGNB, and to show that although differing groups of healthy individuals may acquire oropharyngeal AGNB at differing frequencies, carriage is rare in healthy individuals. PARTICIPANTS:Two oral rinses were obtained within a 2-day interval from 120 healthy individuals comprising 40 nurses, 40 students, and 40 laboratory-associated persons. DESIGN:Two hundred forty oral rinses were quantitatively (1:10 dilution series) cultured for AGNB by using broth enrichment. MEASUREMENTS AND RESULTS:The rate of AGNB carriage based on two consecutive samples positive for the same AGNB was 6.6%; the rate of AGNB acquisition based on one positive sample was 35.8%. The concentrations of all carried and acquired AGNB were < or = 103 cfu/mL. AGNB acquisition was significantly higher in students (52.5%) compared to nurses (32.5%) and laboratory-associated persons (22.5%; p < 0.05). CONCLUSION:Healthy individuals rarely carry oropharyngeal AGNB, suggesting effective oropharyngeal clearance in a healthy population predisposed to acquisition. Apparently, the oropharyngeal mucosa in healthy individuals is not receptive to adhesins of AGNB, resulting in rapid elimination of these bacteria.
journal_name
Chestjournal_title
Chestauthors
Mobbs KJ,van Saene HK,Sunderland D,Davies PDdoi
10.1378/chest.115.6.1570subject
Has Abstractpub_date
1999-06-01 00:00:00pages
1570-5issue
6eissn
0012-3692issn
1931-3543pii
S0012-3692(15)38290-8journal_volume
115pub_type
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