Abstract:
:When cells are exposed to ionizing radiation, they initiate a complex response that includes the arrest of cell cycle progression in G1 and G2, apoptosis and DNA repair. DNA is an important subcellular target of ionizing radiation, but oxydative damage to plasma membrane lipids initiates signal transduction pathways that activate apoptosis and that may play a role in cell cycle regulation. How is DNA damage converted into intracellular signals for cell cycle arrest? The ataxia telangectasia mutant (ATM) protein and/or the DNA-dependent protein kinase (DNA-PK), that are both activated by DNA damage, may initiate cell cycle arrest by activating the p53 tumor suppressor protein. The p53 protein acts as a transcription factor and regulates expression of several components implicated in pathways that regulate cell cycle progression. The best known, p21WAF1/CIP1 protein, is an inhibitor of cyclin-dependent kinases (CDK), a family of protein kinases known as key regulators of cell cycle progression. p21WAF1/CIP1 was shown to be able to inhibit several CDK, but is most effective toward G1/S cyclins. Other CDK inhibitors, p27KIP1 and p15INK4b are activated by irradiation and contribute to the G1 arrest. Moreover, radiation-induced G2 arrest was shown to require inhibitory phosphorylation of the kinase cdc2 via an ATM-dependent pathway. Mutations in cell cycle regulatory genes are common in human cancer and cell cycle regulatory deficiency can lead to increase resistance to ionizing radiation in cancer cells. The major function of p53-dependent G1 arrest may be elimination of cells containing DNA damage whereas G2 arrest following radiation has been shown to be important in protecting cells from death. Cell cycle checkpoints offer a new set of potential targets for chemotherapeutic compounds, especially the G2 checkpoint. Thus, abrogation of the G2 checkpoint with methylxanthines such as caffeine or protein kinase inhibitors such as staurosporine and UCN-01 (7-hydroxystaurosporine) was found to sensitize cells to ionizing radiation. These data did not lead to clinical applications, but confirm targeting of the G2 checkpoint may be an important strategy for cancer therapy.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Teyssier F,Bay JO,Dionet C,Verrelle Psubject
Has Abstractpub_date
1999-04-01 00:00:00pages
345-57issue
4eissn
0007-4551issn
1769-6917journal_volume
86pub_type
杂志文章,评审abstract::With 2 436 deaths in 1979, ovarian cancer is relatively infrequent in France comprising but 5 per cent of female mortality from malignant disease. However, the rate of increase in mortality is considerable, 70 per cent between 1955 and 1979 or 2,9 per cent per year, greater than that for female bladder and breast canc...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::A retrospective review was made of 1 400 cases of cancer of the esophagus treated at the Centre "Francois Baclesse" between 1964 and 1975. The disease appeared at an earlier age and more frequently in men (95%) than in women. The lesions were located predominantly in the middle third of the esophagus. There was a high...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Blood glucose levels were temporarily elevated in normal and in tumor bearing Lewis rats subjected to one local hyperthermic treatment in the leg or in the upper abdomen. Serum transferred from locally heated animals or serum heated in-vitro and injected to normal recipients resulted in elevated blood glucose levels. ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Many complementary and alternatives medicines are offered to patients with cancer. Among them, herbal medicines have a substantial place. These plants are mainly used to reduce adverse effects of anticancer treatments and for specific anticancer properties. Our review shows that only few clinical data support medicina...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2013.1741
更新日期:2013-05-01 00:00:00
abstract::Carbon ion therapy is an innovative radiation therapy. It has been first proposed in the forties by Robert Wilson, however the first dedicated centres for human care have been build up only recently in Japan and Germany. The interest of carbon ion is twofold: 1) the very sharp targeting of the tumour with the so calle...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2010.1151
更新日期:2010-07-01 00:00:00
abstract::Angiogenesis inhibition is a major antitumor strategy that has emerged during the last decade. Oral tyrosine kinase inhibitors (TKI) targeting the VEGF receptor, including sunitinib, sorafenib, axitinib, regorafenib, pazopanib, and vandetanib reduce tumor growth and metastasis. These agents are approved for the treatm...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2015.10.020
更新日期:2016-03-01 00:00:00
abstract:INTRODUCTION:An in-patient clinical service has been set up in March 2016 in the Occupational Diseases Center of Brest University Hospital, France, to seek for work-relatedness of diseases in patients hospitalized into the oncology and hematology departments. We present here data after two years of existence. METHODS:...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2020.01.013
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:Cancers of adolescents and young adults have particular epidemiological specificities. The improvement in their survival should be accompanied by an increased consideration of the treatments' side effects, among which the potential decrease in fertility. The objective of the study was to describe the acces...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2020.03.013
更新日期:2020-01-01 00:00:00
abstract::The authors report their ultrastructural findings of 36 involved lymph-nodes in Hodgkin's disease (HD), before any treatment. More than 400 tumour cells were studied. An analytical study was carried out on the different aspects presented by the nuclei (uni or multi-lobated); the nucleoli (compact, reticulate or disper...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Lung and head and neck cancers result from a multistep process involving activation of oncogenes and inactivation of tumor-suppressor genes. These two processes share common features and molecular players, while their corresponding clinical entities are both triggered by the tobacco carcinogens. In many cases, the mol...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2009.0786
更新日期:2009-01-01 00:00:00
abstract::For two decades, the prognostic of adult patients with ALL was improved based on pediatric-inspired protocols. These approaches based on less myelosuppressive drugs have led to improved response rates, decreased relapse rates, with a benefit in survival observed in patients aged up to 50-60-years-old. Therapeutic inte...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2020.07.008
更新日期:2020-09-24 00:00:00
abstract::Over the past decade, trastuzumab was the only available monoclonal anti-HER2 antibody for the treatment of HER2 positive breast and gastric cancer. Recently, pertuzumab added to docetaxel and trastuzumab showed dramatic overall survival improvement in first line treatment of HER2 positive metastatic breast cancer. Pe...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2014.2026
更新日期:2014-12-01 00:00:00
abstract::Oral cavity and pharyngeal cancers account for 75% of head and neck cancers and are the fourth most spread cancer in men. Their incidence has decreased since 1980 in men (incidence from 2011 gives 13,930 for lip, oral cavity, pharyngeal and laryngeal carcinomas) but has increased in women, linked to the more recent sm...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2014.1962
更新日期:2014-05-01 00:00:00
abstract:UNLABELLED:This CORCAN study is concerned with the way patients hospitalised for peritoneal carcinosis perceive surgical treatment and hyperthermic intraperitoneal chemotherapy (HIPEC). OBJECTIVES:(1) To identify and analyse, using concepts of social representation and accounts of the illness, characteristics of the w...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2015.10.015
更新日期:2016-02-01 00:00:00
abstract::It is not apparent that advanced human carcinomas of the breast or the large bowel are conprised of at least two populations: those responding to treatment with 5-fluorouracil (approximately 20 per cent) and those unresponsive to this drug. This classification cannot be made before chemotherapy on the basis of any cli...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to explore the risk factors that were associated with central lymph node metastasis (CLNM) in patients with clinical nodal negative differentiated thyroid carcinoma (cN0 DTC) after prophylactic central neck dissection (pCND). The influence of pCND on TNM staging and recurrence ri...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2016.04.003
更新日期:2016-06-01 00:00:00
abstract::The treatment of the advanced ovarian adenocarcinoma, most frequently stage at diagnostic, relies on association of surgery and chemotherapy. The current standard is the association carboplatine-paclitaxel. In spite of this treatment, relapses are frequent, and the prognosis thus remains very reserved. Presently the c...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2009.0987
更新日期:2009-12-01 00:00:00
abstract::Image guided radiation therapy (IGRT) is a major technical innovation of radiotherapy. It allows locating the tumor under the linear accelerator just before the irradiation, by direct visualization (3D mode soft tissue) or indirect visualization (2D mode and radio-opaque markers). The technical implementation of IGRT ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2010.1140
更新日期:2010-07-01 00:00:00
abstract::Patients wish to be fully informed about their health, but some information and its disclosure may pose special challenges depending on the severity of the illness. This prospective observational study investigates the content of information about the disease and treatment, as well as the process by which information ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2011.1530
更新日期:2012-02-01 00:00:00
abstract::Antineoplastic drug induced nausea and vomiting are common adverse events in cancer care of paediatric patients ; therefore, prevention and management of these adverse events is a major concern for healthcare professionals. There are common features between paediatric and adult patients in terms of the emetogenic leve...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2020.03.015
更新日期:2020-01-01 00:00:00
abstract::Lung cancer is the first cause of death from cancer in males in France. This cancer is responsible for 19,000 deaths in males and 3,000 deaths in females. We studied the geographical and temporal variations in lung cancer mortality in France. The average increase in mortality clearly decreased in males, changing from ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::Two hundred and twenty-three patients with disseminated breast cancer entered in a randomized trial: Group I: 130 patients were given a monthly 5 day- course of a cytotoxic chemotherapy protocol including Adriamycine, Vincristine, Cyclophosphamide, 5 Fluoro-uracile (A.V.L.F.); Group II: 93 patients were given alternat...
journal_title:Bulletin du cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1984-01-01 00:00:00
abstract::Despite surgery, post-operative irradiation and adjuvant conventional chemotherapy, prognosis of high-grade gliomas remains poor. Carmustine (BCNU) has been shown to have limited activity at conventional dosage but is still the standard chemotherapy. Activity of chemotherapy is limited by the blood-brain barrier imper...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:2001-09-01 00:00:00
abstract::Newly synthesized dipyrido [4,3-b] [3,4-f] indole compounds have a structural similarity with the DNA intercalating agents ellipticines (pyrido-carbazoles). The procedure of synthesis of these compounds allows the addition of a lateral chain in position 1 of the nucleus. Comparison is made between different substituti...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract:INTRODUCTION:Since the last cancer plan 2014-2019, the assessment of the impact of the disease on caregivers became essential. The quality of caregiving represents an important part of the patient's quality of life. The main objective was to describe the evolution of caregiver's attachment style during the first three ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2020.08.011
更新日期:2020-11-01 00:00:00
abstract::EXPRESSION III was designed to evaluate the information, needs and expectations of patients with ovarian cancer in different European countries. This abstract focuses on specific results from French OC patients. Two hundred and fifty-seven patients filled a 27-item questionnaire during a medical visit. Median age rang...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2014.09.004
更新日期:2015-03-01 00:00:00
abstract::Death still occurs in Hodgkin's disease (HD) patients with advanced stages, but also in early stages. Therefore, the identification of the population of HD patients who would best benefit from an intensification of treatment is a prerequisite in all stages. The best known prognostic factors are bulky mediastinum, B sy...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:1995-08-01 00:00:00
abstract::Paclitaxel is often used as an adjuvant antineoplastic agent. However, very little data is available in literature on its potential genotoxicity on healthy human cells. Our objective is to study the potential in vitro genotoxicity of paclitaxel, by using the cytokinesis-blocked micronucleus assay in combination with f...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::By the genetic localization of the first melanoma susceptibility gene on chromosome 1p we thought that the puzzle on familial melanoma families would soon be solved. Now, almost fifteen years later we have learned that inherited melanoma is not a simple genetic disorder and that multiple genes, modifying genes and env...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::In Europe, renal tumours are 7th in frequency of men cancers. They are rare tumours in 10 to 15% of cases. Collecting ducts carcinomas or Bellini tumours, described for the first time in 1949, are a distinct clinical and pathological entity. They represented 1% of epithelial cancers. Nephrectomy is the treatment of lo...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2011.1462
更新日期:2011-10-01 00:00:00