Abstract：
:Carbon ion therapy is an innovative radiation therapy. It has been first proposed in the forties by Robert Wilson, however the first dedicated centres for human care have been build up only recently in Japan and Germany. The interest of carbon ion is twofold: 1) the very sharp targeting of the tumour with the so called spread out Bragg peak that delivers most of the beam energy in the tumour and nothing beyond it, sparing very efficiently the healthy tissues; 2) the higher relative biological efficiency compared to X rays or protons, able to kill radioresistant tumour cells. Both properties make carbon ions the elective therapy for non resectable radioresistant tumours loco-regionally threatening. The technical and clinical experience accumulated during the recent decades is summarized in this paper along with a detailed presentation of the elective indications. A short comparison between conventional radiotherapy and hadrontherapy is proposed for the indications which are considered as priority for carbon ions.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Pommier P,Hu Y,Baron MH,Chapet O,Balosso Jdoi
10.1684/bdc.2010.1151subject
Has Abstractpub_date
2010-07-01 00:00:00pages
819-29issue
7eissn
0007-4551issn
1769-6917pii
S0007-4551(15)30812-2journal_volume
97pub_type
杂志文章,评审abstract：BACKGROUND:To establish the recommended dose (RD) of the thymidylate-synthase inhibitor ZD9331 administered with irinotecan (CPT-11) in patients with pretreated metastatic colorectal cancer, and to assess toxicity profile, pharmacokinetics (PK), and anti-tumor activity in a phase I/II open, multicenter, intrapatient ch...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：2004-12-01 00:00:00
abstract：:This study was performed in a group of 89 patients treated for breast carcinoma with a FEC regimen (5-fluorouracil, epirubicin, cyclophosphamide). The aim was to evaluate the antiemetic efficacy of one 8 mg tablet ondansetron (OND), and in case of failure, to measure the recovering level by the administration of 8 mg ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Forty-six tumors from patients with oropharyngeal carcinoma were analysed by flow cytometry after injection of bromodeoxyuridine (Budr) for the labelling index, the duration of S phase and the potential doubling time (Tpot). The results show large variations in Tpot (from 2.6 to 16.7 days) among these tumors from the ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:Despite development and widespread of PSA, current tools evaluating prostate cancer still give inconsistent or insufficiently relevant results. As encouraging data raised from circulating tumor cells detection in colon or breast cancer, they were evaluated as a surrogate prostate cancer biomarker. Tumor cells need to ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2012.1565
更新日期：2012-07-01 00:00:00
abstract：:Adhesion molecules play a major role in the regulation of normal hematopoiesis. Precursor/cell matrix/endothelial interactions determine retainment or release of hematopoietic cells from the bone marrow microenvironment. Consequently, changes in the affinity or quantitative expression of adhesion molecules on either t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：:A retrospective, morphological and immunochemical study was performed on 60 bone marrow biopsies (BOM) and 12 tumor specimens surgically excised, from 9 patients with neuroblastoma (NB). Immunochemistry concerned "neuron-specific enolase" (NSE), chromogranin A (CGA) and synaptophysin (SP). The results of immunochemica...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:We analyzed renal cell carcinoma (RCC) brain metastasis (BM) risk factors and compared BM occurrence in metastatic RCC (mRCC) treated with or without anti-angiogenic agents (AA). METHODS:Data from all consecutive metastatic RCC patients (patients) treated in a french cancer center between 1995 and 2008 were...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2012.1672
更新日期：2012-12-01 00:00:00
abstract：:In recent studies, the economic criteria has begun to be integrated to the appraisal in cancerology. The question asked by the economist can be framed as follows: what incremental cost should the collectivity or the health insurance system consent, in order to improve the care of cancer patients? This involves first t...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:In industrialized countries cervical cancer has decreased over the past decades. This, thanks to wide spread screening campaigns of precancerous lesions and microinvasive diseases through regular pap smears starting from the beginning of sexual activity. The diagnostic is realized earlier, thus increasing the rate of ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：:The endothelins (ET1, ET2, ET3) are a family of peptides that exert vasoactive and mitogenic effects. ETs bind to at least two subtypes of receptors: the ETA subtype is ET1 selective whereas the ETB subtype binds ET1, ET2 and ET3. By RT-PCR, we detected ETA receptor mRNA and ETB receptor mRNA in leiomyoma and in homol...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:To assess the feasibility and efficacy of cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) without adjuvant chemotherapy for relapsed or persistent advanced ovarian cancer. METHODS:This observational study included stage IIIC ovarian cancer patients due to undergo CRS...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2010.1063
更新日期：2010-04-01 00:00:00
abstract：:Whereas it has been proposed almost one century ago, brachytherapy for prostate cancer has only recently emerged, especially thanks to endorectal echography, allowing to visualize seed implantation, to the development of seeds for permanent delivery and of micro-sources for high-dose rate delivery, and also to the dev...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2006-08-01 00:00:00
abstract：:Twenty-eight patients with poor prognosis, advanced metastatic non seminomatous germ cell tumors (NSGCT) were treated with early high dose chemotherapy and autologous bone marrow transplantation (ABMT) rescue. The primary tumor was testicular in 19 patients and extragonadal in nine patients. For 19 patients with a tes...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-01-01 00:00:00
abstract：:The antiestrogen tamoxifen (TAM) has been successfully used to treat breast cancer expressing estrogen and progesterone receptors (ER+ and PR+). However, the development of antiestrogen resistance is frequently observed in patients following long-term treatment. To better understand the mechanism of action of TAM and ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1996-10-01 00:00:00
abstract：:Since the results of bone marrow transplantation for acute leukemia in relapse have been poor (less than 20% long term survival), an attempt of bone marrow transplantation for acute leukemia in remission has been performed since 1976 by the Seattle Group. The results are very encouraging. In ANL transplanted in first ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Recommendations for the management of gastrointestinal stromal tumours (GIST) in children and adolescents do presently not exist. Thus, a summary of the current literature was conducted serving as a basis for the development of optimal management strategies for childhood GIST. Pediatric cases of GIST may occur sporadi...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1296
更新日期：2011-01-01 00:00:00
abstract：:Important improvements in local control with increasing function-sparing treatment have been achieved in adult soft tissue sarcomas (STS). However, the global prognosis of these diseases remains poor and 40% of patients with STS currently die of metastases within 5 years. In fact, the impact of chemotherapy remains de...
journal_title：Bulletin du cancer
pub_type： 杂志文章,meta分析
doi：
更新日期：1997-06-01 00:00:00
abstract：:Genomic DNA displays a non canonical structure prone to be damaged and modified by genotoxic stresses, which are induced either by the endogenous metabolism or attacks from environment or therapeutic pressure. Several molecular pathways allow cells to repair such DNA lesions. Additional mechanisms have been selected t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1202
更新日期：2010-11-01 00:00:00
abstract：:Gemcitabine has demonstrated a good efficacy in number of tumor types. Thanks to its favourable toxicity profile, gemcitabine can be used in combination with a number of drugs. Single agent gemcitabine and gemcitabine-based combinations have been evaluated in metastatic breast cancer. Some of these combinations, such ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-08-01 00:00:00
abstract：:Metastases are responsible for the majority of deaths from solid cancers. Metastatic phenomenon, complex, is a multi-step process where interactions between cells and with the microenvironment are essential. The organ tropism, that is the propensity of a cancer to metastasize to specific organs, can be explained by se...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2014.1889
更新日期：2014-02-01 00:00:00
abstract：:We have previously shown that the addition of 4-methylthio-2-oxobutanoate (MTOB) to cultures of methionine dependent neoplastic cells which lack endogenous MTOB restores their capacity to grow in the absence of exogenous methionine. Transition state inhibitors of the MTOB transaminase,responsible for the transaminatio...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
abstract：INTRODUCTION:Genetic predisposition to familial hematological malignancies was previously described through several epidemiological analyses, but the genetic basis remains unclear. The tumor-suppressor ARLTS1 gene was previously described in sporadic hematological malignancies and familial cancer context. METHODS:In t...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2016.10.016
更新日期：2017-02-01 00:00:00
abstract：:Chemoprevention is the use of natural or synthetic compounds in order to reverse, suppress or prevent the carcinogenic process. Among the many pathways dysregulated during the carcinogenic process, cyclooxygenase-2 (Cox2) seems to be one of the most promising pathways to target in order to achieve chemopreventive and ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2004-05-01 00:00:00
abstract：:Breast cancer (BC) has the highest incidence rate in women in industrialized countries. Statistically, it is estimated that one out of 10 women will develop BC during her life. Evidence is accumulating for the role of ion channels in the development of cancer. Most studied ion channels in BC are K(+) channels, which a...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2012.1595
更新日期：2012-06-01 00:00:00
abstract：:THE ROLE OF RUXOLITINIB IN THE TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS: The discovery of the JAK2V617F mutation in 2005, present in 95% of polycythemia vera (PV) and in 55% of myelofibrosis (MF) patients, opened the way for a new era of targeted therapies for myeloproliferative neoplasms. Ruxolitinib was the first-i...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/S0007-4551(16)30143-6
更新日期：2016-06-01 00:00:00
abstract：:Over the last decade, the development of new therapeutic options has made more patients benefit from antitumoral strategies including several lines of chemotherapy, the aim of which is a long-term control of the disease progression. In such a context of "chronic" management, the choice of tumor response as a single pa...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2008.0738
更新日期：2008-11-01 00:00:00
abstract：:Twenty-five adult patients, 15 men and 10 women, with a median age of 49, and presenting with metastatic or locally advanced soft tissue sarcomas, have been treated with chemotherapy protocol combining cisplatinum, 100 mg/m2, vindesine, 4 mg/m2, and either adriamycin, 50 mg/m2 (APEL) (16 patients), or epirubicin, 100 ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：INTRODUCTION:French national guidelines lead us to increase the part of one-day breast cancer conservative surgery. Our objective was to check if we can enhance our outpatient part and to identify solutions to improve our practices. METHODS:From 01/01/2013 to 31/12/2014, we conducted a monocentric and retrospective re...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2015.09.010
更新日期：2015-12-01 00:00:00
abstract：:At the time of diagnosis, central nervous system (CNS) involvement is identified in less than 10% of adult acute lymphoblastic leukemia (ALL). Long-term disease-free survival can be achieved in these patients. CNS disease at presentation does not appear to be an independent poor prognostic factor. In CNS leukemia, inn...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2008.0645
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Depression is a sustainable state of deep sadness and abatement. It is frequently identified in patients with cancer and often undervalued by oncologists. The reduced PRIME-MD questionnaire is a questionnaire of 2 items validated in French. However, it has been neither translated nor validated in French. The...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2015.09.008
更新日期：2016-02-01 00:00:00
