Abstract:
:The dihydrofolate reductases were purified from Neisseria gonorrhoeae strains CDC 9 and 7134, for which MICs of trimethoprim differ twofold and MICs of sulfadiazine differ sixtyfold. Although affinities of the dihydropteroate synthetases from the two strains for sulfonamide were known to differ markedly, no conclusive difference in the extents of binding of trimethoprim by the dihydrofolate reductases from these organisms could be demonstrated. Thus, it was concluded that permeability of the cell envelope or increased production of dihydrofolate reductase may be an important factor among strains of N. gonorrhoeae that have low- and middle-range resistance to trimethoprim.
journal_name
Sex Transm Disjournal_title
Sexually transmitted diseasesauthors
Ho RI,Lai PH,Corman L,Ho J,Morse SAdoi
10.1097/00007435-197804000-00002subject
Has Abstractpub_date
1978-04-01 00:00:00pages
43-50issue
2eissn
0148-5717issn
1537-4521journal_volume
5pub_type
杂志文章abstract::Erythromycin is recommended as the alternative to tetracyclines for the treatment of Chlamydia trachomatis infections. However, the usual dose of erythromycin (2 g daily for a week) is frequently associated with gastrointestinal side effects. The goal of this study was to determine whether 1 g of erythromycin daily fo...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-04-01 00:00:00
abstract::Although human immunodeficiency virus-infected men who have sex with men are at high risk for anal cancer, little is known about the prevalence of anal dysplasia in human immunodeficiency virus (HIV)-infected transgender women. Our study found that prevalence rates of abnormal anal cytology and histology in HIV-infect...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000673
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:To study the incidence, persistence, and determinants of human papillomavirus (HPV) infection in a population of Inuit women from Nunavik, Quebec, by overall HPV infection, Alphapapillomavirus (α) species, and oncogenic risk grouping. METHODS:We recruited a cohort of Inuit women living in communities in Nun...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000272
更新日期:2015-05-01 00:00:00
abstract::The Gonozyme test (Abbott Laboratories; North Chicago, IL), a solid-phase enzyme immunoassay (EIA), was evaluated for direct detection of antigens from Neisseria gonorrhoeae in clinical specimens. Results of the EIA were compared with those of culture and gram stain. Separate swab specimens for each procedure were col...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198510000-00006
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:In January 2001 we investigated an outbreak of Neisseria gonorrhoeae in a northern region of Alberta, Canada, and here we report on the epidemiology of the outbreak. GOAL:The goal was to examine the outbreak etiology and make recommendations for strengthening regional STD programs. STUDY DESIGN:Provincial ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200306000-00005
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Chronic nongonococcal urethritis (NGU) is a well-recognized clinical problem in genitourinary medicine clinics, but its etiology and optimal management are poorly understood. GOAL:The authors showed previously that antibody to chlamydial hsp60 is associated with urethritis 30 to 92 days after treatment of a...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200302000-00007
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Little non-clinic-based data are available on incident genital warts rates and related healthcare use. GOAL:: The goal of this study was to describe the incidence and predictors of genital warts and associated healthcare utilization patterns among a group of privately insured patients in the United States. ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000145851.76025.ad
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:The integration of HPV-16 DNA into the host genome is considered an important event in the progression of premalignant cervical lesions to cervical cancer. The aim of our study was to assess the prevalence of HPV-16 integration in anal cytologic specimens of HIV-1 infected men and its association with risk f...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3181c9c23f
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Sexually transmitted disease clinics can deliver hepatitis vaccines to men who have sex with men, but have been reluctant to do so because of perceived low vaccination completion rates. GOAL:The goal was to evaluate hepatitis A and B vaccination eligibility, acceptance, and completion and the effectiveness ...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/01.OLQ.0000079524.04451.4C
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Sexual partnership dates are critical to sexually transmitted infection/HIV research and control programs, although validity is limited by inaccurate recall and reporting. METHODS:We examined data from 302 heterosexual adults (151 index-partner dyads) to assess reliability of reporting. Dates of first sex a...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000428
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:In resource-poor settings, control of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) among female sex workers (FSWs) is difficult. We sought to determine whether periodical antibiotic treatment (PAT) might be effective in controlling these infections among West African FSWs. Secondary objectives w...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,随机对照试验
doi:10.1097/OLQ.0b013e318244aaa0
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND GOAL:The changing epidemiology of genital herpes with the increasing importance of herpes simplex virus (HSV) type 1 prompted a study on the relative prevalence of HSV-1 and HSV-2 among cases of genital herpes in the Tel Aviv area, Israel. STUDY DESIGN:A retrospective laboratory-based study of positive ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.OLQ.0000079517.04451.79
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Sexual behaviors have been linked to seropositivity for human papillomavirus (HPV) but not with the magnitude of the seroreactivity. GOALS:The objective of this analysis was to examine the association of sexual behavior, cervical HPV 16 DNA positivity at enrollment (past) and at diagnosis (current), and oth...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-200203000-00009
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Youth in detention represent a medically underserved population at risk for a variety of medical and emotional disorders. GOAL OF THE STUDY:To determine prevalence of STDs and high-risk sexual behaviors for HIV/STD among adolescent males admitted to a juvenile detention facility. STUDY DESIGN:Cross-section...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199405000-00001
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Whether male circumcision reduces the risk of acquiring human immunodeficiency virus (HIV) infection remains controversial. STUDY DESIGN:As there have now been a number of studies conducted that have examined this issue, we undertook to review their findings. Thirty epidemiological studies id...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,评审
doi:10.1097/00007435-199407000-00004
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Bacterial vaginosis (BV) is a frequent cause of vaginal discharge that may be more common among women reporting sex with women (WSW). The objective of this study was to determine the prevalence of BV and predictors of infection among a sample of African American WSW. METHODS:African American WSW aged 18 yea...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000004
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Juvenile detention facilities house adolescents at high risk for sexually transmitted diseases. Collaboration between health departments and juvenile detention authorities can provide routine, cost-efficient chlamydia screening and treatment to females with limited access to care. We describe trends in scree...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000382
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Different models of sexually transmitted infections (STIs) can yield substantially different conclusions about STI epidemiology, and it is important to understand how and why models differ. Frequency-dependent models make the simplifying assumption that STI incidence is proportional to STI prevalence in the ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000000412
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Sexual partnerships between people at higher and lower risk for sexually transmitted infections (STIs) (i.e., bridging) occur through dissortative mixing and concurrent partnerships, yet the relative effects of these network patterns on population STI spread are poorly understood. GOAL:Using a stochastic mo...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000194586.66409.7a
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Azithromycin, an approved single-dose therapy for cervical chlamydia infections, costs four times as much as doxycycline, the standard multidose theapy. GOAL OF THIS STUDY:This study examined whether azithromycin is cost effective for treating cervical chlamydia infections. STUDY DESIGN:Two ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-199509000-00002
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Human immunodeficiency virus (HIV) and sexually transmitted infections (STI) are prevalent among men who have sex with men (MSM). GOAL:To estimate the prevalence of HIV and STIs in this group. STUDY:A total of 694 MSM were tested for HIV, hepatitis B (HBV), hepatitis C (HCV), human T-cell lymphotropic (HTL...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000194578.06795.2d
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Community Approaches to Reducing Sexually Transmitted Disease (CARS), a unique initiative of the US Centers for Disease Control and Prevention, promotes the use of community engagement to increase sexually transmitted disease (STD) prevention, screening, and treatment and to address locally prioritized STD-r...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0000000000001267
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:In the Russian Federation, large sectors of the population regularly undergo mandatory occupational screening for sexually transmitted infections (STIs). Objectives of our study were to determine the prevalence of syphilis and gonorrhea in the screened occupational groups in Moscow and to conduct a cost-effe...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e31816f1c65
更新日期:2008-05-01 00:00:00
abstract::A previously healthy 19-year-old nonpregnant woman had disseminated infection with herpes simplex virus. The disseminated disease was accompanied by hepatitis. The patient was treated with parenteral acyclovir (5 mg/kg) given every 8 hr. The patient's symptoms resolved after three days of therapy. A review of five sim...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198607000-00014
更新日期:1986-07-01 00:00:00
abstract:SHORT SUMMARY:Syphilis cases were reviewed to see if reported stages met the Centers for Disease Control and Prevention case definition. Classification was excellent for primary and secondary and good for late latent, but half of early latent and unknown duration were misclassified. New surveillance definitions are sug...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/01.olq.0000156552.91788.25
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:High rates of sexually transmitted diseases (STDs) present an ongoing costly public health challenge. One approach to reduce STD transmission is to increase the number of clinicians adopting the Centers for Disease Control and Prevention's STD Treatment Guidelines. This evaluation assesses the effectiveness ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e3182045306
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Human immunodeficiency virus (HIV)/sexually transmitted disease (STD)-related interventions rely on self-reported risk behavioral data, which are biased toward social desirability. It is warranted to develop methods for data triangulation. METHODS:Some questions on HIV/STD-related behaviors that were asked ...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/OLQ.0b013e318218cc66
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Quinolones have a broad spectrum of antimicrobial activity and are widely used for the treatment of uncomplicated Neisseria gonorrhoeae infections. A dramatic increase in the number of reported N. gonorrhoeae infections as well as quinolone-resistant isolates in Vienna prompted us to investigate the pattern o...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/01.olq.0000140019.18390.28
更新日期:2004-10-01 00:00:00
abstract::Although sexually abused children are usually evaluated only for the presence of infections with Neisseria gonorrhoeae and Treponema pallidum, they are also at risk for acquiring other sexually transmitted organisms prevalent in the adult population. Accordingly, we examined pharyngeal, anorectal and genital specimens...
journal_title:Sexually transmitted diseases
pub_type: 杂志文章
doi:10.1097/00007435-198701000-00005
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Risk factors for bacterial vaginosis (BV) include douching and sexual activity, although the exact cause of BV is unknown. GOAL:The goal of this study was to determine the relative significance of douching as a risk factor for BV. STUDY DESIGN:Two hundred fifty adolescent women who regularly douched were en...
journal_title:Sexually transmitted diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.olq.0000129948.91055.9f
更新日期:2004-07-01 00:00:00