Abstract：
:Clinical evidence indicates that parasympatholytic effects of tricyclic antidepressants increase with age. The aim of the present study was to determine the possible physiological reason for this phenomenon. Subjects included 23 patients (14 female) with major depression, melancholic type, and 23 age- and sex-matched healthy control subjects. Cardiac vagal tone was measured at rest using both spectral analysis and a time domain beat-to-beat method. Results of the spectral and time domain methods for the estimation of vagal tone used in this study were highly correlated in control subjects as well as in medicated depressed subjects. Both patients and control subjects showed an age-related decline in cardiac vagal tone. Tricyclic antidepressants decreased vagal tone significantly by 25-49% depending on age (20-60 years), although the age difference was not significant. The greater effect of tricyclic antidepressants on parasympathetic activity typically seen in older age groups may reflect the fact that predrug levels of vagal tone are already low in older patients. Measurement of vagal tone prior to drug administration may therefore be of prognostic value for anticholinergic side effects.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Lehofer M,Moser M,Hoehn-Saric R,McLeod D,Hildebrandt G,Egner S,Steinbrenner B,Liebmann P,Zapotoczky HGdoi
10.1016/s0165-1781(99)00005-0subject
Has Abstractpub_date
1999-02-22 00:00:00pages
199-207issue
2eissn
0165-1781issn
1872-7123pii
S0165-1781(99)00005-0journal_volume
85pub_type
临床试验,杂志文章abstract：:Recent evidence demonstrates that hippocampal hyperactivity helps mediate psychosis. Using resting state functional magnetic resonance imaging (rsfMRI), we examined hippocampal connectivity alterations in individuals with psychosis (PS) versus healthy controls (HC). Because of its putative greater involvement in psych...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.06.004
更新日期：2015-08-30 00:00:00
abstract：:Structural neuroimaging studies of the amygdala and hippocampus in bipolar disorder have been largely inconsistent. This may be due in part to differences in the proportion of subjects taking lithium or experiencing an acute mood state, as both factors have recently been shown to influence gray matter structure. To av...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.08.002
更新日期：2013-03-30 00:00:00
abstract：:Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determin...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(03)00040-4
更新日期：2003-03-25 00:00:00
abstract：:In this longitudinal study we compared brain volume changes in first- and multiple-episode patients with schizophrenia to normal aging changes observed in healthy control subjects scanned at comparable times. Two to four years after an initial examination including MRI volumetry, we followed up 21 first episode patien...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2005.07.006
更新日期：2005-12-30 00:00:00
abstract：:Recent studies have demonstrated the usefulness of 123I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy for the diagnosis of dementia with Lewy bodies (DLB). In this study, we investigated the relationship between decreased cardiac MIBG uptake and clinical symptoms in DLB. Thirty-six patients with probable DLB...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.02.006
更新日期：2009-10-30 00:00:00
abstract：:Recent magnetic resonance imaging (MRI) studies using diffusion tensor imaging (DTI) have suggested reduced fractional anisotropy (FA) in the white matter (WM) of the brain in patients with schizophrenia. We tried to examine whether such reduction in FA exists and whether such changes in FA progress in an age-dependen...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.09.004
更新日期：2007-02-28 00:00:00
abstract：:Disorders of the basal ganglia (BG) alter perception and experience of emotions. Left hemisphere BG (LBG) stroke is also associated with depression. The interplay between depression and alterations in emotional processing following LBG stroke was examined. Evoked affective responses to emotion-laden pictorial stimuli ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.05.008
更新日期：2013-02-28 00:00:00
abstract：:Computed axial brain tomograms were recorded in four groups of subjects: (a) subjects who had never taken benzodiazepines (n = 25); (b) subjects who had taken them in the past for less than a year (n = 9); (c) patients currently taking benzodiazepines (n = 30); and (d) patients who had taken benzodiazepines in the pas...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90037-h
更新日期：1993-08-01 00:00:00
abstract：:It has been suggested that reversal learning deficits might be an endophenotype of OCD. To investigate this hypothesis, we administered a probabilistic reversal learning task (ProbRev) to OCD patients, their unaffected first-degree relatives, and healthy controls. Although the relatives had a performance in between OC...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.03.001
更新日期：2017-06-01 00:00:00
abstract：:Mental disorders and sleep dysfunction are common among Chinese university students. This study aimed to evaluate a low cost scalable mindfulness intervention program to improve psychological health and sleep quality among Chinese university students. A randomized controlled trial with 101 university students (mean ag...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2018.09.060
更新日期：2018-12-01 00:00:00
abstract：:Studies have documented a link between gun ownership and suicide, but little is known about characteristics of those most likely to use a gun in a suicide attempt rather than alternative methods. We examined which factors differentiate suicide decedents who died using a gun from those who died by other methods. We fur...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.02.048
更新日期：2017-06-01 00:00:00
abstract：:Past studies suggest that phenylthiocarbamide (PTC) taste status is related to vulnerability to depression, such that those sensitive to PTC are more vulnerable. We questioned this, reasoning that those insensitive to PTC may be more vulnerable (because they may have lower hedonic tone and higher risk for alcohol abus...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2003.12.020
更新日期：2004-04-15 00:00:00
abstract：:Post-traumatic Stress Disorder (PTSD) and Major Depressive Disorder (MDD) are the most common psychiatric consequences among caregivers of pediatric patients affected by severe chronic illnesses. The aims of this study were to describe rates of PTSD and MDD in a sample of parents of epileptic children, and to examine ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.02.062
更新日期：2019-09-01 00:00:00
abstract：:We present psychometric properties and normative data by gender and educational level in scales related to schizotypy and affective disorders in a large population-based adult sample. As part of the 31-year follow-up survey of the Northern Finland 1966 Birth Cohort; Bipolar II scale (BIP2), Hypomanic Personality Scale...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.07.022
更新日期：2010-07-30 00:00:00
abstract：:The goal of this study was to assess integrity of the cingulum bundle in patients diagnosed with first episode schizophrenia, chronic schizophrenia, and matched controls as well as to determine the relationship between diffusion measures of cingulum bundle integrity and severity of patients' delusions of reference. Pa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.08.002
更新日期：2014-11-30 00:00:00
abstract：:Motivation deficits within Schizophrenia Spectrum Disorders (SSDs) are associated with abnormal striatal dopamine responses during reward processing. Eye blink rate (EBR) has been used as a proxy for striatal dopamine; however, it is unclear whether EBR is sensitive to individual differences in amotivation. Amotivatio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113490
更新日期：2020-12-01 00:00:00
abstract：:The purpose of this study was to determine the impact of locus of control, social support and their interaction on acute stress indicators as a consequence of the communication of the results of a breast biopsy. Immunological and psychological indicators were evaluated in 50 patients with breast tenderness. We found l...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(98)00136-x
更新日期：1999-01-18 00:00:00
abstract：:Cognitive insight in schizophrenia encompasses the evaluation and reinterpretation of distorted beliefs and appraisals. We investigated the neuropsychological basis of cognitive insight in psychosis. It was predicted that, like clinical insight, cognitive insight would be associated with a wide range of neuropsycholog...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.05.009
更新日期：2010-07-30 00:00:00
abstract：:Eating disorders (EDs) are psychiatric disorders associated with high morbidity and mortality. It is well established that patients with anorexia nervosa (AN) have an increased risk of premature death, whereas mortality data are lacking for the other EDs. This study aimed to establish mortality rates in a sample of ED...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.08.032
更新日期：2015-12-15 00:00:00
abstract：:A COVID-19 epidemic has been spreading in China and other parts of the world since December 2019. The epidemic has brought not only the risk of death from infection but also unbearable psychological pressure. We sampled college students from Changzhi medical college by using cluster sampling. They responded to a quest...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112934
更新日期：2020-05-01 00:00:00
abstract：:Toxoplasmosis has been previously associated with an increased risk of having schizophrenia in several epidemiological studies. The aim of this prospective study was to examine for the first time a possible association between positive serology to Toxoplasma gondii (T. gondii) and schizophrenia in the Algerian populat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113293
更新日期：2020-09-01 00:00:00
abstract：:In Chinese adolescents exposed to the Wenchuan earthquake, we used the Children's Revised Impact of Event Scale (CRIES) as the screening tool, and Post-traumatic Cognitions Inventory (PTCI) and the Social Support Rating Scale (SSRS) were used to assess the cognitive status and their social supports, to evaluate the pr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.12.016
更新日期：2011-10-30 00:00:00
abstract：:There is evidence for blood inflammatory abnormalities in patients with first-episode psychosis (FEP). The monocyte- and neutrophil-to-lymphocyte ratios (MLR; NLR) are markers of inflammation and endothelial dysfunction, and predictors of cardiovascular disease, the leading cause of death in schizophrenia. We investig...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.11.086
更新日期：2018-02-01 00:00:00
abstract：:Many studies have demonstrated that depression is associated with a worse cardiovascular outcome and increased risk of death in those experiencing an acute coronary syndrome (ACS). Recent studies have suggested, however, that any association is strongly influenced by the timing of the depression, with post-ACS depress...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.07.015
更新日期：2011-02-28 00:00:00
abstract：:The centrally active muscarinic agonist RS-86 elicited a dose-dependent anergic-anhedonic syndrome in a double-blind dose-response study in one healthy volunteer. At 4 and 5 mg, RS-86 induced escape from cortisol suppression by dexamethasone parallel to an increase in prolactin. The time course, as well as the absence...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(88)90103-5
更新日期：1988-09-01 00:00:00
abstract：:We report the initial results of the first controlled double-blind trial of nimodipine, a calcium channel antagonist, in the acute and prophylactic treatment of patients with treatment-refractory affective dysregulation. Active drug nimodipine (A) was substituted for placebo (B) in 12 patients. Patients were studied i...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0165-1781(93)90066-p
更新日期：1993-12-01 00:00:00
abstract：:The aim of this study was to examine insomnia symptoms, behavioral problems, and suicidality among adolescents of insomniac parents (IP) and non-insomniac parents (NIP). A family survey of sleep and health was conducted among 1090 adolescents and their parents in Jinan, China. Adolescents completed a sleep and health ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.05.023
更新日期：2015-08-30 00:00:00
abstract：:The lack of social contacts may be an important element in the presumed vicious circle aggravating, or at least stabilising negative symptoms in patients with schizophrenia. A European 2-year cohort study collected negative symptom scores, psychosocial functioning scores, objective social contact frequency scores and ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.11.039
更新日期：2015-12-30 00:00:00
abstract：:Metacognitive theories describe relationships between mental-affective self-states, including the capacity of one self-state to reflect upon another self-state. The assimilation model is a metacognitive approach that understands self-states as made of traces of experiences at different levels of integration. Psycholog...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.11.001
更新日期：2011-11-30 00:00:00
abstract：OBJECTIVES:The current study aimed to investigate the psychometric properties of the DSM-5 dimensional severity scales for social anxiety disorder (SAD) and panic disorder (PD) using a past 30 day timeframe. METHODS:Data were from a sample of 1,052 Australian community dwelling adults (aged 18 years or older) recruite...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113229
更新日期：2020-09-01 00:00:00
