The estimation of maternal genetic variances.

abstract：:In this article, we describe a Bayesian approach to the calibration of a stochastic computer model of chemical kinetics. As with many applications in the biological sciences, the data available to calibrate the model come from different sources. Furthermore, these data appear to provide somewhat conflicting informatio...

journal_title：Biometrics

authors： Henderson DA,Boys RJ,Wilkinson DJ

更新日期：2010-03-01 00:00:00

abstract：:Unless the true association is very strong, simple large-sample confidence intervals for the odds ratio based on the delta method perform well even for small samples. Such intervals include the Woolf logit interval and the related Gart interval based on adding .5 before computing the log odds ratio estimate and its st...

journal_title：Biometrics

authors： Agresti A

更新日期：1999-06-01 00:00:00

abstract：:We consider a capture-recapture model in which capture probabilities vary with time and with behavioral response. Two inference procedures are developed under the assumption that recapture probabilities bear a constant relationship to initial capture probabilities. These two procedures are the maximum likelihood metho...

journal_title：Biometrics

authors： Chao A,Chu W,Hsu CH

更新日期：2000-06-01 00:00:00

abstract：:Precision medicine seeks to provide treatment only if, when, to whom, and at the dose it is needed. Thus, precision medicine is a vehicle by which healthcare can be made both more effective and efficient. Individualized treatment rules operationalize precision medicine as a map from current patient information to a re...

journal_title：Biometrics

authors： Butler EL,Laber EB,Davis SM,Kosorok MR

更新日期：2018-03-01 00:00:00

abstract：:In this paper we consider the use of within-subject coefficient of variation (WCV) for assessing the reproducibility or reliability of a measurement. Application to assessing reproducibility of biochemical markers for measuring bone turnover is described and the comparison with intraclass correlation is discussed. Bot...

journal_title：Biometrics

authors： Quan H,Shih WJ

更新日期：1996-12-01 00:00:00

abstract：:We develop locally D-optimal designs for nonlinear models when the variance of the response is a function of its mean. Using the two-parameter Michaelis-Menten model as an example, we show that the optimal design depends on both the type of heteroscedasticity and the magnitude of the variation. In addition, our result...

journal_title：Biometrics

authors： Dette H,Wong WK

更新日期：1999-09-01 00:00:00

abstract：:This paper focuses on the methodology developed for analyzing a multivariate interval-censored data set from an AIDS observational study. A purpose of the study was to determine the natural history of the opportunistic infection cytomeglovirus (CMV) in an HIV-infected individual. For this observational study, laborato...

journal_title：Biometrics

authors： Goggins WB,Finkelstein DM

更新日期：2000-09-01 00:00:00

abstract：:Development of HIV resistance mutations is a major cause for failure of antiretroviral treatment. This article proposes a method for jointly modeling the processes of viral genetic changes and treatment failure. Because the viral genome is measured with uncertainty, a hidden Markov model is used to fit the viral genet...

journal_title：Biometrics

authors： Hu C,De Gruttola V

更新日期：2007-03-01 00:00:00

abstract：:This article proposes a two-stage simultaneous confidence procedure for the comparisons of k pairs of population means, without using multiplicity adjustment of more than two populations. The proposed procedure can be broadly applied to parametric or nonparametric models. It is robust and versatile because its derivat...

journal_title：Biometrics

authors： Chen JT

更新日期：2008-06-01 00:00:00

abstract：:In longitudinal studies and in clustered situations often binary and continuous response variables are observed and need to be modeled together. In a recent publication Dunson, Chen, and Harry (2003, Biometrics 59, 521-530) (DCH) propose a Bayesian approach for joint modeling of cluster size and binary and continuous ...

journal_title：Biometrics

authors： Gueorguieva RV

更新日期：2005-09-01 00:00:00

abstract：:Stepped wedge designed trials are a type of cluster-randomized study in which the intervention is introduced to each cluster in a random order over time. This design is often used to assess the effect of a new intervention as it is rolled out across a series of clinics or communities. Based on a permutation argument, ...

journal_title：Biometrics

authors： Hughes JP,Heagerty PJ,Xia F,Ren Y

更新日期：2020-03-01 00:00:00

abstract：:In multivariate survival analysis, investigators are often interested in testing for heterogeneity among clusters, both overall and within specific classes. We represent different hypotheses about the heterogeneity structure using a sequence of gamma frailty models, ranging from a null model with no random effects to ...

journal_title：Biometrics

authors： Dunson DB,Chen Z

更新日期：2004-06-01 00:00:00

abstract：:We consider a semiparametric regression model that relates a normal outcome to covariates and a genetic pathway, where the covariate effects are modeled parametrically and the pathway effect of multiple gene expressions is modeled parametrically or nonparametrically using least-squares kernel machines (LSKMs). This un...

journal_title：Biometrics

authors： Liu D,Lin X,Ghosh D

更新日期：2007-12-01 00:00:00

abstract：:Traditional paradigms for clinical translation are challenged in settings where multiple contemporaneous therapeutic strategies have been identified as potentially beneficial. Platform trials have emerged as an approach for sequentially comparing multiple trials using a single protocol. The Ebola virus disease outbrea...

journal_title：Biometrics

authors： Kaizer AM,Hobbs BP,Koopmeiners JS

更新日期：2018-09-01 00:00:00

abstract：:The aim of this study is to estimate incidence rates of onchocerciasis from skin-snip biopsies, based on incomplete data obtained in field surveys, with consideration of false negatives. The method of maximum likelihood is employed and the effect of false negatives on the incidence rates is discussed. ...

journal_title：Biometrics

authors： Yanagawa T,Kasagi F,Yoshimura T

更新日期：1984-06-01 00:00:00

abstract：:This note discusses the use of capture-mark-recapture methods and log-linear, linear, product models for incomplete tables (Espeland, 1986, Communications in Statistics--Simulation and Computing 15, 405-424) to estimate completeness of reporting in a disease registry and to estimate incompleteness-adjusted incidence r...

journal_title：Biometrics

authors： Hilsenbeck SG,Kurucz C,Duncan RC

更新日期：1992-12-01 00:00:00

abstract：:In this article, we demonstrate a statistical method for fitting the parameters of a sophisticated network and epidemic model to disease data. The pattern of contacts between hosts is described by a class of dyadic independence exponential-family random graph models (ERGMs), whereas the transmission process that runs ...

journal_title：Biometrics

authors： Groendyke C,Welch D,Hunter DR

更新日期：2012-09-01 00:00:00

abstract：:Genomic data are often characterized by a moderate to large number of categorical variables observed for relatively few subjects. Some of the variables may be missing or noninformative. An example of such data is loss of heterozygosity (LOH), a dichotomous variable, observed on a moderate number of genetic markers. We...

journal_title：Biometrics

authors： Houseman EA,Coull BA,Betensky RA

更新日期：2006-12-01 00:00:00

abstract：:Tang, Gnecco, and Geller (1989, Biometrika 76, 577-583) proposed an approximate likelihood ratio (ALR) test of the null hypothesis that a normal mean vector equals a null vector against the alternative that all of its components are nonnegative with at least one strictly positive. This test is useful for comparing a t...

journal_title：Biometrics

authors： Tamhane AC,Logan BR

更新日期：2002-09-01 00:00:00

abstract：:Alterations in DNA methylation have been linked to the development and progression of many diseases. The bisulfite sequencing technique presents methylation profiles at base resolution. Count data on methylated and unmethylated reads provide information on the methylation level at each CpG site. As more bisulfite sequ...

journal_title：Biometrics

authors： Ji T

更新日期：2019-06-01 00:00:00

abstract：:Cancer population studies based on cancer registry databases are widely conducted to address various research questions. In general, cancer registry databases do not collect information on cause of death. The net survival rate is defined as the survival rate if a subject would not die for any causes other than cancer....

journal_title：Biometrics

authors： Komukai S,Hattori S

更新日期：2017-03-01 00:00:00

abstract：:This article is motivated by a lung cancer study where a regression model is involved and the response variable is too expensive to measure but the predictor variable can be measured easily with relatively negligible cost. This situation occurs quite often in medical studies, quantitative genetics, and ecological and ...

journal_title：Biometrics

authors： Chen Z,Wang YG

更新日期：2004-12-01 00:00:00

abstract：:Link et al. (2010, Biometrics 66, 178-185) define a general framework for analyzing capture-recapture data with potential misidentifications. In this framework, the observed vector of counts, y, is considered as a linear function of a vector of latent counts, x, such that y=Ax, with x assumed to follow a multinomial d...

journal_title：Biometrics

authors： Schofield MR,Bonner SJ

更新日期：2015-12-01 00:00:00

abstract：:Covariate-specific receiver operating characteristic (ROC) curves are often used to evaluate the classification accuracy of a medical diagnostic test or a biomarker, when the accuracy of the test is associated with certain covariates. In many large-scale screening tests, the gold standard is subject to missingness due...

journal_title：Biometrics

authors： Liu D,Zhou XH

更新日期：2011-09-01 00:00:00

abstract：:Given a large number of t-statistics, we consider the problem of approximating the distribution of noncentrality parameters (NCPs) by a continuous density. This problem is closely related to the control of false discovery rates (FDR) in massive hypothesis testing applications, e.g., microarray gene expression analysis...

journal_title：Biometrics

authors： Qu L,Nettleton D,Dekkers JC

更新日期：2012-12-01 00:00:00

abstract：:If the regulatory requirements are symmetrical, the use of symmetrical confidence intervals as a decision rule for bioequivalence assessment leads, as shown by simulations, to better level properties and an inferior power compared to a rule based on shortest confidence intervals. A choice between these two approaches ...

journal_title：Biometrics

authors： Mandallaz D,Mau J

更新日期：1981-06-01 00:00:00

abstract：:Dynamic treatment regimes (DTRs) aim to formalize personalized medicine by tailoring treatment decisions to individual patient characteristics. G-estimation for DTR identification targets the parameters of a structural nested mean model, known as the blip function, from which the optimal DTR is derived. Despite its po...

journal_title：Biometrics

authors： Wallace MP,Moodie EEM,Stephens DA

更新日期：2019-12-01 00:00:00

abstract：:In an analysis of capture-recapture data, the identification of a model that fits is a critical step. For the multisite (also called multistate) models used to analyze data gathered at several sites, no reliable test for assessing fit is currently available. We propose a test for the JMV model, a simple generalization...

journal_title：Biometrics

authors： Pradel R,Wintrebert CM,Gimenez O

更新日期：2003-03-01 00:00:00

abstract：:We introduce a nearly automatic procedure to locate and count the quantum dots in images of kinesin motor assays. Our procedure employs an approximate likelihood estimator based on a two-component mixture model for the image data; the first component has a normal distribution, and the other component is distributed as...

journal_title：Biometrics

authors： Hughes J,Fricks J

更新日期：2011-06-01 00:00:00

abstract：:For the analysis of time trends in incidence and mortality rates, the age-period-cohort (apc) model has became a widely accepted method. The considered data are arranged in a two-way table by age group and calendar period, which are mostly subdivided into 5- or 10-year intervals. The disadvantage of this approach is t...

journal_title：Biometrics

authors： Heuer C

更新日期：1997-03-01 00:00:00