Abstract:
:Oligonucleotide microarray (DNA chip)-based hybridization analysis is a promising new technology which potentially allows rapid and cost-effective screens for all possible mutations and sequence variations in genomic DNA. Here, I review current strategies and uses for DNA chip-based resequencing and mutational analysis, the underlying principles of experimental designs, and future efforts to improve the sensitivity and specificity of chip-based assays.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Hacia JGdoi
10.1038/4469subject
Has Abstractpub_date
1999-01-01 00:00:00pages
42-7issue
1 Suppleissn
1061-4036issn
1546-1718journal_volume
21pub_type
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