当前位置： SCI文献检索 > NATURE GENETICS期刊下所有文献 > Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Abstract：

:To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.

journal_name

Nat Genet

journal_title

Nature genetics

authors

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium.,Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium.,South Asian Type 2 Diabetes (SAT2D) Consortium.,Mexican American Type 2 Diabetes (MAT2D) Consortium.,

doi

10.1038/ng.2897

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

234-44

issue

3

eissn

1061-4036

issn

1546-1718

pii

ng.2897

journal_volume

46

pub_type

杂志文章,meta分析

相关文献

NATURE GENETICS文献大全
  • Lipid transport and human brain development.

    abstract：:How the human brain rapidly builds up its lipid content during brain growth and maintains its lipids in adulthood has remained elusive. Two new studies show that inactivating mutations in MFSD2A, known to be expressed specifically at the blood-brain barrier, lead to microcephaly, thereby offering a simple and surprisi...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3348

    authors： Betsholtz C

    更新日期：2015-07-01 00:00:00

  • Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.

    abstract：:The cardiac homeobox protein Nkx2-5 is essential in cardiac development, and mutations in Csx (which encodes Nkx2-5) cause various congenital heart diseases. Using the yeast two-hybrid system with Nkx2-5 as the 'bait', we isolated the T-box-containing transcription factor Tbx5; mutations in TBX5 cause heart and limb m...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/90123

    authors： Hiroi Y,Kudoh S,Monzen K,Ikeda Y,Yazaki Y,Nagai R,Komuro I

    更新日期：2001-07-01 00:00:00

  • Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency.

    abstract：:All molybdoenzymes other than nitrogenase require molybdopterin as a metal-binding cofactor. Several genes necessary for the synthesis of the molybdenum cofactor (MoCo) have been characterized in bacteria and plants. The proteins encoded by the Escherichia coli genes moaA and moaC catalyse the first steps in MoCo synt...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/1706

    authors： Reiss J,Cohen N,Dorche C,Mandel H,Mendel RR,Stallmeyer B,Zabot MT,Dierks T

    更新日期：1998-09-01 00:00:00

  • Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans.

    abstract：:More than 5 million single-nucleotide polymorphisms (SNPs) with minor-allele frequency greater than 10% are expected to exist in the human genome. Some of these SNPs may be associated with risk of developing common diseases. To assess the power of currently available SNPs to detect such associations, we resequenced 50...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1128

    authors： Carlson CS,Eberle MA,Rieder MJ,Smith JD,Kruglyak L,Nickerson DA

    更新日期：2003-04-01 00:00:00

  • Soundbites.

    abstract：:Dentinogenesis imperfecta (DGI) is characterized by discolored teeth with an opalescent sheen and dentin that fails to support enamel, causing it to easily chip. Two new studies show that DGI is associated with mutations in DSPP, a gene encoding dentin sialophosphoprotein that is processed into two proteins: dentin si...

    journal_title：Nature genetics

    pub_type： 评论,杂志文章

    doi：10.1038/84728

    authors： Patel P

    更新日期：2001-02-01 00:00:00

  • Analysis of the coding genome of diffuse large B-cell lymphoma.

    abstract：:Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. Although a number of structural alterations have been associated with the pathogenesis of this malignancy, the full spectrum of genetic lesions that are present in the DLBCL genome, and therefore the identity of dysregulated cellular path...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.892

    authors： Pasqualucci L,Trifonov V,Fabbri G,Ma J,Rossi D,Chiarenza A,Wells VA,Grunn A,Messina M,Elliot O,Chan J,Bhagat G,Chadburn A,Gaidano G,Mullighan CG,Rabadan R,Dalla-Favera R

    更新日期：2011-07-31 00:00:00

  • Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.

    abstract：:Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people. Although 4 million people are bilaterally blind from ACG, the causative molecular mechanisms of ACG remain to be defined. High intraocular pressure induces glaucoma in ACG. High intraocular pressure traditionally was suggested to result ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.813

    authors： Nair KS,Hmani-Aifa M,Ali Z,Kearney AL,Ben Salem S,Macalinao DG,Cosma IM,Bouassida W,Hakim B,Benzina Z,Soto I,Söderkvist P,Howell GR,Smith RS,Ayadi H,John SW

    更新日期：2011-06-01 00:00:00

  • Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa.

    abstract：:Junctional epidermolysis bullosa (JEB) is a heterogeneous autosomal recessively inherited blistering skin disorder associated with fragility at the dermal-epidermal junction. Characteristic ultrastructural findings in JEB are abnormalities in the hemidesmosome-anchoring filament complexes. These focal attachment struc...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0995-83

    authors： McGrath JA,Gatalica B,Christiano AM,Li K,Owaribe K,McMillan JR,Eady RA,Uitto J

    更新日期：1995-09-01 00:00:00

  • Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome.

    abstract：:The overgrowth- and tumor-associated Beckwith-Wiedemann syndrome results from dysregulation of imprinted genes on chromosome 11p15.5. Here we show that inherited microdeletions in the H19 differentially methylated region (DMR) that abolish two CTCF target sites cause this disease. Maternal transmission of the deletion...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1410

    authors： Sparago A,Cerrato F,Vernucci M,Ferrero GB,Silengo MC,Riccio A

    更新日期：2004-09-01 00:00:00

  • Lung cancer susceptibility locus at 5p15.33.

    abstract：:We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.254

    authors： McKay JD,Hung RJ,Gaborieau V,Boffetta P,Chabrier A,Byrnes G,Zaridze D,Mukeria A,Szeszenia-Dabrowska N,Lissowska J,Rudnai P,Fabianova E,Mates D,Bencko V,Foretova L,Janout V,McLaughlin J,Shepherd F,Montpetit A,Narod S

    更新日期：2008-12-01 00:00:00

  • A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients.

    abstract：:It is generally assumed that the male:female (M:F) ratio in patients with type 1 (insulin-dependent) diabetes mellitus (IDDM) is 1. A recent survey, however, revealed that high incidence countries (mainly European) have a high M:F ratio and low incidence ones (Asian and African) have a low M:F ratio. We have now analy...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/995

    authors： Cucca F,Goy JV,Kawaguchi Y,Esposito L,Merriman ME,Wilson AJ,Cordell HJ,Bain SC,Todd JA

    更新日期：1998-07-01 00:00:00

  • Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

    abstract：:Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European anc...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.941

    authors： Soler Artigas M,Loth DW,Wain LV,Gharib SA,Obeidat M,Tang W,Zhai G,Zhao JH,Smith AV,Huffman JE,Albrecht E,Jackson CM,Evans DM,Cadby G,Fornage M,Manichaikul A,Lopez LM,Johnson T,Aldrich MC,Aspelund T,Barroso I,Cam

    更新日期：2011-09-25 00:00:00

  • Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity.

    abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, replicates as an intracellular parasite of amoebae and persists in the environment as a free-living microbe. Here we have analyzed the complete genome sequences of L. pneumophila Paris (3,503,610 bp, 3,077 genes), an endemic strain that is predomina...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1447

    authors： Cazalet C,Rusniok C,Brüggemann H,Zidane N,Magnier A,Ma L,Tichit M,Jarraud S,Bouchier C,Vandenesch F,Kunst F,Etienne J,Glaser P,Buchrieser C

    更新日期：2004-11-01 00:00:00

  • Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage.

    abstract：:Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng.3195

    authors： Merker M,Blin C,Mona S,Duforet-Frebourg N,Lecher S,Willery E,Blum MG,Rüsch-Gerdes S,Mokrousov I,Aleksic E,Allix-Béguec C,Antierens A,Augustynowicz-Kopeć E,Ballif M,Barletta F,Beck HP,Barry CE 3rd,Bonnet M,Borroni E,

    更新日期：2015-03-01 00:00:00

  • Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy.

    abstract：:DNA repair defects in the xeroderma pigmentosum (XP) group D complementation group can be associated with the clinical features of two quite different disorders; XP, a sun-sensitive and cancer-prone disorder, or trichothiodystrophy (TTD) which is characterized by sulphur-deficient brittle hair and a variety of other a...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0694-189

    authors： Broughton BC,Steingrimsdottir H,Weber CA,Lehmann AR

    更新日期：1994-06-01 00:00:00

  • Polygenic control of autoimmune diabetes in nonobese diabetic mice.

    abstract：:Partial exclusion mapping of the nonobese (NOD) diabetic mouse genome has shown linkage of diabetes to at least five different chromosomes. We have now excluded almost all of the genome for the presence of susceptibility genes with fully recessive effects and have obtained evidence of linkage of ten distinct loci to d...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0893-404

    authors： Ghosh S,Palmer SM,Rodrigues NR,Cordell HJ,Hearne CM,Cornall RJ,Prins JB,McShane P,Lathrop GM,Peterson LB

    更新日期：1993-08-01 00:00:00

  • Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors.

    abstract：:Tumor mutational burden correlates with response to immune checkpoint blockade in multiple solid tumors, although in microsatellite-stable tumors this association is of uncertain clinical utility. Here we uniformly analyzed whole-exome sequencing (WES) of 249 tumors and matched normal tissue from patients with clinica...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-018-0200-2

    authors： Miao D,Margolis CA,Vokes NI,Liu D,Taylor-Weiner A,Wankowicz SM,Adeegbe D,Keliher D,Schilling B,Tracy A,Manos M,Chau NG,Hanna GJ,Polak P,Rodig SJ,Signoretti S,Sholl LM,Engelman JA,Getz G,Jänne PA,Haddad RI,Chouei

    更新日期：2018-09-01 00:00:00

  • The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA.

    abstract：:Mitochondrial DNA (mtDNA)-depletion syndromes (MDS; OMIM 251880) are phenotypically heterogeneous, autosomal-recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of MDS have early progressive liver failure and neurological abnormalities,...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng746

    authors： Mandel H,Szargel R,Labay V,Elpeleg O,Saada A,Shalata A,Anbinder Y,Berkowitz D,Hartman C,Barak M,Eriksson S,Cohen N

    更新日期：2001-11-01 00:00:00

  • Minisatellite diversity supports a recent African origin for modern humans.

    abstract：:In a study of human diversity at a highly variable locus, we have mapped the internal structures of tandem-repetitive alleles from different populations at the minisatellite MS205 (D16S309). The results give an unusually detailed view of the different allelic structures represented on modern human chromosomes, and of ...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0696-154

    authors： Armour JA,Anttinen T,May CA,Vega EE,Sajantila A,Kidd JR,Kidd KK,Bertranpetit J,Pääbo S,Jeffreys AJ

    更新日期：1996-06-01 00:00:00

  • iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

    abstract：:We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. We have further shown that 53BP2, which corresponds to a C-terminal fragment of ASPP2, acts as a dominant negative inhibitor of p5...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1070

    authors： Bergamaschi D,Samuels Y,O'Neil NJ,Trigiante G,Crook T,Hsieh JK,O'Connor DJ,Zhong S,Campargue I,Tomlinson ML,Kuwabara PE,Lu X

    更新日期：2003-02-01 00:00:00

  • A reference genome for pea provides insight into legume genome evolution.

    abstract：:We report the first annotated chromosome-level reference genome assembly for pea, Gregor Mendel's original genetic model. Phylogenetics and paleogenomics show genomic rearrangements across legumes and suggest a major role for repetitive elements in pea genome evolution. Compared to other sequenced Leguminosae genomes,...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-019-0480-1

    authors： Kreplak J,Madoui MA,Cápal P,Novák P,Labadie K,Aubert G,Bayer PE,Gali KK,Syme RA,Main D,Klein A,Bérard A,Vrbová I,Fournier C,d'Agata L,Belser C,Berrabah W,Toegelová H,Milec Z,Vrána J,Lee H,Kougbeadjo A,Térézol

    更新日期：2019-09-01 00:00:00

  • Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.

    abstract：:Restless legs syndrome (RLS) is a frequent neurological disorder characterized by an imperative urge to move the legs during night, unpleasant sensation in the lower limbs, disturbed sleep and increased cardiovascular morbidity. In a genome-wide association study we found highly significant associations between RLS an...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng2099

    authors： Winkelmann J,Schormair B,Lichtner P,Ripke S,Xiong L,Jalilzadeh S,Fulda S,Pütz B,Eckstein G,Hauk S,Trenkwalder C,Zimprich A,Stiasny-Kolster K,Oertel W,Bachmann CG,Paulus W,Peglau I,Eisensehr I,Montplaisir J,Turecki G

    更新日期：2007-08-01 00:00:00

  • Mammalian ultraconserved elements are strongly depleted among segmental duplications and copy number variants.

    abstract：:An earlier search in the human, mouse and rat genomes for sequences that are 100% conserved in orthologous segments and > or = 200 bp in length identified 481 distinct sequences. These human-mouse-rat sequences, which represent ultraconserved elements (UCEs), are believed to be important for functions involving DNA bi...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1888

    authors： Derti A,Roth FP,Church GM,Wu CT

    更新日期：2006-10-01 00:00:00

  • Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis.

    abstract：:The GM2 gangliosidoses, Tay-Sachs and Sandhoff diseases, are caused by mutations in the HEXA (alpha-subunit) and HEXB (beta-subunit) genes, respectively. Each gene encodes a subunit for the heterodimeric lysosomal enzyme, beta-hexosaminidase A (alpha beta), as well as for the homodimers beta-hexosaminidase B (beta bet...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng1196-348

    authors： Sango K,McDonald MP,Crawley JN,Mack ML,Tifft CJ,Skop E,Starr CM,Hoffmann A,Sandhoff K,Suzuki K,Proia RL

    更新日期：1996-11-01 00:00:00

  • Author Correction: The copy number variation landscape of congenital anomalies of the kidney and urinary tract.

    abstract：:In the version of this article initially published, affiliation 38 incorrectly read "ICNU-Nephrology and Urology Department, Barcelona, Spain"; "Renal Division, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain" is the correct affiliation. The error has been corrected in the HTML and PDF versions of ...

    journal_title：Nature genetics

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41588-019-0376-0

    authors： Verbitsky M,Westland R,Perez A,Kiryluk K,Liu Q,Krithivasan P,Mitrotti A,Fasel DA,Batourina E,Sampson MG,Bodria M,Werth M,Kao C,Martino J,Capone VP,Vivante A,Shril S,Kil BH,Marasa M,Zhang JY,Na YJ,Lim TY,Ahram

    更新日期：2019-04-01 00:00:00

  • Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.

    abstract：:To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = ...

    journal_title：Nature genetics

    pub_type： 杂志文章,meta分析

    doi：10.1038/ng.567

    authors： Freathy RM,Mook-Kanamori DO,Sovio U,Prokopenko I,Timpson NJ,Berry DJ,Warrington NM,Widen E,Hottenga JJ,Kaakinen M,Lange LA,Bradfield JP,Kerkhof M,Marsh JA,Mägi R,Chen CM,Lyon HN,Kirin M,Adair LS,Aulchenko YS,Benne

    更新日期：2010-05-01 00:00:00

  • Recombination and linkage disequilibrium in Arabidopsis thaliana.

    abstract：:Linkage disequilibrium (LD) is a major aspect of the organization of genetic variation in natural populations. Here we describe the genome-wide pattern of LD in a sample of 19 Arabidopsis thaliana accessions using 341,602 non-singleton SNPs. LD decays within 10 kb on average, considerably faster than previously estima...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng2115

    authors： Kim S,Plagnol V,Hu TT,Toomajian C,Clark RM,Ossowski S,Ecker JR,Weigel D,Nordborg M

    更新日期：2007-09-01 00:00:00

  • PKD1 interacts with PKD2 through a probable coiled-coil domain.

    abstract：:Autosomal dominant polycystic kidney disease (ADPKD) describes a group of at least three genetically distinct disorders with almost identical clinical features that collectively affects 1:1,000 of the population. Affected individuals typically develop large cystic kidneys and approximately one half develop end-stage r...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0697-179

    authors： Qian F,Germino FJ,Cai Y,Zhang X,Somlo S,Germino GG

    更新日期：1997-06-01 00:00:00

  • Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes.

    abstract：:The human genome can be segmented into topologically associating domains (TADs), which have been proposed to spatially sequester genes and regulatory elements through chromatin looping. Interactions between TADs have also been suggested, presumably because of variable boundary positions across individual cells. Howeve...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/s41588-020-0647-9

    authors： Luppino JM,Park DS,Nguyen SC,Lan Y,Xu Z,Yunker R,Joyce EF

    更新日期：2020-08-01 00:00:00

  • Integrated human genome-wide maps constructed using the CEPH reference panel.

    abstract：:High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were construc...

    journal_title：Nature genetics

    pub_type： 杂志文章

    doi：10.1038/ng0494-391

    authors： Buetow KH,Weber JL,Ludwigsen S,Scherpbier-Heddema T,Duyk GM,Sheffield VC,Wang Z,Murray JC

    更新日期：1994-04-01 00:00:00