Variation in the pattern of nucleotide substitution across sites.

abstract：:Selection pressures on proteins are usually measured by comparing homologous nucleotide sequences (Zuckerkandl and Pauling 1965). Recently we introduced a novel method, termed volatility, to estimate selection pressures on proteins on the basis of their synonymous codon usage (Plotkin and Dushoff 2003; Plotkin et al. ...

journal_title：Journal of molecular evolution

authors： Plotkin JB,Dushoff J,Desai MM,Fraser HB

更新日期：2006-11-01 00:00:00

abstract：:Amino acid substitution models represent substitution rates among amino acids during the evolution. The models play an important role in analyzing protein sequences, especially inferring phylogenies. The rapid evolution of flaviviruses is expanding the threat in public health. A number of models have been estimated fo...

journal_title：Journal of molecular evolution

authors： Le TK,Vinh LS

更新日期：2020-07-01 00:00:00

abstract：:The evolutionary relationships among arthropod hemocyanins and insect hexamerins were investigated. A multiple sequence alignment of 12 hemocyanin and 31 hexamerin subunits was constructed and used for studying sequence conservation and protein phylogeny. Although hexamerins and hemocyanins belong to a highly divergen...

journal_title：Journal of molecular evolution

authors： Burmester T,Massey HC Jr,Zakharkin SO,Benes H

更新日期：1998-07-01 00:00:00

abstract：:We have determined the genomic structure of an integrin beta-subunit gene from the coral, Acropora millepora. The coding region of the gene contains 26 introns, spaced relatively uniformly, and this is significantly more than have been found in any integrin beta-subunit genes from higher animals. Twenty-five of the 26...

journal_title：Journal of molecular evolution

authors： Schmitt DM,Brower DL

更新日期：2001-12-01 00:00:00

abstract：:Translation termination is catalyzed by release factors that recognize stop codons. However, previous works have shown that in some bacteria, the termination process also involves bases around stop codons. Recently, Ito et al. analyzed release factors and identified the amino acids therein that recognize stop codons. ...

journal_title：Journal of molecular evolution

authors： Ozawa Y,Saito R,Washio T,Tomita M

更新日期：2003-06-01 00:00:00

abstract：:Available molecular and biochemical data offer conflicting evidence for the origin of the cyanelle of Cyanophora paradoxa. We show that the similarity of cyanelle and green chloroplast sequences is probably a result of these two lineages independently developing the same pattern of directional nucleotide change (subst...

journal_title：Journal of molecular evolution

authors： Lockhart PJ,Howe CJ,Bryant DA,Beanland TJ,Larkum AW

更新日期：1992-02-01 00:00:00

abstract：:Fox and Woese (1975a) have shown that a model of 5S RNA secondary structure similar to the one originally derived for Chlorella 5S RNA can be generalized with relatively minor variations to all sequenced 5S RNA molecules, i.e. that corresponding base paired regions can be formed at approximately the same positions. We...

journal_title：Journal of molecular evolution

authors： Vigne R,Jordan BR

更新日期：1977-09-20 00:00:00

abstract：:Since the genetic code first was determined, many have claimed that it is organized adaptively, so as to assign similar codons to similar amino acids. This claim has proved difficult to establish due to the absence of relevant comparative data on alternative primordial codes and of objective measures of amino acid exc...

journal_title：Journal of molecular evolution

authors： Stoltzfus A,Yampolsky LY

更新日期：2007-10-01 00:00:00

abstract：:Computational and experimental attempts tried to characterize a universal core of genes representing the minimal set of functional needs for an organism. Based on the increasing number of available complete genomes, comparative genomics has concluded that the universal core contains < 50 genes. In contrast, experiment...

journal_title：Journal of molecular evolution

authors： Carbone A

更新日期：2006-12-01 00:00:00

abstract：:Four genes in the P450 IID gene subfamily were isolated from Sprague-Dawley rat lambda EMBL 3 and Charon 4A genomic libraries and completely sequenced. Their transcription start sites were determined by primer extension analysis. The four genes designated IID2, IID3, IID4, and IID5 span 4036, 4371, 4678, and 4567 bp, ...

journal_title：Journal of molecular evolution

authors： Matsunaga E,Umeno M,Gonzalez FJ

更新日期：1990-02-01 00:00:00

abstract：:Complement control proteins (CCPs) contain repeated protein domains, short consensus repeats (SCRs), which must be relevant to diverse functions such as complement activation, coagulation, viral binding, fetal implantation, and self-nonself recognition. Although SCRs share some discontinuous and imperfect motifs, ther...

journal_title：Journal of molecular evolution

authors： McLure CA,Dawkins RL,Williamson JF,Davies RA,Berry J,Natalie LJ,Laird R,Gaudieri S

更新日期：2004-08-01 00:00:00

abstract：:Analysis of cDNAs from Macrovipera lebetina transmediterranea (Mlt) and Echis ocellatus (Eo) venom gland libraries encoding disintegrins argued strongly for a common ancestry of the messengers of short disintegrins and those for precursors of dimeric disintegrin chains. We now report the sequence analysis of disintegr...

journal_title：Journal of molecular evolution

authors： Bazaa A,Juárez P,Marrakchi N,Bel Lasfer Z,El Ayeb M,Harrison RA,Calvete JJ,Sanz L

更新日期：2007-02-01 00:00:00

abstract：:A 2550-bp portion of the mitochondrial genome of a Demosponge, genus Tetilla, was amplified from whole genomic DNA extract and sequenced. The sequence was found to code for the 3' end of the 16S rRNA gene, cytochrome c oxidase subunit II, a lysine tRNA, ATPase subunit 8, and a 5' portion of ATPase subunit 6. The Porif...

journal_title：Journal of molecular evolution

authors： Watkins RF,Beckenbach AT

更新日期：1999-05-01 00:00:00

abstract：:Examination of the mitochondrial small subunit ribosomal RNA (rns) gene of five species of the fungal genus Leptographium revealed that the gene has been invaded at least once at position 952 by a group II intron encoding a LAGLIDADG homing endonuclease gene. Phylogenetic analyses of the intron and homing endonuclease...

journal_title：Journal of molecular evolution

authors： Mullineux ST,Willows K,Hausner G

更新日期：2011-06-01 00:00:00

abstract：:The diversity of functional genes and the related processes are important issues for conservation biology. This is especially relevant for populations that have suffered from demographic reduction as a consequence of the processes of postglacial colonization. In this perspective, the aims of the present study are (1) ...

journal_title：Journal of molecular evolution

authors： Girard P,Angers B

更新日期：2011-08-01 00:00:00

abstract：:We have determined the nucleotide sequence of the 26S large subunit (LSU) rRNA genes for two Tetrahymena species, T. thermophila and T. pyriformis. The inferred rRNA sequences are presented in their most probable secondary structures based on compensatory mutations, energy, and conservation criteria. The majority of t...

journal_title：Journal of molecular evolution

authors： Engberg J,Nielsen H,Lenaers G,Murayama O,Fujitani H,Higashinakagawa T

更新日期：1990-06-01 00:00:00

abstract：:Intron-encoded U17 RNA is a member of the H/ACA box class of small nucleolar RNAs (snoRNAs) involved in ribosomal RNA (rRNA) maturation. U17 snoRNA shows typical characteristics of guide RNAs, which specify sites of pseudouridylation on the precursor rRNA (pre-rRNA). However, in spite of the presence of H and ACA boxe...

journal_title：Journal of molecular evolution

authors： Cervelli M,Cecconi F,Giorgi M,Annesi F,Oliverio M,Mariottini P

更新日期：2002-02-01 00:00:00

abstract：:Hemoglobin Vancouver is a new abnormal hemoglobin with an amino acid substitution of the normal aspartyl residue 73 of the beta chain by a tyrosyl residue. It was discovered in a man of Chinese descent in association with beta thalassemia. It was subsequently detected in a sister in association with normal Hb A. The o...

journal_title：Journal of molecular evolution

authors： Jones RT,Brimhall B,Pootrakul S,Gray G

更新日期：1976-12-31 00:00:00

abstract：:We have used three reference sequences representative of bacterial drug resistance pumps and sugar transport proteins to collect the 91 most closely related sequences from a composite, nonredundant protein sequence database. Having eliminated certain very close relatives, the remainder were subjected to analysis and a...

journal_title：Journal of molecular evolution

authors： Parish JH,Bentley J

更新日期：1996-02-01 00:00:00

abstract：:We constructed a cDNA library for the beetle, Tribolium castaneum. This library was screened using a cloned amylase gene from Drosophila melanogaster as a molecular probe. Beetle amylase cDNA clones were isolated from this bank, and the nucleotide sequence was obtained for a cDNA clone with a coding capacity for 228 a...

journal_title：Journal of molecular evolution

authors： Hickey DA,Benkel BF,Boer PH,Genest Y,Abukashawa S,Ben-David G

更新日期：1987-01-01 00:00:00

abstract：:Synonymous codon usage in yeast appears to be influenced by natural selection on gene expression, as well as regional variation in compositional bias. Because of the large number of potential targets of selection (i.e., most of the codons in the genome) and presumed small selection coefficients, codon usage is an exce...

journal_title：Journal of molecular evolution

authors： Kliman RM,Irving N,Santiago M

更新日期：2003-07-01 00:00:00

abstract：:Several studies in Drosophila have shown a paucity of male-biased genes (i.e., genes that express higher in males than in females) on the X chromosome. Dosage compensation (DC) is a regulatory mechanism of gene expression triggered in males that hypertranscribes the X-linked genes to the level of transcription in fema...

journal_title：Journal of molecular evolution

authors： Gallach M,Betrán E

更新日期：2016-05-01 00:00:00

abstract：:Abortive cycling features transcription initiation by RNA polymerase in both prokaryote and eukaryote. It is known that T7 RNA polymerase produces abortive transcripts up to eight ribonucleotides in length depending on the initial sequence of the DNA message. On the other hand, T7 RNA polymerase initiates DNA replicat...

journal_title：Journal of molecular evolution

authors： Matsumoto J

更新日期：1994-12-01 00:00:00

abstract：:Studies so far have correlated the variation in the composition of snake venoms with the target prey population and snake's diet. Here we present the first example of an alternative evolutionary link between venom composition and dietary adaptation of snakes. We describe a dinucleotide deletion in the only three finge...

journal_title：Journal of molecular evolution

authors： Li M,Fry BG,Kini RM

更新日期：2005-01-01 00:00:00

abstract：:Introns are generally believed to evolve too rapidly and too erratically to be of much use in phylogenetic reconstructions. Few phylogenetically informative intron sequences are available, however, to ascertain the validity of this supposition. In the present study the supposition was tested on the example of the mamm...

journal_title：Journal of molecular evolution

authors： Kupfermann H,Satta Y,Takahata N,Tichy H,Klein J

更新日期：1999-06-01 00:00:00

abstract：:Two types of gene encoding small subunits (SSU) of ADP-glucose pyrophosphorylase, a starch-biosynthetic enzyme, have been found in cereals and other grasses. One of these genes encodes two SSU proteins. These are targeted to different subcellular compartments and expressed in different organs of the plant: the endospe...

journal_title：Journal of molecular evolution

authors： Rösti S,Denyer K

更新日期：2007-09-01 00:00:00

abstract：:The retrieval of Neanderthal (Homo neanderthalsensis) mitochondrial DNA is thought to be among the most significant ancient DNA contributions to date, allowing conflicting hypotheses on modern human (Homo sapiens) evolution to be tested directly. Recently, however, both the authenticity of the Neanderthal sequences an...

journal_title：Journal of molecular evolution

authors： Hebsgaard MB,Wiuf C,Gilbert MT,Glenner H,Willerslev E

更新日期：2007-01-01 00:00:00

abstract：:Fish protamines are highly specialized molecules which are responsible for chromatin condensation during the last stages of spermatogenesis (spermiogenesis). However, not all fish contain protamines in their sperm nuclei; rather, there seems to be a random distribution of protamines within this group. The origin of th...

journal_title：Journal of molecular evolution

authors： Saperas N,Ausio J,Lloris D,Chiva M

更新日期：1994-09-01 00:00:00

abstract：:The simple codominant expression of the alleles at the self-incompatibility locus ( S) of Solanaceae and their extraordinary spectrum of sequence diversity present an ideal case for understanding the molecular forces that shape the sequence polymorphism of genes involved in recognition reactions. Here, with unpreceden...

journal_title：Journal of molecular evolution

authors： Lu Y

更新日期：2002-06-01 00:00:00

abstract：:Antibody binding site are formed by six hypervariable regions or complementarity determining regions (CDRs). The CDRs, three from the heavy chain and three from the light chain, are known as hypervariable segments and provide a surface complementary to that of the epitope. In recent work it was found that the amino ac...

journal_title：Journal of molecular evolution

authors： Vargas-Madrazo E,Lara-Ochoa F,Jiménez-Montaño M

更新日期：1994-01-01 00:00:00