5-oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of L-selectin shedding, surface expression of CD11b, actin polymerization, and calcium mobilization in human eosinophils.

abstract：:Combustion-generated radicals interact to form polynuclear aromatic hydrocarbons (PAHs), including carcinogens. PAHs aggregate into 20- to 50-nm particles, which extend into branched-chain structures (soots). Incomplete combustion yields black soot particles and black smoke. Many PAHs, including those in soots, fluore...

journal_title：American journal of respiratory cell and molecular biology

authors： Murphy G Jr,Rouse RL,Polk WW,Henk WG,Barker SA,Boudreaux MJ,Floyd ZE,Penn AL

更新日期：2008-05-01 00:00:00

abstract：:IL-27 is involved in inflammatory reactions. CXCL10 is an important chemokine contributing to airway inflammatory disease. In this study, we investigated whether IL-27 modulated the synthesis of CXCL10 in primary human lung fibroblasts (HLFs). HLFs were activated by IL-27 alone, or in combination with other cytokines....

journal_title：American journal of respiratory cell and molecular biology

authors： Dong S,Zhang X,He Y,Xu F,Li D,Xu W,Wang H,Yin Y,Cao J

更新日期：2013-04-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) was the original "second messenger" to be discovered. Its formation is promoted by adenylyl cyclase activation after ligation of G protein-coupled receptors by ligands including hormones, autocoids, prostaglandins, and pharmacologic agents. Increases in intracellular cAMP generall...

journal_title：American journal of respiratory cell and molecular biology

authors： Serezani CH,Ballinger MN,Aronoff DM,Peters-Golden M

更新日期：2008-08-01 00:00:00

abstract：:Humans and rodents exposed to an aerosol of asbestos fibers develop lung injury that can lead to a fibroproliferative response culminating in excessive scarring and impaired lung function. To define the early events that precede asbestos-induced fibrotic lung disease, rats were exposed to an aerosol of chrysotile asbe...

journal_title：American journal of respiratory cell and molecular biology

authors： Mishra A,Liu JY,Brody AR,Morris GF

更新日期：1997-04-01 00:00:00

abstract：:Rat alveolar type II pneumocytes, in situ, label with Maclura pomifera agglutinin (MPA), a plant lectin that recognizes alpha-galactosyl oligosaccharide residues of glycoproteins and glycolipids. To study the glycoproteins recognized by the lectin, MPA lectin affinity chromatography was used to isolate a novel glycopr...

journal_title：American journal of respiratory cell and molecular biology

authors： Lwebuga-Mukasa JS

更新日期：1991-06-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a fatal disorder resulting from the progressive remodeling of lungs, with no known effective treatment. Although transforming growth factor (TGF)-β has a well-established role in lung fibrosis, clinical experience with neutralizing antibodies to TGF-β has been disappointing, and ...

journal_title：American journal of respiratory cell and molecular biology

authors： Das S,Kumar M,Negi V,Pattnaik B,Prakash YS,Agrawal A,Ghosh B

更新日期：2014-05-01 00:00:00

abstract：:In these studies, we examined signaling through the transcription factor STAT5 in human peripheral blood eosinophils after treatment with granulocyte macrophage colony-stimulating factor (GM-CSF) or interleukin (IL)-5. In response to either cytokine, STAT5 was rapidly tyrosine phosphorylated and acquired interferon ga...

journal_title：American journal of respiratory cell and molecular biology

authors： Bhattacharya S,Stout BA,Bates ME,Bertics PJ,Malter JS

更新日期：2001-03-01 00:00:00

abstract：:Chloride (Cl(-)) movement across fetal lung epithelia is thought to be mediated by the sodium-potassium-2-Cl(-) cotransporter NKCC1. We studied the role of NKCC1 in Cl(-) and liquid secretion in late-gestation NKCC-null (-/-) and littermate control fetal mouse lung. NKCC -/- mice had decreased lung water compared with...

journal_title：American journal of respiratory cell and molecular biology

authors： Gillie DJ,Pace AJ,Coakley RJ,Koller BH,Barker PM

更新日期：2001-07-01 00:00:00

abstract：:Recent evidence suggests that tyrosine kinases play an important role in signal transduction mechanisms utilized by a range of different agonists in many cell types. We have investigated the effects of four different inhibitors of tyrosine kinases on IgE-dependent histamine release from human lung mast cells and basop...

journal_title：American journal of respiratory cell and molecular biology

authors： Lavens SE,Peachell PT,Warner JA

更新日期：1992-12-01 00:00:00

abstract：:Pulmonary fibrosis is an enigmatic and devastating disease with few treatment options, now thought to result from abnormal wound healing in the lung in response to injury. We have previously noted a role for the chemokine interferon gamma-inducible protein of 10 kD (IP-10)/CXC chemokine ligand 10 in the regulation of ...

journal_title：American journal of respiratory cell and molecular biology

authors： Tager AM,Kradin RL,LaCamera P,Bercury SD,Campanella GS,Leary CP,Polosukhin V,Zhao LH,Sakamoto H,Blackwell TS,Luster AD

更新日期：2004-10-01 00:00:00

abstract：:The cells/proteases responsible for the development of smoke-induced emphysema is an area of intense investigation. Mice with knockout of macrophage metalloelastase genes (MME(-/-)) do not develop emphysema after smoke exposure, but we also observed that neutrophils (PMN) in lavage appeared to be a requirement for acu...

journal_title：American journal of respiratory cell and molecular biology

authors： Churg A,Zay K,Shay S,Xie C,Shapiro SD,Hendricks R,Wright JL

更新日期：2002-09-01 00:00:00

abstract：:The hydroxyl radical (.OH) is a highly reactive oxygen free radical that has been implicated as a cause of lung injury following exposure to silica and silicates. Despite evidence that silica generates .OH in vitro, there has been no previous demonstration of in vivo production of .OH after exposure to nonfibrous mine...

journal_title：American journal of respiratory cell and molecular biology

authors： Schapira RM,Ghio AJ,Effros RM,Morrisey J,Almagro UA,Dawson CA,Hacker AD

更新日期：1995-02-01 00:00:00

abstract：:Dendritic cells (DCs) play a pivotal role in shaping antiviral immune responses in the respiratory tract. Human metapneumovirus (hMPV) is a recently identified pathogen and like its better known relative, respiratory syncytial virus (RSV), has been increasingly recognized as a major cause of respiratory morbidity in i...

journal_title：American journal of respiratory cell and molecular biology

authors： Guerrero-Plata A,Casola A,Suarez G,Yu X,Spetch L,Peeples ME,Garofalo RP

更新日期：2006-03-01 00:00:00

abstract：:Receptors for advanced glycation end-products (RAGEs) are multiligand cell surface receptors highly expressed in the lung that contribute to alveolar epithelial cell differentiation during embryogenesis and the modulation of pulmonary inflammation during disease. When RAGEs are overexpressed throughout embryogenesis, ...

journal_title：American journal of respiratory cell and molecular biology

authors： Stogsdill JA,Stogsdill MP,Porter JL,Hancock JM,Robinson AB,Reynolds PR

更新日期：2012-07-01 00:00:00

abstract：:Studies in animals and in human atopic skin suggest that allergen challenge may activate acute tissue remodeling changes via transforming growth factor-beta pathways. We determined whether inhalational allergen challenge in subjects with mild asthma induces similar acute changes to the airway epithelial mesenchymal tr...

journal_title：American journal of respiratory cell and molecular biology

authors： Phipps S,Benyahia F,Ou TT,Barkans J,Robinson DS,Kay AB

更新日期：2004-12-01 00:00:00

abstract：:Recent studies have indicated that, during the development of pulmonary hypertension (PH), there is a switch from oxidative phosphorylation to glycolysis in the pulmonary endothelium. However, the mechanisms underlying this phenomenon have not been elucidated. Endothelin (ET)-1, an endothelial-derived vasoconstrictor ...

journal_title：American journal of respiratory cell and molecular biology

authors： Sun X,Kumar S,Sharma S,Aggarwal S,Lu Q,Gross C,Rafikova O,Lee SG,Dasarathy S,Hou Y,Meadows ML,Han W,Su Y,Fineman JR,Black SM

更新日期：2014-06-01 00:00:00

abstract：:We hypothesized that, as in animal models, localized deposition of antigen into the human lung would induce local inflammatory and immune responses in antigen-exposed sites. To test this hypothesis, segmental instillation of a well-characterized, highly immunogenic, soluble antigen, keyhole limpet hemocyanin (KLH) was...

journal_title：American journal of respiratory cell and molecular biology

authors： Weissman DN,Bice DE,Crowell RE,Schuyler MR

更新日期：1994-11-01 00:00:00

abstract：:Recently, investigators demonstrated associations between fine particulate matter (PM)-associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product of fossil fuel combustion from boilers, is rich in the transition metals Fe, Ni, and V, and when released as a fugitive particle, is an impor...

journal_title：American journal of respiratory cell and molecular biology

authors： Farraj AK,Hazari MS,Haykal-Coates N,Lamb C,Winsett DW,Ge Y,Ledbetter AD,Carll AP,Bruno M,Ghio A,Costa DL

更新日期：2011-02-01 00:00:00

abstract：:Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease. Cigarette smoking is the primary risk factor for the development of chronic obstructive pulmonary disease, and 25% of individuals with asthma smoke. Smokers experience both longer and more severe colds. We previously sho...

journal_title：American journal of respiratory cell and molecular biology

authors： Hudy MH,Traves SL,Proud D

更新日期：2014-03-01 00:00:00

abstract：:Remodeling of the airways, as occurs in asthmatic patients, is associated with the continual presence of inflammatory mediators and Th2 cytokines, especially interleukin (IL)-13, during cycles of epithelial injury and repair. In this study, we examined the effect of IL-13 on well-differentiated normal human bronchial ...

journal_title：American journal of respiratory cell and molecular biology

authors： Booth BW,Adler KB,Bonner JC,Tournier F,Martin LD

更新日期：2001-12-01 00:00:00

abstract：:The application of conditional reprogramming culture (CRC) methods to nasal airway epithelial cells would allow more wide-spread incorporation of primary airway epithelial culture models into complex lung disease research. In this study, we adapted the CRC method to nasal airway epithelial cells, investigated the grow...

journal_title：American journal of respiratory cell and molecular biology

authors： Reynolds SD,Rios C,Wesolowska-Andersen A,Zhuang Y,Pinter M,Happoldt C,Hill CL,Lallier SW,Cosgrove GP,Solomon GM,Nichols DP,Seibold MA

更新日期：2016-09-01 00:00:00

abstract：:Vitamin A deficiency strongly predicts the risk of developing tuberculosis (TB) in individuals exposed to Mycobacterium tuberculosis (Mtb). The burden of antibiotic-resistant TB is increasing globally; therefore, there is an urgent need to develop host-directed adjunctive therapies to treat TB. Alveolar macrophages, t...

journal_title：American journal of respiratory cell and molecular biology

authors： Coleman MM,Basdeo SA,Coleman AM,Cheallaigh CN,Peral de Castro C,McLaughlin AM,Dunne PJ,Harris J,Keane J

更新日期：2018-11-01 00:00:00

abstract：:Alveolar epithelial type II cells secrete lung surfactant via exocytosis. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) are implicated in this process. Lipid rafts, the cholesterol- and sphingolipid-rich microdomains, may offer a platform for protein organization on the cell membrane. ...

journal_title：American journal of respiratory cell and molecular biology

authors： Chintagari NR,Jin N,Wang P,Narasaraju TA,Chen J,Liu L

更新日期：2006-06-01 00:00:00

abstract：:The present study utilized the monocrotaline (MCT) model of pulmonary hypertension in rats to examine temporal alterations in steady-state levels of basement membrane (BM) component mRNA and deposition of protein using Northern analysis and immunohistochemistry, respectively. MCT (60 mg/kg, subcutaneous) produced sust...

journal_title：American journal of respiratory cell and molecular biology

authors： Lipke DW,Arcot SS,Gillespie MN,Olson JW

更新日期：1993-10-01 00:00:00

abstract：:Normal lung structure is maintained by the presence of mesenchymal cells and their extracellular matrix products. The slow normal turnover of these cells is disrupted in fibrotic disorders, resulting in the in situ accumulation of mesenchymal cells and their extracellular matrix leading to a progressive alveolar wall ...

journal_title：American journal of respiratory cell and molecular biology

authors： Vignaud JM,Allam M,Martinet N,Pech M,Plenat F,Martinet Y

更新日期：1991-12-01 00:00:00

abstract：:In rat models of Gram-negative pneumonia, pulmonary emigration of neutrophils (polymorphonuclear leukocytes [PMNs]) is blocked when rats are made endotoxemic by an intravenous administration of endotoxin (lipopolysaccharide [LPS]). To test whether dysfunctional PMN migratory responses in the endotoxemic rat are specif...

journal_title：American journal of respiratory cell and molecular biology

authors： Wagner JG,Driscoll KE,Roth RA

更新日期：1999-04-01 00:00:00

abstract：:Nicotinamide phosphoribosyltransferase (NAMPT) exists as both intracellular NAMPT and extracellular NAMPT (eNAMPT) proteins. eNAMPT is secreted into the blood and functions as a cytokine/enzyme (cytozyme) that activates NF-κB signaling via ligation of Toll-like receptor 4 (TLR4), further serving as a biomarker for inf...

journal_title：American journal of respiratory cell and molecular biology

authors： Oita RC,Camp SM,Ma W,Ceco E,Harbeck M,Singleton P,Messana J,Sun X,Wang T,Garcia JGN

更新日期：2018-07-01 00:00:00

abstract：:Fibroblasts are the central target cell in pulmonary fibrotic diseases, and their proliferation is mediated largely by platelet-derived growth factor (PDGF) isoforms secreted by activated lung macrophages. Several other macrophage-derived cytokines that are increased during fibrogenesis, including interleukin-1 beta a...

journal_title：American journal of respiratory cell and molecular biology

authors： Bonner JC,Badgett A,Lindroos PM,Osornio-Vargas AR

更新日期：1995-10-01 00:00:00

abstract：:Oxidants in cigarette smoke inhibit pathogen recognition receptor function and phagocytosis, but the molecular basis of this inhibition remains obscure. We sought to identify the inhibitory mechanisms that impair alveolar macrophage function. Balb/c mice were acutely exposed to four cigarettes for 4 hours before treat...

journal_title：American journal of respiratory cell and molecular biology

authors： Bozinovski S,Vlahos R,Zhang Y,Lah LC,Seow HJ,Mansell A,Anderson GP

更新日期：2011-08-01 00:00:00

abstract：:Human tracheal gland serous (HTGS) cells are now considered one principal pulmonary target for the gene therapy of cystic fibrosis (CF). We developed a CF tracheal gland serous cell line, CF-KM4, obtained by the transformation of primary cultures of CF tracheal gland serous cells homozygous for the DeltaF508 mutation ...

journal_title：American journal of respiratory cell and molecular biology

authors： Kammouni W,Moreau B,Becq F,Saleh A,Pavirani A,Figarella C,Merten MD

更新日期：1999-04-01 00:00:00