Genetic polymorphism and their contribution to cancer susceptibility.

Abstract:

:Since the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the individual variations in responses to exposures to carcinogens. The amount of the ultimate carcinogen produced depends on the action of competing activation and detoxification pathways involving cytochrome P450 and glutathione-S-transferases enzymes.

journal_name

Cad Saude Publica

authors

Conforti-Froes N,el-Zein R,Au W

doi

10.1590/s0102-311x1998000700002

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

7-13

eissn

0102-311X

issn

1678-4464

journal_volume

14 Suppl 3

pub_type

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