Abstract:
:The study aimed to identify the cutoff points for inflammatory markers that best discriminate the occurrence of metabolic syndrome in community-dwelling older adults. Baseline data were used from the elderly cohort in the city of Bambuí, Minas Gerais State, Brazil. The target exposure was presence of metabolic syndrome, defined according to the Adult Treatment Panel III criterion, and the outcomes included the following inflammatory markers: cytokines (IL-1β, IL-6, IL-10, IL-12 e TNF), chemokines (CXCL8, CXCL9, CCL2, CXCL10, and CCL5), and C-reactive protein (CRP). Definition of the cutoff points for the inflammatory markers was based on the Classification and Regression Tree (CART) method. The associations between these markers and metabolic syndrome were estimated by logistic regression models, obtaining odds ratios and 95% confidence intervals, considering adjustment for confounding factors. Prevalence of metabolic syndrome was 49.1%, and IL-1β, IL-12, and TNF levels were not associated statistically with this exposure. After adjustment, presence of metabolic syndrome was associated with higher IL-6 and CRP levels and lower CXCL8 and CCL5. Significant associations were also observed with intermediate serum CXCL9 and CXCL10 levels. The combination of markers also showed a significant and consistent association with metabolic syndrome. In addition to demonstrating an association between metabolic syndrome and a wide range of biomarkers (some not previously described in the literature), the results highlight that this association occurs at much lower levels than previously demonstrated, suggesting that metabolic syndrome plays an important role in the inflammatory profile of the older adults. :O objetivo do trabalho foi identificar os pontos de corte dos marcadores inflamatórios que melhor discriminassem a ocorrência da síndrome metabólica entre idosos residentes na comunidade. Foram utilizados os dados da linha de base da coorte de idosos conduzida na cidade de Bambuí, Minas Gerais, Brasil. A exposição de interesse foi a presença da síndrome metabólica, definida pelo critério Adult Treatment Panel III, e os desfechos incluíram os seguintes marcadores inflamatórios: citocinas (IL-1β, IL-6, IL-10, IL-12 e TNF), quimiocinas (CXCL8, CXCL9, CCL2, CXCL10 e CCL5) e proteína C-reativa (PCR). A definição dos pontos de corte dos marcadores inflamatórios foi baseada no método Classification and Regression Tree (CART). As associações entre esses marcadores e a síndrome metabólica foram estimadas por modelos de regressão logística, obtendo-se odds ratio e intervalos de 95% de confiança (IC95%), considerando o ajustamento por fatores de confusão. A prevalência da síndrome metabólica foi de 49,1%, e os níveis de IL-1β, IL-12 e TNF não se mostraram associados a essa exposição. Após ajustamento, a presença da síndrome metabólica foi associada a maiores valores de IL-6 e PCR e a menores valores de CXCL8 e CCL5. Associações significativas ainda foram observadas com níveis séricos intermediários de CXCL9 e CXCL10. Além disso, a combinação dos marcadores apresentou associação significativa e consistente com a síndrome metabólica. Além de demonstrar associação entre síndrome metabólica e uma ampla gama de biomarcadores, alguns ainda não descritos na literatura, os resultados ressaltam que essa associação ocorre em níveis muito inferiores aos já demonstrados, sugerindo que a síndrome metabólica desempenha importante papel no perfil inflamatório dos idosos. :El objetivo del trabajo fue identificar los puntos de corte de los marcadores inflamatorios que mejor discriminaran la ocurrencia del síndrome metabólico entre ancianos residentes en comunidades. Se utilizaron datos de referencia de una cohorte de ancianos, realizada en la ciudad de Bambuí, Minas Gerais, Brasil. La exposición de interés fue la presencia del síndrome metabólico, definida por el criterio Adult Treatment Panel III, y los desenlaces incluyeron los siguientes marcadores inflamatorios: citocinas (IL-1β, IL-6, IL-10, IL-12 e TNF), quimiocinas (CXCL8, CXCL9, CCL2, CXCL10 y CCL5) y proteína C-reactiva (PCR). La definición de los puntos de corte de los marcadores inflamatorios se basó en el método Classification and Regression Tree (CART). Las asociaciones entre esos marcadores y el síndrome metabólico se estimaron mediante modelos de regresión logística, obteniéndose odds ratio e intervalos con 95% de confianza, considerando el ajuste por factores de confusión. La prevalencia del síndrome metabólico fue de 49,1%, y los niveles de IL-1β, IL12 y TNF no se mostraron asociados a esa exposición. Tras el ajuste, la presencia del síndrome metabólico se asoció a mayores valores de IL-6 y PCR y a menores valores de CXCL8 y CCL5. Las asociaciones significativas se observaron incluso con niveles séricos intermedios de CXCL9 y CXCL10. Asimismo, la combinación de los marcadores presentó una asociación significativa y consistente con el síndrome metabólico. Además de demostrar asociación entre el síndrome metabólico y una amplia gama de biomarcadores, algunos todavía no descritos en la literatura, los resultados resaltan que esa asociación ocurre en niveles muy inferiores a los ya demostrados, sugiriendo que el síndrome metabólico desempeña un importante papel en el perfil inflamatorio de los ancianos.
journal_name
Cad Saude Publicajournal_title
Cadernos de saude publicaauthors
Neves CVB,Mambrini JVM,Torres KCL,Teixeira-Carvalho A,Martins-Filho OA,Lima-Costa MF,Peixoto SVdoi
10.1590/0102-311X00129918subject
Has Abstractpub_date
2019-03-25 00:00:00pages
e00129918issue
3eissn
0102-311Xissn
1678-4464pii
S0102-311X2019000305009journal_volume
35pub_type
杂志文章abstract::This article takes an ethical approach to briefly analyze current therapeutic guidelines in Brazil for cases diagnosed as "ambiguous genitalia" (one of the "disorders of sexual development", DSD) in intersex children. Except when there is clear risk to the infant's life, there is no medical or institutional consensus ...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311x00168613
更新日期:2014-10-01 00:00:00
abstract::The aim of this study was to evaluate the prevalence of iodine deficiency in children aged 6 to 71 months in Novo Cruzeiro, Minas Gerais State, Brazil. A total of 475 children, allocated by stratified probability sampling, were analyzed with respect to the iodine concentrations in the salt consumed by the family and u...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2012000200013
更新日期:2012-02-01 00:00:00
abstract::This paper focuses on specific aspects of male sexuality and how this sexual identity is built in the Aids era, based on conversations with low-income youth, ages 14-21 years, living in Greater Metropolitan Rio de Janeiro. We examine how Aids is perceived and investigate sexuality in this epidemic context. The goal is...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x1998000100022
更新日期:1998-04-30 00:00:00
abstract::This article proposes a model for quality evaluation of oral health care in children. The conceptual framework for the evaluation matrix consisted of evaluation studies on oral health care services in Brazil and other countries and a survey and review of prevailing public policies for children's health in Brazil. Two ...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311X00006415
更新日期:2016-03-01 00:00:00
abstract::This study aimed to evaluate user experiences with primary care for children and adolescents according to health, socio-demographic characteristics, and use of healthcare services. The 2006 Catalan Health Interview Survey studied a representative sample of the population aged 0 to 14 (n = 2,200). Parents reported thei...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311X00001014
更新日期:2014-12-01 00:00:00
abstract::This article debates the principal guidelines and procedures that shape HIV/AIDS prevention in Portugal, focusing on risk reduction in the two major scenarios for spread of the epidemic: sexuality and injection drug use. The analysis views the risks of infection as expressions of practices that are densely interwoven ...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311X00129715
更新日期:2016-06-20 00:00:00
abstract::The objectives of this article are to propose indicators for evaluation of the quality of hospital management of bronchial asthma patients, based on explicit criteria from literature reviews. The central problem identified in the literature review is the erroneous evaluation of severity of asthma crises, either by pat...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Thirteen years after the Unified National Health System was implemented in Brazil, the Federal government increased the use of norms and regulations aimed at rationalizing resources and prioritizing basic care within the system. In other words, although actions and services are the responsibility of Municipal governme...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The current study describes the eco-epidemiological aspects of arbovirus diseases in the municipalities (counties) of Novo Progresso and Trairão, Para State, Brazil, in the area affected by highway BR-163. Hemagglutination inhibition (HI) antibodies to different arboviruses were detected, with monotypic reactions to M...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2009001200006
更新日期:2009-12-01 00:00:00
abstract::A population-based survey to provide information on the prevalence of hepatitis viral infection and the pattern of risk factors was carried out in the urban population of all Brazilian state capitals and the Federal District, between 2005 and 2009. This paper describes the design and methodology of the study which inv...
journal_title:Cadernos de saude publica
pub_type: 杂志文章,评审
doi:10.1590/s0102-311x2010000900003
更新日期:2010-09-01 00:00:00
abstract::The study aimed to analyze the association between accessibility to public spaces for leisure activities, availability of equipment for physical exercise in these spaces, and leisure-time physical activity (PA) in adults. A household survey was conducted with 699 adults from 32 census tracts selected according to inco...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311X00020719
更新日期:2019-11-28 00:00:00
abstract::This qualitative study explores the illness experiences, the efficacy of pulmonary rehabilitation as perceived by patients with chronic obstructive pulmonary disease (COPD) and their rationale for improvements in health. 23 patients participated in a daily, three-month home-based pulmonary rehabilitation. A pre-post s...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311x00072313
更新日期:2014-06-01 00:00:00
abstract::Performance assessment in health services is essential. The comparison of performance indicators requires the use of risk adjustment strategies. The objective of this paper was to assess variations in clinical performance, measured by hospital mortality and length of stay, between private and public hospitals, while t...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2004000800021
更新日期:2004-01-01 00:00:00
abstract::This cross-sectional study investigates the use of health services and associated factors in individuals > or = 14 years of age in Canoas, Rio Grande do Sul, Brazil. 1,954 persons were interviewed in 40 census tracts. One-year prevalence of hospital admissions was 9.4%. Adjusted data analysis showed that hospitalizati...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2007000100023
更新日期:2007-01-01 00:00:00
abstract::Among the ten leading causes of disability-adjusted life years, seven are mental disorders. Primary health care centers are crucial to public mental health policies, according to the World Health Organization. This study aimed to verify the prevalence of mental disorders among individuals seeking care at the referral ...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2008000900010
更新日期:2008-09-01 00:00:00
abstract::This study evaluated the cervical cancer mortality trend from 1980 to 2005 in the State of Minas Gerais, Brazil. The demographic and mortality data available on the website of the Statistics Department of the Unified National Health System (DATASUS) were used to estimate the mortality rate for uterine cervical cancer ...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2009000800005
更新日期:2009-08-01 00:00:00
abstract::In July 27th, 2010, witnessed the late notification of a positive test result for measles IgM antibodies in Belém, Pará State, Brazil, sparking an epidemiological investigation and control and preventive measures. Two more confirmed cases were identified, both of whom were siblings of the index case, with clinical sig...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311X00017515
更新日期:2015-10-01 00:00:00
abstract::This study proposed the application of structural equation modeling (SEM) to investigate variables associated with preterm birth based on a theoretical model analyzed previously by hierarchical logistic regression. The data came from a population-based case-control observational study of hospital births to mothers res...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311X00211917
更新日期:2019-01-21 00:00:00
abstract::This article was based on an analysis of three hundred articles from mainstream Brazilian periodicals over a period of eighteen months, beginning with the announcement of the Dolly case in February 1997. There were two main objectives: to outline the moral constants in the press associated with the possibility of clon...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2000000100016
更新日期:2000-01-01 00:00:00
abstract::The current article aimed to verify the degree of agreement in classification of nutritional status according to body mass index (BMI) and corrected body mass index (BMIc). Data were used from a cross-sectional study of Japanese-Brazilians. Statistical analysis provided prevalence rates for chronic diseases, kappa sta...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2006000800017
更新日期:2006-08-01 00:00:00
abstract::Given the characteristics of the COVID-19 pandemic and the limited tools for orienting interventions in surveillance, control, and clinical care, the current article aims to identify areas with greater vulnerability to severe cases of the disease in Rio de Janeiro, Brazil, a city characterized by huge social and spati...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311x00075720
更新日期:2020-01-01 00:00:00
abstract::This article evaluates the degree of implementation of ten urgent and emergency hospital services comprising the macro and micro-regional referral system in Pernambuco State, Northeast Brazil. The study analyzes criteria related to structure (physical and organizational, and material and human resources) and process (...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2010000800005
更新日期:2010-08-01 00:00:00
abstract::This study analyzed the effectiveness of weekly iron supplementation on hemoglobin concentration, nutritional status, and mental and motor development of infants at four public daycare centers in Recife, Pernambuco State, Brazil. This was a before-after intervention study conducted with weekly iron supplementation for...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2008001400015
更新日期:2008-01-01 00:00:00
abstract::This study evaluated fetomaternal hemorrhage (FMH) in 343 postpartum patients who required prophylaxis of Rh alloimmunization with anti-D immunoglobulin. The rosette test was applied to screen for patients needing quantitative determination of fetal blood transferred from the maternal circulation, which was then measu...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2005000500007
更新日期:2005-09-01 00:00:00
abstract::This study focuses on conditions in the public health centers providing comprehensive care to the adolescent population in the city of Rio de Janeiro. A structured questionnaire was administered to the coordinators of 70 public health centers (70/78). Based on the data, the public health centers were stratified accord...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2002000300013
更新日期:2002-05-01 00:00:00
abstract::This research note is the result of a qualitative study in Porto Alegre, Rio Grande do Sul, Brazil, aimed at exploring traffic accident risk from the motorcycle couriers' point of view. The research results highlight the importance of accident prevention and health promotion for these workers. The study was based on s...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2006001200021
更新日期:2006-12-01 00:00:00
abstract::This is a descriptive study to assess the leprosy control program in the municipality of Buriticupu in Maranhão State, Brazil. The records of 214 patients with different forms of leprosy were studied. Patients were treated at a health center of the Federal University in Maranhão located in the above-mentioned municipa...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2003000100013
更新日期:2003-01-01 00:00:00
abstract::The aim of this study was to estimate the role of victimization by violence among Mexican adolescents that have considered or attempted migrating to the United States, including mental health variables (emotional self-esteem, self-esteem in school, depression, suicidal ideation, and attempted suicide) as mediators of ...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311X00119516
更新日期:2017-07-13 00:00:00
abstract::This study investigates factors associated with psychological distress among military police (n = 1,120) in Rio de Janeiro, Brazil. The article describes their social, economic, and demographic characteristics, quality of life, mental health, and work conditions. Measurement of psychological distress used the Self-Rep...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/s0102-311x2012000700008
更新日期:2012-07-01 00:00:00
abstract::The current study aimed to determine the seroprevalence of Trypanosoma cruzi infection in Sucre State, Venezuela, and its association with epidemiological risk factors. The cluster sampling design allowed selecting 96 villages and 576 dwellings in the State's 15 municipalities. A total of 2,212 serum samples were anal...
journal_title:Cadernos de saude publica
pub_type: 杂志文章
doi:10.1590/0102-311X00050216
更新日期:2017-10-26 00:00:00