Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients.

abstract：:Several studies provided evidence of a consistent antileukemic effect induced by cytomegalovirus (CMV) replication in acute myeloid leukemia (AML) patients receiving allogeneic hematopoietic stem cell transplantation (HSCT), however the use of antithymocyte globulin (ATG) as graft-versus-host disease prophylaxis, may ...

journal_title：American journal of hematology

authors： Busca A,Passera R,Pini M,Zallio F,Dellacasa C,Audisio E,Giaccone L,Maffini E,Costa C,Cavallo R,Bruno B

更新日期：2015-06-01 00:00:00

abstract：:Severe chronic neutropenia (SCN) is defined as an absolute neutrophil (ANC) of less than 0.5 x 10(9)/L, lasting for months or years. Congenital, cyclic, and idiopathic neutropenia are principal categories of SCN. Since 1994, the Severe Chronic Neutropenia International Registry (SCNIR) has collected data to monitor th...

journal_title：American journal of hematology

authors： Dale DC,Cottle TE,Fier CJ,Bolyard AA,Bonilla MA,Boxer LA,Cham B,Freedman MH,Kannourakis G,Kinsey SE,Davis R,Scarlata D,Schwinzer B,Zeidler C,Welte K

更新日期：2003-02-01 00:00:00

abstract：:Fifty-nine HIV-1 antibody positive and 58 antibody negative hemophiliacs were evaluated over a 2 year study period to gain insight into the natural history and prognosis of HIV-1 disease in members of this risk group. Mean CD4 (Leu 3+) cell counts calculated at 6 month intervals decreased gradually in seropositive pat...

journal_title：American journal of hematology

authors： Teitel JM,Freedman JJ,Garvey MB,Kardish M

更新日期：1989-12-01 00:00:00

abstract：:A 49-year-old Caucasian woman presented with features suggestive of thrombotic microangiopathy (TMA). She did not respond to treatment with repeated plasma exchange and corticosteroids. A bone marrow biopsy revealed presence of metastatic carcinoma. A limited autopsy revealed presence of breast cancer with rib metasta...

journal_title：American journal of hematology

authors： Werner TL,Agarwal N,Carney HM,Rodgers GM

更新日期：2007-04-01 00:00:00

abstract：:Gaucher disease (GD) is a lysosomal storage disorder; symptomatic patients with type 1 GD need long-term disease-specific therapy of which the standard of care has been enzyme replacement therapy (ERT). Thirty-eight of 40 patients (aged 9-71 years) clinically stable on ERT with imiglucerase, safely switched to a compa...

journal_title：American journal of hematology

authors： Elstein D,Mehta A,Hughes DA,Giraldo P,Charrow J,Smith L,Shankar SP,Hangartner TN,Kunes Y,Wang N,Crombez E,Zimran A

更新日期：2015-07-01 00:00:00

abstract：:This retrospective study included 246 patients with a new diagnosis of Hodgkin Lymphoma (HL) with a localized-stage (IA-IIA), consecutively admitted from January 2002 to December 2008, by twelve Italian hematological centers on behalf of Fondazione Italiana Linfomi (FIL). Patients were staged at baseline and after two...

journal_title：American journal of hematology

authors： Rigacci L,Puccini B,Zinzani PL,Biggi A,Castagnoli A,Merli F,Balzarotti M,Stelitano C,Spina M,Vitolo U,Stefoni V,Levis A,Gotti M,Rosaria S,Maria SP,Bosi A,Gallamini A

更新日期：2015-06-01 00:00:00

abstract：:We aimed to comprehensively study sex differences in disease and patients' characteristics, treatment and outcomes in patients with follicular lymphoma (FL) in the United States (USA) utilizing the National LymphoCare Study registry (2004-2014). Among evaluable males (n = 1277) and females (n = 1375) with FL, females ...

journal_title：American journal of hematology

authors： Nabhan C,Zhou X,Day BM,Dawson K,Zelenetz AD,Friedberg JW,Cerhan JR,Link BK,Flowers CR

更新日期：2016-08-01 00:00:00

abstract：:Extensive extralymphatic Hodgkin disease developed in a young man with common variable immunodeficiency manifested by hypogammaglobulinemia, recurrent sinopulmonary infections, and multiple autoimmune phenomena. Both humoral and cell-mediated immune dysfunction were present prior to treatment. After two cycles of chem...

journal_title：American journal of hematology

authors： Fesus SM,Hagemeister FB,Manning J

更新日期：1989-10-01 00:00:00

abstract：:Hydroxyurea (HU) is a widely used cytotoxic agent that is known to induce fetal hemoglobin (HbF) production and is presently used to ameliorate the severity of pain episodes in patients with sickle cell anemia (HbSS). Previously we have shown that HU inhibits growth of burst forming unit-erythroid (BFU-E) colonies in ...

journal_title：American journal of hematology

authors： Baliga BS,Pace BS,Chen HH,Shah AK,Yang YM

更新日期：2000-11-01 00:00:00

abstract：:This case report describes a patient with hepatitis C virus infection responding to pegylated INF/ribaviron therapy, who developed immune thrombocytopenia. The severe thrombocytopenia failed to resolve with cessation of the peg-IFN/ribaviron. Because of rising hepatitis C virus RNA levels and evidence of rising serum ...

journal_title：American journal of hematology

authors： Weitz IC

更新日期：2005-02-01 00:00:00

abstract：:In a pilot study to reduce the duration of treatment and potential long-term toxicities, 39 patients with acute promyelocytic leukemia in remission received a single cycle of intensive consolidation therapy, followed by intermittent ATRA maintenance. Consolidation therapy required prolonged hospitalization and was ass...

journal_title：American journal of hematology

authors： Gore SD,Smith BD,Gojo I,Grever M,Kaufmann SH,Letendre L,Leonard DG,Marcucci G,Miller CB,Morris L,Piantadosi S,Prior T,Stock W,Karp JE

更新日期：2005-06-01 00:00:00

abstract：:A 50-year-old woman with muscular fatigue and monoclonal gammopathy of unknown significance was shown to have high levels of antibodies against the acetylcholine receptor of the skeletal muscle endplate. The specific antibody activity was exclusively associated with the monoclonal component. There were no objective si...

journal_title：American journal of hematology

authors： Ahlberg RE,Lefvert AK

更新日期：1988-09-01 00:00:00

abstract：:Coagulation factor VIII and von Willebrand factor (VWF) are key proteins in procoagulant activation. Higher FVIII coagulant activity (FVIII :C) and VWF antigen (VWF :Ag) are risk factors for cardiovascular disease and venous thromboembolism. Beyond associations with ABO blood group, genetic determinants of FVIII and V...

journal_title：American journal of hematology

authors： Tang W,Cushman M,Green D,Rich SS,Lange LA,Yang Q,Tracy RP,Tofler GH,Basu S,Wilson JG,Keating BJ,Weng LC,Taylor HA,Jacobs DR Jr,Delaney JA,Palmer CD,Young T,Pankow JS,O'Donnell CJ,Smith NL,Reiner AP,Folsom AR

更新日期：2015-06-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)-ALL 2008 was a prospective clinical trial designed to improve treatment outcome of childhood ALL through the first nation-wide collaborative study in China. Totally 2231 patients were recru...

journal_title：American journal of hematology

authors： Cui L,Li ZG,Chai YH,Yu J,Gao J,Zhu XF,Jin RM,Shi XD,Zhang LP,Gao YJ,Zhang RD,Zheng HY,Hu SY,Cui YH,Zhu YP,Zou Y,Ng MHL,Xiao Y,Li JH,Zhang YH,He HL,Xian Y,Wang TY,Li CK,Wu MY,Chinese Children Leukemia Gro

更新日期：2018-07-01 00:00:00

abstract：:In order to assess the functional property of neonatal polymorphonuclear leukocytes (PMNs), we studied their chemoattractant-stimulated superoxide anion (O2-) production using a soluble chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) as a PMN stimulus. O2- production by neonatal PMNs was increased: ...

journal_title：American journal of hematology

authors： Yamazaki M,Matsuoka T,Yasui K,Komiyama A,Akabane T

更新日期：1988-03-01 00:00:00

abstract：:Multiple myeloma (MM) and primary systemic light chain amyloidosis (AL) are both chronic plasma cell dyscrasias with different clinical expression but limited treatment options for relapsed refractory disease. We report the effect of the addition of clarithromycin on 31 MM and 17 AL with relapsed or refractory disease...

journal_title：American journal of hematology

authors： Shaulov A,Ganzel C,Benyamini N,Barshay Y,Goldschmidt N,Lavie D,Libster D,Gural A,Avni B,Gatt ME

更新日期：2017-02-01 00:00:00

abstract：:A patient is described who had blastic transformation of Ph1 negative chronic myelogenous leukemia (Ph1 - CML). Characterization of the leukemic cells revealed a population with a lymphoid stem cell phenotype (cALL-, TdT+, Ia+, cIgM-). This particular phenotype may be responsible for the refractoriness to vincristine ...

journal_title：American journal of hematology

authors： Kessler JF,Grogan TM,Greenberg BR

更新日期：1985-02-01 00:00:00

abstract：:The increased adhesiveness of sickle erythrocytes (SS RBC) to endothelial cells has been confirmed in a static system utilizing fresh umbilical vein endothelium. Adherence of SS RBC to the endothelium was as great in the presence of calcium-containing buffer as when incubated in plasma. SS RBC suspended in autologous ...

journal_title：American journal of hematology

authors： Antonucci R,Walker R,Herion J,Orringer E

更新日期：1990-05-01 00:00:00

abstract：:The incidence of drug-induced neutropenia has not changed in the western hemisphere over the last 30 years. Yet, the drug panorama has changed considerably. This implies that host factors may play an intriguing role for this idiosyncratic reaction. The knowledge as to mechanisms for the reaction has advanced with emer...

journal_title：American journal of hematology

authors： Tesfa D,Keisu M,Palmblad J

更新日期：2009-07-01 00:00:00

abstract：:Recombinant DNA technology and protein engineering are creating hope that we can address ongoing challenges in hemophilia care such as reducing the costs of therapy, increasing the availability to the developing world, and improving the functional properties of these proteins. Technological advances to improve the hal...

journal_title：American journal of hematology

authors： Pipe SW

更新日期：2012-05-01 00:00:00

abstract：:HIV infection has been associated with an increased risk of developing several types of malignancies, including aggressive peripheral T-cell lymphomas (PTCL). However, this is a rare occurrence with no more than a hundred cases reported in the literature. The purpose of this multicenter study is to describe the charac...

journal_title：American journal of hematology

authors： Castillo JJ,Beltran BE,Bibas M,Bower M,Collins JA,Cwynarski K,Diez-Martin JL,Hernandez-Ilizaliturri F,Horwitz SM,Montoto S,Pantanowitz L,Ribera JM,Vose JM

更新日期：2011-03-01 00:00:00

abstract：:The underlying mechanisms of reactive macrophage activation syndromes (rMAS) are not understood in detail, and there is no specific treatment. This observational study was prompted by intravenous immunoglobulin (IVIG), dramatically halting two distinct rMAS episodes in the same patient. We evaluated the potential bene...

journal_title：American journal of hematology

authors： Emmenegger U,Frey U,Reimers A,Fux C,Semela D,Cottagnoud P,Spaeth PJ,Neftel KA

更新日期：2001-09-01 00:00:00

abstract：:The purpose of this study was to determine if therapeutic levels of Rituximab could be achieved in a patient with renal failure being dialyzed and if Rituximab is removed by hemodialysis. A 54-year-old man with low-grade lymphoma and renal failure on hemodialysis received 8 weekly treatments of Rituximab at 375 mg/M(2...

journal_title：American journal of hematology

authors： Jillella AP,Dainer PM,Kallab AM,Ustun C

更新日期：2002-11-01 00:00:00

abstract：:A variability in DNA content detected was found with image cytometry, in immature bone marrow cells from 13 healthy donors (median age 31 yr). The mean coefficient of variation (C.V.) of the DNA content was found to be significantly (P = 0.0002) higher in immature blasts and promyelocytes than in mature granulocytes, ...

journal_title：American journal of hematology

authors： Widell S,Auer G,Hast R,Reizenstein P

更新日期：1993-08-01 00:00:00

abstract：:Hemoglobin Lyon-Bron was found in two members of a family of German ascent presenting with a moderate normocytic anemia. In this alpha 2 globin variant, the N-terminal valine of the chain was replaced by an alanine. Electrospray mass spectrometry of the alpha chain showed that, as normally, the initiator methionine wa...

journal_title：American journal of hematology

authors： Lacan P,Souillet G,Aubry M,Promé D,Richelme-David S,Kister J,Wajcman H,Francina A

更新日期：2002-03-01 00:00:00

abstract：:Red blood cells from patients with sickle cell disease (SS RBC) adhere to laminin and over-express the high-affinity laminin receptor basal cell adhesion molecule/Lutheran protein (B-CAM/LU). This receptor has recently been shown to undergo activation in vitro through a protein kinase A-dependent mechanism. Low-densit...

journal_title：American journal of hematology

authors： Zen Q,Batchvarova M,Twyman CA,Eyler CE,Qiu H,De Castro LM,Telen MJ

更新日期：2004-02-01 00:00:00

abstract：:A rare association of congenital afibrinogenemia and hereditary protein C deficiency is described in a 37-year-old female who suffered from ischemic necrosis in the left first toe. The diagnosis of afibrinogenemia was assessed by the absence of fibrinogen in clotting and immunological assays. The diagnosis of heredita...

journal_title：American journal of hematology

authors： Hanano M,Takahashi H,Itoh M,Shibata A

更新日期：1992-09-01 00:00:00

abstract：:During the 5-year period from 1981 to 1985, we have observed 8 cases of acquired immunodeficiency syndrome (AIDS) among our 85 patients with hemophilia A. Thus, the prevalence of AIDS with hemophilia A is 9.4% in our patient population. By utilizing stored serum or plasma samples dating back to 1978, antibody against ...

journal_title：American journal of hematology

authors： Kim HC,Nahum K,Raska K Jr,Gocke DJ,Kosmin M,Karp GI,Saidi P

更新日期：1987-02-01 00:00:00

abstract：:Iron deposition in combination with inflammatory and immunogenetic factors is involved in the pathophysiology of cardiac dysfunction in β-thalassemia major. We investigated the mechanical and endocrine function of the left atrium and ventricle to identify early signs of dysfunction. We studied 90 patients (mean age: 2...

journal_title：American journal of hematology

authors： Kostopoulou AG,Tsiapras DP,Chaidaroglou AS,De Giannis DE,Farmakis D,Kremastinos DT

更新日期：2014-01-01 00:00:00

abstract：:A minority of super-utilizing adults with sickle cell disease (SCD) account for a disproportionate number of emergency department (ED) and hospital admissions. We performed a retrospective cohort study comparing the rate of admission before and after the opening of a clinic for adults with SCD. Unique to this clinic w...

journal_title：American journal of hematology

authors： Koch KL,Karafin MS,Simpson P,Field JJ

更新日期：2015-03-01 00:00:00