Treatment of a patient with end-stage renal disease with Rituximab: pharmacokinetic evaluation suggests Rituximab is not eliminated by hemodialysis.

abstract：:A 69-year-old man with immunoblastic lymphadenopathy and autoimmune hemolytic anemia who had no previous exposure to blood products developed a severe febrile nonhemolytic transfusion reaction following the initial infusion of packed red blood cells. The reaction recurred with transfusion of packed red blood cells, bu...

journal_title：American journal of hematology

authors： Barnes HM,Poon MC,Huang ST,Conrad ME,Lin J,McGowan EI

更新日期：1983-02-01 00:00:00

abstract：:Although acute myeloid leukemia (AML) with t(8;21) belongs to the favorable risk AML subset, relapse incidence may reach 30% in those patients. RUNX1-RUNX1T1 fusion transcript is a well-established marker for minimal residual disease (MRD) monitoring. In this study, we investigated the feasibility and performances of ...

journal_title：American journal of hematology

authors： Duployez N,Nibourel O,Marceau-Renaut A,Willekens C,Helevaut N,Caillault A,Villenet C,Celli-Lebras K,Boissel N,Jourdan E,Dombret H,Figeac M,Preudhomme C,Renneville A

更新日期：2014-06-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is an innate immunodeficiency with a genetic defect of the nicotinamide adenosine dinucleotide phosphate, reduced, oxidase components. This leads to decreased reactive oxygen species (ROS) production, which renders patients susceptible to life-threatening infections. Over the course...

journal_title：American journal of hematology

authors： Wolach B,Gavrieli R,de Boer M,van Leeuwen K,Berger-Achituv S,Stauber T,Ben Ari J,Rottem M,Schlesinger Y,Grisaru-Soen G,Abuzaitoun O,Marcus N,Zion Garty B,Broides A,Levy J,Stepansky P,Etzioni A,Somech R,Roos D

更新日期：2017-01-01 00:00:00

abstract：:Philadelphia chromosome (Ph1) positive, or "adult-type," chronic granulocytic leukemia (CGL) differs in many clinical and laboratory aspects from PH1-negative, or "juvenile," CGL. Because of these differences, the disorders have been considered two distinct disease entities. We present a child with Ph1-positive CGL wh...

journal_title：American journal of hematology

authors： Gay JC,Dessypris EN,Roloff JS,Lukens JN

更新日期：1984-01-01 00:00:00

abstract：:Quantitative changes of hemostatic molecular markers were studied in patients with nephrotic syndrome. The plasma levels of fibrinopeptide A (FPA), thrombin-antithrombin III complex (TAT), products of thrombin activation, and fragment F1 + 2 (F1 + 2), a product of prothrombin activation, were measured by enzyme immuno...

journal_title：American journal of hematology

authors： Chen TY,Huang CC,Tsao CJ

更新日期：1993-12-01 00:00:00

abstract：:Thrombospondin (TSP), a large protein found in platelet alpha-granules (as TSP-1), mediates adhesion of sickle reticulocytes to cultured vascular endothelium. To further explore the physiologic relevance of this observation, we have measured plasma TSP levels and platelet TSP-1 content in subjects with sickle cell dis...

journal_title：American journal of hematology

authors： Browne PV,Mosher DF,Steinberg MH,Hebbel RP

更新日期：1996-04-01 00:00:00

abstract：:Eighteen patients with acute nonlymphocytic leukemia (ANLL), aged 17-73 years, were treated with high-dose cytosine arabinoside (HD-Ara-C) using 3 g/m2 IV q 12 hours X 12 doses. Seven patients were treated for relapse and four (57%) obtained a complete remission with a median duration of 19.5 weeks. In nine patients, ...

journal_title：American journal of hematology

authors： Cantin G,Brennan JK

更新日期：1984-01-01 00:00:00

abstract：:Autoimmune hemolytic anemia is thought to be mediated via auto-antibodies produced by lymphoid B cells. This may be an idiopathic process or secondary to an underlying infection or lymphoproliferative disorder. Conventional treatment comprises immunosuppression with corticosteroids and, in some cases, splenectomy. A p...

journal_title：American journal of hematology

authors： Ramanathan S,Koutts J,Hertzberg MS

更新日期：2005-02-01 00:00:00

abstract：:Leukemic cells of 43 patients with acute promyelocytic leukemia (M3) were investigated morphologically and cytochemically to determine the percentage of aberrant enzymes and whether or not the presence impacts on the clinical outcome. Twelve patients (27.9%) showed alpha-naphthyl acetate esterase (ANAE) activity in th...

journal_title：American journal of hematology

authors： Matsuo T,Jain NC,Bennett JM

更新日期：1988-11-01 00:00:00

abstract：:Chuvash polycythemia results from a homozygous 598C>T mutation in exon 3 of the von Hippel-Lindau (VHL) gene. This disrupts the normoxia pathway for degrading hypoxia inducible factor (HIF)-1alpha and HIF-2alpha causing altered expression of HIF-1 and HIF-2 inducible genes. As hypoxia induces expression of pro-inflamm...

journal_title：American journal of hematology

authors： Niu X,Miasnikova GY,Sergueeva AI,Polyakova LA,Okhotin DJ,Tuktanov NV,Nouraie M,Ammosova T,Nekhai S,Gordeuk VR

更新日期：2009-02-01 00:00:00

abstract：:The role of peripheral platelet destruction as a reversible etiology of thrombocytopenia in chronic lymphocytic leukemia (CLL) was evaluated in nine patients with CLL and refractory thrombocytopenia who underwent splenectomy. The patients' ages ranged from 54 to 74 years. Progressive thrombocytopenia refractory to ant...

journal_title：American journal of hematology

authors： Merl SA,Theodorakis ME,Goldberg J,Gottlieb AJ

更新日期：1983-11-01 00:00:00

abstract：:We describe a unique case of adult T-cell leukemia/lymphoma (ATL). The patient had typical clinicohematological features as ATL, but showed a lack of antibody to human T-cell leukemia virus type-1 (HTLV-1) and was negative for HTLV-1 proviral DNA in the peripheral mononuclear cells by means of polymerase chain reactio...

journal_title：American journal of hematology

authors： Nakase K,Hasegawa M,Tsuji K,Ikeda T,Tamaki S,Tanigawa M,Miyanishi E,Shiku H

更新日期：2000-05-01 00:00:00

abstract：:The effect of several iron chelators on iron uptake and release by mouse peritoneal macrophages has been investigated. The 1,2-dimethyl (L1) and 1-ethyl-2-methyl (L1NEt) derivatives of 3-hydroxypyrid-4-one markedly enhanced iron mobilisation from macrophages pulsed with 59Fe-transferrin-antitransferrin immune complexe...

journal_title：American journal of hematology

authors： Brock JH,Licéaga J,Arthur HM,Kontoghiorghes GJ

更新日期：1990-05-01 00:00:00

abstract：:Several syndromes characterized by striking eosinophilia may be complicated by thrombosis. The experiments described indicate that, paradoxically, eosinophils and certain of their constituents inhibit the activation of Hageman factor (HF, factor XII). In earlier studies, suspensions of mixed types of granulocytes, oth...

journal_title：American journal of hematology

authors： Ratnoff OD,Gleich GJ,Shurin SB,Kazura J,Everson B,Embury P

更新日期：1993-01-01 00:00:00

abstract：:Total body irradiation (TBI) has been thought to promote donor cell engraftment in allogeneic hematopoietic cell transplantation (HCT) from alternative donors. However, recent progress in HCT strategies may affect the clinical significance of TBI on neutrophil engraftment. With the use of a Japanese transplant registr...

journal_title：American journal of hematology

authors： Nakasone H,Fuji S,Yakushijin K,Onizuka M,Shinohara A,Ohashi K,Miyamura K,Uchida N,Takanashi M,Ichinohe T,Atsuta Y,Fukuda T,Ogata M,Complication Working Group of Japanese Society for Hematopoietic Cell Transplantation.

更新日期：2017-02-01 00:00:00

abstract：:Unprecedented advances in our understanding of the pathobiology, prognostication, and therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years. Heterogeneity in the clinical course of MCL-indolent vs aggressive-is further delineated by a correlation with the mutational status of the var...

journal_title：American journal of hematology

authors： Jain P,Wang M

更新日期：2019-06-01 00:00:00

abstract：:AL amyloidosis, a systemic disorder characterized by widespread deposition of amyloid fibrils derived from monoclonal Ig light chains in organs and soft tissues, is typically caused by an underlying plasma cell dyscrasia. However, this disease can also be associated rarely with a B-cell lymphoproliferative disorder. I...

journal_title：American journal of hematology

authors： Sanchorawala V,Blanchard E,Seldin DC,O'Hara C,Skinner M,Wright DG

更新日期：2006-09-01 00:00:00

abstract：:In light of the relationship between immune system dysregulation and multiple myeloma (MM) risk, we investigated whether genetic variation in 92 immune function genes among 77 gene regions are associated with MM susceptibility in a population-based case-control study (108 cases and 482 controls) conducted among Caucas...

journal_title：American journal of hematology

authors： Lee KM,Baris D,Zhang Y,Hosgood HD 3rd,Menashe I,Yeager M,Zahm SH,Wang SS,Purdue MP,Chanock S,Zheng T,Rothman N,Lan Q

更新日期：2010-08-01 00:00:00

abstract：:We retrospectively measured various hemostatic markers in 240 patients with disseminated intravascular coagulation (DIC) before the onset of DIC and in 110 non-DIC patients, and examined their usefulness for the diagnosis of pre-DIC. Changes in prothrombin time ratio and fibrinogen levels were not significant before t...

journal_title：American journal of hematology

authors： Wada H,Sakuragawa N,Mori Y,Takagi M,Nakasaki T,Shimura M,Hiyoyama K,Nisikawa M,Gabazza EC,Deguchi K,Kazama M,Shiku H

更新日期：1999-04-01 00:00:00

abstract：:Splenectomy is a time-honoured well established approach for patients with steroid-resistant immune thrombocytopenia (ITP). However, due to the more recent availability of therapeutic options alternative to splenectomy, such as rituximab and agonists of the thrombopoietin-receptor, the choice of second-line therapy is...

journal_title：American journal of hematology

authors： Palandri F,Polverelli N,Catani L,Sollazzo D,Romano M,Levorato M,Vianelli N

更新日期：2014-11-01 00:00:00

abstract：:The roles of fibrinogen and fibronectin were contasted in the responses of human platelets to Staphylococcus aureus and collagen. Congenital afibrinogenemic (CA) platelets and washed normal platelets had delayed aggregation due to a prolonged latent phase in response to contact with the bacteria when fibrinogen was ab...

journal_title：American journal of hematology

authors： Clawson CC,White JG,Herzberg MC

更新日期：1980-01-01 00:00:00

abstract：:Relapsed or refractory acute myeloid leukemia (R/R AML) has a poor prognosis and is best treated with salvage chemotherapy as a bridge to allogeneic stem cell transplant (alloSCT). However, the optimal salvage therapy remains unknown. Here we compared two salvage regimens; mitoxantrone, etoposide, and cytarabine (MEC)...

journal_title：American journal of hematology

authors： Christian S,Arain S,Patel P,Khan I,Calip GS,Agrawal V,Sweiss K,Griffin S,Cahill K,Konig H,Esen A,Shergill A,Odenike O,Stock W,Quigley JG

更新日期：2020-08-01 00:00:00

abstract：:Non-Hodgkin lymphoma arising in the context of immunosuppression is an important adverse outcome after solid organ transplantation. Diffuse large B-cell lymphoma (DLBCL) is the most commonly diagnosed subtype of post-transplantation non-Hodgkin lymphoma, but few studies of transplant recipients have examined subtype-s...

journal_title：American journal of hematology

authors： Gibson TM,Engels EA,Clarke CA,Lynch CF,Weisenburger DD,Morton LM

更新日期：2014-07-01 00:00:00

abstract：:Although treatment with plasma exchange increased the survival of patients with thrombotic thrombocytopenia purpura to 80% in the 1980s, no further increase of survival occurred over the next 20 years. However, more consistent use of adjuvant treatment with corticosteroids and rituximab in recent years has begun to fu...

journal_title：American journal of hematology

authors： George JN

更新日期：2012-05-01 00:00:00

abstract：:The Sickle Cell Disease Clinical Research Network (SCDCRN) designed the PROACTIVE Feasibility Study (ClinicalTrials.gov NCT00951808) to determine whether elevated serum levels of secretory phospholipase A2 (sPLA2) during hospitalization for pain would permit preemptive therapy of sickle cell acute chest syndrome (ACS)...

journal_title：American journal of hematology

authors： Miller ST,Kim HY,Weiner D,Wager CG,Gallagher D,Styles L,Dampier CD,Investigators of the Sickle Cell Disease Clinical Research Network (SCDCRN).

更新日期：2012-03-01 00:00:00

abstract：:The case of a 21 year-old female with echinocytosis and a littoral cell hemangioma is reported. The patient had no significant past medical history and presented with abdominal pain and splenomegaly. A large percentage of echinocytes were noted on her peripheral smear in the absence of any known causes. A CT-recognize...

journal_title：American journal of hematology

authors： Altomare I,Desman G,Aledort LM

更新日期：2006-07-01 00:00:00

abstract：:During 1971-1988, 194 adults with de novo acute myeloid leukemia (AML) received initial therapy at the University of Minnesota with an anthracycline-based regimen. Seventy-two of the 194 required further chemotherapy and received a second cycle of the same or similar therapy; 63 of these 72 were evaluable. For each ma...

journal_title：American journal of hematology

authors： Hammerschmidt DE,Crea MT

更新日期：1994-11-01 00:00:00

abstract：:The optimal treatment of advanced sporadic Burkitt lymphoma in adults is still a matter of debate. The salutary results of pediatric therapies did open the road for improving the adult outcome. Between May 1988 and March 2009, 71 consecutive patients-46 adults, 25 children-affected by Burkitt lymphoma/leukemia were tr...

journal_title：American journal of hematology

authors： Todeschini G,Bonifacio M,Tecchio C,Balter R,Carli G,Stefani PM,Adami F,Zamò A,Dei Tos AP,Marino F,Gherlinzoni F,Marradi P,Semenzato G,Pizzolo G

更新日期：2012-01-01 00:00:00

abstract：:The specificity of autoantibodies in autoimmune hemolytic anemia (AIHA) has been studied using the serological procedure and immunoprecipitation technique with rare phenotype red cells. We attempted to analyze specificity using recombinant rhesus (Rh) blood group and band3 antigens expressed on erythroleukemic cell li...

journal_title：American journal of hematology

authors： Iwamoto S,Kamesaki T,Oyamada T,Okuda H,Kumada M,Omi T,Takahashi J,Tani Y,Omine M,Kajii E

更新日期：2001-10-01 00:00:00

abstract：:We recently defined event-free survival at 24 months (EFS24) as a clinically relevant outcome for patients with DLBCL. Patients who fail EFS24 have very poor overall survival, while those who achieve EFS24 have a subsequent overall survival equivalent to that of the age- and sex-matched general population. Here, we de...

journal_title：American journal of hematology

authors： Maurer MJ,Jais JP,Ghesquières H,Witzig TE,Hong F,Haioun C,Thompson CA,Thieblemont C,Micallef IN,Porrata LF,Ribrag V,Nowakowski GS,Casasnovas O,Bologna S,Morschhauser F,Morrison VA,Peterson BA,Macon WR,Copie-Bergman C

更新日期：2016-02-01 00:00:00