Integrin alphavbeta5 participates in the binding of photoreceptor rod outer segments during phagocytosis by cultured human retinal pigment epithelium.

abstract：PURPOSE:Leber congenital amaurosis (LCA) is a group of childhood-onset retinal diseases characterized by severe visual impairment or blindness. One form is caused by mutations in the RPE65 gene, which encodes the retinal pigment epithelium (RPE) isomerase. In this study, the retinal structure and expression of molecula...

journal_title：Investigative ophthalmology & visual science

authors： Hernández M,Pearce-Kelling SE,Rodriguez FD,Aguirre GD,Vecino E

更新日期：2010-12-01 00:00:00

abstract：:The overall morphology of corneal fibroblasts in the rat was examined by scanning electron microscopy after removal of stromal connective tissue elements by tryptic digestion and HCl hydrolysis. Fibroblasts thus exposed were flattened and stellate cells with a diameter of about 10 micron and had a number of ramified c...

journal_title：Investigative ophthalmology & visual science

authors： Nishida T,Yasumoto K,Otori T,Desaki J

更新日期：1988-12-01 00:00:00

abstract：PURPOSE:This study aims to determine the in vivo effectiveness of low-frequency ultrasound in mediating the transport of macromolecules to the posterior segment of the eye via transscleral route. It investigates if damage is caused by ultrasound at the tested operation parameters on the posterior ocular tissues and vis...

journal_title：Investigative ophthalmology & visual science

authors： Suen WL,Wong HS,Yu Y,Lau LC,Lo AC,Chau Y

更新日期：2013-06-26 00:00:00

abstract：Purpose:The three-dimensional configurations of rod and cone bipolar cell (BC) dendrites and horizontal cell (HC) processes outside rod and cone synaptic terminals have not been fully elucidated. We reveal how these neurites are mutually arranged to coordinate formation and maintenance of the postsynaptic complex of ri...

journal_title：Investigative ophthalmology & visual science

authors： Tsukamoto Y,Iseki K,Omi N

更新日期：2021-01-04 00:00:00

abstract：Purpose:Asymmetry in disease progression between left and right eyes can occur in Stargardt disease (STGD1), and this needs to be considered in novel therapeutic trials with a fellow-eye paired controlled design. This study investigated the inter-eye discordance of best-corrected visual acuity (BCVA) and progression of...

journal_title：Investigative ophthalmology & visual science

authors： Lambertus S,Bax NM,Groenewoud JM,Cremers FP,van der Wilt GJ,Klevering BJ,Theelen T,Hoyng CB

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To describe an in vivo mouse model for the study of recurrent corneal erosion syndrome (RCES) in mice and to characterize the changes in alpha9 integrin expression during wound healing. METHODS:Corneal epithelial debridement wounds of two sizes (1.5 and 2.5 mm) were made on the ocular surface of BALB/c mice an...

journal_title：Investigative ophthalmology & visual science

authors： Pal-Ghosh S,Pajoohesh-Ganji A,Brown M,Stepp MA

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:This study was performed to investigate motion perception in patients with glaucoma. METHODS:A random dot motion test was used to measure three aspects of central motion perception: minimum displacement threshold (Dmin), maximum displacement threshold (Dmax), and coherence threshold (signal to noise). Motion p...

journal_title：Investigative ophthalmology & visual science

authors： Bullimore MA,Wood JM,Swenson K

更新日期：1993-12-01 00:00:00

abstract：PURPOSE:The stratified squamous epithelial covering of the cornea provides one of the first physical and immunological lines of defense. A breach in its integrity results in a wound healing response that resolves quickly. However, under certain conditions-for example, when migrating cells are unable to adhere to the ba...

journal_title：Investigative ophthalmology & visual science

authors： Chow S,Di Girolamo N

更新日期：2014-09-18 00:00:00

abstract：PURPOSE:To estimate the heritability of the iridotrabecular angle width measured by anterior segment optical coherence tomography (ASOCT) in a classic twin study. METHODS:Twins aged 8 to 16 years were identified from the Guangzhou Twin Registry. ASOCT was used to obtain one horizontal scan, and the images were analyze...

journal_title：Investigative ophthalmology & visual science

authors： He M,Ge J,Wang D,Zhang J,Hewitt AW,Hur YM,Mackey DA,Foster PJ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:We evaluated whether UVA-riboflavin collagen cross-linking (CXL) increases transverse stromal shear moduli ex vivo, whether the shear moduli are greater in the anterior compared to the posterior stroma, and whether the shear moduli are affected by CXL. METHODS:The resistance to unidirectional transverse shear ...

journal_title：Investigative ophthalmology & visual science

authors： Søndergaard AP,Ivarsen A,Hjortdal J

更新日期：2013-07-26 00:00:00

abstract：Purpose:To elucidate the molecular events in solute carrier family 4 member 11 (SLC4A11)-deficient corneal endothelium that lead to the endothelial dysfunction that characterizes the dystrophies associated with SLC4A11 mutations, congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy...

journal_title：Investigative ophthalmology & visual science

authors： Zhang W,Frausto R,Chung DD,Griffis CG,Kao L,Chen A,Azimov R,Sampath AP,Kurtz I,Aldave AJ

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical coherence tomography (SD-OCT). METHODS:Images were captured on B...

journal_title：Investigative ophthalmology & visual science

authors： Lin P,Mettu PS,Pomerleau DL,Chiu SJ,Maldonado R,Stinnett S,Toth CA,Farsiu S,Mruthyunjaya P

更新日期：2012-04-06 00:00:00

abstract：:The irides of albino guinea pigs were photographed, and the iris arteriolar diameters were measured with the animal breathing room air, 10% O2/90% N2, or 100% O2. The iris arterioles constrict significantly in hyperoxia and dilate in hypoxia. The average constriction in 100% O2 was 27% +/- 8%, and the average dilatati...

journal_title：Investigative ophthalmology & visual science

authors： Stefansson E,Shelton RA,Landers MB 3rd,Walsh AW,Wolbarsht ML

更新日期：1983-06-01 00:00:00

abstract：PURPOSE:To determine associations between retinopathy status and detailed serum lipoprotein subclass profiles in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) cohort. METHODS:Persons with type 1 diabetes (440 women, 548 men) from the DCCT/EDIC c...

journal_title：Investigative ophthalmology & visual science

authors： Lyons TJ,Jenkins AJ,Zheng D,Lackland DT,McGee D,Garvey WT,Klein RL

更新日期：2004-03-01 00:00:00

abstract：:Three methods of corneal epithelial preparation for subsequent analysis of epithelial glycogen and DNA content were compared: scraping, lamellar stripping, and in situ freezing. All three methods gave good recovery of these substances. However, there was incomplete recovery of the sample using the in situ freezing met...

journal_title：Investigative ophthalmology & visual science

authors： Friend J,Kiorpes T,Kinoshita S

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:This study describes the effects of the cyclic adenosine monophosphate (cAMP) pathway on the tight junctional barrier of the corneal endothelium, which plays a critical role in maintaining the corneal stroma in an underhydrated, transparent state. METHODS:Subcultured bovine corneal endothelial cells grown on f...

journal_title：Investigative ophthalmology & visual science

authors： Le Varlet B,Ducroc R,Dagonet FB,Pouliquen Y,Vandewalle A,Hirsch M

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether a better IOP reduction can be observed in conscious, normotensive monkeys treated with ONO-9054, a novel dual EP3 and FP receptor agonist, compared with prostaglandin F2α analogs. METHODS:The binding affinities and agonistic activities of ONO-AG-367, a carboxy...

journal_title：Investigative ophthalmology & visual science

authors： Yamane S,Karakawa T,Nakayama S,Nagai K,Moriyuki K,Neki S,Suto F,Kambe T,Hirota Y,Kawabata K

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta-1 (TGF beta-1) can modulate inflammation. Endotoxin-induced uveitis (EIU) is characterized by acute ocular inflammation related to the release of cytokines, including interleukin (IL)-6. The authors investigated the effect of TGF beta-1 on EIU in mice. METHODS:Three independent ...

journal_title：Investigative ophthalmology & visual science

authors： Peng B,Li Q,Roberge FG,Chan CC

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:To determine the effect of bimatoprost on intraocular pressure in the prostaglandin FP receptor knockout mouse. METHODS:The IOP response to a single 1.2-microg (4 microL) dose of bimatoprost was measured in the treated and untreated fellow eyes of homozygote (FP+/+, n = 9) and heterozygote (FP+/-, n = 10) FP-k...

journal_title：Investigative ophthalmology & visual science

authors： Crowston JG,Lindsey JD,Morris CA,Wheeler L,Medeiros FA,Weinreb RN

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:Leber hereditary optic neuropathy (LHON) is an inherited mitochondrial optic neuropathy characterized by bilateral, severe loss of central vision. In this study, the first formal assessment was conducted of visual disability in affected and unaffected individuals from molecularly confirmed LHON pedigrees. METH...

journal_title：Investigative ophthalmology & visual science

authors： Kirkman MA,Korsten A,Leonhardt M,Dimitriadis K,De Coo IF,Klopstock T,Griffiths PG,Hudson G,Chinnery PF,Yu-Wai-Man P

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To investigate the effect of varying levels of ocular surface stimulation on the timing and amplitude of the blink and tear secretion. METHODS:Following instillation of fluorescein dye, increasing levels of air flow were directed toward the central corneas of 10 healthy subjects. Interblink interval (IBI), tea...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Begley CG,Port N,Bradley A,Braun R,King-Smith E

更新日期：2015-07-01 00:00:00

abstract：:Purpose. Experimental autoimmune uveoretinitis (EAU), a Th1/Th17 cell-mediated autoimmune disease induced in mice, serves as a model of human endogenous uveitis. In this model, proinflammatory cytokines and various stimuli activate the transcriptional factor, nuclear factor-kappaB (NF-kappaB), in the retina. The thera...

journal_title：Investigative ophthalmology & visual science

authors： Iwata D,Kitaichi N,Miyazaki A,Iwabuchi K,Yoshida K,Namba K,Ozaki M,Ohno S,Umezawa K,Yamashita K,Todo S,Ishida S,Onoé K

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:To determine the efficacy of the M1-selective muscarinic antagonist, pirenzepine, in preventing experimentally induced myopia in a mammalian model, the tree shrew. METHODS:Tree shrews were monocularly deprived (MD) using translucent goggles or negative lenses for a period of 12 days. In two of the MD groups, t...

journal_title：Investigative ophthalmology & visual science

authors： Cottriall CL,McBrien NA

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:To develop a new test of activities of daily living (ADLs) appropriate for the low-vision population: the Melbourne Low-Vision ADL Index (MLVAI). METHODS:The MLVAI was designed as a desk-based clinical assessment, comprising 18 observed items on complex ADLs in part (a) and 9 questions on broad self-care ADLs ...

journal_title：Investigative ophthalmology & visual science

authors： Haymes SA,Johnston AW,Heyes AD

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:To determine the effects of silicone hydrogel lens wear and lens-solution interactions on ocular surface sensitivity. METHODS:Forty-eight adapted lens wearers completed the study, which comprised two phases. Phase 1 included habitual lens wear, no lens wear (7 ± 3 days), and balafilcon A lenses (PV; PureVision...

journal_title：Investigative ophthalmology & visual science

authors： Situ P,Simpson TL,Jones LW,Fonn D

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To characterize the effect of postural IOP elevation and pharmacological IOP lowering on retinal ganglion cell (RGC) function in the DBA/2J mouse model of glaucoma. METHODS:Four groups of DBA/2J mice (3 months old, n = 7; 5 months old, n = 7; 10 months old, n = 7; and 11 months old, n = 8) were anesthetized by...

journal_title：Investigative ophthalmology & visual science

authors： Nagaraju M,Saleh M,Porciatti V

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:To evaluate the feasibility of introducing exogenous genes and phosphorothioate oligonucleotides into the anterior chamber tissues of rats and monkeys using the authors' fusogenic liposomes. METHODS:Hemagglutinating virus of Japan liposomes containing LacZ DNA-high-mobility group 1 complexes or fluorescein iso...

journal_title：Investigative ophthalmology & visual science

authors： Hangai M,Tanihara H,Honda Y,Kaneda Y

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:Subjects with macular disorders need longer time to plan and execute a reaching and grasping task compared with normally sighted controls. In everyday life it is normal to perform reaching and grasping movements while simultaneously carrying out a cognitively demanding task. We investigated whether a simultaneo...

journal_title：Investigative ophthalmology & visual science

authors： Pardhan S,Zuidhoek S

更新日期：2013-05-07 00:00:00

abstract：PURPOSE:To examine the effects of modification of immune effector cells, including macrophages, in the pathogenesis of herpes simplex virus retinitis in BALB/c mice. METHODS:Two intravitreal injections (2 microliters each) of anti-CD11b monoclonal antibody (mAb) [13 micrograms/microliters] were administered to the con...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Rodriguez A,Heiligenhaus A,Pazos B,Van Rooijen N,Foster CS

更新日期：1994-06-01 00:00:00

abstract：Purpose:To quantify and evaluate macular superficial capillaries and large vessels separately using an optical coherence tomographic angiography (OCTA)-based automatic segmentation algorithm. Methods:In this cross-sectional study, all eyes were scanned using an OCTA device with 3 × 3 mm cube centered on the fovea. Ret...

journal_title：Investigative ophthalmology & visual science

authors： Lei J,Yi E,Suo Y,Chen C,Xu X,Ding W,Abdelfattah NS,Fan X,Lu H

更新日期：2018-04-01 00:00:00