Role of Oct-6 in Schwann cell differentiation.

Abstract:

:Research into the POU transcription factor Oct-6 has been the focus of much current attention, in particular its role in Schwann cell development and differentiation. Based on published data and data presented here, we propose a model for Oct-6 function at two distinct stages of Schwann cell maturation. First, Oct-6 function is required in promyelin cells for their timely differentiation into myelinating cells. Second, Oct-6 functions during myelination and is required for the proper downregulation of its own gene. While the first function of Oct-6 is firmly established, the second function is still highly hypothetical. Experiments to establish a distinct role for Oct-6 in late Schwann cell differentiation are discussed.

journal_name

Microsc Res Tech

authors

Jaegle M,Meijer D

doi

10.1002/(SICI)1097-0029(19980601)41:5<372::AID-JEM

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

372-8

issue

5

eissn

1059-910X

issn

1097-0029

pii

10.1002/(SICI)1097-0029(19980601)41:5<372::AID-JEM

journal_volume

41

pub_type

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